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2. Hasegawa, R., Ogiso, T., Imaida, K., Shirai, T., Ito, N.: Analysis of the potential carcinogenicity of coffee and its related compounds in a medium-term liver bioassay of rats. Fd Chem Toxicol, 33: 15-20, 1995.

3. Shibata, MA., Sano, M., Hagiwara, A., Hasegawa, R., Shirai, T.: Modification by analgesics of lesion development in the urinary tract and various other organs of rats pretreated with dihydroxy-di-N- propylnitrosamine and uracil. Jpn J Cancer Res, 86: 160-167, 1995.

4. Tanaka, H., Hirose, M., Hagiwara, A., Imaida, K., Shirai, T., Ito, N.: Rat strain differences in catechol carcinogenicity to the stomach. Fd Chem Toxicol, 33: 93-98, 1995.

5. Ito, N., Hasegawa, R., Imaida, K., Kurata, Y., Hagiwara, A., Shirai, T.: Effect of ingestion of 20 pesticides in combination at acceptable daily intake levels on rat liver carcinogenesis. Fd Chem Toxicol, 33: 159-163, 1995.

6. Ito, N., Hagiwara, A., Tamano, S., Hasegawa, R., Imaida, K., Hirose, M., Shirai, T.: Lack of carcinogenicity of pesticide mixtures administered in the diet at acceptable daily intake (ADI) dose levels in rats. Toxicol Lett, 82-82: 513-520, 1995.

7. Hirose, M., Akagi, K., Hasegawa, R., Yaono, M., Satoh, T., Hara, Y., Wakabayashi, K., Ito, N.: Chemoprevention of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced mammary gland carcinogenesis by antioxidants in F344 female rats. Carcinogenesis, 16: 217-221, 1995.

8. Shirai, T., Shibata, MA., Takahashi, S., Tagawa, Y., Imaida, K., Hirose, M.: Differences in cell proliferation and apoptosis between reversible and irreversible mucosal lesions associated with uracil-induced urolithiasis in N-butyl-N-(4-hydroxybutyl)nitrosamine-pretreated rats. Carcinogenesis, 16: 501-505, 1995.

9. Tsukamoto, S., Akaza, H., Imada, S., Koiso, K., Shirai, T., Ideyama, Y., Kudo, M.: Chemoprevention of rat prostate carcinogenesis by use of finasteride or casodex. J Natl Cancer Inst, 87: 842-843, 1995.

10. Shibata, MA., Tanaka, H., Kawabe, M., Sano, M., Hagiwara, A., Shirai, T.: Lack of carcinogenicity of monosodium L-glutamate in Fischer 344 rats. Fd Chem Toxicol, 33: 383-391, 1995.

11. Iwata, H., Otoshi, T., Takada, N., Murai, T., Tamano, S., Watanabe, T., Katsura, Y., Fukushima, S.: Validation of silver-stained nucleolar organizer regions for evaluation of invasive character of urinary bladder carcinoma in rats and mice. Urol Res, 23: 27-32, 1995.

12. Tamano, S., Jakubczak, J., Takagi, H., Merlino, G., Ward, JM.: Increased susceptibility to N-nitrosomethylurea gastric carcinogenesis in transforming growth factor alpha transgenic mice with gastric hyperplasia. Jpn J Cancer Res, 86: 435-443, 1995.

13. Masui, T., Shirai, T., Imaida, K., Hirose, M., Futakuchi, M., Tatematsu, M., Ito, N.: Ki-ras mutations with frequent normal allele loss versus absence of p53 mutations in rat prostate and seminal vesicle carcinomas induced with 3,2′-dimethyl-4-aminobiphenyl. Mol Carcinog, 13: 21-26, 1995.

14. Liang, YY., Esteve, A., Martel-Planche, G., Takahashi, S., Lu, SH., Montesano, R., Hollstein, M.: p53 mutations in esophageal tumors from high-incidence areas of China. Int J Cancer, 61: 611-614, 1995.

15. Shirai, T., Tamano, S., Sano, M., Imaida, K., Hagiwara, A., Futakuchi, M., Takahashi, S., Hirose, M.: Site-specific effects of testosterone propionate on the prostate of rat pretreated with 3,2′-dimethyl-4-aminobiphenyl: Dose-dependent induction of invasive carcinomas. Jpn J Cancer Res, 86: 645-648, 1995.

16. Tiwawech, D., Shibata, MA., Hasegawa, R., Hagiwara, A., Shirai, T., Thamavit, W., Fukushima, S.: Weak synergistic effect of uracil and N-butyl-N-(4-hydroxybutyl)nitrosamine on urine composition, epithelial morphology, and DNA synthesis in the urinary bladder of Syrian golden hamster. J Toxicol Pathol, 8: 129-137, 1995.

17. Kataoka, H., Katsumi, K., Kutsuna, T., Suzumura, H., Kojima, S., Takeshima, A., Ban, Y., Itoh, T., Kishimoto, A., Kato, M., Iwata, F., Itoh, M., Takeuchi, T., Ogawa, K., Shirai, T.: A case of familial adenomatous polyposis associated with colon cancer, ureteral cancer and two early gastric cancers. Dig Endosc, 7: 278-284, 1995.

18. Akagi, K., Hirose, M., Hoshiya, T., Mizoguchi, Y., Ito, N., Shirai, T.: Modulating effects of ellagic acid, vanillin and quercetin in a rat medium term multi-organ carcinogenesis model. Cancer Lett. 94: 113-121, 1995.

19. Yaono, M., Hasegawa, R., Mizoguchi, Y., Futakuchi, M., Nakamura, T., Ito, N., Shirai, T.: Hepatocyte growth factor enhancement of preneoplastic hepatic foci development in rats treated with diethylnitrosamine and N-ethyl-N-hydroxyethylnitrosamine. Jpn J Cancer Res, 86: 718-723, 1995.

20. Shirai, T., Fradet, Y., Huland, H., Bollack, C., Droller, M., Janknegt, R., Jones, P., Kagawa, S.: The etiology of bladder cancer — Are there any new clues or predictors of behavior? Int J Urol, 2 Suppl 2: 64-75, 1995.

21. Hirose, M., Iwata, S., Ito, E., Nihro, Y., Takahashi, S., Mizoguchi, Y., Miki, T., Satoh, T., Ito, N., Shirai, T.: Strong anti-mutagenic activity of the novel lipophilic antioxidant 1-O-hexyl-2,3,5-trimethylhydroquinone against heterocyclic amine-induced mutagenesis in the Ames assay and its effect on metabolic activation of 2-amino-6-methyldipyrido [1,2-a:3′,2′-d] imidazole (Glu-P-1). Carcinogenesis, 16: 2227-2232, 1995.

22. Hasegawa, R., Hirose, M., Kato, T., Hagiwara, A., Boonyaphiphat, P., Nagao, M., Ito, N., Shirai, T.: Inhibitory effect of chlorophyllin on PhIP-induced mammary carcinogenesis in female F344 rats. Carcinogenesis, 16: 2243-2246, 1995.

