1. Hirose, M., Masuda, A., Fukushima, S., Ito, N.: Effects of subsequent antioxidant treatment on 7,12-dimethylbenz[a]anthracene-initiated carcinogenesis of the mammary gland, ear duct and forestomach in Sprague-Dawley rats. Carcinogenesis, 9: 101-104, 1988.

2. Tatematsu, M., Mera, Y., Inoue, T., Satoh, K., Sato, K., Ito, N.: Stable phenotypic expression of glutathione S-transferase placental type and unstable phenotypic expression of γ-glutamyltransferase in rat liver preneoplastic and neoplastic lesions. Carcinogenesis, 9: 215-220, 1988.

3. Tatematsu, M., Aoki, T., Kagawa, M., Mera, Y., Ito, N.: Reciprocal relationship between development of glutathione S-transferase positive liver foci and proliferation of surrounding hepatocytes in rats. Carcinogenesis, 9: 221-225, 1988.

4. Masui, T., Shirai, T., Imaida, K., Uwagawa, S., Fukushima, S.: Effects of urinary crystals induced by acetazolamide, uracil, and diethylene glycol on urinary bladder carcinogenesis in N-butyl-N-(4-hydroxybutyl)nitrosamine-initiated rats. Toxicol Lett, 40: 119-126, 1988.

5. Ito, N., Tsuda, H., Tatematsu, M., Inoue, T., Tagawa, Y., Aoki, T., Uwagawa, S., Kagawa, M., Ogiso, T., Masui, T., Imaida, K., Fukushima, S., Asamoto, M.: Enhancing effect of various hepatocarcinogens on induction of preneoplastic glutathione S-transferase placental form positive foci in rat — an approach for a new medium-term bioassay system. Carcinogenesis, 9: 387-394, 1988.

6. Tatematsu, M., Aoki, T., Inoue, T., Mutai, M., Furihata, C., Ito, N.: Coefficient induction of pepsinogen 1-decreased pyloric glands and gastric cancers in five different strains of rats treated with N-methyl-N’-nitro-N-nitrosoguanidine. Carcinogenesis, 9: 495-498, 1988.

7. Hayashi, M., Tsuda, H., Okumura, M., Sakata, T., Ito, N., Suchi, T.: Histopathological classification of malignant lymphomas in slaughtered swine. J Comp Pathol, 98: 11-21, 1988.

8. Shirai, T., Yamamoto, K., Adachi, T., Imaida, K., Masui, T., Ito, N.: Condyloma acuminatum of the bladder in two autopsy cases. Acta Pathol Jpn, 38: 399-405, 1988.

9. Mori, S., Takeuchi, Y., Toyama, M., Makino, S., Harauchi, T., Kurata, Y., Fukushima, S.: Assessment of L-ascorbic acid requirement for prolonged survival in ODS rats and their susceptibility to urinary bladder carcinogenesis by N-butyl-N-(4-hydroxybutyl)nitrosamine. Cancer Lett, 38: 275-282, 1988.

10. Tsuda, H., Moore, MA., Asamoto, M., Inoue, T., Ito, N., Satoh, K., Ichihara, A., Nakamura, T., Amelizad, Z., Oesch, F.: Effect of modifying agents on the phenotypic expression of cytochrome P-450, glutathione S-transferase molecular forms, microsomal epoxide hydrolase, glucose-6-phosphate dehydrogenase and γ-glutamyltranspeptidase in rat liver preneoplastic lesions. Carcinogenesis, 9: 547-554, 1988.

11. Nakanowatari, JI., Fukushima, S., Imaida, K., Ito, N., Nagase, S.: Strain differences in N-butyl-N-(4-hydroxybutyl)nitrosamine bladder carcinogenesis in rats. Jpn J Cancer Res (Gann), 79: 453-459, 1988.

12. Ito, N., Imaida, K., Tsuda, H., Shibata, MA., Aoki, T., de Camargo, JLV., Fukushima, S.: Wide-spectrum initiation models: possible applications to medium-term multiple organ bioassays for carcinogenesis modifiers. Jpn J Cancer Res (Gann), 79: 413-417, 1988.

13. Shirai, T., Masuda, A., Imaida, K., Ogiso, T., Ito, N.: Effects of phenobarbital and carbazole on carcinogenesis of the lung, thyroid, kidney, and bladder of rats pretreated with N-Bis(2-hydroxypropyl)nitrosamine. Jpn J Cancer Res (Gann), 79: 460-465, 1988.

14. Masui, T., Asamoto, M., Imaida, K., Fukushima, S., Okamura, T., Ohtaguro, K.: Primary choriocarcinoma of the urinary bladder. Jpn J Clin Oncol, 18: 59-64, 1988.

15. Ito, N., Imaida, K., de Camargo, JLV., Takahashi, S., Asamoto, M., Tsuda, H.: A new medium-term bioassay system for detection of environmental carcinogens using diethylnitrosamine-initiated rat liver followed by D-galactosamine treatment and partial hepatectomy. Jpn J Cancer Res (Gann), 79: 573-575, 1988.

