1. Takahashi, S., Hall, J., Montesano, R.: Temporal cell-type-specific mRNA expression of O6-methylguanine-DNA methyltransferases in liver of rats treated with dimethylnitrosamine. Am J Pathol, 148: 497-507, 1996.

2. Yaono, M., Hasegawa, R., Kato, K., Kimura, J., Cui, L., Tada, M., Shirai, T.: Immunohistochemical demonstration of 3,2′-dimethyl-4-aminobiphenyl DNA adduct formation in various organs of Syrian golden hamsters. Cancer Lett, 98: 145-149, 1996.

3. Cui, L., Hasegawa, R., Ogawa, K., Yamada, Y., Takahashi, S., Shirai, T.: Histopathological analysis of invasive bladder carcinomas induced by 3,2′-dimethyl-4-aminobiphenyl in hamsters. Jpn J Cancer Res, 87: 37-43, 1996.

4. Ogawa, K., Imaida, K., Masui, T., Kawabe, M., Hasegawa, R., Kato, K., Ito, N., Shirai, T.: Chemically induced lung and forestomach neoplasias in transgenic mice carry mutant forms of the human c-Ha-ras transgene. Carcinogenesis, 17: 341-345, 1996.

5. Totsuka, Y., Fukutome, K., Takahashi, M., Takahashi, S., Tada, A., Sugimura, T., Wakabayashi, K.: Presence of N2-(deoxyguanosin-8-yl)-2-amino3,8-dimethylimidazo[4,5-f]quinoxaline (dG-C8-MeIQx) in human tissues. Carcinogenesis, 17: 1029-1034, 1996.

6. Chemin, I., Takahashi, S., Belloc, C., Lang, MA., Ando, K., Guidotti, LG., Chisari, FV., Wild, CP.: Differential induction of carcinogen metabolizing enzymes in a transgenic mouse model of fulminant hepatitis. Hepatology, 24: 649-656, 1996.

7. Kimura, J., Hasegawa, R., Yaono, M., Kato, T., Wakabayashi, K., Sugimura, T., Ito, N., Shirai, T.: Inhibitory potential of pregnancy and lactation on mammary carcinogenesis induced by a food-derived carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, in Sprague-Dawley rats. Cancer Lett, 101: 73-78, 1996.

8. Kato, T., Hasegawa, R., Nakae, D., Hirose, M., Yaono, M., Cui, L., Kobayashi, Y., Konishi, Y., Ito, N., Shirai, T.: Dose-dependent induction of 8-hydroxyguanine and preneoplastic foci in rat liver by a food-derived carcinogen, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline, at low dose levels., Jpn J Cancer Res, 87: 127-133, 1996.

9. Wada, S., Kato, T., Mutai, M., Ozaki, K., Yamaguchi, S., Kim, DJ., Baba-Toriyama, H., Asamoto, M., Ito, N., Tsuda, H.: Modifying influence of swine serum-induced liver fibrosis on development of preneoplastic lesions in rat liver. Jpn J Cancer Res, 87: 240-246, 1996.

10. Ito, N., Hasegawa, R., Imaida, K., Hirose, M., Shirai, T.: Medium-term liver and multi-organ carcinogenesis bioassays for carcinogens and chemopreventive agents. Exp Toxicol Pathol, 48: 113-119, 1996.

11. Tanaka, H., Hasegawa, R., Takesada, Y., Ogiso, T., Hirose, M., Shirai, T.: Effects of carbamate insecticides in a rat medium-term bioassay for hepatocarcinogens. J Toxicol Environ Health, 47: 493-498, 1996.

12. Kawabe, M., Takesada, Y., Tamano, S., Hagiwara, A., Ito, N., Shirai, T.: Subchronic toxicity study of L-isoleucine in F344 rats. J Toxicol Environ Health, 47: 499-508, 1996.

13. Wild, CP., Hasegawa, R., Barraud, L., Chutimataewin, S., Chapot, B., Ito, N., Montesano, R.: Aflatoxin-albumin adducts: A basis for comparative carcinogenesis between animals and humans. Cancer Epidemiol Biomarkers Prev, 5: 179-189, 1996.

14. Futakuchi, M., Hasegawa, R., Yamamoto, A., Cui, L., Ogiso, T., Ito, N., Shirai, T.: Low susceptibility of the spontaneously hypertensive rat (SHR) to quinoline-induction of hepatic hemangioendothelial sarcomas. Cancer Lett, 104: 37-41, 1996.

15. Sano, M., Miyata, E., Tamano, S., Hagiwara, A., Ito, N., Shirai, T.: Lack of carcinogenicity of tamarind seed polysaccharide in B6C3F1 mice. Fd Chem Toxicol, 34: 463-467, 1996.

16. Mori, T., Cui, L., Kato, K., Takahashi, S., Imaida, K., Iwasaki, S., Ito, N., Shirai, T.: Direct effects of testosterone, dihydrotestosterone and estrogen on 3,2′-dimethyl-4-aminobiphenyl-induced prostate carcinogenesis in castrated F344 rats. Jpn J Cancer Res, 87: 570-574, 1996.

17. Kimura, J., Takahashi, S., Ogiso, T., Yoshida, Y., Akagi, K., Hasegawa, R., Kurata, M., Hirose, M., Shirai, T.: Lack of chemoprevention effects of the monoterpene d-limonene in a rat multi-organ carcinogenesis model. Jpn J Cancer Res, 87: 589-594, 1996.

18. Cui, L., Hasegawa, R., Ogawa, K., Futakuchi, M., Shirai, T.: Enhancing effects of high-fat diet on 3,2′-dimethyl-4-aminobiphenyl urinary bladder carcinogenesis in the hamster. J Toxicol Pathol, 9: 169-174, 1996.

19. Takahashi, S., Imaida, K., Shirai, T., Wakabayashi, K., Nagao, M., Sugimura, T., Ito, N.: Chronic administration of the mutagenic heterocyclic amine, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine induces cardiac damage with characteristic mitochondrial changes in Fischer rats. Toxicol Pathol, 24: 273-277, 1996.

20. Hagiwara, A., Miyata, E., Tamano, S., Shibata, MA., Sugiura, S., Inoue, M., Hirose, M.: Non-carcinogenicity of 2,2′-[(4-aminophenyl)imino]bisethanol sulfate in a long-term feeding study in Fischer 344 rats. Fd Chem Toxicol, 34: 537-546, 1996.

21. Thamavit, W., Tiwawech, D., Moore, MA., Ito, N., Shirai, T.: Equivocal evidence of complete carcinogenicity after repeated infection of Syrian hamsters with Opisthorchis viverrini. Toxicol Pathol, 24: 493-497, 1996.

22. Futakuchi, M., Lijinsky, W., Hasegawa, R., Hirose, M., Ito, N., Shirai, T.: Effects of low dose mixtures of four N-nitroso compounds on hepatic foci development in the rat. Cancer Lett, 106: 263-269, 1996.

23. Hasegawa, R., Shirai, T., Ito, N.: Synergism in hepatocarcinogenesis induced by heterocyclic amines in rats. J Toxicol Pathol, 9: 241-248, 1996.

24. Tamano, S., Hagiwara, A., Tanaka, H., Kawabe, M., Sano, M., Takahashi, S., Shirai, T.: Histopathological evaluation of spontaneous hepatocellular tumors in B6C3F1 hybrid mice. J Toxicol Pathol, 9: 263-271, 1996.

25. Tamano, S., Rehm, S., Waalkes, MP., Ward, JM.: High incidence and histogenesis of seminal vesicle adenocarcinoma and lower incidence of prostate carcinomas in the Lobund-Wistar prostate cancer rat model using N-nitrosomethylurea and testosterone. Vet Pathol, 33: 557-567, 1996.

26. Imaida, K., Hagiwara, A., Yada, H., Masui, T., Hasegawa, R., Hirose, M., Sugimura, T., Ito, N., Shirai, T.: Dose-dependent induction of mammary carcinomas in female Sprague-Dawley rats with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. Jpn J Cancer Res, 87: 1116-1120, 1996.

27. Hasegawa, R., Yoshimura, I., Imaida, K., Ito, N., Shirai, T.: Analysis of synergism in hepatocarcinogenesis based on preneoplastic foci induction by 10 heterocyclic amines in the rat. Jpn J Cancer Res, 87: 1125-1133, 1996.

28. Hashimoto, Y., Asamoto, M., Futakuchi, M., Okamura, T., Kohri, K., Shirai, T.: Immunohistochemical demonstration of p53 protein nuclear accumulation in preneoplastic and neoplastic lesions of the human urinary bladder. J Urol Pathol, 5: 21-27, 1996.

29. Imaida, K., Fukushima, S.: Initiation-promotion model for assessment of carcinogenicity: Medium-term liver bioassay in rats for rapid detection of carcinogenic agents. J Toxicol Sci, 21: 483-487, 1996.

30. Tamano, S., Ward, JM., Diwan, BA., Keefer, LK., Weghorst, CM., Calvert, RJ., Henneman, JR., Ramljak, D., Rice, JM.: Histogenesis and the role of p53 and K-ras mutations in hepatocarcinogenesis by glyceryl trinitrate (nitroglycerin) in male F344 rats. Carcinogenesis, 17: 2477-2486, 1996.

31. Nakanishi, H., Takeuchi, S., Kato, K., Shimizu, S., Kobayashi, K., Tatematsu, M., Shirai, T.: Establishment and characterization of three androgen-independent, metastatic carcinoma cell lines from 3,2′-dimethyl-4-aminobiphenyl-induced prostatic tumors in F344 rats. Jpn J Cancer Res, 87: 1218-1226, 1996.

32. Kobayashi, K., Nakanishi, H., Inada, K., Fujimitsu, Y., Yamachika, T., Shirai, T., Tatematsu, M.: Growth characteristics in the initial stage of micrometastasis formation by bacterial lacZ gene-tagged rat prostatic adenocarcinoma cells. Jpn J Cancer Res, 87: 1227-1234, 1996.

33. Hagiwara, A., Matsuda, T., Tamano, S., Kitano, M., Imaoka, S., Funae, Y., Takesada, Y., Shirai, T., Fukushima, S.: Dose-related increases in quantitative values for altered hepatocytic foci and cytochrome P-450 levels in the livers of rats exposed to phenobarbital in a medium-term bioassay. Cancer Lett, 110: 155-162, 1996.

34. Ito, N., Hagiwara, A., Tamano, S., Futakuchi, M., Imaida, K., Shirai, T.: Effects of pesticide mixtures at the acceptable daily intake levels on rat carcinogenesis. Fd Chem Toxicol, 34: 1091-1096, 1996.

35. Cabral, R., Hoshiya, T., Hakoi, K., Hasegawa, R., Ito, N.: Medium-term bioassay for the hepatocarcinogenicity of hexachlorobenzene., Cancer Lett, 100: 223-226, 1996.

36. Hasegawa, R., Kato, T., Hirose, M., Takahashi, S., Shirai, T., Ito, N.: Enhancement of hepatocarcinogenesis by combined administration of food-derived heterocyclic amines at low doses in the rat. Fd Chem Toxicol, 34: 1097-1101, 1996.

37. Sano, M., Tamano, S., Hagiwara, A., Kawabe, M., Nakamura, M., Imaida, K., Hirose, M.: 13-week oral toxicity study of pigments extracted from the purple sweet potato in F344/DuCrj rats. Jpn J Fd Chem, 3: 99-105, 1996.

38. Hagiwara, A., Kokubo, Y., Takesada, Y., Tanaka, H., Tamano, S., Hirose, M., Shirai, T., Ito, N.: Inhibitory effects of phenolic compounds on development of naturally occurring preneoplastic hepatocytic foci in long-term feeding studies using male F344 rats. Teratog Carcinog Mutagen, 16: 317-325, 1996.

39. Sano, M., Tamano, S., Hagiwara, A., Shirai, T., Hasegawa, R., Imaida, K., Ito, N.: Dose-response study of di(2-ethylhexyl)phthalate associated rat hepatocarcinogenesis. In: Tahara, E., Sugimachi, K., Oohara, T. (eds.), Recent Advances in Gastroenterological Carcinogenesis I. pp501-511. Monduzzi Editore S.p.A., Bologna, 1996.

40. Hagiwara, A., Tamano, S., Hirose, M.: Changes in the heart. In: U. Mohr, U. et al. (eds.), Pathobiology of the Aging Mouse. pp361-371, International Life Sciences Institute Press, Washington, DC., 1996.

41. Ito, N., Hirose, M., Futakuchi, M., Tamano, S., Shirai, T.: Chemoprevention of heterocyclic amine-induced carcinogenesis by exogenous agents: Stage dependent paradoxical effects. In: Conney, AH. Et al. (eds.), Fundamentals of Cancer Prevention. pp48-51. Princess Takamatsu Cancer Research Fund, Tokyo, 1996.

1. Kato, T., Ogiso, T., Kato, K., Sano, M., Hasegawa, R., Shirai, T., Ito, N.: Lack of promoting activity of four pesticides on induction of preneoplastic liver cell foci in rats. Teratog Carcinog Mutagen, 15: 251-257, 1995.

2. Hasegawa, R., Ogiso, T., Imaida, K., Shirai, T., Ito, N.: Analysis of the potential carcinogenicity of coffee and its related compounds in a medium-term liver bioassay of rats. Fd Chem Toxicol, 33: 15-20, 1995.

3. Shibata, MA., Sano, M., Hagiwara, A., Hasegawa, R., Shirai, T.: Modification by analgesics of lesion development in the urinary tract and various other organs of rats pretreated with dihydroxy-di-N- propylnitrosamine and uracil. Jpn J Cancer Res, 86: 160-167, 1995.

4. Tanaka, H., Hirose, M., Hagiwara, A., Imaida, K., Shirai, T., Ito, N.: Rat strain differences in catechol carcinogenicity to the stomach. Fd Chem Toxicol, 33: 93-98, 1995.

5. Ito, N., Hasegawa, R., Imaida, K., Kurata, Y., Hagiwara, A., Shirai, T.: Effect of ingestion of 20 pesticides in combination at acceptable daily intake levels on rat liver carcinogenesis. Fd Chem Toxicol, 33: 159-163, 1995.

6. Ito, N., Hagiwara, A., Tamano, S., Hasegawa, R., Imaida, K., Hirose, M., Shirai, T.: Lack of carcinogenicity of pesticide mixtures administered in the diet at acceptable daily intake (ADI) dose levels in rats. Toxicol Lett, 82-82: 513-520, 1995.

7. Hirose, M., Akagi, K., Hasegawa, R., Yaono, M., Satoh, T., Hara, Y., Wakabayashi, K., Ito, N.: Chemoprevention of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced mammary gland carcinogenesis by antioxidants in F344 female rats. Carcinogenesis, 16: 217-221, 1995.

8. Shirai, T., Shibata, MA., Takahashi, S., Tagawa, Y., Imaida, K., Hirose, M.: Differences in cell proliferation and apoptosis between reversible and irreversible mucosal lesions associated with uracil-induced urolithiasis in N-butyl-N-(4-hydroxybutyl)nitrosamine-pretreated rats. Carcinogenesis, 16: 501-505, 1995.

9. Tsukamoto, S., Akaza, H., Imada, S., Koiso, K., Shirai, T., Ideyama, Y., Kudo, M.: Chemoprevention of rat prostate carcinogenesis by use of finasteride or casodex. J Natl Cancer Inst, 87: 842-843, 1995.

10. Shibata, MA., Tanaka, H., Kawabe, M., Sano, M., Hagiwara, A., Shirai, T.: Lack of carcinogenicity of monosodium L-glutamate in Fischer 344 rats. Fd Chem Toxicol, 33: 383-391, 1995.

11. Iwata, H., Otoshi, T., Takada, N., Murai, T., Tamano, S., Watanabe, T., Katsura, Y., Fukushima, S.: Validation of silver-stained nucleolar organizer regions for evaluation of invasive character of urinary bladder carcinoma in rats and mice. Urol Res, 23: 27-32, 1995.

12. Tamano, S., Jakubczak, J., Takagi, H., Merlino, G., Ward, JM.: Increased susceptibility to N-nitrosomethylurea gastric carcinogenesis in transforming growth factor alpha transgenic mice with gastric hyperplasia. Jpn J Cancer Res, 86: 435-443, 1995.

13. Masui, T., Shirai, T., Imaida, K., Hirose, M., Futakuchi, M., Tatematsu, M., Ito, N.: Ki-ras mutations with frequent normal allele loss versus absence of p53 mutations in rat prostate and seminal vesicle carcinomas induced with 3,2′-dimethyl-4-aminobiphenyl. Mol Carcinog, 13: 21-26, 1995.

