1. Shirai, T., Fukushima, S., Tagawa, Y., Okumura, M., Ito, N.: Cell proliferation induced by uracil-calculi and subsequent development of reversible papillomatosis in the rat urinary bladder. Cancer Res, 49: 378-383, 1989.

2. Thornton, M., Moore, MA., Ito, N.: Modifying influence of dehydroepiandrosterone or butylated hydroxytoluene treatment on initiation and development stages of azaserine-induced acinar pancreatic preneoplastic lesions in the rat. Carcinogenesis, 10: 407-410, 1989.

3. Hasegawa, R., Fukushima, S., Hagiwara, A., Masui, T., Masuda, A., Ito, N.: Long-term feeding study of N,N’-diphenyl-p-phenylenediamine in F344 rats. Toxicology, 54: 69-78, 1989.

4. Tsuda, H., Inoue, T., Asamoto, M., Fukushima, S., Ito, N., Okamura, T., Ohtaguro, K., Washida, H., Satoh, K., Amelizad, Z., Oesch, F.: Comparison of enzyme phenotypes in human bladder tumours and experimentally induced hyperplastic and neoplastic lesions of the rat urinary bladder. Virchows Arch B Cell Pathol, 56: 307-316, 1989.

5. Asamoto, M., Fukushima, S., Tatemoto, Y., Yamada, K., Fukui, S., Mori, M.: Immunohistochemical expression of keratin proteins in urinary bladder carcinoma. Pathol Res Pract, 184: 194-201, 1989.

6. Fukushima, S., Asamoto, M., Imaida, K., El-Bolkainy, MN., Tawfik, HN., Ito, N.: Comparative study of urinary bladder carcinomas in Japanese and Egyptians. Acta Pathol Jpn, 39: 176-179, 1989.

7. Ito, N., Fukushima, S.: Promotion of urinary bladder carcinogenesis in experimental animals. Exp Pathol, 36: 1-15, 1989.

8. Shirai, T., Nakamura, A., Fukushima, S., Takahashi, S., Ogawa, K., Ito, N.: Effects of age on multiple organ carcinogenesis induced by 3,2′-dimethyl-4-aminobiphenyl in rats, with particular reference to the prostate. Jpn J Cancer Res, 80: 312-316, 1989.

9. Ito, N., Hagiwara, A., Tamano, S., Kagawa, M., Shibata, MA., Kurata, Y., Fukushima, S.: Lack of carcinogenicity of quercetin in F344/DuCrj rats. Jpn J Cancer Res, 80: 317-325, 1989.

10. Tatematsu, M., Mutai, M., Aoki, T., de Camargo, JLV., Furihata, C., Ito, N.: Proliferation kinetics of pepsinogen altered pyloric gland cells in rats treated with N-methyl-N’-nitro-N-nitrosoguanidine. Carcinogenesis, 10: 907-911, 1989.

11. Shibata, MA., Hagiwara, A., Tamano, S., Ono, S., Fukushima, S.: Lack of a modifying effect by the diuretic drug furosemide on the development of neoplastic lesions in rat two-stage urinary bladder carcinogenesis. J Toxicol Environ Health, 26: 255-265, 1989.

12. Imaida, K., Tatematsu, M., Kato, T., Tsuda, H., Ito, N.: Advantages and limitations of stereological estimation of placental glutathione S-transferase-positive rat liver cell foci by computerized three-dimensional reconstruction. Jpn J Cancer Res, 80: 326-330, 1989.

13. Hagiwara, A., Tamano, S., Shibata, MA., Arai, M., Tsuda, H.: Lack of modifying effects of 2,2′-[(4-aminophenyl)imino]bisethanol sulfate on induction of preneoplastic γ-glutamyl transpeptidase-positive foci in a medium-term bioassay system using F344 rats. J Toxicol Sci, 14: 77-86, 1989.

14. Tatematsu, M., Katsuyama, T., Mutai, M., Asakawa, E., Ito, N.: Pyloric gland phenotypic expression of gastric cancers developing in the rat fundic glandular stomach. Carcinogenesis, 10: 1033-1039, 1989.

15. Shirai, T., Nakamura, A., Wada, S., Ito, N.: Pancreatic acinar cell tumors in rats induced by 3,2′-dimethyl-4-aminobiphenyl. Carcinogenesis, 10: 1127-1130, 1989.

16. Thamavit, W., Fukushima, S., Kurata, Y., Asamoto, M., Ito, N.: Modification by sodium L-ascorbate, butylated hydroxytoluene, phenobarbital and pepleomycin of lesion development in a wide-spectrum initiation rat model. Cancer Lett, 45: 93-101, 1989.

17. Hagiwara, A., Hirose, M., Miyata, Y., Fukushima, S., Ito, N.: Modulation of N-butyl-N-(4-hydroxybutyl)- nitrosamine-induced rat urinary bladder carcinogenesis by post-treatment with combinations of three phenolic antioxidants. J Toxicol Pathol, 2: 33-39, 1989.

