1. Takahashi, S., Hall, J., Montesano, R.: Temporal cell-type-specific mRNA expression of O6-methylguanine-DNA methyltransferases in liver of rats treated with dimethylnitrosamine. Am J Pathol, 148: 497-507, 1996.

2. Yaono, M., Hasegawa, R., Kato, K., Kimura, J., Cui, L., Tada, M., Shirai, T.: Immunohistochemical demonstration of 3,2′-dimethyl-4-aminobiphenyl DNA adduct formation in various organs of Syrian golden hamsters. Cancer Lett, 98: 145-149, 1996.

3. Cui, L., Hasegawa, R., Ogawa, K., Yamada, Y., Takahashi, S., Shirai, T.: Histopathological analysis of invasive bladder carcinomas induced by 3,2′-dimethyl-4-aminobiphenyl in hamsters. Jpn J Cancer Res, 87: 37-43, 1996.

4. Ogawa, K., Imaida, K., Masui, T., Kawabe, M., Hasegawa, R., Kato, K., Ito, N., Shirai, T.: Chemically induced lung and forestomach neoplasias in transgenic mice carry mutant forms of the human c-Ha-ras transgene. Carcinogenesis, 17: 341-345, 1996.

5. Totsuka, Y., Fukutome, K., Takahashi, M., Takahashi, S., Tada, A., Sugimura, T., Wakabayashi, K.: Presence of N2-(deoxyguanosin-8-yl)-2-amino3,8-dimethylimidazo[4,5-f]quinoxaline (dG-C8-MeIQx) in human tissues. Carcinogenesis, 17: 1029-1034, 1996.

6. Chemin, I., Takahashi, S., Belloc, C., Lang, MA., Ando, K., Guidotti, LG., Chisari, FV., Wild, CP.: Differential induction of carcinogen metabolizing enzymes in a transgenic mouse model of fulminant hepatitis. Hepatology, 24: 649-656, 1996.

7. Kimura, J., Hasegawa, R., Yaono, M., Kato, T., Wakabayashi, K., Sugimura, T., Ito, N., Shirai, T.: Inhibitory potential of pregnancy and lactation on mammary carcinogenesis induced by a food-derived carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, in Sprague-Dawley rats. Cancer Lett, 101: 73-78, 1996.

8. Kato, T., Hasegawa, R., Nakae, D., Hirose, M., Yaono, M., Cui, L., Kobayashi, Y., Konishi, Y., Ito, N., Shirai, T.: Dose-dependent induction of 8-hydroxyguanine and preneoplastic foci in rat liver by a food-derived carcinogen, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline, at low dose levels., Jpn J Cancer Res, 87: 127-133, 1996.

9. Wada, S., Kato, T., Mutai, M., Ozaki, K., Yamaguchi, S., Kim, DJ., Baba-Toriyama, H., Asamoto, M., Ito, N., Tsuda, H.: Modifying influence of swine serum-induced liver fibrosis on development of preneoplastic lesions in rat liver. Jpn J Cancer Res, 87: 240-246, 1996.

10. Ito, N., Hasegawa, R., Imaida, K., Hirose, M., Shirai, T.: Medium-term liver and multi-organ carcinogenesis bioassays for carcinogens and chemopreventive agents. Exp Toxicol Pathol, 48: 113-119, 1996.

11. Tanaka, H., Hasegawa, R., Takesada, Y., Ogiso, T., Hirose, M., Shirai, T.: Effects of carbamate insecticides in a rat medium-term bioassay for hepatocarcinogens. J Toxicol Environ Health, 47: 493-498, 1996.

12. Kawabe, M., Takesada, Y., Tamano, S., Hagiwara, A., Ito, N., Shirai, T.: Subchronic toxicity study of L-isoleucine in F344 rats. J Toxicol Environ Health, 47: 499-508, 1996.

13. Wild, CP., Hasegawa, R., Barraud, L., Chutimataewin, S., Chapot, B., Ito, N., Montesano, R.: Aflatoxin-albumin adducts: A basis for comparative carcinogenesis between animals and humans. Cancer Epidemiol Biomarkers Prev, 5: 179-189, 1996.

14. Futakuchi, M., Hasegawa, R., Yamamoto, A., Cui, L., Ogiso, T., Ito, N., Shirai, T.: Low susceptibility of the spontaneously hypertensive rat (SHR) to quinoline-induction of hepatic hemangioendothelial sarcomas. Cancer Lett, 104: 37-41, 1996.