14. Liang, YY., Esteve, A., Martel-Planche, G., Takahashi, S., Lu, SH., Montesano, R., Hollstein, M.: p53 mutations in esophageal tumors from high-incidence areas of China. Int J Cancer, 61: 611-614, 1995.

15. Shirai, T., Tamano, S., Sano, M., Imaida, K., Hagiwara, A., Futakuchi, M., Takahashi, S., Hirose, M.: Site-specific effects of testosterone propionate on the prostate of rat pretreated with 3,2′-dimethyl-4-aminobiphenyl: Dose-dependent induction of invasive carcinomas. Jpn J Cancer Res, 86: 645-648, 1995.

16. Tiwawech, D., Shibata, MA., Hasegawa, R., Hagiwara, A., Shirai, T., Thamavit, W., Fukushima, S.: Weak synergistic effect of uracil and N-butyl-N-(4-hydroxybutyl)nitrosamine on urine composition, epithelial morphology, and DNA synthesis in the urinary bladder of Syrian golden hamster. J Toxicol Pathol, 8: 129-137, 1995.

17. Kataoka, H., Katsumi, K., Kutsuna, T., Suzumura, H., Kojima, S., Takeshima, A., Ban, Y., Itoh, T., Kishimoto, A., Kato, M., Iwata, F., Itoh, M., Takeuchi, T., Ogawa, K., Shirai, T.: A case of familial adenomatous polyposis associated with colon cancer, ureteral cancer and two early gastric cancers. Dig Endosc, 7: 278-284, 1995.

18. Akagi, K., Hirose, M., Hoshiya, T., Mizoguchi, Y., Ito, N., Shirai, T.: Modulating effects of ellagic acid, vanillin and quercetin in a rat medium term multi-organ carcinogenesis model. Cancer Lett. 94: 113-121, 1995.

19. Yaono, M., Hasegawa, R., Mizoguchi, Y., Futakuchi, M., Nakamura, T., Ito, N., Shirai, T.: Hepatocyte growth factor enhancement of preneoplastic hepatic foci development in rats treated with diethylnitrosamine and N-ethyl-N-hydroxyethylnitrosamine. Jpn J Cancer Res, 86: 718-723, 1995.

20. Shirai, T., Fradet, Y., Huland, H., Bollack, C., Droller, M., Janknegt, R., Jones, P., Kagawa, S.: The etiology of bladder cancer — Are there any new clues or predictors of behavior? Int J Urol, 2 Suppl 2: 64-75, 1995.

21. Hirose, M., Iwata, S., Ito, E., Nihro, Y., Takahashi, S., Mizoguchi, Y., Miki, T., Satoh, T., Ito, N., Shirai, T.: Strong anti-mutagenic activity of the novel lipophilic antioxidant 1-O-hexyl-2,3,5-trimethylhydroquinone against heterocyclic amine-induced mutagenesis in the Ames assay and its effect on metabolic activation of 2-amino-6-methyldipyrido [1,2-a:3′,2′-d] imidazole (Glu-P-1). Carcinogenesis, 16: 2227-2232, 1995.

22. Hasegawa, R., Hirose, M., Kato, T., Hagiwara, A., Boonyaphiphat, P., Nagao, M., Ito, N., Shirai, T.: Inhibitory effect of chlorophyllin on PhIP-induced mammary carcinogenesis in female F344 rats. Carcinogenesis, 16: 2243-2246, 1995.

23. Ogawa, K., Shichino, Y., Tatematsu, M., Furihata, C., Asamoto, M., Nagase, S., Shirai, T., Ito, N.: Increasing development of pepsinogen-altered pyloric glands and adenocarcinoma in glandular stomach of analbuminemic rats. Cancer Lett, 96: 219-224, 1995.

24. Hasegawa, R., Kimura, J., Yaono, M., Takahashi, S., Kato, T., Futakuchi, M., Fukutake, M., Fukutome, K., Wakabayashi, K., Sugimura, T., Ito, N., Shirai, T.: Increased risk of mammary carcinoma development following transplacental and trans-breast milk exposure to a food-derived carcinogen, 2-amino-1-methyl-6- phenylimidazo[4,5-b]pyridine (PhIP), in Sprague-Dawley rats. Cancer Res, 55: 4333-4338, 1995.

25. Hirose, M., Takahashi, S., Shirai, T.: Characteristics of forestomach carcinogenesis by non-genotoxic phenolic compounds. J Toxicol Pathol, 8: 277-284, 1995.

26. Shirai, T., Takahashi, S., Mori, T., Imaida, K., Futakuchi, M., Ye, SH., Prins, GS., Ito, N.: Immunohistochemically demonstrated androgen receptor expression in the rat prostate during carcinogenesis induced by 3,2’-dimethyl-4-aminobiphenyl with or without testosterone. Urol Oncol, 1: 263-268, 1995.

27. Shibata, M., Hasegawa, R., Imaida, K., Hagiwara, A., Ogawa, K., Hirose, M., Ito, N., Shirai, T.: Chemoprevention by dehydroepiandrosterone and indomethacin in a rat multiorgan carcinogenesis model. Cancer Res, 55: 4870-4874, 1995.

28. Ogasawara, H., Imaida, K., Ishiwata, H., Toyoda, K., Kawanishi, T., Uneyama, C., Hayashi, S., Takahashi, M., Hayashi, Y.: Urinary bladder carcinogenesis induced by melamine in F344 male rats: correlation between carcinogenicity and urolith formation. Carcinogenesis, 16: 2773-2777, 1995.

29. Hirose, M., Hasegawa, R., Kimura, J., Akagi, K., Yoshida, Y., Tanaka, H., Miki, T., Satoh, T., Wakabayashi, K., Ito, N., Shirai, T.: Inhibitory effects of 1-O-hexyl-2,3,5-trimethylhydroquinone (HTHQ), green tea catechins and other antioxidants on 2-amino-6-methyldipyrido[1,2-a:3′,2′-d]imidazole (Glu-P-1)-induced rat hepatocarcinogenesis and dose-dependent inhibition by HTHQ of lesion induction by Glu-P-1 or 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline(MeIQx). Carcinogenesis, 16: 3049-3055, 1995.

30. Ito, N., Hasegawa, R., Imaida, K., Hirose, M., Asamoto, M., Shirai, T.: Concepts in multistage carcinogenesis. Crit Rev Oncol Hematol, 21: 105-133, 1995.

31. Shirai, T., Tamano, S., Sano, M., Masui, T., Hasegawa, R., Ito, N.: Carcinogenicity of 2-amino-1-methyl- 6-phenylimidazo[4,5-b]pyridine (PhIP) in rats: dose-response studies. In: Adamson, RH. et al. (eds.), Heterocyclic amines in cooked foods: Possible human carcinogens. pp232-239, Princeton Scientific Publishing Co. Inc., New Jersey, 1995.

32. Ito, N., Hasegawa, R., Asakawa, E., Hirose, M., Imaida, K., Hagiwara, A.: Enhancement of rat liver cell foci development by combined treatment with heterocyclic amines at low doses. In: In: Adamson, RH. et al. (eds.), Heterocyclic amines in cooked foods: Possible human carcinogens. pp251-258. Princeton Scientific Publishing Co. Inc., New Jersey, 1995.

1. Asakawa, E., Hirose, M., Hagiwara, A., Takahashi, S., Ito, N.: Carcinogenicity of 4-methoxyphenol and 4-methylcatechol in F344 rats. Int J Cancer, 56: 146-152, 1994.

2. Yoshida, Y., Hirose, M., Takaba, K., Kimura, J., Ito, N.: Induction and promotion of forestomach tumors by sodium nitrite in combination with ascorbic acid or sodium ascorbate in rats with or without N-methy1-N’-nitro-N-nitrosoguanidine pre-treatment. Int J Cancer, 56: 124-128, 1994.

3. Kawabe, M., Takaba, K., Yoshida, Y., Hirose, M.: Effects of combined treatment with phenolic compounds and sodium nitrite on two-stage carcinogenesis and cell proliferation in the rat stomach. Jpn J Cancer Res, 85: 17-25, 1994.

4. Hasegawa, R., Miyata, E., Futakuchi, M., Hagiwara, A., Nagao, M., Sugimura, T., Ito, N.: Synergistic enhancement of hepatic foci development by combined treatment of rats with 10 heterocyclic amines at low doses. Carcinogenesis, 15: 1037-1041,1994.

5. Shioya, S., Nagami-Oguihara, R., Oguihara, S., Kimura, T., Imaida, K., Fukushima, S.: Roles of bladder distention, urinary pH and urinary sodium ion concentration in cell proliferation of urinary bladder epithelium in rats ingesting sodium salts. Fd Chem Toxicol, 32: 165-171, 1994.

6. Thamavit, W., Pairojkul, C., Tiwawech, D., Shirai, T., Ito, N.: Strong promoting effect of Opistohorchis viverrini infection on dimethylnitrosamine-initiated hamster liver. Cancer Lett, 78: 121-125, 1994.

7. Puapairoj, P., Cui, L., Ogawa, K., Akagi, K., Hasegawa, R., Ito, N.: Effect of ethanol on papaquat toxicity in F344 rats. Fd Chem Toxicol, 32: 379-386, 1994.

8. de Camargo, JLV., de Oliveira, MLCS., Rocha, NS., Ito, N.: A deteccao de substancias cancerigenas em estudos experimentais. Rev Bras Cancerol, 40: 21-30, 1994.

9. Hirose, M., Satoh, T., Ito, N.: A strong new antioxidant with potent chemopreventive activity against heterocyclic amine-induced mutagenesis and carcinogenesis. HTHQ. Drug News Perspect, 7: 167-170, 1994.

10. Takaba, K., Hirose, M., Ogawa, K., Hakoi, K., Fukushima, S.: Modification of N-butyl-N -(4-hydroxybutyl)nitrosamine-initiated urinary bladder carcinogenesis in rats by phytic acid and its salts. Fd Chem Toxicol, 32: 499-503, 1994.

11. Ito, N., Hasegawa, R., Imaida, K., Takahashi, S., Shirai, T.: Medium-term rat liver bioassay for rapid detection of carcinogens and modifiers of hepatocarcinogenesis. Drug Metab Rev, 26: 431-442, 1994.

12. Tanaka, H., Hagiwara, A., Kurata, Y., Ogiso, T., Futakuchi, M., Ito, N.: Thirteen-week oral toxicity study of magnesium chloride in B6C3F1 mice. Toxicol Lett, 73: 25-32, 1994.

13. Cui, L., Hasegawa, R., Zajdela, F., Puapairoj, P., Shirai, T., Ito, N.: Lack of promoting activity of 7-methoxy-2-nitro-naphtho-[2,1-b] furan (R7000) in a medium-term rat liver bioassay. Cancer Lett, 76: 161-166, 1994.

14. Nagao, M., Ushijima, T., Wakabayashi, K., Ochiai, M., Kushida, H., Sugimura, T., Hasegawa, R., Shirai, T., Ito, N.: Dietary carcinogens and mammary carcinogenesis. Induction of rat mammary carcinomas by administration of heterocyclic amines in cooked foods. Cancer, 74: 1063-1069, 1994.

15. Shibata, MA., Shirai, T., Takahashi, S., Takesada, Y., Iwata, H., Okumura, M., Fukushima, S.: Progressive growth of rat bladder carcinomas after exposure to prolonged uracil-induced urolithiasis. Teratog Carcinog Mutagen, 14: 157-168, 1994.

16. Thamavit, W., Pairojkul, C., Tiwawech, D., Shirai, T., Ito, N.: Lack of promoting effect of proline on bile duct cancer development in dimethylnitrosamine-initiated hamster livers. Teratog Carcinog Mutagen, 14: 169-174, 1994.

17. Hirose, M., Hoshiya, T., Akagi, K., Futakuchi, M., Ito, N.: Inhibition of mammary gland carcinogenesis by green tea catechins and other naturally occurring antioxidants in female Sprague-Dawley rats pretreated with 7,12-dimethylbenz[a]anthracene. Cancer Lett, 83: 149-156, 1994.

18. Hasegawa, R., Yoshida, T., Mizoguchi, Y., Futakuchi, M., Kim, DJ., Cui, L., Ito, N.: Phenotypic alteration of hepatocellular foci in rats treated with clofibrate and phenobarbital. Cancer Lett, 83: 89-95, 1994.

19. Shirai, T., Sano, M., Imaida, K., Takahashi, S., Mori, T., Ito, N.: Duration dependent induction of invasive prostatic carcinomas with pharmacological dose of testosterone propionate in rats pretreated with 3,2′-dimethyl-4-aminobiphenyl and development of androgen-independent carcinomas after castration. Cancer Lett, 83: 111-116, 1994.

20. Yuasa, H., Hirano, K., Kodama, H., Nakanishi, H., Imai, T., Tsuda, H., Imaida, K., Tatematsu, M.: Immunohistochemical demonstration of intestinal-type alkaline phosphatase in stomach tumors induced by N-methyl-N’-nitro-N-nitrosoguanidine in rats. Jpn J Cancer Res, 85: 897-903, 1994.

21. Asamoto, M., Takahashi, S., Imaida, K., Shirai, T., Fukushima, S.: Increased gap junctional intercellular communication capacity and connexin 43 and 26 expression in rat bladder carcinogenesis. Carcinogenesis, 15: 2163-2166, 1994.

22. Shirai, T., Tada, M., Kojima, M., Hasegawa, R., Masui, T., Ito, N.: DNA adducts in target and nontarget tissues of 3,2′-dimethyl-4-aminobiphenyl in rats. Environ Health Perspect, 102: 167-172, 1994.

23. Hasegawa, R., Tanaka, H., Tamano, S., Shirai, T., Nagao, M., Sugimura, T., Ito, N.: Synergistic enhancement of small and large intestinal carcinogenesis by combined treatment of rats with five heterocyclic amines in a medium-term multi-organ bioassay. Carcinogenesis, 15: 2567-2573, 1994.

24. Tamano, S., Hasegawa, R., Hagiwara, A., Nagao, M., Sugimura, T., Ito, N.: Carcinogenicity of a mutagenic compound from food, 2-amino-3-methyl-9H-pyrido[2,3-b] indole (MeAαC), in male F344 rats. Carcinogenesis, 15: 2009-2015, 1994.

25. Hagiwara, A., Tanaka, H., Tamano, S., Imaida, K., Takahashi, S., Fukushima, S.: Inhibiting effects of diethylmaleate or NH4Cl on NaHCO3, but not butylated hydroxyanisole, promotion of urinary bladder carcinogenesis in male F344 rats initiated with N-butyl-N-(4-hydroxybutyl)nitrosamine. J Toxicol Sci, 19: 189-195, 1994.

26. Itoh, M., Pairojkul, C., Thamawit, W., Sithithaworn, P., Tiwawech, D., Uttaravicien, T., Shirai, T., Ito, N.: Association of antibodies to Opisthorchis viverrini with hepatobiliary disease in northeastern Thailand. Am J Trop Med Hyg, 51: 424-429,1994.

27. Masui, T., Don, I., Takada, N., Ogawa, K., Shirai, T., Fukushima, S.: p53 mutations in early neoplastic lesions of the urinary bladder in rats treated with N-butyl-N-(4-hydroxybutyl)nitrosamine. Carcinogenesis, 15: 2379-2381, 1994.

28. Ushijima, T., Kakiuchi, H., Makino, H., Hasegawa, R., Ishizaka, Y., Hirai, H., Yazaki, Y., Ito, N., Sugimura, T., Nagao, M.: Infrequent mutation of Ha-ras and p53 in rat mammary carcinomas induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. Mol Carcinog, 10: 38-44, 1994.

29. Shibata, MA., Shirai, T., Ogawa, K., Takahashi, S., Wild, CP., Montesano, R., Tsuda, H., Ito, N.: DNA methylation adduct formation and H-ras gene mutations in progression of N-butyl-N-(4-hydroxybutyl)- nitrosamine-induced bladder tumors caused by a single exposure to N-methyl-N-nitrosourea. Carcinogenesis, 15: 2965-2968, 1994.

30. Shirai, T., Imaida, K., Masui, T., Iwasaki, S., Mori, T., Kato, T., Ito, N.: Effects of testosterone, dihydrotestosterone and estrogen on 3,2-dimethyl-4-aminobiphenyl-induced rat prostate carcinogenesis. Int J Cancer, 57: 224-228, 1994.

31. Takahashi, S., Asamoto, M., Nakazawa, T., Kosaki, T., Katsumi, K., Shirai, T.: Robb-Smith type malignant histiocytosis associated with a mediastinal germ cell tumor. Jpn J Clin Oncol, 24: 327-330, 1994.