16. Thamavit, W., Moore, MA., Hiasa, Y., Ito, N.: Enhancement of DHPN induced hepatocellular, cholangiocellular and pancreatic carcinogenesis by Opisthorchis viverrini infestation in Syrian golden hamsters. Carcinogenesis, 9: 1095-1098, 1988.

17. Tsuda, H., Asamoto, M., Kagawa, M., Uwagawa, S., Inoue, K., Inui, M., Ito, N.: Positive influence of dietary deoxycholic acid on development of pre-neoplastic lesions initiated by N-methyl-N-nitrosourea in rat liver. Carcinogenesis, 9: 1103-1105, 1988.

18. Ichinose, M., Miki, K., Tatematsu, M., Furihata, C., Nobuhara, M., Ichihara, Y., Tanji, M., Sogawa, K., Fujii-Kuriyama, Y., Oka, H., Takahashi, T., Kageyama, T., Takahashi, K.: Hypomethylation and expression of pepsinogen A genes in the fundic mucosa of human stomach. Biochem Biophys Res Commun, 151: 275-282, 1988.

19. Ichinose, M., Miki, K., Furihata, C., Tatematsu, M., Ichihara, Y., Ishihara, T., Katsura, I., Sogawa, K., Fujii-Kuriyama, Y., Tanji, M., Oka, H., Matsushima, T., Takahashi, K.: DNA methylation and expression of the rat pepsinogen gene in embryonic, adult, and neoplastic tissues. Cancer Res, 48: 1603-1609, 1988.

20. Sumitomo, S., Tatemoto, Y., Tanimura, T., Mori, M., Nakamura, T., Fukushima, S., Ito, N.: Immunohistochemical identification of keratin, involucrin, and epithelial membrane antigen in Paget’s disease. Acta Histochem Cytochem, 21: 61-72, 1988.

21. Tsuda, H., Asamoto, M., Ogiso, T., Inoue, T., Ito, N., Nagao, M.: Does-dependent induction of liver and thyroid neoplastic lesions by short-term administration of 2-amino-3-methylimidazo[4,5-f]quinoline combined with partial hepatectomy followed by phenobarbital or low does 3′-methyl-4-dimethylaminoazobenzene promotion. Jpn J Cancer Res (Gann), 79: 691-697, 1988.

22. Inoue, T., Imaida, K., Suzuki, E., Okada, M., Fukushima, S.: Combined effects of L-ascorbic acid, citric acid or their sodium salts on tumor induction by N-butyl-N-(4-hydroxybutyl)nitrosamine or N-ethyl-N-(4-hydroxybutyl)nitrosamine in the rat urinary bladder. Cancer Lett, 40: 265-273, 1988.

23. Masui, T., Fukushima, S., Katoh, F., Yamasaki, H., Ito, N.: Effects of sodium L-ascorbate, uracil, butylated hydroxyanisole and extracellular pH on junctional intercellular communication of BALB/c 3T3 cells. Carcinogenesis, 9: 1143-1146, 1988.

24. Moore, MA., Thamavit, W., Hiasa, Y., Ito, N.: Early lesions induced by DHPN in Syrian golden hamsters: influence of concomitant Opisthorchis infestation, dehydroepiandrosterone or butylated hydroxyanisole administration. Carcinogenesis, 9: 1185-1189, 1988.

25. Fukushima, S., Tamano, S., Shibata, MA., Kurata, Y., Hirose, M., Ito, N.: The role of urinary pH and sodium ion concentration in the promotion stage of two-stage carcinogenesis of the rat urinary bladder. Carcinogenesis, 9: 1203-1206, 1988.

26. Tatematsu, M., Ichinose, M., Miki, K., Tatematsu, K., Kishikawa, H., Ito, N.: Gastric phenotypic expression in human gallbladder cancers revealed by pepsinogen immunohistochemistry and mucin histochemistry. Virchow Archiv A Pathol Anat, 413: 25-32, 1988.

27. Thamavit, W., Moore, MA., Hiasa, Y., Ito, N.: Generation of high yields of Syrian hamster cholangiocellular carcinomas and hepatocellular nodules by combined nitrite and aminopyrine administration and Opisthorchis viverrini infection. Jpn J Cancer Res (Gann), 79: 909-916, 1988.

28. Ito, N., Shirai, T., Tagawa, Y., Nakamura, A., Fukushima, S.: Variation in tumor yield in the prostate and other target organs of the rat in response to varied dosage and duration of administration of 3,2′-dimethyl-4-aminobiphenyl. Cancer Res, 48: 4629-4632, 1988.

29. Ward, JM., Ito, N.: Development of new medium-term bioassays for carcinogens. Cancer Res, 48: 5051-5054, 1988.

30. Hirose, M., Fukushima, S., Kurata, Y., Tsuda, H., Tatematsu, M., Ito, N.: Modification of N-methyl-N’-nitro-N-nitrosoguanidine-induced forestomach and glandular stomach carcinogenesis by phenolic antioxidants in rats. Cancer Res., 48: 5310-5315, 1988.