15. Sano, M., Miyata, E., Tamano, S., Hagiwara, A., Ito, N., Shirai, T.: Lack of carcinogenicity of tamarind seed polysaccharide in B6C3F1 mice. Fd Chem Toxicol, 34: 463-467, 1996.

16. Mori, T., Cui, L., Kato, K., Takahashi, S., Imaida, K., Iwasaki, S., Ito, N., Shirai, T.: Direct effects of testosterone, dihydrotestosterone and estrogen on 3,2′-dimethyl-4-aminobiphenyl-induced prostate carcinogenesis in castrated F344 rats. Jpn J Cancer Res, 87: 570-574, 1996.

17. Kimura, J., Takahashi, S., Ogiso, T., Yoshida, Y., Akagi, K., Hasegawa, R., Kurata, M., Hirose, M., Shirai, T.: Lack of chemoprevention effects of the monoterpene d-limonene in a rat multi-organ carcinogenesis model. Jpn J Cancer Res, 87: 589-594, 1996.

18. Cui, L., Hasegawa, R., Ogawa, K., Futakuchi, M., Shirai, T.: Enhancing effects of high-fat diet on 3,2′-dimethyl-4-aminobiphenyl urinary bladder carcinogenesis in the hamster. J Toxicol Pathol, 9: 169-174, 1996.

19. Takahashi, S., Imaida, K., Shirai, T., Wakabayashi, K., Nagao, M., Sugimura, T., Ito, N.: Chronic administration of the mutagenic heterocyclic amine, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine induces cardiac damage with characteristic mitochondrial changes in Fischer rats. Toxicol Pathol, 24: 273-277, 1996.

20. Hagiwara, A., Miyata, E., Tamano, S., Shibata, MA., Sugiura, S., Inoue, M., Hirose, M.: Non-carcinogenicity of 2,2′-[(4-aminophenyl)imino]bisethanol sulfate in a long-term feeding study in Fischer 344 rats. Fd Chem Toxicol, 34: 537-546, 1996.

21. Thamavit, W., Tiwawech, D., Moore, MA., Ito, N., Shirai, T.: Equivocal evidence of complete carcinogenicity after repeated infection of Syrian hamsters with Opisthorchis viverrini. Toxicol Pathol, 24: 493-497, 1996.

22. Futakuchi, M., Lijinsky, W., Hasegawa, R., Hirose, M., Ito, N., Shirai, T.: Effects of low dose mixtures of four N-nitroso compounds on hepatic foci development in the rat. Cancer Lett, 106: 263-269, 1996.

23. Hasegawa, R., Shirai, T., Ito, N.: Synergism in hepatocarcinogenesis induced by heterocyclic amines in rats. J Toxicol Pathol, 9: 241-248, 1996.

24. Tamano, S., Hagiwara, A., Tanaka, H., Kawabe, M., Sano, M., Takahashi, S., Shirai, T.: Histopathological evaluation of spontaneous hepatocellular tumors in B6C3F1 hybrid mice. J Toxicol Pathol, 9: 263-271, 1996.

25. Tamano, S., Rehm, S., Waalkes, MP., Ward, JM.: High incidence and histogenesis of seminal vesicle adenocarcinoma and lower incidence of prostate carcinomas in the Lobund-Wistar prostate cancer rat model using N-nitrosomethylurea and testosterone. Vet Pathol, 33: 557-567, 1996.

26. Imaida, K., Hagiwara, A., Yada, H., Masui, T., Hasegawa, R., Hirose, M., Sugimura, T., Ito, N., Shirai, T.: Dose-dependent induction of mammary carcinomas in female Sprague-Dawley rats with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. Jpn J Cancer Res, 87: 1116-1120, 1996.

27. Hasegawa, R., Yoshimura, I., Imaida, K., Ito, N., Shirai, T.: Analysis of synergism in hepatocarcinogenesis based on preneoplastic foci induction by 10 heterocyclic amines in the rat. Jpn J Cancer Res, 87: 1125-1133, 1996.

28. Hashimoto, Y., Asamoto, M., Futakuchi, M., Okamura, T., Kohri, K., Shirai, T.: Immunohistochemical demonstration of p53 protein nuclear accumulation in preneoplastic and neoplastic lesions of the human urinary bladder. J Urol Pathol, 5: 21-27, 1996.