32. Takahashi, S., Hasegawa, R., Mutai, M., Ito, N., Ochiai, M., Nagao, M., Sugimura, T.: Additive action of five heterocyclic amines in terms of induction of GST-P positive　single cells and foci in rat liver. Correlation with DNA adduct formation. J Toxicol Pathol, 7: 423-428, 1994.

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37. Hasegawa, R., Takayama, S., Ito, N.: Effects of low level exposure to multiple carcinogens in combination. Toxicology of Chemical Mixtures, 15: pp361-382, Academic Press, 1994.

38. Ito, N., Imaida, K.: Identification of chemopreventive agents and their evaluation. In: Rao, RS et al. (eds.) XVI Proceedings of the International Cancer Congress, pp159-164, Monduzzi Editore S.p.A., Bologna, 1994.

1. Shirai, T., Imaida, K., Iwasaki, S., Mori, T., Tada, M., Ito, N.: Sequential observation of rat prostate lesion development induced by 3,2′-dimethyl-4-aminobiphenyl and testosterone. Jpn J Cancer Res, 84: 20-25, 1993.

2. Hirose, M., Tanaka, H., Takahashi, S., Futakuchi, M., Fukushima, S., Ito, N.: Effects of sodium nitrite and catechol, 3-methoxycatechol, or butylated hydroxyanisole in combination in a rat multiorgan carcinogenesis model. Cancer Res, 53: 32-37, 1993.

3. Thamavit, W., Moore, MA., Sirisinha, S., Shirai, T., Ito, N.: Time-dependent modulation of liver lesion development in Opisthorchis-infected Syrian hamster by an antihelminthic drug, praziquantel. Jpn J Cancer Res, 84: 135-138, 1993.

4. Shibata, MA., Hirose, M., Kagawa, M., Boonyaphiphat, P., Ito, N.: Enhancing effect of concomitant L-ascorbic acid administration on BHA-induced forestomach carcinogenesis in rats. Carcinogenesis, 14: 275-280, 1993.

5. Mizoguchi, M., Naito, H., Kurata, Y., Shibata, MA., Tsuda, H., Wild, CP., Montesano, R., Fukushima, S.: Influence of aging on multi-organ carcinogenesis in rats induced by N-methyl-N-nitrosourea. Jpn J Cancer Res, 84: 139-146, 1993.

6. Tamano, S., Kawabe, F., Sano, M., Masui, T., Ito, N.: Subchronic oral toxicity study of captafol in B6C3F1 mice. J Toxicol Environ Health, 38: 69-75, 1993.

7. Hagiwara, A., Tanaka, H., Imaida, K., Tamano, S., Fukushima, S., Ito, N.: Correlation between medium-term multi-organ carcinogenesis bioassay data and long-term observation results in rats. Jpn J Cancer Res, 84: 237-245, 1993.

8. Hirose, M., Fukushima, S., Tanaka, H., Asakawa, E., Takahashi, S., Ito, N.: Carcinogenicity of catechol in F344 rats and B6C3F1 mice. Carcinogenesis, 14: 525-529, 1993.

9. Shibata, MA., Shirai, T., Asakawa, E., Hirose, M., Fukushima, S.: Inhibition by dehydroepiandrosterone of butylated hydroxyanisole (BHA) promotion of rat-bladder carcinogenesis and enhancement of BHA-induced forestomach hyperplasia. Int J Cancer, 53: 819-823, 1993.

10. Hirose, M., Akagi, K., Hasegawa, R., Satoh, T., Nihro, Y., Miki, T., Sugimura, T., Ito, N.: Strong inhibition of 2-amino-6-methyldipyrido[1,2-a: 3′, 2′-d]imidazole-induced mutagenesis and hepatocarcinogenesis by 1-O-hexyl-2,3,5-trimethylhydroquinone. Jpn J Cancer Res, 84: 481-484, 1993.

11. Tamano, S., Tanaka, H., Kawabe, M., Asakawa, E., Sano, M., Shioya, S., Shirai, T., Fukushima, S.: No enhancing effects of calcium / magnesium salts of L-glutamate and L-ascorbate on tumor development in a rat medium-term multiorgan carcinogenesis bioassay. J Toxicol Environ Health, 39: 43-58, 1993.

12. Toyoda, K., Imaida, K., Shirai, T., Imazawa, T., Takahashi, M.: Relationship between bisacodyl-induced urolithiasis and rat urinary bladder tumorigenesis. J Toxicol Environ Health, 39: 59-78, 1993.

13. Hasegawa, R., Cabral, R., Hoshiya, T., Hakoi, K., Ogiso, T., Boonyaphiphat, P., Shirai, T., Ito, N.: Carcinogenic potential of some pesticides in a medium-term multi-organ bioassay in rats. Int J Cancer, 54: 489-493, 1993.

14. Suzuki, S., Tamura, Y., Takazawa, Y., Mashimo, T., Imai, K., Yuasa, H., Yamanaka, H., Shirai, T.: Ultrasonic diagnosis of 3,2′-dimethyl-4-aminobiphenyl induced tumors in the urogenital organs of F344 rats. Prostate, 22: 235-241, 1993.

15. Tatematsu, M., Ichinose, M., Tsukada, S., Kakei, N., Takahashi, S., Ogawa, K., Hirose, M., Furihata, C., Miki, K., Kurokawa, K., Ito, N.: DNA methylation of the pepsinogen 1 gene during rat glandular stomach carcinogenesis induced by N-methyl-N’-nitro-N-nitrosoguanidine or catechol. Carcinogenesis, 14: 1415-1419, 1993.

16. Shibata, MA., Hirose, M., Masuda, A., Kato, T., Mutai, M., Ito, N.: Modification of BHA forestomach carcinogenesis in rats: inhibition by diethylmaleate or indomethacin and enhancement by a retinoid. Carcinogenesis, 14: 1265-1269, 1993.

17. Tamano, S., Asakawa, E., Boonyaphiphat, P., Masui, T., Fukushima, S.: Lack of promotion of N-butyl-N-(4-hydroxybutyl)nitrosamine-initiated urinary bladder carcinogenesis in mice by rat cancer promoters. Teratog Carcinog Mutagen, 13: 89-96, 1993.

18. Kurata, Y., Diwan, BA., Uno, H., Rice, JM., Ward. JM.: Pathology of preneoplastic and neoplastic renal tubular lesions induced in F-344 rats by sodium barbital, a nongenotoxic renal carcinogen and nephrotoxin. Toxicol Pathol, 21: 35-45, 1993.

19. Shrai, T.: Etiology of bladder cancer. Semin Urol, 11: 113-126, 1993.

20. Shibata, MA., Sano, M., Shirai, T., Imaida, K., Fukushima, S.: Epithelial hyperplasia in the renal papilla and pelvis but not the urinary bladder of male F344 rats associated with dietary sodium phosphates after uracil exposure. Toxicol Appl Pharmacol, 121: 303-312, 1993.

21. Okazaki, S., Hoshiya, T., Takahashi, S., Futakuchi, M., Saito, K., Hirose, M.: Modification of hepato- and renal carcinogenesis by catechol and its isomers in rats pretreated with N-ethyl-N-hydroxyethylnitrosamine. Teratog Carcinog Mutagen, 13: 127-137, 1993

22. Hirose, M., Hoshiya, T., Akagi, K., Takahashi, S., Hara, Y., Ito, N.: Effects of green tea catechins in a rat multi-organ carcinogenesis model. Carcinogenesis, 14: 1549-1553, 1993.

23. Tatematsu, M., Iwata, H., Ichinose, M., Kakei, N., Tsukada, S., Miki, K., Imai, S., Imaida, K.: Markers of surface mucous cell type human gastric cancer cells: Galactose oxidase-Schiff reactive mucins, monoclonal antibody SH-9 reactive mucins and cathepsin E. Acta Pathol Jpn, 43: 500-506, 1993.

24. Kawabe, M., Tamano, S., Shibata, MA., Hirose, M., Fukushima, S., Ito, N.: Subchornic toxicity study of methyl hesperidin in mice. Toxicol Lett, 69: 37-44, 1993.

25. Hoshiya, T., Hasegawa, R., Hakoi, K., Cui, L., Ogiso, T., Cabral, R., Ito, N.: Enhancement by non-mutagenic pesticides of GST-P positive hepatic foci development initiated with diethylnitrosamine in the rat. Cancer Lett, 72: 59-64, 1993.

26. Hagiwara, A., Ogiso, T., Shibata, MA., Shirai, T.: Spontaneous pleomorphic adenoma in the submandibular salivary gland of an aged male (C57BL/6N×C3H/HeN) F1 (B6C3F1) mouse. Vet Pathol, 30: 394-396, 1993.

27. Tiwawech, D., Siripong, P., Kupradinun, P., Thamavit, W., Shirai, T., Hagiwara, A., Ito, N.: Inhibition of diethylnitrosamine (DEN)-induced hepatic foci by pre and post treatment with Acanthus ebracteatus Vahl. in rats. Thai Cancer J, 19: 7-13, 1993.

28. Shirai, T., Iwasaki, S., Masui, T., Mori, T., Kato, T., Ito, N.: Enhancing effect of cadmium on rat ventral prostate carcinogenesis induced by 3,2′-dimethyl-4-aminobiphenyl. Jpn J Cancer Res, 84: 1023-1030, 1993.

29. Kagawa, M., Hakoi, K., Yamamoto, A., Futakuchi, M., Hirose, M.: Comparison of reversibility of rat forestomach lesions induced by genotoxic and non-genotoxic carcinogens. Jpn J Cancer Res, 84: 1120-1129, 1993.

30. Takahashi, S., Shirai, T., Ogawa, K., Imaida, K., Yamazaki, C., Ito, A., Masuko, K., Ito, N.: Renal cell adenomas and carcinomas in hemodialysis patients: Relationship between hemodialysis period and development of lesions. Acta Pathol Jpn, 43: 674-682, 1993.

31. Hirose, M., Yada, H., Hakoi, K., Takahashi, S., Ito, N.: Modification of carcinogenesis by α-tocopherol, t-butylhydroquinone, propyl gallate and butylated hydroxytoluene in a rat multi-organ carcinogenesis model. Carcinogenesis, 14: 2359-2364, 1993.

32. Thamavit, W., Pairojkul, C., Tiwawech, D., Itoh, M., Shirai, T., Ito, N.: Promotion of cholangiocarcinogenesis in the hamster liver by bile duct ligation after dimethylnitrosamine initiation. Carcinogenesis, 14: 2415-2417, 1993.

33. Yamaguchi, S., Hakoi, K., Ozaki, K., Kato, T., Tiwawech, D., Nagao, S., Takahashi, H., Matsumoto, K., Tsuda, H.: Number of simultaneously expressed enzyme alterations correlates with progression of N-ethyl-N-hydroxyethylnitrosamine-induced hepatocarcinogenesis in rat. Jpn J Cancer Res, 84: 1237-1244, 1993.

34. Ozaki, K., Kato, T., Asamoto, M., Wild, CP., Montesano, R., Nagao, S., Iwase, T., Matsumoto, K., Tsuda, H.: Decreased dimethylnitrosamine-induced O6-and N7-methy1deoxyguanosine levels correlate with development and progression of lesions in rat hepatocarcinogenesis. Jpn J Cancer Res, 84: 1245-1251, 1993.

35. Kato, T., Imaida, K., Ogawa, K., Hasegawa, R., Shirai, T., Tatematsu, M.: Three-dimensional analysis of glutathione S-transferase placental form-positive lesion development in early stages of rat hepatocarcinogenesis. Jpn J Cancer Res, 84: 1252-1257, 1993.

36. de Camargo, JLV., Tsuda, H., Asamoto, M., Tagawa, Y., Wada, S., Nagase, S., Ito, N.: Modifying effects of chemicals on the development of liver preneoplastic placental glutathione S-transferase positive foci in analbuminemic and Sprague-Dawley rats. Toxicol Pathol, 21: 409-416, 1993.

37. Shibata, MA., Hasegawa, R., Shirai, T., Takesada, Y., Fukushima, S.: Chemoprevention by indomethacin of tumor promotion in a rat urinary bladder carcinogenesis model. Int J Cancer, 55: 1011-1017, 1993.

38. Hagiwara, A., Tiwawech, D., Imaida, K., Tamano, S., Shibata, MA., Fukushima, S., Ito, N.: Modifying influence of prior treatment with toxic agents on induction of preneoplastic and neoplastic lesions in a medium-term multi-organ carcinogenesis bioassay. Teratog Carcinog Mutagen, 13: 277-287, 1993.

39. Yoshida, Y., Tatematsu, M., Takaba, K., Iwasaki, S., Ito, N.: Target organ specificity of cell proliferation induced by various carcinogenesis. Toxicol Pathol, 21: 436-442, 1993.

40. Hasegawa, R., Sano, M., Tamano, S., Imaida, K., Shirai, T., Nagao, M., Sugimura, T., Ito, N.: Dose-dependence of 2-amino-1-methyl-6-phenylimidazo[4,5-b]-pyridine (PhIP) carcinogenicity in rats. Carcinogenesis, 14: 2553-2557, 1993.

41. Shibata, MA., Kurata, Y., Hagiwara, A., Shirai, T., Fukushima, S: Lack of tumorigenic effects on rat renal pelvic transitional epithelium of lifespan exposure to low doses of a bladder carcinogen. J Toxicol Pathol, 6: 47-53, 1993.

42. Ito, N., Hirose, M., Takahashi, S.: Cell proliferation and forestomach carcinogenesis. Environ Health Perspect, 101: 107-110, 1993.

43. Ito, N., Hasegawa, R., Cabral, JRP.: Medium-term in vivo bioassays for carcinogenicity of pesticides. In: Roe, RM. & Kuhr, RJ. (eds.) Rev Pestic Toxicol, 2, pp115-132: Toxicology Communications Inc., Raleigh, NC, 1993.

44. Hirose, M., Shirai, T., Takahashi, S., Ogawa, K., Ito, N.: Organ-specific modification of carcinogenesis by antioxidants in rats. In: Bronzetti, G., et al.(eds.) Antimutagenesis and Anticarcinogenesis Mechanisms III, pp 181-188. Plenum Press, New York, 1993.

1. Thamavit, W., Boonpucknavig, V., Boonpucknavig, S., Moore, MA., Ito, N.: Secondary enhancing effect of Opisthirchis viverrini infection on development of hepatocellular nodules in Syrain golden hamsters initiated with diethylnitrosamine. Thai J Toxicol, 8: 35-40, 1992.

2. Shibata, MA., Fukushima, S., Asakawa, E., Hirose, M., Ito, N.: The modifying effects of indomethacin or ascorbic acid on cell proliferation induced by different types of bladder tumor promoters in rat urinary bladder and forestomach mucosal epithelium. Jpn J Cancer Res, 83: 31-39, 1992.

3. Kojima, M., Morita, T., Shirai, T., Degawa, M., Tada, M.: Immunological detection and quantitation of DNA adducts formed by 4-aminoazobenzene species in vivo. Jpn J Cancer Res, 83: 78-85, 1992.

4. Thamavit, W., Moore, MA., Ruchirawat, S., Ito, N.: Repeated exposure to Opisthorchis viverrini and treatment with the antihelminthic Praziquantel lacks carcinogenic potential. Carcinogenesis, 13: 309-311, 1992.

5. Ito, N.: Is quercetin carcinogenic? Jpn J Cancer Res, 83: 312-314, 1992.

6. Asamoto, M., Imaida, K., Hasegawa, R., Hotta, K., Fukushima, S.: Change of membrane potential in rat urinary bladder epithelium treated with sodium L-ascorbate. Cancer Lett, 63: 1-5, 1992.

7. Hirose, M., Wada, S., Yamaguchi, S., Masuda, A., Okazaki, S., Ito, N.: Reversibility of catechol-induced rat glandular stomach lesions. Cancer Res, 52: 787-790, 1992.

8. Ueno, Y., Yabe, T., Hashimoto, H., Sekijima, M., Masuda, T., Kim, DJ., Hasegawa, R., Ito, N.: Enhancement of GST-P-positive liver cell foci development by nivalenol, a trichothecene mycotoxin. Carcinogenesis, 13: 787-791, 1992.

9. Hasegawa, R., Tiwawech, D., Hirose, M., Takaba, K., Hoshiya, T., Shirai, T., Ito, N.: Suppression of diethylnitrosamine-initiated preneoplastic foci development in the rat liver by combined administration of four antioxidants at low doses. Jpn J Cancer Res, 83: 431-437, 1992.

10. Kushida, H., Wakabayashi, K., Suzuki, M., Takahashi, S., Imaida, K., Sugimura, T., Nagao, M.: Suppression of spontaneous hepatocellular carcinoma development in C3H/HeNCrj mice by the lipophilic ascorbic acid, 2-O-octadecylascorbic acid (CV-3611). Carcinogenesis, 13: 913-915, 1992.

