1995年

1. Kato, T., Ogiso, T., Kato, K., Sano, M., Hasegawa, R., Shirai, T., Ito, N.: Lack of promoting activity of four pesticides on induction of preneoplastic liver cell foci in rats. Teratog Carcinog Mutagen, 15: 251-257, 1995.

2. Hasegawa, R., Ogiso, T., Imaida, K., Shirai, T., Ito, N.: Analysis of the potential carcinogenicity of coffee and its related compounds in a medium-term liver bioassay of rats. Fd Chem Toxicol, 33: 15-20, 1995.

3. Shibata, MA., Sano, M., Hagiwara, A., Hasegawa, R., Shirai, T.: Modification by analgesics of lesion development in the urinary tract and various other organs of rats pretreated with dihydroxy-di-N- propylnitrosamine and uracil. Jpn J Cancer Res, 86: 160-167, 1995.

4. Tanaka, H., Hirose, M., Hagiwara, A., Imaida, K., Shirai, T., Ito, N.: Rat strain differences in catechol carcinogenicity to the stomach. Fd Chem Toxicol, 33: 93-98, 1995.

5. Ito, N., Hasegawa, R., Imaida, K., Kurata, Y., Hagiwara, A., Shirai, T.: Effect of ingestion of 20 pesticides in combination at acceptable daily intake levels on rat liver carcinogenesis. Fd Chem Toxicol, 33: 159-163, 1995.

6. Ito, N., Hagiwara, A., Tamano, S., Hasegawa, R., Imaida, K., Hirose, M., Shirai, T.: Lack of carcinogenicity of pesticide mixtures administered in the diet at acceptable daily intake (ADI) dose levels in rats. Toxicol Lett, 82-82: 513-520, 1995.

7. Hirose, M., Akagi, K., Hasegawa, R., Yaono, M., Satoh, T., Hara, Y., Wakabayashi, K., Ito, N.: Chemoprevention of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced mammary gland carcinogenesis by antioxidants in F344 female rats. Carcinogenesis, 16: 217-221, 1995.

8. Shirai, T., Shibata, MA., Takahashi, S., Tagawa, Y., Imaida, K., Hirose, M.: Differences in cell proliferation and apoptosis between reversible and irreversible mucosal lesions associated with uracil-induced urolithiasis in N-butyl-N-(4-hydroxybutyl)nitrosamine-pretreated rats. Carcinogenesis, 16: 501-505, 1995.

9. Tsukamoto, S., Akaza, H., Imada, S., Koiso, K., Shirai, T., Ideyama, Y., Kudo, M.: Chemoprevention of rat prostate carcinogenesis by use of finasteride or casodex. J Natl Cancer Inst, 87: 842-843, 1995.

10. Shibata, MA., Tanaka, H., Kawabe, M., Sano, M., Hagiwara, A., Shirai, T.: Lack of carcinogenicity of monosodium L-glutamate in Fischer 344 rats. Fd Chem Toxicol, 33: 383-391, 1995.

11. Iwata, H., Otoshi, T., Takada, N., Murai, T., Tamano, S., Watanabe, T., Katsura, Y., Fukushima, S.: Validation of silver-stained nucleolar organizer regions for evaluation of invasive character of urinary bladder carcinoma in rats and mice. Urol Res, 23: 27-32, 1995.

12. Tamano, S., Jakubczak, J., Takagi, H., Merlino, G., Ward, JM.: Increased susceptibility to N-nitrosomethylurea gastric carcinogenesis in transforming growth factor alpha transgenic mice with gastric hyperplasia. Jpn J Cancer Res, 86: 435-443, 1995.

13. Masui, T., Shirai, T., Imaida, K., Hirose, M., Futakuchi, M., Tatematsu, M., Ito, N.: Ki-ras mutations with frequent normal allele loss versus absence of p53 mutations in rat prostate and seminal vesicle carcinomas induced with 3,2′-dimethyl-4-aminobiphenyl. Mol Carcinog, 13: 21-26, 1995.

14. Liang, YY., Esteve, A., Martel-Planche, G., Takahashi, S., Lu, SH., Montesano, R., Hollstein, M.: p53 mutations in esophageal tumors from high-incidence areas of China. Int J Cancer, 61: 611-614, 1995.