23. Ogawa, K., Shichino, Y., Tatematsu, M., Furihata, C., Asamoto, M., Nagase, S., Shirai, T., Ito, N.: Increasing development of pepsinogen-altered pyloric glands and adenocarcinoma in glandular stomach of analbuminemic rats. Cancer Lett, 96: 219-224, 1995.

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10. Hirose, M., Akagi, K., Hasegawa, R., Satoh, T., Nihro, Y., Miki, T., Sugimura, T., Ito, N.: Strong inhibition of 2-amino-6-methyldipyrido[1,2-a: 3′, 2′-d]imidazole-induced mutagenesis and hepatocarcinogenesis by 1-O-hexyl-2,3,5-trimethylhydroquinone. Jpn J Cancer Res, 84: 481-484, 1993.

11. Tamano, S., Tanaka, H., Kawabe, M., Asakawa, E., Sano, M., Shioya, S., Shirai, T., Fukushima, S.: No enhancing effects of calcium / magnesium salts of L-glutamate and L-ascorbate on tumor development in a rat medium-term multiorgan carcinogenesis bioassay. J Toxicol Environ Health, 39: 43-58, 1993.

12. Toyoda, K., Imaida, K., Shirai, T., Imazawa, T., Takahashi, M.: Relationship between bisacodyl-induced urolithiasis and rat urinary bladder tumorigenesis. J Toxicol Environ Health, 39: 59-78, 1993.

13. Hasegawa, R., Cabral, R., Hoshiya, T., Hakoi, K., Ogiso, T., Boonyaphiphat, P., Shirai, T., Ito, N.: Carcinogenic potential of some pesticides in a medium-term multi-organ bioassay in rats. Int J Cancer, 54: 489-493, 1993.

14. Suzuki, S., Tamura, Y., Takazawa, Y., Mashimo, T., Imai, K., Yuasa, H., Yamanaka, H., Shirai, T.: Ultrasonic diagnosis of 3,2′-dimethyl-4-aminobiphenyl induced tumors in the urogenital organs of F344 rats. Prostate, 22: 235-241, 1993.

15. Tatematsu, M., Ichinose, M., Tsukada, S., Kakei, N., Takahashi, S., Ogawa, K., Hirose, M., Furihata, C., Miki, K., Kurokawa, K., Ito, N.: DNA methylation of the pepsinogen 1 gene during rat glandular stomach carcinogenesis induced by N-methyl-N’-nitro-N-nitrosoguanidine or catechol. Carcinogenesis, 14: 1415-1419, 1993.

16. Shibata, MA., Hirose, M., Masuda, A., Kato, T., Mutai, M., Ito, N.: Modification of BHA forestomach carcinogenesis in rats: inhibition by diethylmaleate or indomethacin and enhancement by a retinoid. Carcinogenesis, 14: 1265-1269, 1993.

17. Tamano, S., Asakawa, E., Boonyaphiphat, P., Masui, T., Fukushima, S.: Lack of promotion of N-butyl-N-(4-hydroxybutyl)nitrosamine-initiated urinary bladder carcinogenesis in mice by rat cancer promoters. Teratog Carcinog Mutagen, 13: 89-96, 1993.

18. Kurata, Y., Diwan, BA., Uno, H., Rice, JM., Ward. JM.: Pathology of preneoplastic and neoplastic renal tubular lesions induced in F-344 rats by sodium barbital, a nongenotoxic renal carcinogen and nephrotoxin. Toxicol Pathol, 21: 35-45, 1993.

19. Shrai, T.: Etiology of bladder cancer. Semin Urol, 11: 113-126, 1993.

20. Shibata, MA., Sano, M., Shirai, T., Imaida, K., Fukushima, S.: Epithelial hyperplasia in the renal papilla and pelvis but not the urinary bladder of male F344 rats associated with dietary sodium phosphates after uracil exposure. Toxicol Appl Pharmacol, 121: 303-312, 1993.

21. Okazaki, S., Hoshiya, T., Takahashi, S., Futakuchi, M., Saito, K., Hirose, M.: Modification of hepato- and renal carcinogenesis by catechol and its isomers in rats pretreated with N-ethyl-N-hydroxyethylnitrosamine. Teratog Carcinog Mutagen, 13: 127-137, 1993

22. Hirose, M., Hoshiya, T., Akagi, K., Takahashi, S., Hara, Y., Ito, N.: Effects of green tea catechins in a rat multi-organ carcinogenesis model. Carcinogenesis, 14: 1549-1553, 1993.

23. Tatematsu, M., Iwata, H., Ichinose, M., Kakei, N., Tsukada, S., Miki, K., Imai, S., Imaida, K.: Markers of surface mucous cell type human gastric cancer cells: Galactose oxidase-Schiff reactive mucins, monoclonal antibody SH-9 reactive mucins and cathepsin E. Acta Pathol Jpn, 43: 500-506, 1993.

24. Kawabe, M., Tamano, S., Shibata, MA., Hirose, M., Fukushima, S., Ito, N.: Subchornic toxicity study of methyl hesperidin in mice. Toxicol Lett, 69: 37-44, 1993.

25. Hoshiya, T., Hasegawa, R., Hakoi, K., Cui, L., Ogiso, T., Cabral, R., Ito, N.: Enhancement by non-mutagenic pesticides of GST-P positive hepatic foci development initiated with diethylnitrosamine in the rat. Cancer Lett, 72: 59-64, 1993.

26. Hagiwara, A., Ogiso, T., Shibata, MA., Shirai, T.: Spontaneous pleomorphic adenoma in the submandibular salivary gland of an aged male (C57BL/6N×C3H/HeN) F1 (B6C3F1) mouse. Vet Pathol, 30: 394-396, 1993.

27. Tiwawech, D., Siripong, P., Kupradinun, P., Thamavit, W., Shirai, T., Hagiwara, A., Ito, N.: Inhibition of diethylnitrosamine (DEN)-induced hepatic foci by pre and post treatment with Acanthus ebracteatus Vahl. in rats. Thai Cancer J, 19: 7-13, 1993.

28. Shirai, T., Iwasaki, S., Masui, T., Mori, T., Kato, T., Ito, N.: Enhancing effect of cadmium on rat ventral prostate carcinogenesis induced by 3,2′-dimethyl-4-aminobiphenyl. Jpn J Cancer Res, 84: 1023-1030, 1993.

29. Kagawa, M., Hakoi, K., Yamamoto, A., Futakuchi, M., Hirose, M.: Comparison of reversibility of rat forestomach lesions induced by genotoxic and non-genotoxic carcinogens. Jpn J Cancer Res, 84: 1120-1129, 1993.

30. Takahashi, S., Shirai, T., Ogawa, K., Imaida, K., Yamazaki, C., Ito, A., Masuko, K., Ito, N.: Renal cell adenomas and carcinomas in hemodialysis patients: Relationship between hemodialysis period and development of lesions. Acta Pathol Jpn, 43: 674-682, 1993.