11. Okumura, M., Hasegawa, R., Shirai, T., Ito, M., Yamada, S., Fukushima, S.: Relationship between calculus formation and carcinogenesis in the urinary bladder of rats administered the non-genotoxic agents, thymine or melamine. Carcinogenesis, 13: 1043-1045, 1992.

12. Imaida, K., Uneyama, C., Ogasawara, H., Hayashi, S., Fukuhara, K., Miyata, N., Takahashi, M.: Induction of colon adenocarcinomas in CD rats and lung adenomas in ICR mice by 6-nitrochrysene: Comparison of carcinogenicity and aryl hydrocarbon hydroxylase induction in the target organs of each species. Cancer Res, 52: 1542-1545, 1992.

13. Tagawa, Y., Ozaki, K., Takahashi, S., Ogawa, K., Shirai, T.: Lack of effects of post-initiation cholesterol on 3,2′-dimethyl-4-aminobiphenyl-induced prostate carcinogenesis. Prostate, 20: 179-185, 1992.

14. Kagawa, M., Yamamoto, A., Ogawa, K., Shirai, T., Fukushima, S.: Uracil-induced urolithiasis in the urinary bladder of rats is irritation-dependent. Toxicol Lett, 61: 21-26, 1992.

15. Ogawa, K., Hasegawa, R., Wada, S., Yamaguchi, S., Ito, N.: Dose response study of N-nitrosodiethanolamine initiation of rat hepatocarcinogenesis. Teratog Carcinog Mutagen, 11: 245-250, 1992.

16. Takahashi, S., Shirai, T., Hasegawa, R., Imaida, K., Ito, N.: Latent prostatic carcinomas found at autopsy in men over 90 years old. Jpn J Clin Oncol, 22: 117-121, 1992.

17. Shirai, T., Iwasaki, S., Naito, H., Masui, T., Kato, T., Imaida, K.: Dose dependence of N-hydroxy-3,2′-dimethyl-4-aminobiphenyl-induced rat prostate carcinogenesis. Jpn J Cancer Res, 83: 695-698, 1992.

18. Ogawa, K., Hoshiya, T., Kato, T., Shirai, T., Tatematsu, M.: Reversibility of carcinogen-induced rat forestomach basal cell hyperplasia is due to squamous cell differentiation. Jpn J Cancer Res, 83: 699-704, 1992.

19. Fukushima, S., Tanaka, H., Asakawa, E., Kagawa, M., Yamamoto, A., Shirai, T.: Carcinogenicity of uracil, a nongenotoxic chemical, in rats and mice and its rationale. Cancer Res, 52: 1675-1680, 1992.

20. Uwagawa, S., Tsuda, H., Ozaki, K., Takahashi, S., Yamaguchi, S., Mutai, M., Aoki, T., Ito, N.: Modifying effects of various chemicals on tumor development in a rat wide-spectrum organ carcinogenesis model. Jpn J Cancer Res, 83: 812-820, 1992.

21. Shibata, MA., Tamano, S., Shirai, T., Kawabe, M., Fukushima, S.: Inorganic alkalizers and acidifiers under conditions of high urinary Na+ or K+ on cell proliferation and two-stage carcinogenesis in the rat bladder. Jpn J Cancer Res, 83: 821-829, 1992.

22. Hasegawa, R., Takahashi, S., Shirai, T., Iwasaki, S., Kim, DJ., Ochiai, M., Nagao, M., Sugimura, T., Ito, N.: Dose-dependent formation of preneoplastic foci and DNA adducts in rat liver with 2-amino-3-methyl-9H-pyrido[2,3-b]indole (MeAαC) and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Carcinogenesis, 13: 1427-1431, 1992.

23. Tatematsu, M., Ogawa, K., Hoshiya, T., Shichino, Y., Kato, T., Imaida, K., Ito, N.: Induction of adenocarcinomas in the glandular stomach of BALB/c mice treated with N-methyl-N-nitrosourea. Jpn J Cancer Res, 83: 915-918, 1992.

24. Hagiwara, A., Sano, M., Asakawa, E., Tanaka, H., Hasegawa, R., Ito, N.: Enhancing effects of harman and norharman on induction of preneoplastic and neoplastic kidney lesions in rats initiated with N-ethyl-N-hydroxyethylnitrosamine. Jpn J Cancer Res, 83: 949-954, 1992.

25. Ono, S., Kurata, Y., Shichino, Y., Sano, M., Fukushima, S.: Synergism of environmental carcinogens and promoters on bladder cancer development initiated by N-butyl-N-(4-hydroxybutyl)nitrosamine in F344 rats. Jpn J Cancer Res. 83: 955-963, 1992.

26. Takahashi, S., Hakoi, K., Yada, H., Hirose, M., Ito, N., Fukushima, S.: Enhancing effects of diallyl sulfide on hepatocarcinogenesis and inhibitory actions of the related diallyl disulfide on colon and renal carcinogenesis in rats. Carcinogenesis, 13: 1513-1518, 1992.

27. Hagiwara, A., Boonyaphiphat, P., Kawabe, M., Naito, H., Shirai, T., Ito, N.: Lack of carcinogenicity of tragacanth gum in B6C3F1 mice. Fd Chem Toxicol, 30: 673-679, 1992.

28. Hirose, M., Kawabe, M., Shibata, M., Takahashi, S., Okazaki, S., Ito, N.: Influence of caffeic acid and other o-dihydroxybenzene derivatives on N-methyl-N’-nitro-N-nitrosoguanidine-initiated rat forestomach carcinogenesis. Carcinogenesis, 13: 1825-1828, 1992.

29. Shirai, T., Pairojkul, C., Ogawa, K., Naito, H., Thamavit, W., Bhudhisawat, W., Ito, N.: Histomorphological characteristics of cholangiocellular carcinomas in Northeast Thailand, where a region infection with the liver fluke, Opisthochis viverrini is endemic. Acta Pathol Jpn, 42: 734-739, 1992.

30. Shichino, Y., Tatematsu, M., Ohshima, H., Bartsch, H., Furihata, C., Ito, N.: Effects of hickory-smoke condensate on development of pepsinogen 1-altered pyloric glands in rats. Fd Chem Toxicol, 30: 859-864, 1992.

31. Tsuda, H., Ozaki, K., Uwagawa, S., Yamaguchi, S., Hakoi, K., Aoki, T., Kato, T., Sato, K., Ito, N.: Effects of modifying agents on conformity of enzyme phenotype and proliferative potential in focal preneoplastic and neoplastic liver cell lesions in rats. Jpn J Cancer Res, 83: 1154-1165, 1992.

32. Shirai, T., Yamamoto, A., Imaida, K., Tamano, S., Mori, T., Hasegawa, R.: Lack of synergism among DMAB, BOP, and MNU in induction of carcinomas of the rat ventral prostate. Teratog Carcinog Mutagen, 12: 71-77, 1992.

33. Ito, N., Imaida, K.: Strategy of research for cancer-chemoprevention. Teratog Carcinog Mutagen, 12: 79-95, 1992.

34. Hagiwara, A., Asakawa, E., Kurata, Y., Sano, M., Hirose, M., Ito, N.: Dose-dependent renal tubular toxicity of harman and norharman in male F344 rats. Toxicol Pathol, 20: 197-204, 1992.

35. Tamano, S., Shirai, T., Kawabe, M., Ni-I, H., Mori, Y., Okada, M., Fukushima, S.: Low-susceptibility of nude mice to induction of invasive urinary bladder cancers by N-ethyl-N-(4-hydroxybutyl)nitrosamine. Toxicol Pathol, 20: 205-211, 1992.

36. Tamano, S., Hirose, M., Tanaka, H., Asakawa, E., Ogawa, K., Ito, N.: Forestomach neoplasm induction in F344/DuCrj rats and B6C3F1 mice exposed to sesamol. Jpn J Cancer Res, 83: 1279-1285, 1992.

37. Hasegawa, R., Ogawa, K., Takaba, K., Shirai, T., Ito, N.: 3,2′-dimethyl-4-aminobiphenyl-induced gallbladder carcinogenesis and effects of ethinyl estradiol in hamsters. Jpn J Cancer Res, 83: 1286-1292, 1992.

38. Hasegawa, R., Ito, N.: Liver medium-term bioassay in rats for screening of carcinogens and modifying factors in hepatocarcinogenesis. Fd Chem Toxicol, 30: 979-992, 1992.

39. Harris, CC., Hirohashi, S., Ito, N., Pitot, HC., Sugimura, T., Terada, M., Yokota, J.: Multistage carcinogenesis : The Twenty-Second International Symposium of the Princess Takamatsu Cancer Research Fund (Meeting report). Cancer Res, 52: 4837-4840, 1992.

40. Ito, N., Hasegawa, R., Imaida, K., Masui, T., Takahashi, S., Shirai, T.: Pathological markers for non-genotoxic agent-associated carcinogenesis. Toxicol Lett, 64/65: 613-620, 1992.

41. Takahashi, S., Hasegawa, R., Masui, T., Mizoguchi, M., Fukushima, S., Ito, N.: Establishment of multi-organ carcinogenesis bioassay using rats treated with a combination of five different carcinogens. J Toxicol Pathol, 5: 151-156, 1992.

42. Yoshida, Y., Tatematsu, M., Takaba, K., Shichino, Y., Ito, N.: Effects of various bile acids and their sodium salts on development of pepsinogen-altered pyloric glands in rats. Taratog Carcinog Mutagen, 12: 179-186, 1992.

43. Yoshida, Y., Hasegawa, R., Takaba, K., Imaida, K., Ito, N.: N-nitrosoheptamethyleneimine-induced pulmonary and esophageal carcinogenesis and effects of concomitant treatment with bleomycin in rats. Teratog Carcinog Mutagen, 12: 197-201, 1992.

44. Hakoi, K., Cabral, R., Hoshiya, T., Hasegawa, R., Shirai, T., Ito, N.: Analysis of carcinogenic activity of some pesticides in a medium-term liver bioassay in the rat. Teratog Carcinog Mutagen, 12: 269-276, 1992.

45. Hasegawa, R., Wang, CY., Kim, DJ., Lee, MS., Yoshida, Y., Ito, N.: Effect of acyl derivatives of 4,4,4-trifluoro-1-phenyl-1,3-butanedione on 2-acetylaminofluorene-induced glutathione S-transferase positive foci in the rat liver. Teratog Carcinog Mutagen, 12: 263-268, 1992.

46. Kurata, Y., Diwan, BA., Ward, JM.: Lack of renal tumour-initiating activity of a single does of potassium bromate, a genotoxic renal carcinogen in male F344/NCr rats. Fd Chem Toxicol, 30: 251-259, 1992.

47. Ito, N., Shirai, T., Hasegawa, R.: Medium-term bioassays for carcinogens. In: Vainio, H. et al. (eds.) Mechanisms of Carcinogenesis in Risk Identification, pp353-388. International Agency for Research on Cancer, Lyon, 1992.

48. Shirai, T., Tamano, S., Iwasaki, S., Ito, N.: Enhancement of prostate carcinogenesis in rats by testosterone and prolactin. In: Li, JJ. et al. (eds.) Hormonal Carcinogenesis, pp27-32. Springer-Verlag, 1992.

49. Mori, S., Murai, T., Ohhara, T., Hosono, M., Takeuchi, Y., Makino, S., Hayashi, Y., Fukushima, S.: Renal lesions and urinary bladder carcinogenesis. In: Sakamoto, N., Hotta, N. & Uchiba, K. (eds.) Current concepts of a new animal model: The NON mouse, pp159-174: Elsevier Science Publishers B.V., 1992.

50. Ito, N., Shirai, T., Masui, T., Ogawa, K., Kato, T., Takahashi, S.: Mechanistic analysis of multistage carcinogenesis in the rat prostate. In: Harris, CC. et al. (eds.) Multistage Carcinogenesis, pp125-133. Japan Sci Soc Press/CRC Press, Tokyo, 1992.

51. Shirai, T., Tamano, S., Takahashi, S., Ito, N.: Animal prostate carcinoma models: Limited potential for vertebral metastasis. In: Karr, JP. & Yamanaka, H. (eds.) Prostate Cancer and Bone Metastasis, pp151-158. Plenum Press, New York, 1992.

52. Pairojukul, C., Shirai, T., Hirohashi, S., Thamavit, W., Bhudhisawat, W., Uttaravicien, T., Itoh, M., Ito, N.: Multistage carcinogenesis of liver-fluke-associated cholangiocarcinoma in Thailand. In: Harris, CC. et al. (eds.) Multistage Carcinogenesis, pp77-86. Japan Sci. Soc. Press / CRC Press, Tokyo, 1992.

53. Ito, N., Hirose, M., Shirai, T.: Carcinogenicity and modification of carcinogenic response by plant phenols. In: Huang, MT., Ho, CT. & Lee, CY. (eds.) Phenolic Compounds in Food and Their Effects on Health II, 507, pp269-281. American Chemical Society, Washington D.C., 1992.

54. Cabral, R., Hoshiya, T., Hakoi, K., Hasegawa, R., Fukushima, S., Ito, N: A rapid in-vivo bioassay for the carcinogenicity of pesticides. In: Somogyi, A., Appel, KE. & Katenkamp A. (eds.) Chemical Carcinogenesis, pp91-96. MMV Medizin Verl., Munchen, 1992.

55. Ito, N., Hirose, M., Takahashi, S., Shirai, T.: Antioxidants — carcinogenesis and its modification. In: Somogyi, A., Appel, KE. & Katenkamp A. (eds.) Chemical Carcinogenesis, pp91-96. MMV Medizin Verl., Munchen, 1992.

56. Tsuda, H., Ito, N. : Medium-term bioassays as new tools for prediction of carcinogenicity. In: McAuslane, JAN., Lumley, CE. & Walker, SR. (eds.) The Carcinogenicity Debate, pp197-213. Quay Publishing, London, 1992.

1. Takahashi, S., Ogawa, K., Ohshima, H., Esumi, H., Ito, N., Sugimura, T.: Induction of aberrant crypt foci in the large intestine of F344 rats by oral administration of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. Jpn J Cancer Res, 82: 135-137, 1991.

2. Tatematsu, M., Ogawa, K., Mutai, M., Aoki, T., Hoshiya, T., Ito, N.: Rapid regression of squamous cell hyperplasia and slow regression of basal cell hyperplasia in the forestomach of F344 rats treated with N-methyl-N’-nitro-N-nitrosoguanidine and/or butylated
hydroxyanisole. Cancer Res, 51: 318-323, 1991.

3. Okumura, M., Shirai, T., Tamano, S., Ito, M., Yamada, S., Fukushima, S.: Uracil-induced calculi and carcinogenesis in the urinary bladder of rats treated simultaneously with N-butyl-N-(4-hydroxybutyl)nitrosamine. Carcinogenesis, 12: 35-41, 1991.

4. Shibata, MA., Asakawa, E., Hagiwara, A., Kurata, Y., Fukushima, S.: DNA synthesis and scanning electron microscopic lesions in renal pelvic epithelium of rats treated with bladder cancer promoters. Toxicol Lett, 55: 263-272, 1991.

5. Hasegawa, R., Takahashi, S., Imaida, K., Yamaguchi, S., Shirai, T., Ito, N.: Age-dependent induction of preneoplastic liver cell foci by 2-acetylaminofluorene, phenobarbital and acetaminophen in F344 rats initially treated with diethylnitrosamine. Jpn J Cancer Res, 82: 293-297, 1991.

6. Hirose, M., Mutai, M., Takahashi, S., Yamada, M., Fukushima, S., Ito, N.: Effects of phenolic antioxidants in low dose combination on forestomach carcinogenesis in rats pretreated with N-methyl-N’-nitro-N-nitrosoguanidine. Cancer Res, 51: 824-827,1991.

7. Shirai, T., Tamano, S., Kato, T., Iwasaki, S., Takahashi, S., Ito, N.: Induction of invasive carcinomas in the accessory sex organs other than the ventral prostate of rats given 3,2-dimethyl-4-aminobiphenyl and testosterone propionate. Cancer Res, 51:1264-1269, 1991.

8. Ochiai, M., Ogawa, K., Wakabayashi, K., Sugimura, T., Nagase, S., Esumi, H., Nagao, M.: Induction of intestinal adenocarcinomas by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in Nagase analbuminemic rats. Jpn J Cancer Res, 82:363-366, 1991.

9. Ito, N., Hasegawa, R., Shirai, T., Fukushima, S., Hakoi, K., Takaba, K., Iwasaki, S., Wakabayashi, K., Nagao, M., Sugimura, T.: Enhancement of GST-P positive liver cell foci development by combined treatment of rats with five heterocyclic amines at low doses. Carcinogenesis, 12: 767-772, 1991.