18. Tagawa, Y., Shirai, T., Fukushima, S., Nakamura, A., Hirose, M., Ito, N.: Lack of modification by dietary unsaturated fat of 3,2′-dimethyl-4-aminobiphenyl-induced rat prostate and colon carcinogenesis. J Toxicol Pathol, 2: 49-53, 1989.

19. Ito, N., Imaida, K., Hasegawa, R., Tsuda, H.: Rapid bioassay methods for carcinogens and modifiers of hepatocarcinogenesis. Crit Rev Toxicol, 19: 385-415, 1989.

20. Shibata, MA., Yamada, M., Tanaka, H., Kagawa, M., Fukushima, S.: Changes in urine composition, bladder epithelial morphology, and DNA synthesis in male F344 rats in response to ingestion of bladder tumor promoters. Toxicol Appl Pharmacol, 99: 37-49, 1989.

21. Tada, M., Aoki, H., Kojima, M., Morita, T., Shirai, T., Yamada, H., Ito, N.: Preparation and characterization of antibodies against 3,2′-dimethyl-4-aminobiphenyl-modified DNA. Carcinogenesis, 10: 1397-1402, 1989.

22. Shibata, MA., Tamano, S., Kurata, Y., Hagiwara, A., Fukushima, S.: Participation of urinary Na+, K+, pH, and L-ascorbic acid in the proliferative response of the bladder epithelium after the oral administration of various salts and/or ascorbic acid to rats. Fd Chem Toxicol, 27: 403-413, 1989.

23. Asamoto, M., Fukushima, S., Tatemoto, Y., Yamada, K., Yuba, R., Mori, M.: Immunohistochemical evaluation of nonspecific cross reactive antigen and carcinoembryonic antigen (CEA) in urinary bladder carcinoma. Anticancer Res, 9: 319-326, 1989.

24. Hirose, M., Kurata, Y., Yamada, M., Shirai, T., Ito, N., Ohsawa, T.: Lack of modifying effects of linolic acid hydroperoxides and their secondary oxidative products on combined 7,12-dimethylbenz[a]anthracene and 1,2-dimethylhydrazine-initiated mammary gland, ear duct and colon carcinogenesis in female Sprague-Dawley rats. Cancer Lett, 47: 141-147, 1989.

25. Fukushima, S., Inoue, T., Uwagawa, S., Shibata, MA., Ito, N.: Co-carcinogenic effects of NaHCO3 on o-phenylphenol-induced rat bladder carcinogenesis. Carcinogenesis, 10: 1635-1640, 1989.

26. Shibata, MA., Yamada, M., Asakawa, E., Hagiwara, A., Fukushima, S.: Responses of rat urine and urothelium to bladder tumor promoters: possible roles of prostaglandin E2 and ascorbic acid synthesis in bladder carcinogenesis. Carcinogenesis, 10: 1651-1656, 1989.

27. Asamoto, M., Fukushima, S., Oosumi, H., Tatemoto, Y., Mori, M.: Immunohistochemical distribution of epithelial membrane antigen in bladder carcinomas as detected with a monoclonal antibody. Urol Res, 17: 273-277, 1989.

28. Asamoto, M., Fukushima, S., Horike, H., Tatemoto, Y., Mori, M.: Involucrin expression in urinary bladder carcinoma. Urol Res, 17: 279-283, 1989.

29. Kurata, Y., Tamano, S., Shibata, MA., Hagiwara, A., Fukushima, S., Ito, N.: Lack of carcinogenicity of magnesium chloride in a long-term feeding study in B6C3F1 mice. Fd Chem Toxicol, 27: 559-563, 1989.

30. Hirose, M., Yamaguchi, S., Fukushima, S., Hasegawa, R., Takahashi, S., Ito, N.: Promotion by dihydroxybenzene derivatives of N-methyl-N’-nitro-N-nitrosoguanidine-induced F344 rat forestomach and glandular stomach carcinogenesis. Cancer Res, 49: 5143-5147, 1989.

31. Asamoto, M., Tsuda, H., Kagawa, M., de Camargo, JLV., Ito, N., Nagase, S.: Strain differences in susceptibility to 2-acetylaminofluorone and phenobarbital promotion on rat hepatocarcinogenesis in a medium-term assay system: Quantitation of glutathione S-transferase P-positive foci development. Jpn J Cancer Res, 80: 939-944, 1989.

32. Hasegawa, R., Mutai, M., Imaida, K., Tsuda, H., Yamaguchi, S., Ito, N.: Synergistic effects of low-dose hepatocarcinogens in induction of glutathione S-transferase P-positive foci in the rat liver. Jpn J Cancer Res, 80: 945-951, 1989.

33. Satoh, K., Hatayama, I., Tateoka, N., Tamai, K., Shimizu, T., Tatematsu, M., Ito, N., Sato, K.: Transient induction of single GST-P positive hepatocytes by DEN. Carcinogenesis, 10: 2107-2111, 1989.

34. Ito, N., Hirose, M.: Antioxidants. Carcinogenic and chemopreventive properties. Adv Cancer Res, 53: 247-302, 1989.

35. Tatematsu, M., Mutai, M., Inoue, K., Ozaki, K., Furihata, C., Ito, N.: Synergism between sodium chloride and sodium taurocholate and development of pepsinogen-altered pyloric glands: Relevance to a medium-term bioassay system for gastric carcinogens and promoters in rats. Jpn J Cancer Res, 80: 1035-1040, 1989.

