1. Fukushima, S., Ogiso, T., Kurata, Y., Hirose, M., Ito, N.: Dose-dependent effects of butylated hydroxyanisole, butylated hydroxytoluene and ethoxyquin for promotion of bladder carcinogenesis in N-butyl-N-(4-hydroxybutyl)nitrosamine-initiated, unilaterally ureter-ligated rats. Cancer Lett, 34: 83-90, 1987.

2. Tatematsu, M., Furihata, C., Miki, K., Ichinose, M., Shirai, T., Tatematsu, K., Ito, N.: Complete and incomplete pyloric gland metaplasia of human gallbladder. Acta Pathol Jpn, 37: 39-46, 1987.

3. Hirose, M., Hagiwara, A., Inoue, K., Sakata, T., Ito, N., Kaneko, H., Yoshitake, A., Miyamoto, J.: Metabolism of 2- and 3-tert-butyl-4-hydroxyanisole (2- and 3-BHA) in the rat (I): Excretion of BHA in urine, feces and expired air and distribution of BHA in the main organs. Toxicology, 43: 139-147, 1987.

4. Shirai, T., Tsuda, H., Ogiso, T., Hirose, M., Ito, N.: Organ specific modifying potential of ethinyl estradiol on carcinogenesis initiated with different carcinogens. Carcinogenesis, 8: 115-119, 1987.

5. Moore, MA., Tsuda, H., Thamavit, W., Masui, T., Ito, N.: Differential modification of development of preneoplastic lesions in the Syrian golden hamster initiated with a single does of 2,2′-dioxo-N-nitrosodipropylamine: Influence of subsequent butylated hydroxyanisole, α-tocopherol, or carbazole. J Natl Cancer Inst, 78: 289-293, 1987.

6. Moore, MA., Thamavit, W., Ito, N.: Comparison of lesions induced in the Syrian golden hamster by diethylnitrosamine, dimethylhydrazine, and dibutylnitrosamine: Influence of subsequent butylated hydroxyanisole treatment. J Natl Cancer Inst, 78: 295-301, 1987.

7. Tsuda, H., Mera, Y., Seki, K., Aoki, T., Fukushima, S., Ito, N.: Induction of tumors in the liver, urinary bladder, esophagus and forestomach by short-term treatment with different doses of N,N’-dibutylnitrosamine in rats. Jpn J Cancer Res (Gann), 78: 227-234, 1987.

8. Shirai, T., Tagawa, Y., Fukushima, S., Asamoto, M., Ito, N.: Lack of tumorigenic response in the prostate gland of castrated F344 rats by 3,2′-dimethyl-4-aminobiphenyl given with methyltestosterone. Cancer Lett, 35: 1-6, 1987.

9. Shirai, T., Ikawa, E., Tagawa, Y., Ito, N.: Lesions of the prostate glands and seminal vesicles induced by N-methylnitrosourea in F344 rats pretreated with ethinyl estradiol. Cancer Lett, 35: 7-15, 1987.

10. Fukushima, S., Ogiso, T., Kurata, Y., Shibata, MA., Kakizoe, T.: Absence of promotion potential for calcium L-ascorbate, L-ascorbic dipalmitate, L-ascorbic stearate and erythorbic acid on rat urinary bladder carcinogenesis. Cancer Lett, 35: 17-25, 1987.

11. Tamano, S., Fukushima, S., Shirai, T., Hirose, M., Ito, N.: Modification by α-tocopherol, propyl gallate and tertiary butylhydroquinone of urinary bladder carcinogenesis in Fischer 344 rats pretreated with N-butyl-N-(4-hydroxybutyl)nitrosamine. Cancer Lett, 35: 39-46, 1987.

12. Moore, MA., Bannasch, P., Satoh, T., Hacker, HJ., Ito, N.: Immunohistochemically demonstrated increase in glutathione S-transferase species in propylnitrosamine-induced focal proliferative and neoplastic syrian hamster pancreatic lesions. Virchows Arch [Cell Pathol], 52: 479-488, 1987.

13. Tatematsu, M., Furihata, C., Katsuyama, T., Mera, Y., Inoue, T., Matsushima, T., Ito, N.: Immunohistochemical demonstration of pyloric gland-type cells with low-pepsinogen isozyme 1 in preneoplastic and neoplastic tissues of rat stomachs treated with N-methyl-N’-nitro-N-nitrosoguanidine. J Natl Cancer Inst, 78: 771-777, 1987.

14. Tatematsu, M., Aoki, T., Asamoto, M., Furihata, C., Ito, N.: Enhancing effects of N-ethyl-N’-nitro-N-nitrosoguanidine and sodium taurocholate on development of pepsinogen 1 decreased pyloric glands in rats initiated with N-methyl-N’-nitro-N-nitrosoguanidine. Jpn J
Cancer Res (Gann), 78: 312-316, 1987.