10. Tiwawech, D., Hasegawa, R., Kurata, Y., Tatematsu, M., Shibata, MA., Thamavit, W., Ito, N.: Does-dependent effects of 2-acetylaminofluorene on hepatic foci development and cell proliferation in rats. Carcinogenesis, 12: 985-990, 1991.

11. Fukushima, S., Hagiwara, A., Hirose, M., Yamaguchi, S., Tiwawech, D., Ito, N.: Modifying effects of various chemicals on preneoplastic and neoplastic lesion development in a wide-spectrum organ carcinogenesis model using F344 rats. Jpn J Cancer Res, 82: 642-649, 1991.

12. Tamano, S., Hagiwara, A., Suzuki, E., Okada, M., Shirai, T., Fukushima, S.: Time- and dose-dependent induction of invasive urinary bladder cancers by N-ethyl-N-(4-hydroxybutyl)nitrosamine in B6C3F1 mice. Jpn J Cancer Res, 82: 650-656, 1991.

13. Hasegawa, R., Fukuoka, M., Takahashi, T., Yamamoto, A., Yamaguchi, S., Shibata, MA., Tanaka, A., Fukushima, S.: Sex differences in o-phenylphenol and sodium o-phenylphenate rat urinary bladder carcinogenesis: Urinary metabolites and electrolytes under conditions of aciduria and alkalinuria. Jpn J Cancer Res, 82: 657-664, 1991.

14. Okumura, M., Shirai, T., Asamoto, M., Ogiso, T., Fukushima, S.: Lack of synergism in rat urinary tract carcinogenesis between prior uracil treatment and N-butyl-N-(4-hydroxybutyl)nitrosamine administration. Cancer Lett, 58: 81-85, 1991.

15. Fukushima, S., Kurata, Y., Hasegawa, R., Asamoto, M., Shibata, MA., Tamano, S.: L-Ascorbic acid amplification of bladder carcinogenesis promotion by K2CO3. Cancer Res, 51: 2548-2551, 1991.

16. Fukushima, S., Shibata, MA., Hirose, M., Kato, T., Tatematsu, M., Ito, N.: Organ-specific modification of tumor development by low-dose combinations of agents in a rat wide-spectrum carcinogenesis model. Jpn J Cancer Res, 82: 784-792, 1991.

17. Shirai, T., Fukushima, S., Kawabe, M., Shibata, MA., Iwasaki, S., Tada, M., Ito, N.: Selective induction of rat urinary bladder tumors by simultaneous administration of 3,2′-dimethyl-4-aminobiphenyl (DMAB) and butylated hydroxyanisole or butylated hydroxytoluene is associated with increased DMAB-DNA adduct formation. Carcinogenesis, 12: 1335-1339, 1991.

18. Nakamura, A., Shirai, T., Takahashi, S., Ogawa, K., Hirose, M., Ito, N.: Lack of modification by naturally occurring antioxidants of 3,2′-dimethyl-4-aminobiphenyl-initiated rat prostate carcinogenesis. Cancer Lett, 58: 241-246, 1991.

19. Tamano, S., Kurata, Y., Shibata, MA., Tanaka, H., Ogiso, T., Ito, N.: 13-week oral toxicity study of captafol in F344/DuCrj rats. Fundam Appl Toxicol, 17: 390-398, 1991.

20. Ito, N., Hasegawa, R., Sano, M., Tamano, S., Esumi, H., Takayama, S., Sugimura, T.: A new colon and mammary carcinogen in cooked food, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Carcinogenesis, 12: 1503-1506, 1991.

21. Hasegawa, R., Shirai, T., Hakoi, K., Wada, S., Yamaguchi, K., Takayama, S.: Synergistic enhancement of thyroid tumor induction by 2,4-diaminoanisole sulfate, N,N’-diethylthiourea and 4,4′-thiodianiline in male F344 rats. Carcinogenesis, 12:1515-1518, 1991.

22. Shibata, MA., Hasegawa, R., Sano, M., Shirai, T., Fukushima, S.: Timing effects of uracil-induced urolithiasis on amplification of second-stage promotion in rat bladder carcinogenesis. Jpn J Cancer Res, 82: 1077-1084, 1991.

23. Shirai, T., Joong, KD., Hakoi, K., Thamavit, W., Pairojkul, C., Hoshiya, T., Hasegawa, R., Ito, N.: Promotion of rat hepatocarcinogenesis by praziquantel. Jpn J Cancer Res, 82: 1085-1088, 1991.

24. Hirose, M., Uwagawa, S., Ozaki, K., Takaba, K., Ito, N.: Effects of butylated hydroxyanisole pretreatment on low dose N-methyl-N’-nitro-N-nitrosoguanidine- or N,N-dibutylnitrosamine-induced rat forestomach or esophageal carcinogenesis. Carcinogenesis, 12: 1773-1776, 1991.

25. Hirose, M., Ozaki, K., Takaba, K., Fukushima, S., Shirai, T., Ito, N.: Modifying effects of the naturally occurring antioxidants γ-oryzanol, phytic acid, tannic acid and n-tritriacontane-16,18-dione in a rat wide-spectrum organ carcinogenesis model. Carcinogenesis, 12: 1917-1921, 1991.

26. Mori, S., Murai, T., Takeuchi, Y., Hosono, M., Ohhara, T., Makino, S., Hayashi, Y., Shibata, MA., Kurata, Y., Hagiwara, A., Fukushima, S.: No promotion of urinary bladder carcinogenesis by sodium L-ascorbate in male ODS/Shi-od/od rats lacking L-ascorbic acid-synthesizing ability. Carcinogenesis, 12: 1869-1873, 1991.

27. Shibata, MA., Hirose, M., Tanaka, H., Asakawa, E., Shirai, T., Ito, N.: Induction of renal cell tumors in rats and mice, and enhancement of hepatocellular tumor development in mice after long-term hydroquinone treatment. Jpn J Cancer Res, 82:1211-1219, 1991.

28. Shirai, T., Yamamoto, A., Iwasaki, S., Tamano, S., Masui, T.: Induction of invasive carcinomas of the seminal vesicles and coagulating glands of F344 rats by administration of N-methyl-nitrosourea or N-nitrosobis(2-oxopropyl)amine and followed by testosterone propionate with or without high-fat diet. Carcinogenesis, 12:2169-2173, 1991.

29. Hagiwara, A., Tanaka, H., Tiwawech, D., Shirai, T., Ito, N.: Oral toxicity study of tragacanth gum in B6C3F1 mice: Development of squamous-cell hyperplasia in the forestomach and its reversibility. J Toxicol Environ Health, 34: 207-218, 1991.

30. de Camargo, JLV., Shirai, T., Kato, T., Asamoto, M., Fukushima, S.: Summation effects of uracil and other promoters on epithelial lesion development in the F344 rat urinary bladder initiated by N-butyl-N-(4-hydroxybutyl)nitrosamine. Jpn J Cancer Res, 82: 1220-1225, 1991.

31. Fukushima, S., Mutai, M., Hasegawa, R., Takahashi, S., de Camargo, JLV., Shirai, T.: Enhancing effects of carcinogens or promoters on bladder carcinogenesis in rats. J Toxicol Pathol, 4: 159-164, 1991.

32. Hagiwara, A., Hirose, M., Takahashi, S., Ogawa, K., Shirai, T., Ito, N.: Forestomach and kidney carcinogenicity of caffeic acid in F344 rats and C57BL/6NxC3H/HeN F1 mice. Cancer Res, 51: 5655-5660, 1991.

33. Murai, T., Mori, S., Hosono, M., Takeuchi, Y., Ohara, T., Makino, S., Takeda, R., Hayashi, Y., Fukushima, S.: Renal pelvic carcinoma which shows metastatic potential to distant organs, induced by N-butyl-N-(4-hydroxybutyl)nitrosamine in NON/Shi mice. Jpn J Cancer Res, 82: 1371-1377, 1991.

34. Imaida, K., Furihata, C., Tatematsu, M., Yoon, CH., Furukawa, F., Uneyama, C., Takahashi, M., Ito, N., Hayashi, Y.: Immunohistochemical and biochemical identification of pepsinogen isozymes in the hamster lungs: Induction by polychlorinated biphenyls. Toxicol Pathol, 19: 230-236, 1991.

35. Hasegawa, R., Shirai, T., Hakoi, K., Takaba, K., Iwasaki, S., Hoshiya, T., Ito, N., Nagao, M., Sugimara, T.: Synergistic enhancement of glutathione S-transferase placental form-positive hepatic foci development in diethylnitrosamine-treated rats by combined administration of five heterocyclic amines at low doses. Jpn J Cancer Res, 82: 1378-1384, 1991.

36. Uwagawa, S., Tsuda, H., Inoue, T., Tagawa, Y., Aoki, T., Kagawa, M., Ogiso, T., Ito, N.: Enhancing potential of 6 different carcinogens on multi-organ tumorigenesis after initial treatment with N-methyl-N-nitrosourea in rats. Jpn J Cancer Res, 82:1397-1405, 1991.

37. Thamavit, W., Moore, MA., Ruchirawat, S., Ito, N.: Lack of modulation effects of praziquantel on DMN-induced lesion development in the Syrian hamster liver. Cancer Lett, 61:229-232, 1991.

38. Cabral, R., Hoshiya, T., Hakoi, K., Hasegawa, R., Fukushima, S., Ito, N.: A rapid in vivo bioassay for the carcinogenicity of pesticides. Tumori, 77: 185-188, 1991.

39. Shibata, MA., Kagawa, M., Kawabe, M., Hagiwara, A., Fukushima, S.: Comparative promoting activities of phosphate salts on rat two-stage bladder carcinogenesis under conditions of equivalent urinary Na+ or K+ levels. Teratog Carcinog Mutagen, 11: 305-316, 1991.

40. Ito, N., Shirai, T., Fukushima, S.: Medium-term bioassay for carcinogens using multiorgan models. In: Ito, N. & Sugano, H. (eds.) Modification of Tumor Development in Rodents, Vol. 33, pp.41-57. S. Karger, Basel, 1991.

41. Fukushima, S. Modification of tumors development in the urinary bladder. In: Ito, N. & Sugano, H. (eds.) Modification of Tumor Development in Rodents, Vol. 33, pp.154-174. S. Karger, Basel, 1991.

42. Ito, N., Shirai, T.: Tumors of the accessory male sex organs. In: Turusov, V. & Mohr, U. (eds.) Pathology of Tumours in Laboratory Animals, Vol.1, pp421-443. International Agency for Research on Cancer, Lyon, 1991.

43. Tsuda, H., Ozaki, K., Uwagawa, S., Takahashi, S., Hakoi, K., Kato, T., Fukushima, S., Sato, K., Ito, N.: Analysis of the effects of modifying agents on proliferation and enzyme phenotype in focal preneoplastic and neoplastic liver lesions in rats. In: Columbano, A. et al. (eds.) Chemical Carcinogenesis 2, pp219-229. Plenum Press, New York, 1991.

44. Moore, MA., Thamavit, W., Tiwawech, D., Ito, N.: Cell death and proliferation in Opisthorchis viverrini-DHPN induced carcinogenesis in the Syrian hamster hepato-pancreatic axis. In: Columbano, A. et al. (eds.) Chemical Carcinogenesis 2, pp502-510. Plenum Press, New York, 1991.

45. Fukushima, S., de Camargo, JLV, Asamoto, M., Hasegawa, R., Tsuda, H.: Amplifying effects of uracil on multi-stage bladder carcinogenesis in rats. In: Columbano, A. et al. (eds.) Chemical Carcinogenesis 2, pp611-618. Plenum Press, New York, 1991.

46. Ito, N., Hirose, M., Takahashi, S.: Cellular proliferation and stomach carcinogenesis induced by antioxidants. In: Butterworth, BE. et al. (eds.) Chemically Induced Cell Proliferation: Implications for Risk Assessment, pp43-52. Wiley-Liss, Inc., New York, 1991.

47. Fukushima, S., Shibata, MA., Kurata, Y., Hasegawa, R.: The roles of L-ascorbic acid, urinary pH, and Na or K ion concentration in rat bladder epithelial cell proliferation with special reference to tumor promotion. In: Butterworth, BE. et al. (eds.) Chemically Induced Cell Proliferation: Implications for Risk Assessment, pp195-208. Wiley-Liss, Inc., New York, 1991.

48. Tatematsu, M., Shirai, T., Ogawa, K., Asamoto, M., Ito, N.: Proliferation kinetics and development of pepsinogen-altered pyloric gland cells in the glandular stomach of rats treated with chemicals. In: Butterworth, BE. et al. (eds.) Chemically Induced Cell Proliferation: Implications for Risk Assessment, pp445-455. Wiley-Liss, Inc., New York, 1991.

1. Hirose, M., Masuda, A., Hasegawa, R., Wada, S., Ito, N.: Regression of butylated hydroxyanisole (BHA)-induced hyperplasia but not dysplasia in the forestomach of hamsters. Carcinogenesis, 11: 239-244, 1990.

2. Shibata, MA., Hasegawa, R., Kurata, Y., Yamada, M., Tamano, S., Fukushima, S.: Bladder epithelial hyperplasia in F344 rats after intravesical instillation of the antitumor chemotherapeutic agents Adriamycin and mitomycin C. Cancer Lett, 49: 41-49, 1990.

3. Mutai, M., Tatematsu, M., Aoki, T., Wada, S., Ito, N.: Modulatory interaction between initial clofibrate treatment and subsequent administration of 2-acetylaminofluorene or sodium phenobarbital on glutathione S-transferase positive lesion development. Cancer Lett, 49: 127-132, 1990.

4. Mori, S., Murai, T., Takeuchi, Y., Toyama, M., Makino, S., Konishi, T., Hayashi, Y., Kurata, Y., Fukushima, S.: Dose response of N-butyl-N-(4-hydroxybutyl)nitrosamine on urinary bladder carcinogenesis in mutant ODS rats lacking L-ascorbic acid synthesizing ability. Cancer Lett, 49: 139-145, 1990.

5. Shibata, MA., Yamada, M., Hirose, M., Asakawa, E., Tatematsu, M., Ito, N.: Early proliferative responses of forestomach and glandular stomach of rats treated with five different phenolic antioxidants. Carcinogenesis, 11: 425-429, 1990.

6. Hagiwara, A., Tanaka, H., Kurata, Y., Kato, T., Tsuda, H., Ito, N.: Lack of hepatotoxicity or promotion of enzyme-altered liver foci development in rats treated with harman or norharman. J Toxicol Environ Health, 29: 211-218, 1990.

7. Hirose, M., Fukushima, S., Shirai, T., Hasegawa, R., Kato, T., Tanaka, H., Asakawa, E., Ito, N.: Stomach carcinogenicity of caffeic acid, sesamol and catechol in rats and mice. Jpn J Cancer Res, 81: 207-212, 1990.

8. Shirai, T., Nakamura, A., Fukushima, S., Wang, CY., Yamada, H., Ito, N.: Selective induction of prostate carcinomas in F344 rats treated with intraperitoneal injections of N-hydroxy-3,2′-dimethyl-4-aminobiphenyl. Jpn J Cancer Res, 81:320-323, 1990.

9. Tsuda, H., Takahashi, S., Yamaguchi, S., Ozaki, K., Ito, N.: Comparison of initiation potential of 2-amino-3-methylimidazo[4,5-f]quinoline and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in an in vivo carcinogen bioassay system. Carcinogenesis, 11: 549-552, 1990.

10. Ogiso, T., Tatematsu, M., Tamano, S., Hasegawa, R., Ito, N.: Correlation between medium-term liver bioassay system data and results of long-term testing in rats. Carcinogenesis, 11: 561-566, 1990.

11. Shirai, T., Nakamura, A., Fukushima, S., Tada, M., Morita, T., Ito, N.: Immunohistochemical demonstration of carcinogen-DNA adducts in target and non-target tissues of rats given a prostate carcinogen, 3,2′-dimethyl-4-aminobiphenyl. Carcinogenesis, 11: 653-657, 1990.

12. Hirose, M., Masuda, A., Ito, N., Kamano, K., Okuyama, H.: Effects of dietary perilla oil, soybean oil and safflower oil on 7,12-dimethylbenz[a]anthracene (DMBA) and 1,2-dimethylhydrazine (DMH)-induced mammary gland and colon carcinogenesis in female SD rats. Carcinogenesis, 11: 731-735, 1990.

13. Shirai, T., Nakamura, A., Fukushima, S., Yamamoto, A., Tada, M., Ito, N.: Different carcinogenic responses in a variety of organs, including the prostate, of five different rat strains given 3,2′-dimethyl-4-aminobiphenyl. Carcinogenesis, 11: 793-797, 1990.