29. Imaida, K., Fukushima, S.: Initiation-promotion model for assessment of carcinogenicity: Medium-term liver bioassay in rats for rapid detection of carcinogenic agents. J Toxicol Sci, 21: 483-487, 1996.

30. Tamano, S., Ward, JM., Diwan, BA., Keefer, LK., Weghorst, CM., Calvert, RJ., Henneman, JR., Ramljak, D., Rice, JM.: Histogenesis and the role of p53 and K-ras mutations in hepatocarcinogenesis by glyceryl trinitrate (nitroglycerin) in male F344 rats. Carcinogenesis, 17: 2477-2486, 1996.

31. Nakanishi, H., Takeuchi, S., Kato, K., Shimizu, S., Kobayashi, K., Tatematsu, M., Shirai, T.: Establishment and characterization of three androgen-independent, metastatic carcinoma cell lines from 3,2′-dimethyl-4-aminobiphenyl-induced prostatic tumors in F344 rats. Jpn J Cancer Res, 87: 1218-1226, 1996.

32. Kobayashi, K., Nakanishi, H., Inada, K., Fujimitsu, Y., Yamachika, T., Shirai, T., Tatematsu, M.: Growth characteristics in the initial stage of micrometastasis formation by bacterial lacZ gene-tagged rat prostatic adenocarcinoma cells. Jpn J Cancer Res, 87: 1227-1234, 1996.

33. Hagiwara, A., Matsuda, T., Tamano, S., Kitano, M., Imaoka, S., Funae, Y., Takesada, Y., Shirai, T., Fukushima, S.: Dose-related increases in quantitative values for altered hepatocytic foci and cytochrome P-450 levels in the livers of rats exposed to phenobarbital in a medium-term bioassay. Cancer Lett, 110: 155-162, 1996.

34. Ito, N., Hagiwara, A., Tamano, S., Futakuchi, M., Imaida, K., Shirai, T.: Effects of pesticide mixtures at the acceptable daily intake levels on rat carcinogenesis. Fd Chem Toxicol, 34: 1091-1096, 1996.

35. Cabral, R., Hoshiya, T., Hakoi, K., Hasegawa, R., Ito, N.: Medium-term bioassay for the hepatocarcinogenicity of hexachlorobenzene., Cancer Lett, 100: 223-226, 1996.

36. Hasegawa, R., Kato, T., Hirose, M., Takahashi, S., Shirai, T., Ito, N.: Enhancement of hepatocarcinogenesis by combined administration of food-derived heterocyclic amines at low doses in the rat. Fd Chem Toxicol, 34: 1097-1101, 1996.

37. Sano, M., Tamano, S., Hagiwara, A., Kawabe, M., Nakamura, M., Imaida, K., Hirose, M.: 13-week oral toxicity study of pigments extracted from the purple sweet potato in F344/DuCrj rats. Jpn J Fd Chem, 3: 99-105, 1996.

38. Hagiwara, A., Kokubo, Y., Takesada, Y., Tanaka, H., Tamano, S., Hirose, M., Shirai, T., Ito, N.: Inhibitory effects of phenolic compounds on development of naturally occurring preneoplastic hepatocytic foci in long-term feeding studies using male F344 rats. Teratog Carcinog Mutagen, 16: 317-325, 1996.

39. Sano, M., Tamano, S., Hagiwara, A., Shirai, T., Hasegawa, R., Imaida, K., Ito, N.: Dose-response study of di(2-ethylhexyl)phthalate associated rat hepatocarcinogenesis. In: Tahara, E., Sugimachi, K., Oohara, T. (eds.), Recent Advances in Gastroenterological Carcinogenesis I. pp501-511. Monduzzi Editore S.p.A., Bologna, 1996.

40. Hagiwara, A., Tamano, S., Hirose, M.: Changes in the heart. In: U. Mohr, U. et al. (eds.), Pathobiology of the Aging Mouse. pp361-371, International Life Sciences Institute Press, Washington, DC., 1996.

41. Ito, N., Hirose, M., Futakuchi, M., Tamano, S., Shirai, T.: Chemoprevention of heterocyclic amine-induced carcinogenesis by exogenous agents: Stage dependent paradoxical effects. In: Conney, AH. Et al. (eds.), Fundamentals of Cancer Prevention. pp48-51. Princess Takamatsu Cancer Research Fund, Tokyo, 1996.