31. Masui, T., Shirai, T., Takahashi, S., Mutai, M., Fukushima, S.: Summation effect of uracil on the two-stage and multistage models of urinary bladder carcinogenesis in F344 rats initiated by N-butyl-N-(4-hydroxybutyl)nitrosamine. Carcinogenesis, 9: 1981-1985, 1988.

32. Tamano, S., Hagiwara, A., Shibata, MA., Kurata, Y., Fukushima, S., Ito, N.: Spontaneous tumors in aging (C57BL/6N×C3H/HeN)F1 (B6C3F1) mice. Toxicol Pathol, 16: 321-326, 1988.

33. Fukushima, S., Imaida, K., Shibata, MA., Tamano, S., Kurata, Y., Shirai, T.: L-ascorbic acid amplification of second-stage bladder carcinogenesis promotion by NaHCO3. Cancer Res, 48: 6317-6320, 1988.

34. Hirose, M., Hagiwara, A., Inoue, K., Ito, N., Kaneko, H., Saito, K., Matsunaga, H., Isobe, N., Yoshitake, A., Miyamoto, J.: Metabolism of 2- and 3-tert-butyl-4-hydroxyanisole in the rat (III): Metabolites in the urine and feces. Toxicology, 53: 33-43, 1988.

35. Kitagawa, Y., Sakai, R., Tahira, T., Tsuda, H., Ito, N., Sugimura, T., Nagao, M.: Molecular cloning of rat phosphoprotein phosphatase 2Aβ cDNA and increased expressions of phosphatase 2Aα and 2Aβ in rat liver tumors. Biochem Biophys Res Commmun, 157: 821-827, 1988.

36. Shirai, T., Tagawa, Y., Taguchi, O., Ikawa, E., Mutai, M., Fukushima, S., Ito, N.: Low tumorigenic response to 3,2′-dimethyl-4-aminobiphenyl administration in the prostate of rats castrated at birth. Jpn J Cancer Res (Gann), 79: 1293-1296, 1988.

37. Imaida, K., Fukushima, S., Inoue, K., Masui, T., Hirose, M., Ito, N.: Modifying effects of concomitant treatment with butylated hydroxyanisole or butylated hydroxytoluene on N,N-dibutylnitrosamine-induced liver, forestomach and urinary bladder carcinogenesis in F344 male rats. Cancer Lett, 43: 167-172, 1988.

38. Ichinose, M., Miki, K., Tatematsu, M., Mizuno, T., Mutai, M., Furihata, C., Ichihara, Y., Ishihara, T., Tanji, M., Oka, H., Hinohara, Y., Takahashi, T., Kageyama, T., Takahashi, K.: Cell-specific hypomethylation of the pepsinogen gene in pepsinogen-producing cells. Biochem Biophys Res Commmun, 155: 670-677, 1988.

39. Yamada, H., Shirai, T., Ito, N., Wang, CY.: Species- and strain-specific O-acetylation of N-hydroxy-3,2′-dimethyl-4-aminobiphenyl by liver and prostate cytosol. In: King, CM., Romano, LJ., Schuetzle, D. (eds.) Carcinogenic and Mutagenic Responses to Aromatic Amines and Nitroarenes, pp.223-226. Elsevier Science Publishing Co. Inc., 1988.

40. Wang, CY., Zukowski, K., Imaida, K., Lee, MS.: Effects of arylamine urinary metabolites on urothelial cells. In: King, CM., Romano, LJ., Schuetzle, D. (eds.) Carcinogenic and Mutagenic Responses to Aromatic Amines and Nitroarenes, pp227-236. Elsevier Science Publishing Co. Inc., 1988.

41. Ito, N., Tsuda, H., Masui, T.: In vivo promotion assay of four compounds on enhancement of the development of γ-glutamyl transpeptidase-positive liver cell foci in male F344 rats. In: Ashby, J. et al (eds.) Evaluation of Short-term Tests for Carcinogens, Vol.1, pp1334-1337. Cambridge University Press, New York, 1988.

42. Tsuda, H., Uwagawa, S., Aoki, T., Fukushima, S., Imaida, K., Ito, N., Sato, K., Nakamura, T., Oesch, F.: Analysis of the effects of modifying agents on six different phenotypes in preneoplastic foci in the liver in medium-term bioassay model in rats. In: Feo, F. et al. (eds.) Chemical Carcinogenesis, pp399-405: Plenum Publishing Co., 1988.

43. Ito, N., Tsuda, H., Tatematsu, M., Imaida, K., Kagawa, M., Nakamura, A.,Yamaguchi, S., Mutai, M.: Development and application of an in vivo medium-term bioassay system for the screening of hapatocarcinogens and inhibiting agents of hepatocarcinogenesis. In: Feo, F.et al. (eds.) Chemical Carcinogenesis, pp425-432: Plenum Publishing Co., 1988.