14. Hasegawa, R., Takahashi, S., Asamoto, M., Shirai, T., Fukushima, S.: Species differences in sodium o-phenylphenate induction of urinary bladder lesions. Cancer Lett, 50: 87-91, 1990.

15. Asamoto, M., Hasegawa, R., Masuko, T., Hashimoto, Y., Ueda, K., Ohtaguro, K., Sasaki, S., Washida, H., Fukushima, S.: Immunohistochemical analysis of c-erbB-2 oncogene product and epidermal growth factor receptor expression in human urinary bladder carcinomas. Acta Pathol Jpn, 40: 322-326, 1990.

16. Shibata, MA., Hirose, M., Yamada, M., Tatematsu, M., Uwagawa, S., Ito, N.: Epithelial cell proliferation in rat forestomach and glandular stomach mucosa induced by catechol and analogous dihydroxybenzenes. Carcinogenesis, 11: 997-1000, 1990.

17. Shibata, MA., Fukushima, S., Takahashi, S., Hasegawa, R., Ito, N.: Enhancing effects of sodium phenobarbital and N,N-dibutylnitrosamine on tumor development in a rat wide-spectrum organ carcinogenesis model. Carcinogenesis, 11: 1027-1031, 1990.

18. Hagiwara, A., Kurata, Y., Tamano, S.: Ectopic intestinal glands in the forestomach of a F344 rat. Vet Pathol, 27: 201-203, 1990.

19. Tatematsu, M., Ichinose, M., Miki, K., Hasegawa, R., Kato, T., Ito, N.: Gastric and intestinal phenotypic expression of human stomach cancers as revealed by pepsinogen immunohistochemistry and mucin histochemistry. Acta Pathol Jpn, 40: 494-504,1990.

20. Masui, T., Asamoto, M., Hasegawa, R., Kagawa, M., Fukushima, S.: Effects of monosodium succinate, disodium succinate, and succinic acid on urinary bladder carcinogenesis in N-butyl-N-(4-hydroxybutyl)- nitrosamine-initiated, unilaterally ureter-ligated rats. J Toxicol Pathol, 3: 105-110, 1990.

21. Cova, L., Wild, CP., Mehrotra, R., Turusov, V., Shirai, T., Lambert, V., Jacquet, C., Tomatis, L., Trepo, C., Montesano, R.: Contribution of aflatoxin B1 and hepatitis B virus infection in the induction of liver tumors in ducks. Cancer Res, 50: 2156-2163, 1990.

22. Fukushima, S., Uwagawa, S., Shirai, T., Hasegawa, R., Ogawa, K.: Synergism by sodium L-ascorbate but inhibition by L-ascorbic acid for sodium saccharin promotion of rat two-stage bladder carcinogenesis. Cancer Res, 50: 4195-4198, 1990.

23. Kurata, Y., Fukushima, S., Hasegawa, R., Hirose, M., Shibata, MA., Shirai, T., Ito, N.: Structure-activity relations in promotion of rat urinary bladder carcinogenesis by phenolic antioxidants. Jpn J Cancer Res, 81: 754-759, 1990.

24. Tatematsu, M., Katsuyama, T., Furihata, C., Fukushima, S., Shirai, T., Kato, T., Ito, N.: Cellular differentiation and histogenesis of rat glandular stomach cancers. Jpn J Cancer Res, 81: 760-767, 1990.

25. Hagiwara, A., Tamano, S., Shibata, MA., Arai, M., Tsuda, H.: Lack of modifying effects of p-phenylenediamine on induction of γ-glutamyl transpeptidase-positive foci in a medium-term bioassay system using F344 rats. Toxicol Lett, 52: 261-268, 1990.

26. Hirose, M., Fukushima, S., Hasegawa, R., Kato, T., Tanaka, H., Ito, N.: Effects of sodium nitrite and catechol or 3-methoxycatechol in combination on rat stomach epithelium. Jpn J Cancer Res, 81: 857-861, 1990.

27. Hasegawa, R., Furukawa, F., Toyoda, K., Takahashi, M., Hayashi, Y., Hirose, M., Ito, N.: Inhibitory effects of antioxidants on N-bis(2-hydroxypropyl)nitrosamine-induced lung carcinogenesis in rats. Jpn J Cancer Res, 81: 871-877, 1990.

28. Nakamura, A., Shirai, T., Ogawa, K., Wada, S., Fujimoto, NA., Ito, A., Ito, N.: Promoting action of prolactin released from a grafted transplantable pituitary tumor (MtT/F84) on rat prostate carcinogenesis. Cancer Lett, 53: 151-157, 1990.

29. Hagiwara, A., Yamada, M., Hasegawa, R., Fukushima, S., Ito, N.: Lack of enhancing effects of fenvalerate and esfenvalerate on induction of preneoplastic glutathione S-transferase placental form positive liver cell foci in rats. Cancer Lett, 54: 67-73, 1990.

30. Wada, S., Hirose, M., Takahashi, S., Okazaki, S., Ito, N.: Para-methoxyphenol strongly stimulates cell proliferation in the rat forestomach but is not a promoter of rat forestomach carcinogenesis. Carcinogenesis, 11: 1891-1894, 1990.

31. Asamoto, M., Shichino, Y., Tsuda, H., Ito, N.: Inhibition of rat hepatic glutathione S-transferase placental form positive foci development by concomitant administration of antioxidants to carcinogen-treated rats. Cancer Lett, 55: 25-29, 1990.

32. Imaida, K., Hirose, M., Yamaguchi, S., Takahashi, S., Ito, N.: Effects of naturally occurring antioxidants on combined 1,2-dimethylhydrazine- and 1-methyl-1-nitrosourea-initiated carcinogenesis is F344 male rats. Cancer Lett, 55: 53-59, 1990.

33. Tamano, S., Kurata, Y., Kawabe, M., Yamamoto, A., Hagiwara, A., Cabral, R., Ito, N.: Carcinogenicity of captafol in F344 /DuCrj rats. Jpn J Cancer Res, 81: 1222-1231, 1990.

34. Hagiwara, A., Tamano, S., Ogiso, T., Asakawa, E., Fukushima, S.: Promoting effect of the peroxisome proliferator, clofibrate, but not di(2-ethylhexyl)phthalate, on urinary bladder carcinogenesis in F344 rats initiated by N-butyl-N-(4-hydroxybutyl)nitrosamine. Jpn J Cancer Res, 81: 1232-1238, 1990.

35. Kurata, Y., Fukushima, S., Hagiwara, A., Ito, H., Ogawa, K., Ito, N.: Carcinogenicity study of methyl hesperidin in B6C3F1 mice. Fd Chem Toxicol, 28: 613-618, 1990.

36. Ichinose, M., Miki, K., Tatematsu, M., Furihata, C., Matsushima, M., Ichihara, Y., Tanji, M., Konishi, T., Obara, M., Inoue, H., Kurokawa, K., Takahashi, T., Kageyama, T., Takahashi, K.: Hydrocortisone-induced enhancement of expression and changes in methylation of pepsinogen genes in stomach mucosa of the developing rat. Biochem Biophys Res Comm, 172: 1086-1093, 1990.

37. Yamaguchi, S., Tatematsu, M., Furihata, C., Takaba, K., Ito, N.: Effects of bile acids on development of pepsinogen-altered pyloric glands in rats. Cancer Lett, 55: 129-134, 1990.

38. Ikawa, E., Tagawa, Y., Shirai, T., Hirose, M., Fukushima, S.: Induction of preneoplastic lesions by sequential treatment of rats with three carcinogens: N-butyl-N-(4-hydroxybutyl)nitrosamine, 7,12-dimethylbenz(a)anthracene, and N-methyl-N-nitro-N-nitrosoguanidine. J Toxicol Pathol, 4: 63-66, 1990.

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40. Okamura, T., Tsugaya, M., Watase, H., Ueda, K., Hasegawa, R., Fukushima, S., Ohtaguro, K.: Various urinary properties in bladder tumor patients. Jpn J Clin Oncol, 20: 154-158, 1990.

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44. Mori, S., Murai, T., Toyama, M., Takeuchi, Y., Makino, S., Konishi, T., Hayashi, Y., Kurata, Y., Fukushima, S.: Urinary bladder carcinogenesis by N-butyl-N-(4-hydroxybutyl)nitrosamine in ODS rats. In: Fujita, T., Fukase, M. & Konishi, T. (eds.) Vitamin C and the Scurvy-Prone ODS Rat, pp223-235. Elsevier Science Publishers B.V. (Biomedical Division), 1990.

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1. Shirai, T., Fukushima, S., Tagawa, Y., Okumura, M., Ito, N.: Cell proliferation induced by uracil-calculi and subsequent development of reversible papillomatosis in the rat urinary bladder. Cancer Res, 49: 378-383, 1989.

2. Thornton, M., Moore, MA., Ito, N.: Modifying influence of dehydroepiandrosterone or butylated hydroxytoluene treatment on initiation and development stages of azaserine-induced acinar pancreatic preneoplastic lesions in the rat. Carcinogenesis, 10: 407-410, 1989.

3. Hasegawa, R., Fukushima, S., Hagiwara, A., Masui, T., Masuda, A., Ito, N.: Long-term feeding study of N,N’-diphenyl-p-phenylenediamine in F344 rats. Toxicology, 54: 69-78, 1989.

4. Tsuda, H., Inoue, T., Asamoto, M., Fukushima, S., Ito, N., Okamura, T., Ohtaguro, K., Washida, H., Satoh, K., Amelizad, Z., Oesch, F.: Comparison of enzyme phenotypes in human bladder tumours and experimentally induced hyperplastic and neoplastic lesions of the rat urinary bladder. Virchows Arch B Cell Pathol, 56: 307-316, 1989.

5. Asamoto, M., Fukushima, S., Tatemoto, Y., Yamada, K., Fukui, S., Mori, M.: Immunohistochemical expression of keratin proteins in urinary bladder carcinoma. Pathol Res Pract, 184: 194-201, 1989.

6. Fukushima, S., Asamoto, M., Imaida, K., El-Bolkainy, MN., Tawfik, HN., Ito, N.: Comparative study of urinary bladder carcinomas in Japanese and Egyptians. Acta Pathol Jpn, 39: 176-179, 1989.

7. Ito, N., Fukushima, S.: Promotion of urinary bladder carcinogenesis in experimental animals. Exp Pathol, 36: 1-15, 1989.

8. Shirai, T., Nakamura, A., Fukushima, S., Takahashi, S., Ogawa, K., Ito, N.: Effects of age on multiple organ carcinogenesis induced by 3,2′-dimethyl-4-aminobiphenyl in rats, with particular reference to the prostate. Jpn J Cancer Res, 80: 312-316, 1989.

9. Ito, N., Hagiwara, A., Tamano, S., Kagawa, M., Shibata, MA., Kurata, Y., Fukushima, S.: Lack of carcinogenicity of quercetin in F344/DuCrj rats. Jpn J Cancer Res, 80: 317-325, 1989.

10. Tatematsu, M., Mutai, M., Aoki, T., de Camargo, JLV., Furihata, C., Ito, N.: Proliferation kinetics of pepsinogen altered pyloric gland cells in rats treated with N-methyl-N’-nitro-N-nitrosoguanidine. Carcinogenesis, 10: 907-911, 1989.

11. Shibata, MA., Hagiwara, A., Tamano, S., Ono, S., Fukushima, S.: Lack of a modifying effect by the diuretic drug furosemide on the development of neoplastic lesions in rat two-stage urinary bladder carcinogenesis. J Toxicol Environ Health, 26: 255-265, 1989.

12. Imaida, K., Tatematsu, M., Kato, T., Tsuda, H., Ito, N.: Advantages and limitations of stereological estimation of placental glutathione S-transferase-positive rat liver cell foci by computerized three-dimensional reconstruction. Jpn J Cancer Res, 80: 326-330, 1989.

13. Hagiwara, A., Tamano, S., Shibata, MA., Arai, M., Tsuda, H.: Lack of modifying effects of 2,2′-[(4-aminophenyl)imino]bisethanol sulfate on induction of preneoplastic γ-glutamyl transpeptidase-positive foci in a medium-term bioassay system using F344 rats. J Toxicol Sci, 14: 77-86, 1989.

14. Tatematsu, M., Katsuyama, T., Mutai, M., Asakawa, E., Ito, N.: Pyloric gland phenotypic expression of gastric cancers developing in the rat fundic glandular stomach. Carcinogenesis, 10: 1033-1039, 1989.

15. Shirai, T., Nakamura, A., Wada, S., Ito, N.: Pancreatic acinar cell tumors in rats induced by 3,2′-dimethyl-4-aminobiphenyl. Carcinogenesis, 10: 1127-1130, 1989.

16. Thamavit, W., Fukushima, S., Kurata, Y., Asamoto, M., Ito, N.: Modification by sodium L-ascorbate, butylated hydroxytoluene, phenobarbital and pepleomycin of lesion development in a wide-spectrum initiation rat model. Cancer Lett, 45: 93-101, 1989.

17. Hagiwara, A., Hirose, M., Miyata, Y., Fukushima, S., Ito, N.: Modulation of N-butyl-N-(4-hydroxybutyl)- nitrosamine-induced rat urinary bladder carcinogenesis by post-treatment with combinations of three phenolic antioxidants. J Toxicol Pathol, 2: 33-39, 1989.

18. Tagawa, Y., Shirai, T., Fukushima, S., Nakamura, A., Hirose, M., Ito, N.: Lack of modification by dietary unsaturated fat of 3,2′-dimethyl-4-aminobiphenyl-induced rat prostate and colon carcinogenesis. J Toxicol Pathol, 2: 49-53, 1989.

19. Ito, N., Imaida, K., Hasegawa, R., Tsuda, H.: Rapid bioassay methods for carcinogens and modifiers of hepatocarcinogenesis. Crit Rev Toxicol, 19: 385-415, 1989.

20. Shibata, MA., Yamada, M., Tanaka, H., Kagawa, M., Fukushima, S.: Changes in urine composition, bladder epithelial morphology, and DNA synthesis in male F344 rats in response to ingestion of bladder tumor promoters. Toxicol Appl Pharmacol, 99: 37-49, 1989.

21. Tada, M., Aoki, H., Kojima, M., Morita, T., Shirai, T., Yamada, H., Ito, N.: Preparation and characterization of antibodies against 3,2′-dimethyl-4-aminobiphenyl-modified DNA. Carcinogenesis, 10: 1397-1402, 1989.

22. Shibata, MA., Tamano, S., Kurata, Y., Hagiwara, A., Fukushima, S.: Participation of urinary Na+, K+, pH, and L-ascorbic acid in the proliferative response of the bladder epithelium after the oral administration of various salts and/or ascorbic acid to rats. Fd Chem Toxicol, 27: 403-413, 1989.

23. Asamoto, M., Fukushima, S., Tatemoto, Y., Yamada, K., Yuba, R., Mori, M.: Immunohistochemical evaluation of nonspecific cross reactive antigen and carcinoembryonic antigen (CEA) in urinary bladder carcinoma. Anticancer Res, 9: 319-326, 1989.

24. Hirose, M., Kurata, Y., Yamada, M., Shirai, T., Ito, N., Ohsawa, T.: Lack of modifying effects of linolic acid hydroperoxides and their secondary oxidative products on combined 7,12-dimethylbenz[a]anthracene and 1,2-dimethylhydrazine-initiated mammary gland, ear duct and colon carcinogenesis in female Sprague-Dawley rats. Cancer Lett, 47: 141-147, 1989.

25. Fukushima, S., Inoue, T., Uwagawa, S., Shibata, MA., Ito, N.: Co-carcinogenic effects of NaHCO3 on o-phenylphenol-induced rat bladder carcinogenesis. Carcinogenesis, 10: 1635-1640, 1989.

26. Shibata, MA., Yamada, M., Asakawa, E., Hagiwara, A., Fukushima, S.: Responses of rat urine and urothelium to bladder tumor promoters: possible roles of prostaglandin E2 and ascorbic acid synthesis in bladder carcinogenesis. Carcinogenesis, 10: 1651-1656, 1989.

27. Asamoto, M., Fukushima, S., Oosumi, H., Tatemoto, Y., Mori, M.: Immunohistochemical distribution of epithelial membrane antigen in bladder carcinomas as detected with a monoclonal antibody. Urol Res, 17: 273-277, 1989.

28. Asamoto, M., Fukushima, S., Horike, H., Tatemoto, Y., Mori, M.: Involucrin expression in urinary bladder carcinoma. Urol Res, 17: 279-283, 1989.

