1. Kato, T., Ogiso, T., Kato, K., Sano, M., Hasegawa, R., Shirai, T., Ito, N.: Lack of promoting activity of four pesticides on induction of preneoplastic liver cell foci in rats. Teratog Carcinog Mutagen, 15: 251-257, 1995.

2. Hasegawa, R., Ogiso, T., Imaida, K., Shirai, T., Ito, N.: Analysis of the potential carcinogenicity of coffee and its related compounds in a medium-term liver bioassay of rats. Fd Chem Toxicol, 33: 15-20, 1995.

3. Shibata, MA., Sano, M., Hagiwara, A., Hasegawa, R., Shirai, T.: Modification by analgesics of lesion development in the urinary tract and various other organs of rats pretreated with dihydroxy-di-N- propylnitrosamine and uracil. Jpn J Cancer Res, 86: 160-167, 1995.

4. Tanaka, H., Hirose, M., Hagiwara, A., Imaida, K., Shirai, T., Ito, N.: Rat strain differences in catechol carcinogenicity to the stomach. Fd Chem Toxicol, 33: 93-98, 1995.

5. Ito, N., Hasegawa, R., Imaida, K., Kurata, Y., Hagiwara, A., Shirai, T.: Effect of ingestion of 20 pesticides in combination at acceptable daily intake levels on rat liver carcinogenesis. Fd Chem Toxicol, 33: 159-163, 1995.

6. Ito, N., Hagiwara, A., Tamano, S., Hasegawa, R., Imaida, K., Hirose, M., Shirai, T.: Lack of carcinogenicity of pesticide mixtures administered in the diet at acceptable daily intake (ADI) dose levels in rats. Toxicol Lett, 82-82: 513-520, 1995.

7. Hirose, M., Akagi, K., Hasegawa, R., Yaono, M., Satoh, T., Hara, Y., Wakabayashi, K., Ito, N.: Chemoprevention of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced mammary gland carcinogenesis by antioxidants in F344 female rats. Carcinogenesis, 16: 217-221, 1995.

8. Shirai, T., Shibata, MA., Takahashi, S., Tagawa, Y., Imaida, K., Hirose, M.: Differences in cell proliferation and apoptosis between reversible and irreversible mucosal lesions associated with uracil-induced urolithiasis in N-butyl-N-(4-hydroxybutyl)nitrosamine-pretreated rats. Carcinogenesis, 16: 501-505, 1995.

9. Tsukamoto, S., Akaza, H., Imada, S., Koiso, K., Shirai, T., Ideyama, Y., Kudo, M.: Chemoprevention of rat prostate carcinogenesis by use of finasteride or casodex. J Natl Cancer Inst, 87: 842-843, 1995.

10. Shibata, MA., Tanaka, H., Kawabe, M., Sano, M., Hagiwara, A., Shirai, T.: Lack of carcinogenicity of monosodium L-glutamate in Fischer 344 rats. Fd Chem Toxicol, 33: 383-391, 1995.

11. Iwata, H., Otoshi, T., Takada, N., Murai, T., Tamano, S., Watanabe, T., Katsura, Y., Fukushima, S.: Validation of silver-stained nucleolar organizer regions for evaluation of invasive character of urinary bladder carcinoma in rats and mice. Urol Res, 23: 27-32, 1995.

12. Tamano, S., Jakubczak, J., Takagi, H., Merlino, G., Ward, JM.: Increased susceptibility to N-nitrosomethylurea gastric carcinogenesis in transforming growth factor alpha transgenic mice with gastric hyperplasia. Jpn J Cancer Res, 86: 435-443, 1995.

13. Masui, T., Shirai, T., Imaida, K., Hirose, M., Futakuchi, M., Tatematsu, M., Ito, N.: Ki-ras mutations with frequent normal allele loss versus absence of p53 mutations in rat prostate and seminal vesicle carcinomas induced with 3,2′-dimethyl-4-aminobiphenyl. Mol Carcinog, 13: 21-26, 1995.

14. Liang, YY., Esteve, A., Martel-Planche, G., Takahashi, S., Lu, SH., Montesano, R., Hollstein, M.: p53 mutations in esophageal tumors from high-incidence areas of China. Int J Cancer, 61: 611-614, 1995.

15. Shirai, T., Tamano, S., Sano, M., Imaida, K., Hagiwara, A., Futakuchi, M., Takahashi, S., Hirose, M.: Site-specific effects of testosterone propionate on the prostate of rat pretreated with 3,2′-dimethyl-4-aminobiphenyl: Dose-dependent induction of invasive carcinomas. Jpn J Cancer Res, 86: 645-648, 1995.

16. Tiwawech, D., Shibata, MA., Hasegawa, R., Hagiwara, A., Shirai, T., Thamavit, W., Fukushima, S.: Weak synergistic effect of uracil and N-butyl-N-(4-hydroxybutyl)nitrosamine on urine composition, epithelial morphology, and DNA synthesis in the urinary bladder of Syrian golden hamster. J Toxicol Pathol, 8: 129-137, 1995.

17. Kataoka, H., Katsumi, K., Kutsuna, T., Suzumura, H., Kojima, S., Takeshima, A., Ban, Y., Itoh, T., Kishimoto, A., Kato, M., Iwata, F., Itoh, M., Takeuchi, T., Ogawa, K., Shirai, T.: A case of familial adenomatous polyposis associated with colon cancer, ureteral cancer and two early gastric cancers. Dig Endosc, 7: 278-284, 1995.

18. Akagi, K., Hirose, M., Hoshiya, T., Mizoguchi, Y., Ito, N., Shirai, T.: Modulating effects of ellagic acid, vanillin and quercetin in a rat medium term multi-organ carcinogenesis model. Cancer Lett. 94: 113-121, 1995.