15. Hirose, M., Masuda, A., Imaida, K., Kagawa, M., Tsuda, H., Ito, N.: Induction of forestomach lesions in rats by oral administrations of naturally occurring antioxidants for 4 weeks. Jpn J Cancer Res (Gann), 78: 317-321, 1987.

16. Tatematsu, M., Tsuda, H., Shirai, T., Masui, T., Ito, N.: Placental glutathione S-transferase (GST-P) as a new marker for hepatocarcinogenesis: In vivo short-term screening for hepatocarcinogens. Toxicol Pathol, 15: 60-68, 1987.

17. Tsuda, H., Moore, MA., Asamoto, M., Inoue, T., Fukushima, S., Ito, N., Satoh, K., Amelizad, Z., Oesch, F.: Immunohistochemically demonstrated altered expression of cytochrome P-450 molecular forms and epoxide hydrolase in N-ethyl-N-hydroxyethylnitrosamine-induced rat kidney and liver lesions. Carcinogenesis, 8: 711-717, 1987.

18. Tsuda, H., Ogiso, T., Hasegawa, R., Imaida, K., Masui, T., Ito, N.: Inhibition of neoplastic development in rat liver, kidney, oesophagus and forestomach by 4,4′-diaminodiphenylmethane administration. Carcinogenesis, 8: 719-722, 1987.

19. Furihata, C., Takezawa, R., Matsushima, T., Tatematsu, M.: Potential tumor-promoting activity of bile acids in rat glandular stomach. Jpn J Cancer Res (Gann), 78: 32-39, 1987.

20. Fukushima, S., Sakata, T., Tagawa, Y., Shibata, MA., Hirose, M., Ito, N.: Different modifying response of butylated hydroxyanisole, butylated hydroxytoluene, and other antioxidants in N, N-dibutylnitrosamine esophagus and forestomach carcinogenesis of rats. Cancer Res, 47: 2113-2116, 1987.

21. Hasegawa, R., Fukushima, S., Hirose, M., Seki, K., Takahashi, M., Furukawa, F., Toyoda, K., Ito, N.: Histochemical demonstration of colonic type mucin in glandular metaplasia and adenocarcinoma of the human urinary bladder. Acta Pathol Jpn, 37: 1097-1103, 1987.

22. Hirose, M., Asamoto, M., Hagiwara, A., Ito, N., Kaneko, H., Saito, K., Takamatsu, Y., Yoshitake, A., Miyamoto, J.: Metabolism of 2- and 3-tert-butyl-4-hydroxyanisole (2- and 3-BHA) in the rat (II): Metabolism in forestomach and covalent binding to tissue macromolecules. Toxicology, 45: 13-24, 1987.

23. Funato, T., Yokota, J., Sakamoto, H., Kameya, T., Fukushima, S., Ito, N., Terada, M., Sugimura, T.: Activation of N-ras gene in a rat hepatocellular carcinoma induced by dibutylnitrosamine and butylated hydroxytoluene. Jpn J Cancer Res (Gann), 78: 689-694, 1987.

24. Mori, S., Kurata, Y., Takeuchi, Y., Toyama, M., Makino, S., Fukushima, S.: Influences of strain and diet on the promoting effects of sodium L-ascorbate in two-stage urinary bladder carcinogenesis in rats. Cancer Res, 47: 3492-3495, 1987.

25. Fukushima, S., Ito, N., El-Bolkainy, MN., Tawfik, HN., Tatemoto, Y., Mori, M.: Immunohistochemical observations of keratins, involucrin, and epithelial membrane antigen in urinary bladder carcinomas from patients infected with Schistosoma haematobium. Virchows Arch A, 411: 103-115, 1987.

26. Fukushima, S., Shibata, MA., Tamano, S., Ito, N., Suzuki, E., Okada, M.: Aging and urianary bladder carcinogenesis induced in rats by N-butyl-N-(4-hydroxybutyl)nitrosamine. J Natl Cancer Inst, 79: 263-267, 1987.

27. Shibata, MA., Kurata, Y., Ogiso, T., Tamano, S., Fukushima, S., Ito, N.: Combined chronic toxicity and carcinogenicity studies of morpholine oleic acid salt in B6C3F1 mice. Fd Chem Toxicol, 25: 569-574, 1987.

28. Moore, MA., Tsuda, H., Hacker, HJ., Sato, K., Bannasch, P., Ito, N.: Altered enzyme expression in propylnitrosamine-induced Syrian hamster lung lesions. Virchows Arch B, 53: 272-278, 1987.

29. Kurata, Y., Tsuda, H., Sakata, T., Yamashita, T., Ito, N.: Reciprocal modifying effects of isomeric forms of aminophenol on induction of neoplastic lesions in rat liver and kidney initiated by N-ethyl-N-hydroxyethylnitrosamine. Carcinogenesis, 8: 1281-1285, 1987.