31. Hirose, M., Yada, H., Hakoi, K., Takahashi, S., Ito, N.: Modification of carcinogenesis by α-tocopherol, t-butylhydroquinone, propyl gallate and butylated hydroxytoluene in a rat multi-organ carcinogenesis model. Carcinogenesis, 14: 2359-2364, 1993.

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33. Yamaguchi, S., Hakoi, K., Ozaki, K., Kato, T., Tiwawech, D., Nagao, S., Takahashi, H., Matsumoto, K., Tsuda, H.: Number of simultaneously expressed enzyme alterations correlates with progression of N-ethyl-N-hydroxyethylnitrosamine-induced hepatocarcinogenesis in rat. Jpn J Cancer Res, 84: 1237-1244, 1993.

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47. 宇和川賢：化学物質の発癌性検索のための他臓器中期発癌性試験法の検討. 名古屋市立大学医学会雑誌, 44: 61-86, 1993.

48. 白井智之, 高橋智：前立腺異型過形成. 前がん病変としての意義. CRC, 2: 164-171, 1993.

49. 長谷川良平, 今井田克己, 増井恒夫, 小川久美子, 加藤俊男, 伊東信行：ラット肝中期発がん性試験法の有用性と応用. 変異原性試験, 2: 1-10, 1993.

50. 片岡洋望, 勝見康平, 中沢貴宏, 池戸昌秋, 竹島彰彦, 坂義満, 伊藤龍雄, 岸本明比古, 加藤實, 柴田純孝, 渡辺晋, 白井智之：下行結腸に穿孔を生じた小腸・大腸クローン病の1例. 本邦報告例19例の検討. 消化器内視鏡, 5: 427-432, 1993.

51. 坂野章吾, 仁田正和, 高田勝利, 長谷川良平, 新美達司, 山本俊幸：肺腫瘤で発症し多彩な免疫異常を合併した高齢者非ホジキンリンパ腫の1例. 日本老年医学会雑誌, 30: 506-510, 1993.

52. 井上忠志：o-PhenylphenolおよびそのNa塩のラット膀胱発癌性に関する病理学的研究. 名古屋市立大学医学会雑誌, 44: 463-477, 1993.

53. 橋本俊, 由良二郎, 清水保延, 中村司, 音部好宏, 山守暢子, 林周作, 小野雅之, 田中守嗣, 花井拓美, 白井智之, 河原崎秀雄, 松波英寿：生体肝移植の周術期における免疫抑制と拒絶反応の診断. 移植, 28: 571-579, 1993.

54. 津田洋幸, 松本和幸, 高橋智, 岡村武彦：腎細胞種の形質表現の特異性と組織発生の解析. 病理と臨床, 11: 1105-1110, 1993.

55. 務台衛：ラット肝発癌過程における肝発癌物質・発癌修飾物質の低用量複合曝露の影響の解析. 名古屋市立大学医学会雑誌, 44: 525-548, 1993.

56. 中村厚：ラットにおける3,2′-dimethyl-4-aminobiphenyl(DMAB)の臓器発癌性とDNA付加体形成との関連性に関する研究. 名古屋市立大学医学会雑誌, 44: 549-563, 1993.

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59. 伊藤寛, 江口武史, 全並秀司, 成田清, 堀内格, 本田英邦, 渡辺勇, 坂上充志, 高橋智, 福島昭治 : Malignant rhabdoid tumor of the kidney (MRTK) の1例.日本小児外科学会雑誌, 29: 1266-1272, 1993.

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62. 伊藤寛, 全並秀司, 江口武史, 成田清, 本多英邦, 渡辺勇, 大内正信, 今井田克己 : メッケル憩室による乳児紋扼性腸閉塞症の一例. 名古屋市立病院紀要, 16: 81-84, 1993.

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2. Shibata, MA., Fukushima, S., Asakawa, E., Hirose, M., Ito, N.: The modifying effects of indomethacin or ascorbic acid on cell proliferation induced by different types of bladder tumor promoters in rat urinary bladder and forestomach mucosal epithelium. Jpn J Cancer Res, 83: 31-39, 1992.

3. Kojima, M., Morita, T., Shirai, T., Degawa, M., Tada, M.: Immunological detection and quantitation of DNA adducts formed by 4-aminoazobenzene species in vivo. Jpn J Cancer Res, 83: 78-85, 1992.

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2. Tatematsu, M., Ogawa, K., Mutai, M., Aoki, T., Hoshiya, T., Ito, N.: Rapid regression of squamous cell hyperplasia and slow regression of basal cell hyperplasia in the forestomach of F344 rats treated with N-methyl-N’-nitro-N-nitrosoguanidine and/or butylated
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3. Okumura, M., Shirai, T., Tamano, S., Ito, M., Yamada, S., Fukushima, S.: Uracil-induced calculi and carcinogenesis in the urinary bladder of rats treated simultaneously with N-butyl-N-(4-hydroxybutyl)nitrosamine. Carcinogenesis, 12: 35-41, 1991.

4. Shibata, MA., Asakawa, E., Hagiwara, A., Kurata, Y., Fukushima, S.: DNA synthesis and scanning electron microscopic lesions in renal pelvic epithelium of rats treated with bladder cancer promoters. Toxicol Lett, 55: 263-272, 1991.

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6. Hirose, M., Mutai, M., Takahashi, S., Yamada, M., Fukushima, S., Ito, N.: Effects of phenolic antioxidants in low dose combination on forestomach carcinogenesis in rats pretreated with N-methyl-N’-nitro-N-nitrosoguanidine. Cancer Res, 51: 824-827,1991.

7. Shirai, T., Tamano, S., Kato, T., Iwasaki, S., Takahashi, S., Ito, N.: Induction of invasive carcinomas in the accessory sex organs other than the ventral prostate of rats given 3,2-dimethyl-4-aminobiphenyl and testosterone propionate. Cancer Res, 51:1264-1269, 1991.

8. Ochiai, M., Ogawa, K., Wakabayashi, K., Sugimura, T., Nagase, S., Esumi, H., Nagao, M.: Induction of intestinal adenocarcinomas by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in Nagase analbuminemic rats. Jpn J Cancer Res, 82:363-366, 1991.

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17. Shirai, T., Fukushima, S., Kawabe, M., Shibata, MA., Iwasaki, S., Tada, M., Ito, N.: Selective induction of rat urinary bladder tumors by simultaneous administration of 3,2′-dimethyl-4-aminobiphenyl (DMAB) and butylated hydroxyanisole or butylated hydroxytoluene is associated with increased DMAB-DNA adduct formation. Carcinogenesis, 12: 1335-1339, 1991.

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25. Hirose, M., Ozaki, K., Takaba, K., Fukushima, S., Shirai, T., Ito, N.: Modifying effects of the naturally occurring antioxidants γ-oryzanol, phytic acid, tannic acid and n-tritriacontane-16,18-dione in a rat wide-spectrum organ carcinogenesis model. Carcinogenesis, 12: 1917-1921, 1991.

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30. de Camargo, JLV., Shirai, T., Kato, T., Asamoto, M., Fukushima, S.: Summation effects of uracil and other promoters on epithelial lesion development in the F344 rat urinary bladder initiated by N-butyl-N-(4-hydroxybutyl)nitrosamine. Jpn J Cancer Res, 82: 1220-1225, 1991.

