1. Thamavit, W., Boonpucknavig, V., Boonpucknavig, S., Moore, MA., Ito, N.: Secondary enhancing effect of Opisthirchis viverrini infection on development of hepatocellular nodules in Syrain golden hamsters initiated with diethylnitrosamine. Thai J Toxicol, 8: 35-40, 1992.

2. Shibata, MA., Fukushima, S., Asakawa, E., Hirose, M., Ito, N.: The modifying effects of indomethacin or ascorbic acid on cell proliferation induced by different types of bladder tumor promoters in rat urinary bladder and forestomach mucosal epithelium. Jpn J Cancer Res, 83: 31-39, 1992.

3. Kojima, M., Morita, T., Shirai, T., Degawa, M., Tada, M.: Immunological detection and quantitation of DNA adducts formed by 4-aminoazobenzene species in vivo. Jpn J Cancer Res, 83: 78-85, 1992.

4. Thamavit, W., Moore, MA., Ruchirawat, S., Ito, N.: Repeated exposure to Opisthorchis viverrini and treatment with the antihelminthic Praziquantel lacks carcinogenic potential. Carcinogenesis, 13: 309-311, 1992.

5. Ito, N.: Is quercetin carcinogenic? Jpn J Cancer Res, 83: 312-314, 1992.

6. Asamoto, M., Imaida, K., Hasegawa, R., Hotta, K., Fukushima, S.: Change of membrane potential in rat urinary bladder epithelium treated with sodium L-ascorbate. Cancer Lett, 63: 1-5, 1992.

7. Hirose, M., Wada, S., Yamaguchi, S., Masuda, A., Okazaki, S., Ito, N.: Reversibility of catechol-induced rat glandular stomach lesions. Cancer Res, 52: 787-790, 1992.

8. Ueno, Y., Yabe, T., Hashimoto, H., Sekijima, M., Masuda, T., Kim, DJ., Hasegawa, R., Ito, N.: Enhancement of GST-P-positive liver cell foci development by nivalenol, a trichothecene mycotoxin. Carcinogenesis, 13: 787-791, 1992.

9. Hasegawa, R., Tiwawech, D., Hirose, M., Takaba, K., Hoshiya, T., Shirai, T., Ito, N.: Suppression of diethylnitrosamine-initiated preneoplastic foci development in the rat liver by combined administration of four antioxidants at low doses. Jpn J Cancer Res, 83: 431-437, 1992.

10. Kushida, H., Wakabayashi, K., Suzuki, M., Takahashi, S., Imaida, K., Sugimura, T., Nagao, M.: Suppression of spontaneous hepatocellular carcinoma development in C3H/HeNCrj mice by the lipophilic ascorbic acid, 2-O-octadecylascorbic acid (CV-3611). Carcinogenesis, 13: 913-915, 1992.

11. Okumura, M., Hasegawa, R., Shirai, T., Ito, M., Yamada, S., Fukushima, S.: Relationship between calculus formation and carcinogenesis in the urinary bladder of rats administered the non-genotoxic agents, thymine or melamine. Carcinogenesis, 13: 1043-1045, 1992.

12. Imaida, K., Uneyama, C., Ogasawara, H., Hayashi, S., Fukuhara, K., Miyata, N., Takahashi, M.: Induction of colon adenocarcinomas in CD rats and lung adenomas in ICR mice by 6-nitrochrysene: Comparison of carcinogenicity and aryl hydrocarbon hydroxylase induction in the target organs of each species. Cancer Res, 52: 1542-1545, 1992.

13. Tagawa, Y., Ozaki, K., Takahashi, S., Ogawa, K., Shirai, T.: Lack of effects of post-initiation cholesterol on 3,2′-dimethyl-4-aminobiphenyl-induced prostate carcinogenesis. Prostate, 20: 179-185, 1992.

14. Kagawa, M., Yamamoto, A., Ogawa, K., Shirai, T., Fukushima, S.: Uracil-induced urolithiasis in the urinary bladder of rats is irritation-dependent. Toxicol Lett, 61: 21-26, 1992.

15. Ogawa, K., Hasegawa, R., Wada, S., Yamaguchi, S., Ito, N.: Dose response study of N-nitrosodiethanolamine initiation of rat hepatocarcinogenesis. Teratog Carcinog Mutagen, 11: 245-250, 1992.