29. Kurata, Y., Tamano, S., Shibata, MA., Hagiwara, A., Fukushima, S., Ito, N.: Lack of carcinogenicity of magnesium chloride in a long-term feeding study in B6C3F1 mice. Fd Chem Toxicol, 27: 559-563, 1989.

30. Hirose, M., Yamaguchi, S., Fukushima, S., Hasegawa, R., Takahashi, S., Ito, N.: Promotion by dihydroxybenzene derivatives of N-methyl-N’-nitro-N-nitrosoguanidine-induced F344 rat forestomach and glandular stomach carcinogenesis. Cancer Res, 49: 5143-5147, 1989.

31. Asamoto, M., Tsuda, H., Kagawa, M., de Camargo, JLV., Ito, N., Nagase, S.: Strain differences in susceptibility to 2-acetylaminofluorone and phenobarbital promotion on rat hepatocarcinogenesis in a medium-term assay system: Quantitation of glutathione S-transferase P-positive foci development. Jpn J Cancer Res, 80: 939-944, 1989.

32. Hasegawa, R., Mutai, M., Imaida, K., Tsuda, H., Yamaguchi, S., Ito, N.: Synergistic effects of low-dose hepatocarcinogens in induction of glutathione S-transferase P-positive foci in the rat liver. Jpn J Cancer Res, 80: 945-951, 1989.

33. Satoh, K., Hatayama, I., Tateoka, N., Tamai, K., Shimizu, T., Tatematsu, M., Ito, N., Sato, K.: Transient induction of single GST-P positive hepatocytes by DEN. Carcinogenesis, 10: 2107-2111, 1989.

34. Ito, N., Hirose, M.: Antioxidants. Carcinogenic and chemopreventive properties. Adv Cancer Res, 53: 247-302, 1989.

35. Tatematsu, M., Mutai, M., Inoue, K., Ozaki, K., Furihata, C., Ito, N.: Synergism between sodium chloride and sodium taurocholate and development of pepsinogen-altered pyloric glands: Relevance to a medium-term bioassay system for gastric carcinogens and promoters in rats. Jpn J Cancer Res, 80: 1035-1040, 1989.

36. Asamoto, M., Tsuda, H., Kato, T., Ito, N., Masuko, T., Hashimoto, Y., Nagase, S.: Strain differences in susceptibility to 2-acetylaminofluorene and phenobarbital promotion of hepatocarcinogenesis: Immunohistochemical analysis of cytochrome P-450 isozyme induction by 2-acetylaminofluorene and phenobarbital. Jpn J Cancer Res, 80: 1041-1046, 1989.

37. Shibata, MA., Tanaka, H., Yamada, M., Tamano, S., Fukushima, S.: Proliferative response of renal pelvic epithelium in rats to oral administration of ortho-phenylphenol, sodium ortho-phenylphenate and diphenyl. Cancer Lett, 48: 19-28, 1989.

38. Yamaguchi, S., Hirose, M., Fukushima, S., Hasegawa, R., Ito, N.: Modification by catechol and resorcinol of upper digestive tract carcinogenesis in rats treated with methyl-N-amylnitrosamine. Cancer Res, 49: 6015-6018, 1989.

39. Hirose, M., Kagawa, M., Ogawa, K., Yamamoto, A., Ito, N.: Antagonistic effect of diethylmaleate on the promotion of forestomach carcinogenesis by butylated hydroxyanisole (BHA) in rats pretreated with N-methyl-N’-nitro-N-nitrosoguanidine. Carcinogenesis, 10: 2223-2226, 1989.

40. Hosokawa, S., Tatematsu, M., Aoki, T., Nakanowatari, J., Igarashi, T., Ito, N.: Modulation of diethylnitrosamine-initiated placental glutathione S-transferase positive preneoplastic and neoplastic lesions by clofibrate, a hepatic peroxisome proliferator. Carcinogenesis, 10: 2237-2241, 1989.

41. Ito, N., Hirose, M., Shibata, MA., Tanaka, H., Shirai, T.: Modifying effects of simultaneous treatment with butylated hydroxyanisole (BHA) on rat tumor induction by 3,2′-dimethyl-4-aminobiphenyl, 2,2′-dihydroxy-di-n-propylnitrosamine and N-methylnitrosourea. Carcinogenesis, 10: 2255-2259, 1989.

42. de Camargo, JLV., Tsuda, H., Tatematsu, M., Rodrigues, MAM., Yamada, M.,Tzuji, K., Ito, N.: Placental form of glutathione S-transferase in normal and diseased human uterine cervical mucosa. Carcinogenesis, 10: 2317-2320, 1989.

43. Saito, K., Nakagawa, S., Yoshitake, A., Miyamoto, J., Hirose, M., Ito, N.: DNA-adduct formation in the forestomach of rats treated with 3-tert-butyl-4-hydroxyanisole and its metabolites as assessed by an enzymatic 32P-postlabeling method. Cancer Lett, 48: 189-195, 1989.

44. Fitzgerald, DJ., Mesnil, M., Oyamada, M., Tsuda, H., Ito, N., Yamasaki, H.: Changes in gap junction protein (connexin 32) gene expression during rat liver carcinogenesis. J Cell Biochem, 41: 97-102, 1989.

45. Ito, N., Tatematsu, M., Hasegawa, R., Tsuda, H.: Medium-term bioassay system for detection of carcinogens and modifiers of hepatocarcinogenesis utilizing the GST-P positive liver cell focus as an endpoint marker. Toxicol Pathol, 17: 630-641, 1989.

46. Tatematsu, M., Ozaki, K., Mutai, M., Shichino, Y., Furihata, C., Ito, N.: Enhancing effects of various gastric carcinogens on development of pepsinogen-altered pyloric glands in rats. Carcinogenesis, 11: 1975-1978, 1989.

47. Ito, N., Fukushima, S., Hasegawa, R.: Bladder Cancers. Their process of development and its modification. Acta Pathol Jpn, 39: 1-14, 1989.

48. Ward, JM., Tsuda, H., Tatematsu, M., Hagiwara, A., Ito, N.: Hepatotoxicity of agents that enhance formation of focal hepatocellular proliferative lesions (putative preneoplastic foci) in a rapid rat liver bioassay. Fundam Appl Toxicol, 12: 163-171, 1989.

49. Ito, N., Tsuda, H., Hasegawa, R., Tatematsu, M., Imaida, K., Asamoto, M.: Medium-term bioassay models for environmental carcinogens. Two-step liver and multi-organ carcinogenesis protocols. In: Travis, CC. (ed.) Biologically-Based Methods for Cancer Risk Assessment, pp209-230. Plenum Publishing Co., 1989.

50. Shirai, T., Ito, N.: Rat prostatic carcinogenesis induced by 3,2′-dimethyl-4-aminobiphenyl. In: Karr, JP. & Yamanaka, H. (eds.) Prostate cancer. The Second Tokyo Symposium, pp77-85: Elsevier Sci. Pub. Co. Inc., 1989.

1. Hirose, M., Masuda, A., Fukushima, S., Ito, N.: Effects of subsequent antioxidant treatment on 7,12-dimethylbenz[a]anthracene-initiated carcinogenesis of the mammary gland, ear duct and forestomach in Sprague-Dawley rats. Carcinogenesis, 9: 101-104, 1988.

2. Tatematsu, M., Mera, Y., Inoue, T., Satoh, K., Sato, K., Ito, N.: Stable phenotypic expression of glutathione S-transferase placental type and unstable phenotypic expression of γ-glutamyltransferase in rat liver preneoplastic and neoplastic lesions. Carcinogenesis, 9: 215-220, 1988.

3. Tatematsu, M., Aoki, T., Kagawa, M., Mera, Y., Ito, N.: Reciprocal relationship between development of glutathione S-transferase positive liver foci and proliferation of surrounding hepatocytes in rats. Carcinogenesis, 9: 221-225, 1988.

4. Masui, T., Shirai, T., Imaida, K., Uwagawa, S., Fukushima, S.: Effects of urinary crystals induced by acetazolamide, uracil, and diethylene glycol on urinary bladder carcinogenesis in N-butyl-N-(4-hydroxybutyl)nitrosamine-initiated rats. Toxicol Lett, 40: 119-126, 1988.

5. Ito, N., Tsuda, H., Tatematsu, M., Inoue, T., Tagawa, Y., Aoki, T., Uwagawa, S., Kagawa, M., Ogiso, T., Masui, T., Imaida, K., Fukushima, S., Asamoto, M.: Enhancing effect of various hepatocarcinogens on induction of preneoplastic glutathione S-transferase placental form positive foci in rat — an approach for a new medium-term bioassay system. Carcinogenesis, 9: 387-394, 1988.

6. Tatematsu, M., Aoki, T., Inoue, T., Mutai, M., Furihata, C., Ito, N.: Coefficient induction of pepsinogen 1-decreased pyloric glands and gastric cancers in five different strains of rats treated with N-methyl-N’-nitro-N-nitrosoguanidine. Carcinogenesis, 9: 495-498, 1988.

7. Hayashi, M., Tsuda, H., Okumura, M., Sakata, T., Ito, N., Suchi, T.: Histopathological classification of malignant lymphomas in slaughtered swine. J Comp Pathol, 98: 11-21, 1988.

8. Shirai, T., Yamamoto, K., Adachi, T., Imaida, K., Masui, T., Ito, N.: Condyloma acuminatum of the bladder in two autopsy cases. Acta Pathol Jpn, 38: 399-405, 1988.

9. Mori, S., Takeuchi, Y., Toyama, M., Makino, S., Harauchi, T., Kurata, Y., Fukushima, S.: Assessment of L-ascorbic acid requirement for prolonged survival in ODS rats and their susceptibility to urinary bladder carcinogenesis by N-butyl-N-(4-hydroxybutyl)nitrosamine. Cancer Lett, 38: 275-282, 1988.

10. Tsuda, H., Moore, MA., Asamoto, M., Inoue, T., Ito, N., Satoh, K., Ichihara, A., Nakamura, T., Amelizad, Z., Oesch, F.: Effect of modifying agents on the phenotypic expression of cytochrome P-450, glutathione S-transferase molecular forms, microsomal epoxide hydrolase, glucose-6-phosphate dehydrogenase and γ-glutamyltranspeptidase in rat liver preneoplastic lesions. Carcinogenesis, 9: 547-554, 1988.

11. Nakanowatari, JI., Fukushima, S., Imaida, K., Ito, N., Nagase, S.: Strain differences in N-butyl-N-(4-hydroxybutyl)nitrosamine bladder carcinogenesis in rats. Jpn J Cancer Res (Gann), 79: 453-459, 1988.

12. Ito, N., Imaida, K., Tsuda, H., Shibata, MA., Aoki, T., de Camargo, JLV., Fukushima, S.: Wide-spectrum initiation models: possible applications to medium-term multiple organ bioassays for carcinogenesis modifiers. Jpn J Cancer Res (Gann), 79: 413-417, 1988.

13. Shirai, T., Masuda, A., Imaida, K., Ogiso, T., Ito, N.: Effects of phenobarbital and carbazole on carcinogenesis of the lung, thyroid, kidney, and bladder of rats pretreated with N-Bis(2-hydroxypropyl)nitrosamine. Jpn J Cancer Res (Gann), 79: 460-465, 1988.

14. Masui, T., Asamoto, M., Imaida, K., Fukushima, S., Okamura, T., Ohtaguro, K.: Primary choriocarcinoma of the urinary bladder. Jpn J Clin Oncol, 18: 59-64, 1988.

15. Ito, N., Imaida, K., de Camargo, JLV., Takahashi, S., Asamoto, M., Tsuda, H.: A new medium-term bioassay system for detection of environmental carcinogens using diethylnitrosamine-initiated rat liver followed by D-galactosamine treatment and partial hepatectomy. Jpn J Cancer Res (Gann), 79: 573-575, 1988.

16. Thamavit, W., Moore, MA., Hiasa, Y., Ito, N.: Enhancement of DHPN induced hepatocellular, cholangiocellular and pancreatic carcinogenesis by Opisthorchis viverrini infestation in Syrian golden hamsters. Carcinogenesis, 9: 1095-1098, 1988.

17. Tsuda, H., Asamoto, M., Kagawa, M., Uwagawa, S., Inoue, K., Inui, M., Ito, N.: Positive influence of dietary deoxycholic acid on development of pre-neoplastic lesions initiated by N-methyl-N-nitrosourea in rat liver. Carcinogenesis, 9: 1103-1105, 1988.

18. Ichinose, M., Miki, K., Tatematsu, M., Furihata, C., Nobuhara, M., Ichihara, Y., Tanji, M., Sogawa, K., Fujii-Kuriyama, Y., Oka, H., Takahashi, T., Kageyama, T., Takahashi, K.: Hypomethylation and expression of pepsinogen A genes in the fundic mucosa of human stomach. Biochem Biophys Res Commun, 151: 275-282, 1988.

19. Ichinose, M., Miki, K., Furihata, C., Tatematsu, M., Ichihara, Y., Ishihara, T., Katsura, I., Sogawa, K., Fujii-Kuriyama, Y., Tanji, M., Oka, H., Matsushima, T., Takahashi, K.: DNA methylation and expression of the rat pepsinogen gene in embryonic, adult, and neoplastic tissues. Cancer Res, 48: 1603-1609, 1988.

20. Sumitomo, S., Tatemoto, Y., Tanimura, T., Mori, M., Nakamura, T., Fukushima, S., Ito, N.: Immunohistochemical identification of keratin, involucrin, and epithelial membrane antigen in Paget’s disease. Acta Histochem Cytochem, 21: 61-72, 1988.

21. Tsuda, H., Asamoto, M., Ogiso, T., Inoue, T., Ito, N., Nagao, M.: Does-dependent induction of liver and thyroid neoplastic lesions by short-term administration of 2-amino-3-methylimidazo[4,5-f]quinoline combined with partial hepatectomy followed by phenobarbital or low does 3′-methyl-4-dimethylaminoazobenzene promotion. Jpn J Cancer Res (Gann), 79: 691-697, 1988.

22. Inoue, T., Imaida, K., Suzuki, E., Okada, M., Fukushima, S.: Combined effects of L-ascorbic acid, citric acid or their sodium salts on tumor induction by N-butyl-N-(4-hydroxybutyl)nitrosamine or N-ethyl-N-(4-hydroxybutyl)nitrosamine in the rat urinary bladder. Cancer Lett, 40: 265-273, 1988.

23. Masui, T., Fukushima, S., Katoh, F., Yamasaki, H., Ito, N.: Effects of sodium L-ascorbate, uracil, butylated hydroxyanisole and extracellular pH on junctional intercellular communication of BALB/c 3T3 cells. Carcinogenesis, 9: 1143-1146, 1988.

24. Moore, MA., Thamavit, W., Hiasa, Y., Ito, N.: Early lesions induced by DHPN in Syrian golden hamsters: influence of concomitant Opisthorchis infestation, dehydroepiandrosterone or butylated hydroxyanisole administration. Carcinogenesis, 9: 1185-1189, 1988.

25. Fukushima, S., Tamano, S., Shibata, MA., Kurata, Y., Hirose, M., Ito, N.: The role of urinary pH and sodium ion concentration in the promotion stage of two-stage carcinogenesis of the rat urinary bladder. Carcinogenesis, 9: 1203-1206, 1988.

26. Tatematsu, M., Ichinose, M., Miki, K., Tatematsu, K., Kishikawa, H., Ito, N.: Gastric phenotypic expression in human gallbladder cancers revealed by pepsinogen immunohistochemistry and mucin histochemistry. Virchow Archiv A Pathol Anat, 413: 25-32, 1988.

27. Thamavit, W., Moore, MA., Hiasa, Y., Ito, N.: Generation of high yields of Syrian hamster cholangiocellular carcinomas and hepatocellular nodules by combined nitrite and aminopyrine administration and Opisthorchis viverrini infection. Jpn J Cancer Res (Gann), 79: 909-916, 1988.

28. Ito, N., Shirai, T., Tagawa, Y., Nakamura, A., Fukushima, S.: Variation in tumor yield in the prostate and other target organs of the rat in response to varied dosage and duration of administration of 3,2′-dimethyl-4-aminobiphenyl. Cancer Res, 48: 4629-4632, 1988.

29. Ward, JM., Ito, N.: Development of new medium-term bioassays for carcinogens. Cancer Res, 48: 5051-5054, 1988.

30. Hirose, M., Fukushima, S., Kurata, Y., Tsuda, H., Tatematsu, M., Ito, N.: Modification of N-methyl-N’-nitro-N-nitrosoguanidine-induced forestomach and glandular stomach carcinogenesis by phenolic antioxidants in rats. Cancer Res., 48: 5310-5315, 1988.