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33. Murai, T., Mori, S., Hosono, M., Takeuchi, Y., Ohara, T., Makino, S., Takeda, R., Hayashi, Y., Fukushima, S.: Renal pelvic carcinoma which shows metastatic potential to distant organs, induced by N-butyl-N-(4-hydroxybutyl)nitrosamine in NON/Shi mice. Jpn J Cancer Res, 82: 1371-1377, 1991.

34. Imaida, K., Furihata, C., Tatematsu, M., Yoon, CH., Furukawa, F., Uneyama, C., Takahashi, M., Ito, N., Hayashi, Y.: Immunohistochemical and biochemical identification of pepsinogen isozymes in the hamster lungs: Induction by polychlorinated biphenyls. Toxicol Pathol, 19: 230-236, 1991.

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39. Shibata, MA., Kagawa, M., Kawabe, M., Hagiwara, A., Fukushima, S.: Comparative promoting activities of phosphate salts on rat two-stage bladder carcinogenesis under conditions of equivalent urinary Na+ or K+ levels. Teratog Carcinog Mutagen, 11: 305-316, 1991.

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43. Tsuda, H., Ozaki, K., Uwagawa, S., Takahashi, S., Hakoi, K., Kato, T., Fukushima, S., Sato, K., Ito, N.: Analysis of the effects of modifying agents on proliferation and enzyme phenotype in focal preneoplastic and neoplastic liver lesions in rats. In: Columbano, A. et al. (eds.) Chemical Carcinogenesis 2, pp219-229. Plenum Press, New York, 1991.

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1. Hirose, M., Masuda, A., Hasegawa, R., Wada, S., Ito, N.: Regression of butylated hydroxyanisole (BHA)-induced hyperplasia but not dysplasia in the forestomach of hamsters. Carcinogenesis, 11: 239-244, 1990.

2. Shibata, MA., Hasegawa, R., Kurata, Y., Yamada, M., Tamano, S., Fukushima, S.: Bladder epithelial hyperplasia in F344 rats after intravesical instillation of the antitumor chemotherapeutic agents Adriamycin and mitomycin C. Cancer Lett, 49: 41-49, 1990.

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10. Ogiso, T., Tatematsu, M., Tamano, S., Hasegawa, R., Ito, N.: Correlation between medium-term liver bioassay system data and results of long-term testing in rats. Carcinogenesis, 11: 561-566, 1990.

11. Shirai, T., Nakamura, A., Fukushima, S., Tada, M., Morita, T., Ito, N.: Immunohistochemical demonstration of carcinogen-DNA adducts in target and non-target tissues of rats given a prostate carcinogen, 3,2′-dimethyl-4-aminobiphenyl. Carcinogenesis, 11: 653-657, 1990.

12. Hirose, M., Masuda, A., Ito, N., Kamano, K., Okuyama, H.: Effects of dietary perilla oil, soybean oil and safflower oil on 7,12-dimethylbenz[a]anthracene (DMBA) and 1,2-dimethylhydrazine (DMH)-induced mammary gland and colon carcinogenesis in female SD rats. Carcinogenesis, 11: 731-735, 1990.

13. Shirai, T., Nakamura, A., Fukushima, S., Yamamoto, A., Tada, M., Ito, N.: Different carcinogenic responses in a variety of organs, including the prostate, of five different rat strains given 3,2′-dimethyl-4-aminobiphenyl. Carcinogenesis, 11: 793-797, 1990.

14. Hasegawa, R., Takahashi, S., Asamoto, M., Shirai, T., Fukushima, S.: Species differences in sodium o-phenylphenate induction of urinary bladder lesions. Cancer Lett, 50: 87-91, 1990.

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16. Shibata, MA., Hirose, M., Yamada, M., Tatematsu, M., Uwagawa, S., Ito, N.: Epithelial cell proliferation in rat forestomach and glandular stomach mucosa induced by catechol and analogous dihydroxybenzenes. Carcinogenesis, 11: 997-1000, 1990.

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20. Masui, T., Asamoto, M., Hasegawa, R., Kagawa, M., Fukushima, S.: Effects of monosodium succinate, disodium succinate, and succinic acid on urinary bladder carcinogenesis in N-butyl-N-(4-hydroxybutyl)- nitrosamine-initiated, unilaterally ureter-ligated rats. J Toxicol Pathol, 3: 105-110, 1990.

21. Cova, L., Wild, CP., Mehrotra, R., Turusov, V., Shirai, T., Lambert, V., Jacquet, C., Tomatis, L., Trepo, C., Montesano, R.: Contribution of aflatoxin B1 and hepatitis B virus infection in the induction of liver tumors in ducks. Cancer Res, 50: 2156-2163, 1990.

22. Fukushima, S., Uwagawa, S., Shirai, T., Hasegawa, R., Ogawa, K.: Synergism by sodium L-ascorbate but inhibition by L-ascorbic acid for sodium saccharin promotion of rat two-stage bladder carcinogenesis. Cancer Res, 50: 4195-4198, 1990.

23. Kurata, Y., Fukushima, S., Hasegawa, R., Hirose, M., Shibata, MA., Shirai, T., Ito, N.: Structure-activity relations in promotion of rat urinary bladder carcinogenesis by phenolic antioxidants. Jpn J Cancer Res, 81: 754-759, 1990.

24. Tatematsu, M., Katsuyama, T., Furihata, C., Fukushima, S., Shirai, T., Kato, T., Ito, N.: Cellular differentiation and histogenesis of rat glandular stomach cancers. Jpn J Cancer Res, 81: 760-767, 1990.

25. Hagiwara, A., Tamano, S., Shibata, MA., Arai, M., Tsuda, H.: Lack of modifying effects of p-phenylenediamine on induction of γ-glutamyl transpeptidase-positive foci in a medium-term bioassay system using F344 rats. Toxicol Lett, 52: 261-268, 1990.

26. Hirose, M., Fukushima, S., Hasegawa, R., Kato, T., Tanaka, H., Ito, N.: Effects of sodium nitrite and catechol or 3-methoxycatechol in combination on rat stomach epithelium. Jpn J Cancer Res, 81: 857-861, 1990.

27. Hasegawa, R., Furukawa, F., Toyoda, K., Takahashi, M., Hayashi, Y., Hirose, M., Ito, N.: Inhibitory effects of antioxidants on N-bis(2-hydroxypropyl)nitrosamine-induced lung carcinogenesis in rats. Jpn J Cancer Res, 81: 871-877, 1990.

28. Nakamura, A., Shirai, T., Ogawa, K., Wada, S., Fujimoto, NA., Ito, A., Ito, N.: Promoting action of prolactin released from a grafted transplantable pituitary tumor (MtT/F84) on rat prostate carcinogenesis. Cancer Lett, 53: 151-157, 1990.