16. Takahashi, S., Shirai, T., Hasegawa, R., Imaida, K., Ito, N.: Latent prostatic carcinomas found at autopsy in men over 90 years old. Jpn J Clin Oncol, 22: 117-121, 1992.

17. Shirai, T., Iwasaki, S., Naito, H., Masui, T., Kato, T., Imaida, K.: Dose dependence of N-hydroxy-3,2′-dimethyl-4-aminobiphenyl-induced rat prostate carcinogenesis. Jpn J Cancer Res, 83: 695-698, 1992.

18. Ogawa, K., Hoshiya, T., Kato, T., Shirai, T., Tatematsu, M.: Reversibility of carcinogen-induced rat forestomach basal cell hyperplasia is due to squamous cell differentiation. Jpn J Cancer Res, 83: 699-704, 1992.

19. Fukushima, S., Tanaka, H., Asakawa, E., Kagawa, M., Yamamoto, A., Shirai, T.: Carcinogenicity of uracil, a nongenotoxic chemical, in rats and mice and its rationale. Cancer Res, 52: 1675-1680, 1992.

20. Uwagawa, S., Tsuda, H., Ozaki, K., Takahashi, S., Yamaguchi, S., Mutai, M., Aoki, T., Ito, N.: Modifying effects of various chemicals on tumor development in a rat wide-spectrum organ carcinogenesis model. Jpn J Cancer Res, 83: 812-820, 1992.

21. Shibata, MA., Tamano, S., Shirai, T., Kawabe, M., Fukushima, S.: Inorganic alkalizers and acidifiers under conditions of high urinary Na+ or K+ on cell proliferation and two-stage carcinogenesis in the rat bladder. Jpn J Cancer Res, 83: 821-829, 1992.

22. Hasegawa, R., Takahashi, S., Shirai, T., Iwasaki, S., Kim, DJ., Ochiai, M., Nagao, M., Sugimura, T., Ito, N.: Dose-dependent formation of preneoplastic foci and DNA adducts in rat liver with 2-amino-3-methyl-9H-pyrido[2,3-b]indole (MeAαC) and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Carcinogenesis, 13: 1427-1431, 1992.

23. Tatematsu, M., Ogawa, K., Hoshiya, T., Shichino, Y., Kato, T., Imaida, K., Ito, N.: Induction of adenocarcinomas in the glandular stomach of BALB/c mice treated with N-methyl-N-nitrosourea. Jpn J Cancer Res, 83: 915-918, 1992.

24. Hagiwara, A., Sano, M., Asakawa, E., Tanaka, H., Hasegawa, R., Ito, N.: Enhancing effects of harman and norharman on induction of preneoplastic and neoplastic kidney lesions in rats initiated with N-ethyl-N-hydroxyethylnitrosamine. Jpn J Cancer Res, 83: 949-954, 1992.

25. Ono, S., Kurata, Y., Shichino, Y., Sano, M., Fukushima, S.: Synergism of environmental carcinogens and promoters on bladder cancer development initiated by N-butyl-N-(4-hydroxybutyl)nitrosamine in F344 rats. Jpn J Cancer Res. 83: 955-963, 1992.

26. Takahashi, S., Hakoi, K., Yada, H., Hirose, M., Ito, N., Fukushima, S.: Enhancing effects of diallyl sulfide on hepatocarcinogenesis and inhibitory actions of the related diallyl disulfide on colon and renal carcinogenesis in rats. Carcinogenesis, 13: 1513-1518, 1992.

27. Hagiwara, A., Boonyaphiphat, P., Kawabe, M., Naito, H., Shirai, T., Ito, N.: Lack of carcinogenicity of tragacanth gum in B6C3F1 mice. Fd Chem Toxicol, 30: 673-679, 1992.

28. Hirose, M., Kawabe, M., Shibata, M., Takahashi, S., Okazaki, S., Ito, N.: Influence of caffeic acid and other o-dihydroxybenzene derivatives on N-methyl-N’-nitro-N-nitrosoguanidine-initiated rat forestomach carcinogenesis. Carcinogenesis, 13: 1825-1828, 1992.