15. Shirai, T., Tamano, S., Sano, M., Imaida, K., Hagiwara, A., Futakuchi, M., Takahashi, S., Hirose, M.: Site-specific effects of testosterone propionate on the prostate of rat pretreated with 3,2′-dimethyl-4-aminobiphenyl: Dose-dependent induction of invasive carcinomas. Jpn J Cancer Res, 86: 645-648, 1995.

16. Tiwawech, D., Shibata, MA., Hasegawa, R., Hagiwara, A., Shirai, T., Thamavit, W., Fukushima, S.: Weak synergistic effect of uracil and N-butyl-N-(4-hydroxybutyl)nitrosamine on urine composition, epithelial morphology, and DNA synthesis in the urinary bladder of Syrian golden hamster. J Toxicol Pathol, 8: 129-137, 1995.

17. Kataoka, H., Katsumi, K., Kutsuna, T., Suzumura, H., Kojima, S., Takeshima, A., Ban, Y., Itoh, T., Kishimoto, A., Kato, M., Iwata, F., Itoh, M., Takeuchi, T., Ogawa, K., Shirai, T.: A case of familial adenomatous polyposis associated with colon cancer, ureteral cancer and two early gastric cancers. Dig Endosc, 7: 278-284, 1995.

18. Akagi, K., Hirose, M., Hoshiya, T., Mizoguchi, Y., Ito, N., Shirai, T.: Modulating effects of ellagic acid, vanillin and quercetin in a rat medium term multi-organ carcinogenesis model. Cancer Lett. 94: 113-121, 1995.

19. Yaono, M., Hasegawa, R., Mizoguchi, Y., Futakuchi, M., Nakamura, T., Ito, N., Shirai, T.: Hepatocyte growth factor enhancement of preneoplastic hepatic foci development in rats treated with diethylnitrosamine and N-ethyl-N-hydroxyethylnitrosamine. Jpn J Cancer Res, 86: 718-723, 1995.

20. Shirai, T., Fradet, Y., Huland, H., Bollack, C., Droller, M., Janknegt, R., Jones, P., Kagawa, S.: The etiology of bladder cancer — Are there any new clues or predictors of behavior? Int J Urol, 2 Suppl 2: 64-75, 1995.

21. Hirose, M., Iwata, S., Ito, E., Nihro, Y., Takahashi, S., Mizoguchi, Y., Miki, T., Satoh, T., Ito, N., Shirai, T.: Strong anti-mutagenic activity of the novel lipophilic antioxidant 1-O-hexyl-2,3,5-trimethylhydroquinone against heterocyclic amine-induced mutagenesis in the Ames assay and its effect on metabolic activation of 2-amino-6-methyldipyrido [1,2-a:3′,2′-d] imidazole (Glu-P-1). Carcinogenesis, 16: 2227-2232, 1995.

22. Hasegawa, R., Hirose, M., Kato, T., Hagiwara, A., Boonyaphiphat, P., Nagao, M., Ito, N., Shirai, T.: Inhibitory effect of chlorophyllin on PhIP-induced mammary carcinogenesis in female F344 rats. Carcinogenesis, 16: 2243-2246, 1995.

23. Ogawa, K., Shichino, Y., Tatematsu, M., Furihata, C., Asamoto, M., Nagase, S., Shirai, T., Ito, N.: Increasing development of pepsinogen-altered pyloric glands and adenocarcinoma in glandular stomach of analbuminemic rats. Cancer Lett, 96: 219-224, 1995.

24. Hasegawa, R., Kimura, J., Yaono, M., Takahashi, S., Kato, T., Futakuchi, M., Fukutake, M., Fukutome, K., Wakabayashi, K., Sugimura, T., Ito, N., Shirai, T.: Increased risk of mammary carcinoma development following transplacental and trans-breast milk exposure to a food-derived carcinogen, 2-amino-1-methyl-6- phenylimidazo[4,5-b]pyridine (PhIP), in Sprague-Dawley rats. Cancer Res, 55: 4333-4338, 1995.

25. Hirose, M., Takahashi, S., Shirai, T.: Characteristics of forestomach carcinogenesis by non-genotoxic phenolic compounds. J Toxicol Pathol, 8: 277-284, 1995.