29. Hagiwara, A., Yamada, M., Hasegawa, R., Fukushima, S., Ito, N.: Lack of enhancing effects of fenvalerate and esfenvalerate on induction of preneoplastic glutathione S-transferase placental form positive liver cell foci in rats. Cancer Lett, 54: 67-73, 1990.

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34. Hagiwara, A., Tamano, S., Ogiso, T., Asakawa, E., Fukushima, S.: Promoting effect of the peroxisome proliferator, clofibrate, but not di(2-ethylhexyl)phthalate, on urinary bladder carcinogenesis in F344 rats initiated by N-butyl-N-(4-hydroxybutyl)nitrosamine. Jpn J Cancer Res, 81: 1232-1238, 1990.

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61. 堀内格, 伊藤寛, 坂上充志, 本多英邦, 荻野高敏, 後藤玄夫, 福島昭治：肝内胆管形成不全症の1例. 名古屋市立病院紀要, 11: 87-90, 1988.

1. Fukushima, S., Ogiso, T., Kurata, Y., Hirose, M., Ito, N.: Dose-dependent effects of butylated hydroxyanisole, butylated hydroxytoluene and ethoxyquin for promotion of bladder carcinogenesis in N-butyl-N-(4-hydroxybutyl)nitrosamine-initiated, unilaterally ureter-ligated rats. Cancer Lett, 34: 83-90, 1987.

2. Tatematsu, M., Furihata, C., Miki, K., Ichinose, M., Shirai, T., Tatematsu, K., Ito, N.: Complete and incomplete pyloric gland metaplasia of human gallbladder. Acta Pathol Jpn, 37: 39-46, 1987.

3. Hirose, M., Hagiwara, A., Inoue, K., Sakata, T., Ito, N., Kaneko, H., Yoshitake, A., Miyamoto, J.: Metabolism of 2- and 3-tert-butyl-4-hydroxyanisole (2- and 3-BHA) in the rat (I): Excretion of BHA in urine, feces and expired air and distribution of BHA in the main organs. Toxicology, 43: 139-147, 1987.

4. Shirai, T., Tsuda, H., Ogiso, T., Hirose, M., Ito, N.: Organ specific modifying potential of ethinyl estradiol on carcinogenesis initiated with different carcinogens. Carcinogenesis, 8: 115-119, 1987.

5. Moore, MA., Tsuda, H., Thamavit, W., Masui, T., Ito, N.: Differential modification of development of preneoplastic lesions in the Syrian golden hamster initiated with a single does of 2,2′-dioxo-N-nitrosodipropylamine: Influence of subsequent butylated hydroxyanisole, α-tocopherol, or carbazole. J Natl Cancer Inst, 78: 289-293, 1987.

6. Moore, MA., Thamavit, W., Ito, N.: Comparison of lesions induced in the Syrian golden hamster by diethylnitrosamine, dimethylhydrazine, and dibutylnitrosamine: Influence of subsequent butylated hydroxyanisole treatment. J Natl Cancer Inst, 78: 295-301, 1987.

7. Tsuda, H., Mera, Y., Seki, K., Aoki, T., Fukushima, S., Ito, N.: Induction of tumors in the liver, urinary bladder, esophagus and forestomach by short-term treatment with different doses of N,N’-dibutylnitrosamine in rats. Jpn J Cancer Res (Gann), 78: 227-234, 1987.

8. Shirai, T., Tagawa, Y., Fukushima, S., Asamoto, M., Ito, N.: Lack of tumorigenic response in the prostate gland of castrated F344 rats by 3,2′-dimethyl-4-aminobiphenyl given with methyltestosterone. Cancer Lett, 35: 1-6, 1987.

9. Shirai, T., Ikawa, E., Tagawa, Y., Ito, N.: Lesions of the prostate glands and seminal vesicles induced by N-methylnitrosourea in F344 rats pretreated with ethinyl estradiol. Cancer Lett, 35: 7-15, 1987.

10. Fukushima, S., Ogiso, T., Kurata, Y., Shibata, MA., Kakizoe, T.: Absence of promotion potential for calcium L-ascorbate, L-ascorbic dipalmitate, L-ascorbic stearate and erythorbic acid on rat urinary bladder carcinogenesis. Cancer Lett, 35: 17-25, 1987.

11. Tamano, S., Fukushima, S., Shirai, T., Hirose, M., Ito, N.: Modification by α-tocopherol, propyl gallate and tertiary butylhydroquinone of urinary bladder carcinogenesis in Fischer 344 rats pretreated with N-butyl-N-(4-hydroxybutyl)nitrosamine. Cancer Lett, 35: 39-46, 1987.

12. Moore, MA., Bannasch, P., Satoh, T., Hacker, HJ., Ito, N.: Immunohistochemically demonstrated increase in glutathione S-transferase species in propylnitrosamine-induced focal proliferative and neoplastic syrian hamster pancreatic lesions. Virchows Arch [Cell Pathol], 52: 479-488, 1987.

13. Tatematsu, M., Furihata, C., Katsuyama, T., Mera, Y., Inoue, T., Matsushima, T., Ito, N.: Immunohistochemical demonstration of pyloric gland-type cells with low-pepsinogen isozyme 1 in preneoplastic and neoplastic tissues of rat stomachs treated with N-methyl-N’-nitro-N-nitrosoguanidine. J Natl Cancer Inst, 78: 771-777, 1987.

14. Tatematsu, M., Aoki, T., Asamoto, M., Furihata, C., Ito, N.: Enhancing effects of N-ethyl-N’-nitro-N-nitrosoguanidine and sodium taurocholate on development of pepsinogen 1 decreased pyloric glands in rats initiated with N-methyl-N’-nitro-N-nitrosoguanidine. Jpn J
Cancer Res (Gann), 78: 312-316, 1987.

15. Hirose, M., Masuda, A., Imaida, K., Kagawa, M., Tsuda, H., Ito, N.: Induction of forestomach lesions in rats by oral administrations of naturally occurring antioxidants for 4 weeks. Jpn J Cancer Res (Gann), 78: 317-321, 1987.

16. Tatematsu, M., Tsuda, H., Shirai, T., Masui, T., Ito, N.: Placental glutathione S-transferase (GST-P) as a new marker for hepatocarcinogenesis: In vivo short-term screening for hepatocarcinogens. Toxicol Pathol, 15: 60-68, 1987.

17. Tsuda, H., Moore, MA., Asamoto, M., Inoue, T., Fukushima, S., Ito, N., Satoh, K., Amelizad, Z., Oesch, F.: Immunohistochemically demonstrated altered expression of cytochrome P-450 molecular forms and epoxide hydrolase in N-ethyl-N-hydroxyethylnitrosamine-induced rat kidney and liver lesions. Carcinogenesis, 8: 711-717, 1987.

18. Tsuda, H., Ogiso, T., Hasegawa, R., Imaida, K., Masui, T., Ito, N.: Inhibition of neoplastic development in rat liver, kidney, oesophagus and forestomach by 4,4′-diaminodiphenylmethane administration. Carcinogenesis, 8: 719-722, 1987.

19. Furihata, C., Takezawa, R., Matsushima, T., Tatematsu, M.: Potential tumor-promoting activity of bile acids in rat glandular stomach. Jpn J Cancer Res (Gann), 78: 32-39, 1987.