30. Hirose, M., Inoue, T., Masuda, A., Tsuda, H., Ito, N.: Effects of simultaneous treatment with various chemicals on BHA-induced development of rat forestomach hyperplasia — complete inhibition by diethylmaletate in a 5-week feeding study. Carcinogenesis, 8: 1555-1558, 1987.

31. Tatematsu, M., Fukushima, S., Aoki, T., Mera, Y., Inoue, T., Ito, N.: Patterns of epithelial proliferation revealed by continuous administration of bromodeoxyuridine during urinary bladder carcinogenesis in rats. Jpn J Cancer Res (Gann), 78: 879-882, 1987.

32. Shirai, T., Ikawa, E., Imaida, K., Tagawa, Y., Ito, N.: Proliferative response of rat accessory sex organs to dietary sex hormones after castration or initial dietary administration of estrogen. J Urol, 138: 216-218, 1987.

33. Ito, N., Hirose, M.: The role of antioxidants in chemical carcinogenesis. Jpn J Cancer Res (Gann), 78: 1011-1026, 1987.

34. Shirai, T., Fukushima, S., Hirose, M., Ohshima, M., Ito, N.: Epithelial lesions of the urinary bladder in three hundred and thirteen autopsy cases. Jpn J Cancer Res (Gann), 78: 1073-1080, 1987.

35. Fukushima, S., Shibata, MA., Shirai, T., Kurata, Y., Tamano, S., Imaida, K.: Promotion by L-ascorbic acid of urinary bladder carcinogenesis in rats under conditions of increased urinary K ion concentratin and pH. Cancer Res, 47: 4821-4824, 1987.

36. Masui, T., Asamoto, M., Hirose, M., Fukushima, S., Ito, N.: Regression of simple hyperplasia and papillomas and persistence of basal cell hyperplasia in the forestomach of F344 rats treated with butylated hydroxyanisole. Cancer Res, 47: 5171-5174, 1987.

37. Shibata, MA., Kurata, Y., Tamano, S., Ogiso, T., Fukushima, S., Ito, N.: 13-week subchronic toxicity study with morpholine oleic acid salt administered to B6C3F1 mice. J Toxicol Environ Health, 22: 187-194, 1987.

38. Hirose, M., Masuda, A., Tsuda, H., Uwagawa, S., Ito, N.: Enhancement of BHA-induced proliferative rat forestomach lesion development by simultaneous treatment with other antioxidants. Carcinogenesis, 8: 1731-1735, 1987.

39. Fukushima, S., Shirai, T., Hirose, M.: The role L-ascorbic acid and urinary electolytes in promotion of rat blaader carcinogenesis. Exp Pathol, 31: 69-70, 1987.

40. Hirose, M., Kurata, Y., Tsuda, H., Fukushima, S., Ito, N.: Catechol strongly enhances rat stomach carcinogenesis: A possible new environmental stomach carcinogen. Jpn J Cancer Res (Gann), 78: 1144-1149, 1987.

41. Tsuda, H., Masui, T., Ikawa, E., Imaida, K., Ito, N.: Compared promoting potential of D-galactosamine, carbon tetrachloride and partial hepatectomy in rapid induction of preneoplastic liver lesions in the rat. Cancer Lett, 37: 163-171, 1987.

42. Okamura, T., Ohtani, M., Inoue, K., Fukushima, S., Ohtaguro, K., Kakizoe, T.: Effects of intravesical instillation of antitumor chemotherapeutic and immunotherapeutic agents on bladder lesion development in rats pretreated with N-butyl-N-(4-hydroxybutyl)nitrosamine. J Urol, 138: 1305-1307, 1987.

43. Shirai, T., Tagawa, Y., Fukushima, S., Imaida, K., Ito, N.: Strong promoting activity of reversible uracil-induced urolithiasis on urinary bladder carcinogenesis in rats initiated with N-butyl-N-(4-hydroxybutyl)nitrosamine. Cancer Res, 47: 6726-6730, 1987.

44. Ito, N.: Organ-specific modifying effects of phenobarbital, saccharin and antioxidants on 2-stage chemical carcinogenesis. In: Chambers, PL., Gehring, P., Sakai, F. (eds.) New Concepts and Developments in Toxicology, pp359-369. Elsevier Science Publishers B.V. (Biomedical Division), 1987.

45. Tsuda, H., Aoki, T., Ito, N.: Effects of α-tocopherol on carcinogenesis in various organs of rats. In: Hayashi, O. & Mino, M. (eds.) Clinical and Nutritional Aspects of Vitamin E, pp329-332. Elservier Science Publish BV. (Biomedical Division), 1987.

46. Hiasa, Y., Ito, N.: Experimental induction of renal tumors. CRC Crit Rev Toxicol, 17: 279-343, 1987.