36. Asamoto, M., Tsuda, H., Kato, T., Ito, N., Masuko, T., Hashimoto, Y., Nagase, S.: Strain differences in susceptibility to 2-acetylaminofluorene and phenobarbital promotion of hepatocarcinogenesis: Immunohistochemical analysis of cytochrome P-450 isozyme induction by 2-acetylaminofluorene and phenobarbital. Jpn J Cancer Res, 80: 1041-1046, 1989.

37. Shibata, MA., Tanaka, H., Yamada, M., Tamano, S., Fukushima, S.: Proliferative response of renal pelvic epithelium in rats to oral administration of ortho-phenylphenol, sodium ortho-phenylphenate and diphenyl. Cancer Lett, 48: 19-28, 1989.

38. Yamaguchi, S., Hirose, M., Fukushima, S., Hasegawa, R., Ito, N.: Modification by catechol and resorcinol of upper digestive tract carcinogenesis in rats treated with methyl-N-amylnitrosamine. Cancer Res, 49: 6015-6018, 1989.

39. Hirose, M., Kagawa, M., Ogawa, K., Yamamoto, A., Ito, N.: Antagonistic effect of diethylmaleate on the promotion of forestomach carcinogenesis by butylated hydroxyanisole (BHA) in rats pretreated with N-methyl-N’-nitro-N-nitrosoguanidine. Carcinogenesis, 10: 2223-2226, 1989.

40. Hosokawa, S., Tatematsu, M., Aoki, T., Nakanowatari, J., Igarashi, T., Ito, N.: Modulation of diethylnitrosamine-initiated placental glutathione S-transferase positive preneoplastic and neoplastic lesions by clofibrate, a hepatic peroxisome proliferator. Carcinogenesis, 10: 2237-2241, 1989.

41. Ito, N., Hirose, M., Shibata, MA., Tanaka, H., Shirai, T.: Modifying effects of simultaneous treatment with butylated hydroxyanisole (BHA) on rat tumor induction by 3,2′-dimethyl-4-aminobiphenyl, 2,2′-dihydroxy-di-n-propylnitrosamine and N-methylnitrosourea. Carcinogenesis, 10: 2255-2259, 1989.

42. de Camargo, JLV., Tsuda, H., Tatematsu, M., Rodrigues, MAM., Yamada, M.,Tzuji, K., Ito, N.: Placental form of glutathione S-transferase in normal and diseased human uterine cervical mucosa. Carcinogenesis, 10: 2317-2320, 1989.

43. Saito, K., Nakagawa, S., Yoshitake, A., Miyamoto, J., Hirose, M., Ito, N.: DNA-adduct formation in the forestomach of rats treated with 3-tert-butyl-4-hydroxyanisole and its metabolites as assessed by an enzymatic 32P-postlabeling method. Cancer Lett, 48: 189-195, 1989.

44. Fitzgerald, DJ., Mesnil, M., Oyamada, M., Tsuda, H., Ito, N., Yamasaki, H.: Changes in gap junction protein (connexin 32) gene expression during rat liver carcinogenesis. J Cell Biochem, 41: 97-102, 1989.

45. Ito, N., Tatematsu, M., Hasegawa, R., Tsuda, H.: Medium-term bioassay system for detection of carcinogens and modifiers of hepatocarcinogenesis utilizing the GST-P positive liver cell focus as an endpoint marker. Toxicol Pathol, 17: 630-641, 1989.

46. Tatematsu, M., Ozaki, K., Mutai, M., Shichino, Y., Furihata, C., Ito, N.: Enhancing effects of various gastric carcinogens on development of pepsinogen-altered pyloric glands in rats. Carcinogenesis, 11: 1975-1978, 1989.

47. Ito, N., Fukushima, S., Hasegawa, R.: Bladder Cancers. Their process of development and its modification. Acta Pathol Jpn, 39: 1-14, 1989.

48. Ward, JM., Tsuda, H., Tatematsu, M., Hagiwara, A., Ito, N.: Hepatotoxicity of agents that enhance formation of focal hepatocellular proliferative lesions (putative preneoplastic foci) in a rapid rat liver bioassay. Fundam Appl Toxicol, 12: 163-171, 1989.

49. Ito, N., Tsuda, H., Hasegawa, R., Tatematsu, M., Imaida, K., Asamoto, M.: Medium-term bioassay models for environmental carcinogens. Two-step liver and multi-organ carcinogenesis protocols. In: Travis, CC. (ed.) Biologically-Based Methods for Cancer Risk Assessment, pp209-230. Plenum Publishing Co., 1989.

50. Shirai, T., Ito, N.: Rat prostatic carcinogenesis induced by 3,2′-dimethyl-4-aminobiphenyl. In: Karr, JP. & Yamanaka, H. (eds.) Prostate cancer. The Second Tokyo Symposium, pp77-85: Elsevier Sci. Pub. Co. Inc., 1989.