20. Fukushima, S., Sakata, T., Tagawa, Y., Shibata, MA., Hirose, M., Ito, N.: Different modifying response of butylated hydroxyanisole, butylated hydroxytoluene, and other antioxidants in N, N-dibutylnitrosamine esophagus and forestomach carcinogenesis of rats. Cancer Res, 47: 2113-2116, 1987.

21. Hasegawa, R., Fukushima, S., Hirose, M., Seki, K., Takahashi, M., Furukawa, F., Toyoda, K., Ito, N.: Histochemical demonstration of colonic type mucin in glandular metaplasia and adenocarcinoma of the human urinary bladder. Acta Pathol Jpn, 37: 1097-1103, 1987.

22. Hirose, M., Asamoto, M., Hagiwara, A., Ito, N., Kaneko, H., Saito, K., Takamatsu, Y., Yoshitake, A., Miyamoto, J.: Metabolism of 2- and 3-tert-butyl-4-hydroxyanisole (2- and 3-BHA) in the rat (II): Metabolism in forestomach and covalent binding to tissue macromolecules. Toxicology, 45: 13-24, 1987.

23. Funato, T., Yokota, J., Sakamoto, H., Kameya, T., Fukushima, S., Ito, N., Terada, M., Sugimura, T.: Activation of N-ras gene in a rat hepatocellular carcinoma induced by dibutylnitrosamine and butylated hydroxytoluene. Jpn J Cancer Res (Gann), 78: 689-694, 1987.

24. Mori, S., Kurata, Y., Takeuchi, Y., Toyama, M., Makino, S., Fukushima, S.: Influences of strain and diet on the promoting effects of sodium L-ascorbate in two-stage urinary bladder carcinogenesis in rats. Cancer Res, 47: 3492-3495, 1987.

25. Fukushima, S., Ito, N., El-Bolkainy, MN., Tawfik, HN., Tatemoto, Y., Mori, M.: Immunohistochemical observations of keratins, involucrin, and epithelial membrane antigen in urinary bladder carcinomas from patients infected with Schistosoma haematobium. Virchows Arch A, 411: 103-115, 1987.

26. Fukushima, S., Shibata, MA., Tamano, S., Ito, N., Suzuki, E., Okada, M.: Aging and urianary bladder carcinogenesis induced in rats by N-butyl-N-(4-hydroxybutyl)nitrosamine. J Natl Cancer Inst, 79: 263-267, 1987.

27. Shibata, MA., Kurata, Y., Ogiso, T., Tamano, S., Fukushima, S., Ito, N.: Combined chronic toxicity and carcinogenicity studies of morpholine oleic acid salt in B6C3F1 mice. Fd Chem Toxicol, 25: 569-574, 1987.

28. Moore, MA., Tsuda, H., Hacker, HJ., Sato, K., Bannasch, P., Ito, N.: Altered enzyme expression in propylnitrosamine-induced Syrian hamster lung lesions. Virchows Arch B, 53: 272-278, 1987.

29. Kurata, Y., Tsuda, H., Sakata, T., Yamashita, T., Ito, N.: Reciprocal modifying effects of isomeric forms of aminophenol on induction of neoplastic lesions in rat liver and kidney initiated by N-ethyl-N-hydroxyethylnitrosamine. Carcinogenesis, 8: 1281-1285, 1987.

30. Hirose, M., Inoue, T., Masuda, A., Tsuda, H., Ito, N.: Effects of simultaneous treatment with various chemicals on BHA-induced development of rat forestomach hyperplasia — complete inhibition by diethylmaletate in a 5-week feeding study. Carcinogenesis, 8: 1555-1558, 1987.

31. Tatematsu, M., Fukushima, S., Aoki, T., Mera, Y., Inoue, T., Ito, N.: Patterns of epithelial proliferation revealed by continuous administration of bromodeoxyuridine during urinary bladder carcinogenesis in rats. Jpn J Cancer Res (Gann), 78: 879-882, 1987.

32. Shirai, T., Ikawa, E., Imaida, K., Tagawa, Y., Ito, N.: Proliferative response of rat accessory sex organs to dietary sex hormones after castration or initial dietary administration of estrogen. J Urol, 138: 216-218, 1987.

33. Ito, N., Hirose, M.: The role of antioxidants in chemical carcinogenesis. Jpn J Cancer Res (Gann), 78: 1011-1026, 1987.

34. Shirai, T., Fukushima, S., Hirose, M., Ohshima, M., Ito, N.: Epithelial lesions of the urinary bladder in three hundred and thirteen autopsy cases. Jpn J Cancer Res (Gann), 78: 1073-1080, 1987.

35. Fukushima, S., Shibata, MA., Shirai, T., Kurata, Y., Tamano, S., Imaida, K.: Promotion by L-ascorbic acid of urinary bladder carcinogenesis in rats under conditions of increased urinary K ion concentratin and pH. Cancer Res, 47: 4821-4824, 1987.

36. Masui, T., Asamoto, M., Hirose, M., Fukushima, S., Ito, N.: Regression of simple hyperplasia and papillomas and persistence of basal cell hyperplasia in the forestomach of F344 rats treated with butylated hydroxyanisole. Cancer Res, 47: 5171-5174, 1987.

37. Shibata, MA., Kurata, Y., Tamano, S., Ogiso, T., Fukushima, S., Ito, N.: 13-week subchronic toxicity study with morpholine oleic acid salt administered to B6C3F1 mice. J Toxicol Environ Health, 22: 187-194, 1987.

38. Hirose, M., Masuda, A., Tsuda, H., Uwagawa, S., Ito, N.: Enhancement of BHA-induced proliferative rat forestomach lesion development by simultaneous treatment with other antioxidants. Carcinogenesis, 8: 1731-1735, 1987.

39. Fukushima, S., Shirai, T., Hirose, M.: The role L-ascorbic acid and urinary electolytes in promotion of rat blaader carcinogenesis. Exp Pathol, 31: 69-70, 1987.

40. Hirose, M., Kurata, Y., Tsuda, H., Fukushima, S., Ito, N.: Catechol strongly enhances rat stomach carcinogenesis: A possible new environmental stomach carcinogen. Jpn J Cancer Res (Gann), 78: 1144-1149, 1987.

41. Tsuda, H., Masui, T., Ikawa, E., Imaida, K., Ito, N.: Compared promoting potential of D-galactosamine, carbon tetrachloride and partial hepatectomy in rapid induction of preneoplastic liver lesions in the rat. Cancer Lett, 37: 163-171, 1987.

42. Okamura, T., Ohtani, M., Inoue, K., Fukushima, S., Ohtaguro, K., Kakizoe, T.: Effects of intravesical instillation of antitumor chemotherapeutic and immunotherapeutic agents on bladder lesion development in rats pretreated with N-butyl-N-(4-hydroxybutyl)nitrosamine. J Urol, 138: 1305-1307, 1987.