29. Shirai, T., Pairojkul, C., Ogawa, K., Naito, H., Thamavit, W., Bhudhisawat, W., Ito, N.: Histomorphological characteristics of cholangiocellular carcinomas in Northeast Thailand, where a region infection with the liver fluke, Opisthochis viverrini is endemic. Acta Pathol Jpn, 42: 734-739, 1992.

30. Shichino, Y., Tatematsu, M., Ohshima, H., Bartsch, H., Furihata, C., Ito, N.: Effects of hickory-smoke condensate on development of pepsinogen 1-altered pyloric glands in rats. Fd Chem Toxicol, 30: 859-864, 1992.

31. Tsuda, H., Ozaki, K., Uwagawa, S., Yamaguchi, S., Hakoi, K., Aoki, T., Kato, T., Sato, K., Ito, N.: Effects of modifying agents on conformity of enzyme phenotype and proliferative potential in focal preneoplastic and neoplastic liver cell lesions in rats. Jpn J Cancer Res, 83: 1154-1165, 1992.

32. Shirai, T., Yamamoto, A., Imaida, K., Tamano, S., Mori, T., Hasegawa, R.: Lack of synergism among DMAB, BOP, and MNU in induction of carcinomas of the rat ventral prostate. Teratog Carcinog Mutagen, 12: 71-77, 1992.

33. Ito, N., Imaida, K.: Strategy of research for cancer-chemoprevention. Teratog Carcinog Mutagen, 12: 79-95, 1992.

34. Hagiwara, A., Asakawa, E., Kurata, Y., Sano, M., Hirose, M., Ito, N.: Dose-dependent renal tubular toxicity of harman and norharman in male F344 rats. Toxicol Pathol, 20: 197-204, 1992.

35. Tamano, S., Shirai, T., Kawabe, M., Ni-I, H., Mori, Y., Okada, M., Fukushima, S.: Low-susceptibility of nude mice to induction of invasive urinary bladder cancers by N-ethyl-N-(4-hydroxybutyl)nitrosamine. Toxicol Pathol, 20: 205-211, 1992.

36. Tamano, S., Hirose, M., Tanaka, H., Asakawa, E., Ogawa, K., Ito, N.: Forestomach neoplasm induction in F344/DuCrj rats and B6C3F1 mice exposed to sesamol. Jpn J Cancer Res, 83: 1279-1285, 1992.

37. Hasegawa, R., Ogawa, K., Takaba, K., Shirai, T., Ito, N.: 3,2′-dimethyl-4-aminobiphenyl-induced gallbladder carcinogenesis and effects of ethinyl estradiol in hamsters. Jpn J Cancer Res, 83: 1286-1292, 1992.

38. Hasegawa, R., Ito, N.: Liver medium-term bioassay in rats for screening of carcinogens and modifying factors in hepatocarcinogenesis. Fd Chem Toxicol, 30: 979-992, 1992.

39. Harris, CC., Hirohashi, S., Ito, N., Pitot, HC., Sugimura, T., Terada, M., Yokota, J.: Multistage carcinogenesis : The Twenty-Second International Symposium of the Princess Takamatsu Cancer Research Fund (Meeting report). Cancer Res, 52: 4837-4840, 1992.

40. Ito, N., Hasegawa, R., Imaida, K., Masui, T., Takahashi, S., Shirai, T.: Pathological markers for non-genotoxic agent-associated carcinogenesis. Toxicol Lett, 64/65: 613-620, 1992.

41. Takahashi, S., Hasegawa, R., Masui, T., Mizoguchi, M., Fukushima, S., Ito, N.: Establishment of multi-organ carcinogenesis bioassay using rats treated with a combination of five different carcinogens. J Toxicol Pathol, 5: 151-156, 1992.

42. Yoshida, Y., Tatematsu, M., Takaba, K., Shichino, Y., Ito, N.: Effects of various bile acids and their sodium salts on development of pepsinogen-altered pyloric glands in rats. Taratog Carcinog Mutagen, 12: 179-186, 1992.

43. Yoshida, Y., Hasegawa, R., Takaba, K., Imaida, K., Ito, N.: N-nitrosoheptamethyleneimine-induced pulmonary and esophageal carcinogenesis and effects of concomitant treatment with bleomycin in rats. Teratog Carcinog Mutagen, 12: 197-201, 1992.

