1994

1. Asakawa, E., Hirose, M., Hagiwara, A., Takahashi, S., Ito, N.: Carcinogenicity of 4-methoxyphenol and 4-methylcatechol in F344 rats. Int J Cancer, 56: 146-152, 1994.

2. Yoshida, Y., Hirose, M., Takaba, K., Kimura, J., Ito, N.: Induction and promotion of forestomach tumors by sodium nitrite in combination with ascorbic acid or sodium ascorbate in rats with or without N-methy1-N’-nitro-N-nitrosoguanidine pre-treatment. Int J Cancer, 56: 124-128, 1994.

3. Kawabe, M., Takaba, K., Yoshida, Y., Hirose, M.: Effects of combined treatment with phenolic compounds and sodium nitrite on two-stage carcinogenesis and cell proliferation in the rat stomach. Jpn J Cancer Res, 85: 17-25, 1994.

4. Hasegawa, R., Miyata, E., Futakuchi, M., Hagiwara, A., Nagao, M., Sugimura, T., Ito, N.: Synergistic enhancement of hepatic foci development by combined treatment of rats with 10 heterocyclic amines at low doses. Carcinogenesis, 15: 1037-1041,1994.

5. Shioya, S., Nagami-Oguihara, R., Oguihara, S., Kimura, T., Imaida, K., Fukushima, S.: Roles of bladder distention, urinary pH and urinary sodium ion concentration in cell proliferation of urinary bladder epithelium in rats ingesting sodium salts. Fd Chem Toxicol, 32: 165-171, 1994.

6. Thamavit, W., Pairojkul, C., Tiwawech, D., Shirai, T., Ito, N.: Strong promoting effect of Opistohorchis viverrini infection on dimethylnitrosamine-initiated hamster liver. Cancer Lett, 78: 121-125, 1994.

7. Puapairoj, P., Cui, L., Ogawa, K., Akagi, K., Hasegawa, R., Ito, N.: Effect of ethanol on papaquat toxicity in F344 rats. Fd Chem Toxicol, 32: 379-386, 1994.

8. de Camargo, JLV., de Oliveira, MLCS., Rocha, NS., Ito, N.: A deteccao de substancias cancerigenas em estudos experimentais. Rev Bras Cancerol, 40: 21-30, 1994.

9. Hirose, M., Satoh, T., Ito, N.: A strong new antioxidant with potent chemopreventive activity against heterocyclic amine-induced mutagenesis and carcinogenesis. HTHQ. Drug News Perspect, 7: 167-170, 1994.

10. Takaba, K., Hirose, M., Ogawa, K., Hakoi, K., Fukushima, S.: Modification of N-butyl-N -(4-hydroxybutyl)nitrosamine-initiated urinary bladder carcinogenesis in rats by phytic acid and its salts. Fd Chem Toxicol, 32: 499-503, 1994.

11. Ito, N., Hasegawa, R., Imaida, K., Takahashi, S., Shirai, T.: Medium-term rat liver bioassay for rapid detection of carcinogens and modifiers of hepatocarcinogenesis. Drug Metab Rev, 26: 431-442, 1994.

12. Tanaka, H., Hagiwara, A., Kurata, Y., Ogiso, T., Futakuchi, M., Ito, N.: Thirteen-week oral toxicity study of magnesium chloride in B6C3F1 mice. Toxicol Lett, 73: 25-32, 1994.

13. Cui, L., Hasegawa, R., Zajdela, F., Puapairoj, P., Shirai, T., Ito, N.: Lack of promoting activity of 7-methoxy-2-nitro-naphtho-[2,1-b] furan (R7000) in a medium-term rat liver bioassay. Cancer Lett, 76: 161-166, 1994.

14. Nagao, M., Ushijima, T., Wakabayashi, K., Ochiai, M., Kushida, H., Sugimura, T., Hasegawa, R., Shirai, T., Ito, N.: Dietary carcinogens and mammary carcinogenesis. Induction of rat mammary carcinomas by administration of heterocyclic amines in cooked foods. Cancer, 74: 1063-1069, 1994.