43. Shirai, T., Tagawa, Y., Fukushima, S., Imaida, K., Ito, N.: Strong promoting activity of reversible uracil-induced urolithiasis on urinary bladder carcinogenesis in rats initiated with N-butyl-N-(4-hydroxybutyl)nitrosamine. Cancer Res, 47: 6726-6730, 1987.

44. Ito, N.: Organ-specific modifying effects of phenobarbital, saccharin and antioxidants on 2-stage chemical carcinogenesis. In: Chambers, PL., Gehring, P., Sakai, F. (eds.) New Concepts and Developments in Toxicology, pp359-369. Elsevier Science Publishers B.V. (Biomedical Division), 1987.

45. Tsuda, H., Aoki, T., Ito, N.: Effects of α-tocopherol on carcinogenesis in various organs of rats. In: Hayashi, O. & Mino, M. (eds.) Clinical and Nutritional Aspects of Vitamin E, pp329-332. Elservier Science Publish BV. (Biomedical Division), 1987.

46. Hiasa, Y., Ito, N.: Experimental induction of renal tumors. CRC Crit Rev Toxicol, 17: 279-343, 1987.

47. 井上和彦, 岡村武彦, 福島昭治, 伊東信行, 大田黒和生：Mitomycin C およびCytosine Arabinoside のラットBBN 膀胱発癌に対する膀胱内注入効果. 癌と化学療法, 14: 71-76, 1987.

48. 武内俊彦, 伊藤誠, 加藤政仁, 奥谷博昭, 伊東信行, 福島昭治, 津田洋幸, 朝元誠人：故岸川基明名誉教授の病歴ならびに剖検記録. 名古屋市立大学医学会雑誌, 38: 1987.

49. 福島昭治, 今井田克己：大量のビタミンC 摂取と癌をめぐる問題. ファルマシア, 23: 247-252, 1987.

50. 伊東信行, 吉田修：膀胱の化学発癌をめぐって. 医学のあゆみ, 140: 957-963,1987.

51. 山本崇晴, 鷲見聡, 側島久典, 一木貴, 鈴木重澄, 杉山成司, 渡辺勇, 戸苅創, 和田義郎, 増井恒夫, 津田洋幸, 多田豊曠：極小未熟児の肝不全の3 剖検例. 日本新生児学会雑誌, 23: 396-401, 1987.

52. 山口信行, 大矢晶子, 川北章, 二村真秀, 萩野高敏, 後藤玄夫, 大内正信, 黒柳充男, 福島昭治：重症新生児遷延性肺高血圧症 (PPHN) に対するHyperventilation Therapy 及び薬物療法の検討. Weaning不能となった2 症例.日本新生児学会雑誌, 23: 521-528, 1987.

53. 伊東信行, 広瀬雅雄：酸化防止剤の発癌性と発癌修飾作用. 医学のあゆみ, 141: 964-966, 1987.

54. 乾正彦, 伊藤春雄, 津田洋幸, 増井恒夫, 福島昭治, 伊東信行：空腸の上皮型平滑筋肉腫の1例. 日本臨床外科医学会雑誌, 48: 852-856, 1987.

55. 福島昭治, 今井田克己：膀胱発癌のプロモーション. トキシコロジーフォーラム, 10: 391-398, 1987.

56. 福島昭治：ダンスロンと大黄の発癌性. 日本医事新報, 3310: 139-140, 1987.

57. 津田洋幸：腎. トキシコロジーフォーラム, 10: 468-474, 1987.

58. 立松正衛：腺胃. トキシコロジーフォーラム, 10: 487-496, 1987.

59. 津田洋幸：尿細管上皮の新しい指標酵素. G6PDHとSDHは指標酵素として有用. 医学のあゆみ, 143: 31,
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60. 林昌利：食肉用動物における自然発生腫瘍の病理組織学的研究. ブタの肝と腎腫瘍、ならびにウシ、ブタの悪性リンパ腫と悪性黒色腫の解析. 名古屋市立大学医学会雑誌, 38: 413-441, 1987.

61. 伊東信行：長期毒性. その考え方と評価. 病理学的立場から. J Toxicol Sci, 12: 481-492, 1987.

62. 伊東信行：イニシエーターとプロモーター. 肝胆膵, 15: 853-854, 1987.

63. 榊原堅式, 片岡誠, 坂上充志, 林聰一, 山本純, 藤井康, 高木格, 桑原義之, 谷脇聡, 辻秀樹, 深尾俊一, 正岡昭, 広瀬雅雄, 伊東信行, 中村隆昭：腸間膜腫瘍として発症し剖検にて胃原発と考えられた男子繊毛癌の1病例と男子繊毛癌の文献的考察. 癌の臨床, 33: 1745-1750, 1987.

64. 福島昭治, 朝元誠人：実験的膀胱癌発生の促進と尿性状. 尿pH と電解質, さらにL-ascorbic acid の役割. 医学のあゆみ, 143: 885, 1987.

65. 和志田裕人, 渡辺秀輝, 坂上洋, 佐々木昌一, 堀武, 福島昭治, 朝元誠人：Nd:YAG Laser 治療による膀胱組織の変化について. 日本レーザー医学会誌, 8: 237-238, 1987.

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1. Hirose, M., Masuda, A., Kurata, Y., Ikawa, E., Mera, Y., Ito, N.: Histologic and autoradiographic studies on the forestomach of hamsters treated with 2-tert-butylated hydroxyanisole, 3-tert-butylated hydroxyanisole, crude butylated hydroxyanisole, or butylated hydroxytoluene. J Natl Cancer Inst, 76: 143-149, 1986.

2. Fukushima, S., Thamavit, W., Kurata, Y., Ito, N.: Sodium citrate: A promoter of bladder carcinogenesis. Jpn J Cancer Res (Gann), 77: 1-4, 1986.

3. Moore, MA., Thamavit, W., Tsuda, H., Sato, K., Ichihara, A., Ito, N.: Modifying influence of dehydroepiandrosterone on the development of dihydroxy-di-n-propylnitrosamine-initiated lesions in the thyroid, lung and liver of F344 rats. Carcinogenesis, 7: 311-316, 1986.

4. Moore, MA., Tsuda, H., Ito, N.: Dehydrogenase histochemistry of N-ethyl-N-hydroxyethylnitrosamine- induced focal liver lesions in the rat — increase in NADPH-generating capacity. Carcinogenesis, 7: 339-342, 1986.

5. Moore, MA., Nakamura, T., Shirai, T., Ichihara, A., Ito, N.: Immunohistochemical demonstration of increased glucose-6-phosphate dehydrogenase in preneoplastic and neoplastic lesions induced by propylnitrosamines in F344 rats and syrian hamsters. Jpn J Cancer Res (Gann), 77: 131-138, 1986.

6. Moore, MA., Thamavit, W., Tsuda, H., Ito, N.: The influence of subsequent dehydroepiandrosterone, diaminopropane, phenobarbital, butylated hydroxyanisole and butylated hydroxytoluene treatment on the development of preneoplastic and neoplastic lesions in the rat initiated with di-hydroxy-di-N-propyl nitrosamine. Cancer Lett, 30: 153-160, 1986.