26. Shirai, T., Takahashi, S., Mori, T., Imaida, K., Futakuchi, M., Ye, SH., Prins, GS., Ito, N.: Immunohistochemically demonstrated androgen receptor expression in the rat prostate during carcinogenesis induced by 3,2’-dimethyl-4-aminobiphenyl with or without testosterone. Urol Oncol, 1: 263-268, 1995.

27. Shibata, M., Hasegawa, R., Imaida, K., Hagiwara, A., Ogawa, K., Hirose, M., Ito, N., Shirai, T.: Chemoprevention by dehydroepiandrosterone and indomethacin in a rat multiorgan carcinogenesis model. Cancer Res, 55: 4870-4874, 1995.

28. Ogasawara, H., Imaida, K., Ishiwata, H., Toyoda, K., Kawanishi, T., Uneyama, C., Hayashi, S., Takahashi, M., Hayashi, Y.: Urinary bladder carcinogenesis induced by melamine in F344 male rats: correlation between carcinogenicity and urolith formation. Carcinogenesis, 16: 2773-2777, 1995.

29. Hirose, M., Hasegawa, R., Kimura, J., Akagi, K., Yoshida, Y., Tanaka, H., Miki, T., Satoh, T., Wakabayashi, K., Ito, N., Shirai, T.: Inhibitory effects of 1-O-hexyl-2,3,5-trimethylhydroquinone (HTHQ), green tea catechins and other antioxidants on 2-amino-6-methyldipyrido[1,2-a:3′,2′-d]imidazole (Glu-P-1)-induced rat hepatocarcinogenesis and dose-dependent inhibition by HTHQ of lesion induction by Glu-P-1 or 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline(MeIQx). Carcinogenesis, 16: 3049-3055, 1995.

30. Ito, N., Hasegawa, R., Imaida, K., Hirose, M., Asamoto, M., Shirai, T.: Concepts in multistage carcinogenesis. Crit Rev Oncol Hematol, 21: 105-133, 1995.

31. Shirai, T., Tamano, S., Sano, M., Masui, T., Hasegawa, R., Ito, N.: Carcinogenicity of 2-amino-1-methyl- 6-phenylimidazo[4,5-b]pyridine (PhIP) in rats: dose-response studies. In: Adamson, RH. et al. (eds.), Heterocyclic amines in cooked foods: Possible human carcinogens. pp232-239, Princeton Scientific Publishing Co. Inc., New Jersey, 1995.

32. Ito, N., Hasegawa, R., Asakawa, E., Hirose, M., Imaida, K., Hagiwara, A.: Enhancement of rat liver cell foci development by combined treatment with heterocyclic amines at low doses. In: In: Adamson, RH. et al. (eds.), Heterocyclic amines in cooked foods: Possible human carcinogens. pp251-258. Princeton Scientific Publishing Co. Inc., New Jersey, 1995.

33. 廣瀬雅雄:新しい抗酸化剤による癌予防 — ヒドロキシン誘導体によるヘテロサイクリックアミン発癌の強力な抑制作用. 医学のあゆみ, 172: 216-217, 1995.

34. 白井智之:化学物質による発がん機構. 植物防疫, 49: 283-288, 1995.

35. 白井智之:Hericobacter pylori は胃発癌物質か. 治療学, 29: 58, 1995.

36. 片岡洋望、勝見康平、沓名健雄、鈴村裕、小島照司、竹島彰彦、坂義満、伊藤龍雄、岸本明比古、加藤實、大島辰也、伊藤誠、武内俊彦、白井智之:大腸顆粒細胞腫の1例. 臨牀消化器内科, 10: 711-714, 1995.

37. 長谷川良平、白井智之、伊東信行:ヘテロサイクリックアミンの複合によるラット肝発癌の促進. 日本環境変異原学会誌, 17: 83-91, 1995.

38. 白井智之、高橋智:前立腺がんの発癌病理. Bio Clinica, 10: 267-269, 1995.

39. 白井智之、二口充:ヒト前立腺癌の三次元立体的解析. 医学のあゆみ, 175: 818-819, 1995.

40. 高橋智、白井智之:前立腺癌の発生およびその進展. 現代医学, 43: 267-272, 1995.