15. Shibata, MA., Shirai, T., Takahashi, S., Takesada, Y., Iwata, H., Okumura, M., Fukushima, S.: Progressive growth of rat bladder carcinomas after exposure to prolonged uracil-induced urolithiasis. Teratog Carcinog Mutagen, 14: 157-168, 1994.

16. Thamavit, W., Pairojkul, C., Tiwawech, D., Shirai, T., Ito, N.: Lack of promoting effect of proline on bile duct cancer development in dimethylnitrosamine-initiated hamster livers. Teratog Carcinog Mutagen, 14: 169-174, 1994.

17. Hirose, M., Hoshiya, T., Akagi, K., Futakuchi, M., Ito, N.: Inhibition of mammary gland carcinogenesis by green tea catechins and other naturally occurring antioxidants in female Sprague-Dawley rats pretreated with 7,12-dimethylbenz[a]anthracene. Cancer Lett, 83: 149-156, 1994.

18. Hasegawa, R., Yoshida, T., Mizoguchi, Y., Futakuchi, M., Kim, DJ., Cui, L., Ito, N.: Phenotypic alteration of hepatocellular foci in rats treated with clofibrate and phenobarbital. Cancer Lett, 83: 89-95, 1994.

19. Shirai, T., Sano, M., Imaida, K., Takahashi, S., Mori, T., Ito, N.: Duration dependent induction of invasive prostatic carcinomas with pharmacological dose of testosterone propionate in rats pretreated with 3,2′-dimethyl-4-aminobiphenyl and development of androgen-independent carcinomas after castration. Cancer Lett, 83: 111-116, 1994.

20. Yuasa, H., Hirano, K., Kodama, H., Nakanishi, H., Imai, T., Tsuda, H., Imaida, K., Tatematsu, M.: Immunohistochemical demonstration of intestinal-type alkaline phosphatase in stomach tumors induced by N-methyl-N’-nitro-N-nitrosoguanidine in rats. Jpn J Cancer Res, 85: 897-903, 1994.

21. Asamoto, M., Takahashi, S., Imaida, K., Shirai, T., Fukushima, S.: Increased gap junctional intercellular communication capacity and connexin 43 and 26 expression in rat bladder carcinogenesis. Carcinogenesis, 15: 2163-2166, 1994.

22. Shirai, T., Tada, M., Kojima, M., Hasegawa, R., Masui, T., Ito, N.: DNA adducts in target and nontarget tissues of 3,2′-dimethyl-4-aminobiphenyl in rats. Environ Health Perspect, 102: 167-172, 1994.

23. Hasegawa, R., Tanaka, H., Tamano, S., Shirai, T., Nagao, M., Sugimura, T., Ito, N.: Synergistic enhancement of small and large intestinal carcinogenesis by combined treatment of rats with five heterocyclic amines in a medium-term multi-organ bioassay. Carcinogenesis, 15: 2567-2573, 1994.

24. Tamano, S., Hasegawa, R., Hagiwara, A., Nagao, M., Sugimura, T., Ito, N.: Carcinogenicity of a mutagenic compound from food, 2-amino-3-methyl-9H-pyrido[2,3-b] indole (MeAαC), in male F344 rats. Carcinogenesis, 15: 2009-2015, 1994.

25. Hagiwara, A., Tanaka, H., Tamano, S., Imaida, K., Takahashi, S., Fukushima, S.: Inhibiting effects of diethylmaleate or NH4Cl on NaHCO3, but not butylated hydroxyanisole, promotion of urinary bladder carcinogenesis in male F344 rats initiated with N-butyl-N-(4-hydroxybutyl)nitrosamine. J Toxicol Sci, 19: 189-195, 1994.