7. Hirose, M., Hagiwara, A., Masui, T., Inoue, K., Ito, N.: Combined effects of butylated hydroxyanisole and other antioxidants in induction of forestomach lesions in rats. Cancer Lett, 30: 169-174, 1986.

8. Masui, T., Tsuda, H., Inoue, K., Ogiso, T., Ito, N.: Inhibitory effects of ethoxyquin, 4,4′-diaminodiphenylmethane and acetaminophen on rat hepatocarcinogenesis. Jpn J Cancer Res (Gann), 77: 231-237, 1986.

9. Tatematsu, M., Furihata, C., Mera, Y., Shirai, T., Matsushima, T., Ito, N.: Immunohistochemical demonstration of induction of pyloric glands with low pepsinogen 1 (Pg 1) content in rat stomach by N-methyl-N’-nitro-N-nitrosoguanidine. Jpn J Cancer Res (Gann), 77: 238-243, 1986.

10. Nishio, Y., Kakizoe, T., Ohtani, M., Sato, S., Sugimura, T., Fukushima, S.: L-isoleucine and L-leucine: Tumor promoters of bladder cancer in rats. Science, 231: 843-845, 1986.

11. Ikawa, E., Tsuda, H., Sakata, T., Masui, T., Satoh, K., Sato, K., Ito, N.: Modification potentials of ethyl alcohol and acetaldehyde on development of preneoplastic gultathione S-transferase p-form-positive liver cell foci initiated by diethylnitrosamine in the rat. Cancer Lett, 31: 53-60, 1986.

12. Fukushima, S., Shibata, MA., Shirai, T., Tamano, S., Ito, N.: Roles of urinary sodium ion concentration and pH in promotion by ascorbic acid of urinary bladder carcinogenesis in rats. Cancer Res, 46: 1623-1626, 1986.

13. Ohtani, M., Kakizoe, T., Nishio, Y., Sato, S., Sugimura, T., Fukushima, S., Niijima, T.: Sequential changes of mouse bladder epithelium during induction of invasive carcinomas by N-butyl-N-(4-hydroxybutyl)nitrosamine. Cancer Res, 46: 2001-2004, 1986.

14. Shirai, T., Ikawa, E., Fukushima, S., Masui, T., Ito, N.: Uracil-induced urolithiasis and the development of reversible papillomatosis in the urinary bladder of F344 rats. Cancer Res, 46: 2062-2067, 1986.

15. Sato, A., Yonekura, I., Asakawa, M., Nakahara, H., Nakajima, T., Ohta, S., Shirai, T., Ito, N.: Augmentation of ethanol-induced enhancement of dimethylnitrosamine and diethylnitrosamine metabolism by lowered carbohydrate intake. Jpn J Cancer Res (Gann), 77: 125-130, 1986.

16. Moore, MA., Fukushima, S., Ichihara, A., Sato, K., Ito, N.: Intestinal metaplasia and altered enzyme expression in propylnitrosamine-induced syrian hamster cholangiocellular and gallbladder lesions. Virchows Arch [Cell Pathol], 51: 29-38, 1986.

17. Moore, MA., Thamavit, W., Ichihara, A., Sato, K., Ito, N.: Influence of dehydroepiandrosterone, diaminopropane and butylated hydroxyanisole treatment during the induction phase of rat liver nodular lesions in a short-term system. Carcinogenesis, 7: 1059-1063, 1986.

18. Hirose, M., Masuda, A., Inoue, T., Fukushima, S., Ito, N.: Modification by antioxidants and p,p’-diaminodiphenylmethane of 7,12-dimethylbenz[a]anthracene-induced carcinogenesis of the mammary gland and ear duct in CD rats. Carcinogenesis, 7: 1155-1159, 1986.

19. Hirose, M., Inoue, T., Asamoto, M., Tagawa, Y., Ito, N.: Comparison of the effects of 13 phenolic compounds in induction of proliferative lesions of the forestomach and increase in the labeling indices of the glandular stomach and urinary bladder epithelium of
Syrian golden hamsters. Carcinogenesis, 7: 1285-1289, 1986.

20. Moore, MA., Nakamura, T., Thamavit, W., Ichihara, A., Ito, N.: Immunohistochemically demonstrated suppressed expression of tryptophan oxygenase, a marker for liver differentiation, within putative preneoplastic rat liver lesions. Carcinogenesis, 7: 1393-1396, 1986.

21. Hasegawa, R., Tsuda, H., Shirai, T., Kurata, Y., Masuda, A., Ito, N.: Effect of timing of partial hepatectomy on the induction of preneoplastic liver foci in rats given hepatocarcinogens. Cancer Lett, 32: 15-23, 1986.

22. Hirose, M., Thamavit, W., Asamoto, M., Osawa, T., Ito, N.: Inhibition of glutathione S-transferase P type-positive foci development by linolic acid hydroperoxides and their secondary oxidative products in a rat in vivo mid-term test for liver carcinogens. Toxicol Lett, 32: 51-58, 1986.

23. Tsuda, H., Hacker, HJ., Katayama, H., Masui, T., Ito, N., Bannasch, P.: Correlative histochemical studies on preneoplastic and neoplastic lesions in the kidney of rats treated with nitrosamines. Virchows Arch [Cell Pathol], 51: 385-404, 1986.

24. Tatematsu, M., Furihata, C., Katsuyama, T., Miki, K., Honda, H., Konishi, Y., Ito, N.: Gastric and intestinal phenotypic expressions of human signet ring cell carcinomas revealed by their biochemistry, mucin histochemistry, and ultrastructure. Cancer Res, 46: 4866-4872, 1986.

25. Moore, MA., Nakamura, T., Ito, N.: Immunohistochemically demonstrated glucose-6-phosphate dehydrogenase, γ-glutamyl transpeptidase, ornithine decarboxylase and glutathione S-transferase enzymes: absence of direct correlation with cell proliferation in rat liver putative preneoplastic lesions. Carcinogenesis, 7: 1419-1424, 1986.

26. Masui, T., Asamoto, M., Hirose, M., Fukushima, S., Ito, N.: Disappearance of upward proliferation and persistence of downward basal cell proliferation in rat forestomach papillomas induced by butylated hydroxyanisole. Jpn J Cancer Res (Gann), 77: 854-857, 1986.

27. Hasegawa, R., Fukushima, S., Furukawa, F., Takahashi, M., Ito, N.: Aberrant colonic epithelium in the bladder: Report of a case. J Urol, 136: 901-902, 1986.

28. Ito, N., Hirose, M., Fukushima, S., Tsuda, H., Tatematsu, M., Asamoto, M.: Modifying effects of antioxidants on chemical carcinogenesis. Toxicol Pathol, 14: 315-323, 1986.

29. Kurata, Y., Asamoto, M., Hagiwara, A., Masui, T., Fukushima, S.: Promoting effects of various agents in rat urinary bladder carcinogenesis initiated by N-butyl-N-(4-hydroxybutyl)nitrosamine. Cancer Lett, 32: 125-135, 1986.

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