44. Hakoi, K., Cabral, R., Hoshiya, T., Hasegawa, R., Shirai, T., Ito, N.: Analysis of carcinogenic activity of some pesticides in a medium-term liver bioassay in the rat. Teratog Carcinog Mutagen, 12: 269-276, 1992.

45. Hasegawa, R., Wang, CY., Kim, DJ., Lee, MS., Yoshida, Y., Ito, N.: Effect of acyl derivatives of 4,4,4-trifluoro-1-phenyl-1,3-butanedione on 2-acetylaminofluorene-induced glutathione S-transferase positive foci in the rat liver. Teratog Carcinog Mutagen, 12: 263-268, 1992.

46. Kurata, Y., Diwan, BA., Ward, JM.: Lack of renal tumour-initiating activity of a single does of potassium bromate, a genotoxic renal carcinogen in male F344/NCr rats. Fd Chem Toxicol, 30: 251-259, 1992.

47. Ito, N., Shirai, T., Hasegawa, R.: Medium-term bioassays for carcinogens. In: Vainio, H. et al. (eds.) Mechanisms of Carcinogenesis in Risk Identification, pp353-388. International Agency for Research on Cancer, Lyon, 1992.

48. Shirai, T., Tamano, S., Iwasaki, S., Ito, N.: Enhancement of prostate carcinogenesis in rats by testosterone and prolactin. In: Li, JJ. et al. (eds.) Hormonal Carcinogenesis, pp27-32. Springer-Verlag, 1992.

49. Mori, S., Murai, T., Ohhara, T., Hosono, M., Takeuchi, Y., Makino, S., Hayashi, Y., Fukushima, S.: Renal lesions and urinary bladder carcinogenesis. In: Sakamoto, N., Hotta, N. & Uchiba, K. (eds.) Current concepts of a new animal model: The NON mouse, pp159-174: Elsevier Science Publishers B.V., 1992.

50. Ito, N., Shirai, T., Masui, T., Ogawa, K., Kato, T., Takahashi, S.: Mechanistic analysis of multistage carcinogenesis in the rat prostate. In: Harris, CC. et al. (eds.) Multistage Carcinogenesis, pp125-133. Japan Sci Soc Press/CRC Press, Tokyo, 1992.

51. Shirai, T., Tamano, S., Takahashi, S., Ito, N.: Animal prostate carcinoma models: Limited potential for vertebral metastasis. In: Karr, JP. & Yamanaka, H. (eds.) Prostate Cancer and Bone Metastasis, pp151-158. Plenum Press, New York, 1992.

52. Pairojukul, C., Shirai, T., Hirohashi, S., Thamavit, W., Bhudhisawat, W., Uttaravicien, T., Itoh, M., Ito, N.: Multistage carcinogenesis of liver-fluke-associated cholangiocarcinoma in Thailand. In: Harris, CC. et al. (eds.) Multistage Carcinogenesis, pp77-86. Japan Sci. Soc. Press / CRC Press, Tokyo, 1992.

53. Ito, N., Hirose, M., Shirai, T.: Carcinogenicity and modification of carcinogenic response by plant phenols. In: Huang, MT., Ho, CT. & Lee, CY. (eds.) Phenolic Compounds in Food and Their Effects on Health II, 507, pp269-281. American Chemical Society, Washington D.C., 1992.

54. Cabral, R., Hoshiya, T., Hakoi, K., Hasegawa, R., Fukushima, S., Ito, N: A rapid in-vivo bioassay for the carcinogenicity of pesticides. In: Somogyi, A., Appel, KE. & Katenkamp A. (eds.) Chemical Carcinogenesis, pp91-96. MMV Medizin Verl., Munchen, 1992.

55. Ito, N., Hirose, M., Takahashi, S., Shirai, T.: Antioxidants — carcinogenesis and its modification. In: Somogyi, A., Appel, KE. & Katenkamp A. (eds.) Chemical Carcinogenesis, pp91-96. MMV Medizin Verl., Munchen, 1992.

56. Tsuda, H., Ito, N. : Medium-term bioassays as new tools for prediction of carcinogenicity. In: McAuslane, JAN., Lumley, CE. & Walker, SR. (eds.) The Carcinogenicity Debate, pp197-213. Quay Publishing, London, 1992.