19. Yaono, M., Hasegawa, R., Mizoguchi, Y., Futakuchi, M., Nakamura, T., Ito, N., Shirai, T.: Hepatocyte growth factor enhancement of preneoplastic hepatic foci development in rats treated with diethylnitrosamine and N-ethyl-N-hydroxyethylnitrosamine. Jpn J Cancer Res, 86: 718-723, 1995.

20. Shirai, T., Fradet, Y., Huland, H., Bollack, C., Droller, M., Janknegt, R., Jones, P., Kagawa, S.: The etiology of bladder cancer — Are there any new clues or predictors of behavior? Int J Urol, 2 Suppl 2: 64-75, 1995.

21. Hirose, M., Iwata, S., Ito, E., Nihro, Y., Takahashi, S., Mizoguchi, Y., Miki, T., Satoh, T., Ito, N., Shirai, T.: Strong anti-mutagenic activity of the novel lipophilic antioxidant 1-O-hexyl-2,3,5-trimethylhydroquinone against heterocyclic amine-induced mutagenesis in the Ames assay and its effect on metabolic activation of 2-amino-6-methyldipyrido [1,2-a:3′,2′-d] imidazole (Glu-P-1). Carcinogenesis, 16: 2227-2232, 1995.

22. Hasegawa, R., Hirose, M., Kato, T., Hagiwara, A., Boonyaphiphat, P., Nagao, M., Ito, N., Shirai, T.: Inhibitory effect of chlorophyllin on PhIP-induced mammary carcinogenesis in female F344 rats. Carcinogenesis, 16: 2243-2246, 1995.

23. Ogawa, K., Shichino, Y., Tatematsu, M., Furihata, C., Asamoto, M., Nagase, S., Shirai, T., Ito, N.: Increasing development of pepsinogen-altered pyloric glands and adenocarcinoma in glandular stomach of analbuminemic rats. Cancer Lett, 96: 219-224, 1995.

24. Hasegawa, R., Kimura, J., Yaono, M., Takahashi, S., Kato, T., Futakuchi, M., Fukutake, M., Fukutome, K., Wakabayashi, K., Sugimura, T., Ito, N., Shirai, T.: Increased risk of mammary carcinoma development following transplacental and trans-breast milk exposure to a food-derived carcinogen, 2-amino-1-methyl-6- phenylimidazo[4,5-b]pyridine (PhIP), in Sprague-Dawley rats. Cancer Res, 55: 4333-4338, 1995.

25. Hirose, M., Takahashi, S., Shirai, T.: Characteristics of forestomach carcinogenesis by non-genotoxic phenolic compounds. J Toxicol Pathol, 8: 277-284, 1995.

26. Shirai, T., Takahashi, S., Mori, T., Imaida, K., Futakuchi, M., Ye, SH., Prins, GS., Ito, N.: Immunohistochemically demonstrated androgen receptor expression in the rat prostate during carcinogenesis induced by 3,2’-dimethyl-4-aminobiphenyl with or without testosterone. Urol Oncol, 1: 263-268, 1995.

27. Shibata, M., Hasegawa, R., Imaida, K., Hagiwara, A., Ogawa, K., Hirose, M., Ito, N., Shirai, T.: Chemoprevention by dehydroepiandrosterone and indomethacin in a rat multiorgan carcinogenesis model. Cancer Res, 55: 4870-4874, 1995.

28. Ogasawara, H., Imaida, K., Ishiwata, H., Toyoda, K., Kawanishi, T., Uneyama, C., Hayashi, S., Takahashi, M., Hayashi, Y.: Urinary bladder carcinogenesis induced by melamine in F344 male rats: correlation between carcinogenicity and urolith formation. Carcinogenesis, 16: 2773-2777, 1995.

29. Hirose, M., Hasegawa, R., Kimura, J., Akagi, K., Yoshida, Y., Tanaka, H., Miki, T., Satoh, T., Wakabayashi, K., Ito, N., Shirai, T.: Inhibitory effects of 1-O-hexyl-2,3,5-trimethylhydroquinone (HTHQ), green tea catechins and other antioxidants on 2-amino-6-methyldipyrido[1,2-a:3′,2′-d]imidazole (Glu-P-1)-induced rat hepatocarcinogenesis and dose-dependent inhibition by HTHQ of lesion induction by Glu-P-1 or 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline(MeIQx). Carcinogenesis, 16: 3049-3055, 1995.

30. Ito, N., Hasegawa, R., Imaida, K., Hirose, M., Asamoto, M., Shirai, T.: Concepts in multistage carcinogenesis. Crit Rev Oncol Hematol, 21: 105-133, 1995.

31. Shirai, T., Tamano, S., Sano, M., Masui, T., Hasegawa, R., Ito, N.: Carcinogenicity of 2-amino-1-methyl- 6-phenylimidazo[4,5-b]pyridine (PhIP) in rats: dose-response studies. In: Adamson, RH. et al. (eds.), Heterocyclic amines in cooked foods: Possible human carcinogens. pp232-239, Princeton Scientific Publishing Co. Inc., New Jersey, 1995.

32. Ito, N., Hasegawa, R., Asakawa, E., Hirose, M., Imaida, K., Hagiwara, A.: Enhancement of rat liver cell foci development by combined treatment with heterocyclic amines at low doses. In: In: Adamson, RH. et al. (eds.), Heterocyclic amines in cooked foods: Possible human carcinogens. pp251-258. Princeton Scientific Publishing Co. Inc., New Jersey, 1995.