31. Masui, T., Shirai, T., Takahashi, S., Mutai, M., Fukushima, S.: Summation effect of uracil on the two-stage and multistage models of urinary bladder carcinogenesis in F344 rats initiated by N-butyl-N-(4-hydroxybutyl)nitrosamine. Carcinogenesis, 9: 1981-1985, 1988.

32. Tamano, S., Hagiwara, A., Shibata, MA., Kurata, Y., Fukushima, S., Ito, N.: Spontaneous tumors in aging (C57BL/6N×C3H/HeN)F1 (B6C3F1) mice. Toxicol Pathol, 16: 321-326, 1988.

33. Fukushima, S., Imaida, K., Shibata, MA., Tamano, S., Kurata, Y., Shirai, T.: L-ascorbic acid amplification of second-stage bladder carcinogenesis promotion by NaHCO3. Cancer Res, 48: 6317-6320, 1988.

34. Hirose, M., Hagiwara, A., Inoue, K., Ito, N., Kaneko, H., Saito, K., Matsunaga, H., Isobe, N., Yoshitake, A., Miyamoto, J.: Metabolism of 2- and 3-tert-butyl-4-hydroxyanisole in the rat (III): Metabolites in the urine and feces. Toxicology, 53: 33-43, 1988.

35. Kitagawa, Y., Sakai, R., Tahira, T., Tsuda, H., Ito, N., Sugimura, T., Nagao, M.: Molecular cloning of rat phosphoprotein phosphatase 2Aβ cDNA and increased expressions of phosphatase 2Aα and 2Aβ in rat liver tumors. Biochem Biophys Res Commmun, 157: 821-827, 1988.

36. Shirai, T., Tagawa, Y., Taguchi, O., Ikawa, E., Mutai, M., Fukushima, S., Ito, N.: Low tumorigenic response to 3,2′-dimethyl-4-aminobiphenyl administration in the prostate of rats castrated at birth. Jpn J Cancer Res (Gann), 79: 1293-1296, 1988.

37. Imaida, K., Fukushima, S., Inoue, K., Masui, T., Hirose, M., Ito, N.: Modifying effects of concomitant treatment with butylated hydroxyanisole or butylated hydroxytoluene on N,N-dibutylnitrosamine-induced liver, forestomach and urinary bladder carcinogenesis in F344 male rats. Cancer Lett, 43: 167-172, 1988.

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42. Tsuda, H., Uwagawa, S., Aoki, T., Fukushima, S., Imaida, K., Ito, N., Sato, K., Nakamura, T., Oesch, F.: Analysis of the effects of modifying agents on six different phenotypes in preneoplastic foci in the liver in medium-term bioassay model in rats. In: Feo, F. et al. (eds.) Chemical Carcinogenesis, pp399-405: Plenum Publishing Co., 1988.

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1. Fukushima, S., Ogiso, T., Kurata, Y., Hirose, M., Ito, N.: Dose-dependent effects of butylated hydroxyanisole, butylated hydroxytoluene and ethoxyquin for promotion of bladder carcinogenesis in N-butyl-N-(4-hydroxybutyl)nitrosamine-initiated, unilaterally ureter-ligated rats. Cancer Lett, 34: 83-90, 1987.

2. Tatematsu, M., Furihata, C., Miki, K., Ichinose, M., Shirai, T., Tatematsu, K., Ito, N.: Complete and incomplete pyloric gland metaplasia of human gallbladder. Acta Pathol Jpn, 37: 39-46, 1987.

3. Hirose, M., Hagiwara, A., Inoue, K., Sakata, T., Ito, N., Kaneko, H., Yoshitake, A., Miyamoto, J.: Metabolism of 2- and 3-tert-butyl-4-hydroxyanisole (2- and 3-BHA) in the rat (I): Excretion of BHA in urine, feces and expired air and distribution of BHA in the main organs. Toxicology, 43: 139-147, 1987.

4. Shirai, T., Tsuda, H., Ogiso, T., Hirose, M., Ito, N.: Organ specific modifying potential of ethinyl estradiol on carcinogenesis initiated with different carcinogens. Carcinogenesis, 8: 115-119, 1987.

5. Moore, MA., Tsuda, H., Thamavit, W., Masui, T., Ito, N.: Differential modification of development of preneoplastic lesions in the Syrian golden hamster initiated with a single does of 2,2′-dioxo-N-nitrosodipropylamine: Influence of subsequent butylated hydroxyanisole, α-tocopherol, or carbazole. J Natl Cancer Inst, 78: 289-293, 1987.

6. Moore, MA., Thamavit, W., Ito, N.: Comparison of lesions induced in the Syrian golden hamster by diethylnitrosamine, dimethylhydrazine, and dibutylnitrosamine: Influence of subsequent butylated hydroxyanisole treatment. J Natl Cancer Inst, 78: 295-301, 1987.

7. Tsuda, H., Mera, Y., Seki, K., Aoki, T., Fukushima, S., Ito, N.: Induction of tumors in the liver, urinary bladder, esophagus and forestomach by short-term treatment with different doses of N,N’-dibutylnitrosamine in rats. Jpn J Cancer Res (Gann), 78: 227-234, 1987.

8. Shirai, T., Tagawa, Y., Fukushima, S., Asamoto, M., Ito, N.: Lack of tumorigenic response in the prostate gland of castrated F344 rats by 3,2′-dimethyl-4-aminobiphenyl given with methyltestosterone. Cancer Lett, 35: 1-6, 1987.

9. Shirai, T., Ikawa, E., Tagawa, Y., Ito, N.: Lesions of the prostate glands and seminal vesicles induced by N-methylnitrosourea in F344 rats pretreated with ethinyl estradiol. Cancer Lett, 35: 7-15, 1987.

10. Fukushima, S., Ogiso, T., Kurata, Y., Shibata, MA., Kakizoe, T.: Absence of promotion potential for calcium L-ascorbate, L-ascorbic dipalmitate, L-ascorbic stearate and erythorbic acid on rat urinary bladder carcinogenesis. Cancer Lett, 35: 17-25, 1987.

11. Tamano, S., Fukushima, S., Shirai, T., Hirose, M., Ito, N.: Modification by α-tocopherol, propyl gallate and tertiary butylhydroquinone of urinary bladder carcinogenesis in Fischer 344 rats pretreated with N-butyl-N-(4-hydroxybutyl)nitrosamine. Cancer Lett, 35: 39-46, 1987.

12. Moore, MA., Bannasch, P., Satoh, T., Hacker, HJ., Ito, N.: Immunohistochemically demonstrated increase in glutathione S-transferase species in propylnitrosamine-induced focal proliferative and neoplastic syrian hamster pancreatic lesions. Virchows Arch [Cell Pathol], 52: 479-488, 1987.

13. Tatematsu, M., Furihata, C., Katsuyama, T., Mera, Y., Inoue, T., Matsushima, T., Ito, N.: Immunohistochemical demonstration of pyloric gland-type cells with low-pepsinogen isozyme 1 in preneoplastic and neoplastic tissues of rat stomachs treated with N-methyl-N’-nitro-N-nitrosoguanidine. J Natl Cancer Inst, 78: 771-777, 1987.

14. Tatematsu, M., Aoki, T., Asamoto, M., Furihata, C., Ito, N.: Enhancing effects of N-ethyl-N’-nitro-N-nitrosoguanidine and sodium taurocholate on development of pepsinogen 1 decreased pyloric glands in rats initiated with N-methyl-N’-nitro-N-nitrosoguanidine. Jpn J
Cancer Res (Gann), 78: 312-316, 1987.

15. Hirose, M., Masuda, A., Imaida, K., Kagawa, M., Tsuda, H., Ito, N.: Induction of forestomach lesions in rats by oral administrations of naturally occurring antioxidants for 4 weeks. Jpn J Cancer Res (Gann), 78: 317-321, 1987.

16. Tatematsu, M., Tsuda, H., Shirai, T., Masui, T., Ito, N.: Placental glutathione S-transferase (GST-P) as a new marker for hepatocarcinogenesis: In vivo short-term screening for hepatocarcinogens. Toxicol Pathol, 15: 60-68, 1987.

17. Tsuda, H., Moore, MA., Asamoto, M., Inoue, T., Fukushima, S., Ito, N., Satoh, K., Amelizad, Z., Oesch, F.: Immunohistochemically demonstrated altered expression of cytochrome P-450 molecular forms and epoxide hydrolase in N-ethyl-N-hydroxyethylnitrosamine-induced rat kidney and liver lesions. Carcinogenesis, 8: 711-717, 1987.

18. Tsuda, H., Ogiso, T., Hasegawa, R., Imaida, K., Masui, T., Ito, N.: Inhibition of neoplastic development in rat liver, kidney, oesophagus and forestomach by 4,4′-diaminodiphenylmethane administration. Carcinogenesis, 8: 719-722, 1987.

19. Furihata, C., Takezawa, R., Matsushima, T., Tatematsu, M.: Potential tumor-promoting activity of bile acids in rat glandular stomach. Jpn J Cancer Res (Gann), 78: 32-39, 1987.

20. Fukushima, S., Sakata, T., Tagawa, Y., Shibata, MA., Hirose, M., Ito, N.: Different modifying response of butylated hydroxyanisole, butylated hydroxytoluene, and other antioxidants in N, N-dibutylnitrosamine esophagus and forestomach carcinogenesis of rats. Cancer Res, 47: 2113-2116, 1987.

21. Hasegawa, R., Fukushima, S., Hirose, M., Seki, K., Takahashi, M., Furukawa, F., Toyoda, K., Ito, N.: Histochemical demonstration of colonic type mucin in glandular metaplasia and adenocarcinoma of the human urinary bladder. Acta Pathol Jpn, 37: 1097-1103, 1987.

22. Hirose, M., Asamoto, M., Hagiwara, A., Ito, N., Kaneko, H., Saito, K., Takamatsu, Y., Yoshitake, A., Miyamoto, J.: Metabolism of 2- and 3-tert-butyl-4-hydroxyanisole (2- and 3-BHA) in the rat (II): Metabolism in forestomach and covalent binding to tissue macromolecules. Toxicology, 45: 13-24, 1987.

23. Funato, T., Yokota, J., Sakamoto, H., Kameya, T., Fukushima, S., Ito, N., Terada, M., Sugimura, T.: Activation of N-ras gene in a rat hepatocellular carcinoma induced by dibutylnitrosamine and butylated hydroxytoluene. Jpn J Cancer Res (Gann), 78: 689-694, 1987.

24. Mori, S., Kurata, Y., Takeuchi, Y., Toyama, M., Makino, S., Fukushima, S.: Influences of strain and diet on the promoting effects of sodium L-ascorbate in two-stage urinary bladder carcinogenesis in rats. Cancer Res, 47: 3492-3495, 1987.

25. Fukushima, S., Ito, N., El-Bolkainy, MN., Tawfik, HN., Tatemoto, Y., Mori, M.: Immunohistochemical observations of keratins, involucrin, and epithelial membrane antigen in urinary bladder carcinomas from patients infected with Schistosoma haematobium. Virchows Arch A, 411: 103-115, 1987.

26. Fukushima, S., Shibata, MA., Tamano, S., Ito, N., Suzuki, E., Okada, M.: Aging and urianary bladder carcinogenesis induced in rats by N-butyl-N-(4-hydroxybutyl)nitrosamine. J Natl Cancer Inst, 79: 263-267, 1987.

27. Shibata, MA., Kurata, Y., Ogiso, T., Tamano, S., Fukushima, S., Ito, N.: Combined chronic toxicity and carcinogenicity studies of morpholine oleic acid salt in B6C3F1 mice. Fd Chem Toxicol, 25: 569-574, 1987.

28. Moore, MA., Tsuda, H., Hacker, HJ., Sato, K., Bannasch, P., Ito, N.: Altered enzyme expression in propylnitrosamine-induced Syrian hamster lung lesions. Virchows Arch B, 53: 272-278, 1987.

29. Kurata, Y., Tsuda, H., Sakata, T., Yamashita, T., Ito, N.: Reciprocal modifying effects of isomeric forms of aminophenol on induction of neoplastic lesions in rat liver and kidney initiated by N-ethyl-N-hydroxyethylnitrosamine. Carcinogenesis, 8: 1281-1285, 1987.

30. Hirose, M., Inoue, T., Masuda, A., Tsuda, H., Ito, N.: Effects of simultaneous treatment with various chemicals on BHA-induced development of rat forestomach hyperplasia — complete inhibition by diethylmaletate in a 5-week feeding study. Carcinogenesis, 8: 1555-1558, 1987.

31. Tatematsu, M., Fukushima, S., Aoki, T., Mera, Y., Inoue, T., Ito, N.: Patterns of epithelial proliferation revealed by continuous administration of bromodeoxyuridine during urinary bladder carcinogenesis in rats. Jpn J Cancer Res (Gann), 78: 879-882, 1987.

32. Shirai, T., Ikawa, E., Imaida, K., Tagawa, Y., Ito, N.: Proliferative response of rat accessory sex organs to dietary sex hormones after castration or initial dietary administration of estrogen. J Urol, 138: 216-218, 1987.

33. Ito, N., Hirose, M.: The role of antioxidants in chemical carcinogenesis. Jpn J Cancer Res (Gann), 78: 1011-1026, 1987.

34. Shirai, T., Fukushima, S., Hirose, M., Ohshima, M., Ito, N.: Epithelial lesions of the urinary bladder in three hundred and thirteen autopsy cases. Jpn J Cancer Res (Gann), 78: 1073-1080, 1987.

35. Fukushima, S., Shibata, MA., Shirai, T., Kurata, Y., Tamano, S., Imaida, K.: Promotion by L-ascorbic acid of urinary bladder carcinogenesis in rats under conditions of increased urinary K ion concentratin and pH. Cancer Res, 47: 4821-4824, 1987.

36. Masui, T., Asamoto, M., Hirose, M., Fukushima, S., Ito, N.: Regression of simple hyperplasia and papillomas and persistence of basal cell hyperplasia in the forestomach of F344 rats treated with butylated hydroxyanisole. Cancer Res, 47: 5171-5174, 1987.

37. Shibata, MA., Kurata, Y., Tamano, S., Ogiso, T., Fukushima, S., Ito, N.: 13-week subchronic toxicity study with morpholine oleic acid salt administered to B6C3F1 mice. J Toxicol Environ Health, 22: 187-194, 1987.

38. Hirose, M., Masuda, A., Tsuda, H., Uwagawa, S., Ito, N.: Enhancement of BHA-induced proliferative rat forestomach lesion development by simultaneous treatment with other antioxidants. Carcinogenesis, 8: 1731-1735, 1987.

39. Fukushima, S., Shirai, T., Hirose, M.: The role L-ascorbic acid and urinary electolytes in promotion of rat blaader carcinogenesis. Exp Pathol, 31: 69-70, 1987.

40. Hirose, M., Kurata, Y., Tsuda, H., Fukushima, S., Ito, N.: Catechol strongly enhances rat stomach carcinogenesis: A possible new environmental stomach carcinogen. Jpn J Cancer Res (Gann), 78: 1144-1149, 1987.

41. Tsuda, H., Masui, T., Ikawa, E., Imaida, K., Ito, N.: Compared promoting potential of D-galactosamine, carbon tetrachloride and partial hepatectomy in rapid induction of preneoplastic liver lesions in the rat. Cancer Lett, 37: 163-171, 1987.

42. Okamura, T., Ohtani, M., Inoue, K., Fukushima, S., Ohtaguro, K., Kakizoe, T.: Effects of intravesical instillation of antitumor chemotherapeutic and immunotherapeutic agents on bladder lesion development in rats pretreated with N-butyl-N-(4-hydroxybutyl)nitrosamine. J Urol, 138: 1305-1307, 1987.

43. Shirai, T., Tagawa, Y., Fukushima, S., Imaida, K., Ito, N.: Strong promoting activity of reversible uracil-induced urolithiasis on urinary bladder carcinogenesis in rats initiated with N-butyl-N-(4-hydroxybutyl)nitrosamine. Cancer Res, 47: 6726-6730, 1987.

44. Ito, N.: Organ-specific modifying effects of phenobarbital, saccharin and antioxidants on 2-stage chemical carcinogenesis. In: Chambers, PL., Gehring, P., Sakai, F. (eds.) New Concepts and Developments in Toxicology, pp359-369. Elsevier Science Publishers B.V. (Biomedical Division), 1987.

45. Tsuda, H., Aoki, T., Ito, N.: Effects of α-tocopherol on carcinogenesis in various organs of rats. In: Hayashi, O. & Mino, M. (eds.) Clinical and Nutritional Aspects of Vitamin E, pp329-332. Elservier Science Publish BV. (Biomedical Division), 1987.

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