26. Itoh, M., Pairojkul, C., Thamawit, W., Sithithaworn, P., Tiwawech, D., Uttaravicien, T., Shirai, T., Ito, N.: Association of antibodies to Opisthorchis viverrini with hepatobiliary disease in northeastern Thailand. Am J Trop Med Hyg, 51: 424-429,1994.

27. Masui, T., Don, I., Takada, N., Ogawa, K., Shirai, T., Fukushima, S.: p53 mutations in early neoplastic lesions of the urinary bladder in rats treated with N-butyl-N-(4-hydroxybutyl)nitrosamine. Carcinogenesis, 15: 2379-2381, 1994.

28. Ushijima, T., Kakiuchi, H., Makino, H., Hasegawa, R., Ishizaka, Y., Hirai, H., Yazaki, Y., Ito, N., Sugimura, T., Nagao, M.: Infrequent mutation of Ha-ras and p53 in rat mammary carcinomas induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. Mol Carcinog, 10: 38-44, 1994.

29. Shibata, MA., Shirai, T., Ogawa, K., Takahashi, S., Wild, CP., Montesano, R., Tsuda, H., Ito, N.: DNA methylation adduct formation and H-ras gene mutations in progression of N-butyl-N-(4-hydroxybutyl)- nitrosamine-induced bladder tumors caused by a single exposure to N-methyl-N-nitrosourea. Carcinogenesis, 15: 2965-2968, 1994.

30. Shirai, T., Imaida, K., Masui, T., Iwasaki, S., Mori, T., Kato, T., Ito, N.: Effects of testosterone, dihydrotestosterone and estrogen on 3,2-dimethyl-4-aminobiphenyl-induced rat prostate carcinogenesis. Int J Cancer, 57: 224-228, 1994.

31. Takahashi, S., Asamoto, M., Nakazawa, T., Kosaki, T., Katsumi, K., Shirai, T.: Robb-Smith type malignant histiocytosis associated with a mediastinal germ cell tumor. Jpn J Clin Oncol, 24: 327-330, 1994.

32. Takahashi, S., Hasegawa, R., Mutai, M., Ito, N., Ochiai, M., Nagao, M., Sugimura, T.: Additive action of five heterocyclic amines in terms of induction of GST-P positive single cells and foci in rat liver. Correlation with DNA adduct formation. J Toxicol Pathol, 7: 423-428, 1994.

33. Takashi, M., Sakata, T., Nakano, Y., Takagi, Y., Yamada, Y., Hibi, H., Miyake, K., Shirai, T.: Initiation-stage enhancement by uracil of N-ethyl-N-hydroxyethylnitrosamine-induction of kidney carcinogenesis in rats. Cancer Lett, 87: 151-157, 1994.

34. Tamano, S., Merlino, GT., Ward, JM.: Rapid development of hepatic tumors in transforming growth factor α transgenic mice associated with increased cell proliferation in precancerous hepatocellular lesions initiated by N-nitrosodiethylamine and promoted by phenobarbital. Carcinogenesis, 15: 1791-1798, 1994.

35. Hasegawa, R., Ito, N.: Hepatocarcinogenesis in the rat. In: Waalkes, MP. & Ward, JM. (eds.) Carcinogenesis, pp39-65. Raven Press Ltd., New York, 1994.

36. Hirose, M., Imaida, K., Tamano, S., Ito, N.: Cancer chemoprevention by antioxidants. In: Ho, CH. et al (eds.) Food Phytochemicals for Cancer Prevention II -Teas, Spices, and Herbs-, pp122-132. American Chemical Society, Washington, D.C., 1994.

37. Hasegawa, R., Takayama, S., Ito, N.: Effects of low level exposure to multiple carcinogens in combination. Toxicology of Chemical Mixtures, 15: pp361-382, Academic Press, 1994.

38. Ito, N., Imaida, K.: Identification of chemopreventive agents and their evaluation. In: Rao, RS et al. (eds.) XVI Proceedings of the International Cancer Congress, pp159-164, Monduzzi Editore S.p.A., Bologna, 1994.