1991年

1. Takahashi, S., Ogawa, K., Ohshima, H., Esumi, H., Ito, N., Sugimura, T.: Induction of aberrant crypt foci in the large intestine of F344 rats by oral administration of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. Jpn J Cancer Res, 82: 135-137, 1991.

2. Tatematsu, M., Ogawa, K., Mutai, M., Aoki, T., Hoshiya, T., Ito, N.: Rapid regression of squamous cell hyperplasia and slow regression of basal cell hyperplasia in the forestomach of F344 rats treated with N-methyl-N’-nitro-N-nitrosoguanidine and/or butylated
hydroxyanisole. Cancer Res, 51: 318-323, 1991.

3. Okumura, M., Shirai, T., Tamano, S., Ito, M., Yamada, S., Fukushima, S.: Uracil-induced calculi and carcinogenesis in the urinary bladder of rats treated simultaneously with N-butyl-N-(4-hydroxybutyl)nitrosamine. Carcinogenesis, 12: 35-41, 1991.

4. Shibata, MA., Asakawa, E., Hagiwara, A., Kurata, Y., Fukushima, S.: DNA synthesis and scanning electron microscopic lesions in renal pelvic epithelium of rats treated with bladder cancer promoters. Toxicol Lett, 55: 263-272, 1991.

5. Hasegawa, R., Takahashi, S., Imaida, K., Yamaguchi, S., Shirai, T., Ito, N.: Age-dependent induction of preneoplastic liver cell foci by 2-acetylaminofluorene, phenobarbital and acetaminophen in F344 rats initially treated with diethylnitrosamine. Jpn J Cancer Res, 82: 293-297, 1991.

6. Hirose, M., Mutai, M., Takahashi, S., Yamada, M., Fukushima, S., Ito, N.: Effects of phenolic antioxidants in low dose combination on forestomach carcinogenesis in rats pretreated with N-methyl-N’-nitro-N-nitrosoguanidine. Cancer Res, 51: 824-827,1991.

7. Shirai, T., Tamano, S., Kato, T., Iwasaki, S., Takahashi, S., Ito, N.: Induction of invasive carcinomas in the accessory sex organs other than the ventral prostate of rats given 3,2-dimethyl-4-aminobiphenyl and testosterone propionate. Cancer Res, 51:1264-1269, 1991.

8. Ochiai, M., Ogawa, K., Wakabayashi, K., Sugimura, T., Nagase, S., Esumi, H., Nagao, M.: Induction of intestinal adenocarcinomas by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in Nagase analbuminemic rats. Jpn J Cancer Res, 82:363-366, 1991.

9. Ito, N., Hasegawa, R., Shirai, T., Fukushima, S., Hakoi, K., Takaba, K., Iwasaki, S., Wakabayashi, K., Nagao, M., Sugimura, T.: Enhancement of GST-P positive liver cell foci development by combined treatment of rats with five heterocyclic amines at low doses. Carcinogenesis, 12: 767-772, 1991.

10. Tiwawech, D., Hasegawa, R., Kurata, Y., Tatematsu, M., Shibata, MA., Thamavit, W., Ito, N.: Does-dependent effects of 2-acetylaminofluorene on hepatic foci development and cell proliferation in rats. Carcinogenesis, 12: 985-990, 1991.

11. Fukushima, S., Hagiwara, A., Hirose, M., Yamaguchi, S., Tiwawech, D., Ito, N.: Modifying effects of various chemicals on preneoplastic and neoplastic lesion development in a wide-spectrum organ carcinogenesis model using F344 rats. Jpn J Cancer Res, 82: 642-649, 1991.

12. Tamano, S., Hagiwara, A., Suzuki, E., Okada, M., Shirai, T., Fukushima, S.: Time- and dose-dependent induction of invasive urinary bladder cancers by N-ethyl-N-(4-hydroxybutyl)nitrosamine in B6C3F1 mice. Jpn J Cancer Res, 82: 650-656, 1991.

13. Hasegawa, R., Fukuoka, M., Takahashi, T., Yamamoto, A., Yamaguchi, S., Shibata, MA., Tanaka, A., Fukushima, S.: Sex differences in o-phenylphenol and sodium o-phenylphenate rat urinary bladder carcinogenesis: Urinary metabolites and electrolytes under conditions of aciduria and alkalinuria. Jpn J Cancer Res, 82: 657-664, 1991.

14. Okumura, M., Shirai, T., Asamoto, M., Ogiso, T., Fukushima, S.: Lack of synergism in rat urinary tract carcinogenesis between prior uracil treatment and N-butyl-N-(4-hydroxybutyl)nitrosamine administration. Cancer Lett, 58: 81-85, 1991.

15. Fukushima, S., Kurata, Y., Hasegawa, R., Asamoto, M., Shibata, MA., Tamano, S.: L-Ascorbic acid amplification of bladder carcinogenesis promotion by K2CO3. Cancer Res, 51: 2548-2551, 1991.

16. Fukushima, S., Shibata, MA., Hirose, M., Kato, T., Tatematsu, M., Ito, N.: Organ-specific modification of tumor development by low-dose combinations of agents in a rat wide-spectrum carcinogenesis model. Jpn J Cancer Res, 82: 784-792, 1991.

17. Shirai, T., Fukushima, S., Kawabe, M., Shibata, MA., Iwasaki, S., Tada, M., Ito, N.: Selective induction of rat urinary bladder tumors by simultaneous administration of 3,2′-dimethyl-4-aminobiphenyl (DMAB) and butylated hydroxyanisole or butylated hydroxytoluene is associated with increased DMAB-DNA adduct formation. Carcinogenesis, 12: 1335-1339, 1991.

18. Nakamura, A., Shirai, T., Takahashi, S., Ogawa, K., Hirose, M., Ito, N.: Lack of modification by naturally occurring antioxidants of 3,2′-dimethyl-4-aminobiphenyl-initiated rat prostate carcinogenesis. Cancer Lett, 58: 241-246, 1991.

19. Tamano, S., Kurata, Y., Shibata, MA., Tanaka, H., Ogiso, T., Ito, N.: 13-week oral toxicity study of captafol in F344/DuCrj rats. Fundam Appl Toxicol, 17: 390-398, 1991.

20. Ito, N., Hasegawa, R., Sano, M., Tamano, S., Esumi, H., Takayama, S., Sugimura, T.: A new colon and mammary carcinogen in cooked food, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Carcinogenesis, 12: 1503-1506, 1991.

21. Hasegawa, R., Shirai, T., Hakoi, K., Wada, S., Yamaguchi, K., Takayama, S.: Synergistic enhancement of thyroid tumor induction by 2,4-diaminoanisole sulfate, N,N’-diethylthiourea and 4,4′-thiodianiline in male F344 rats. Carcinogenesis, 12:1515-1518, 1991.

22. Shibata, MA., Hasegawa, R., Sano, M., Shirai, T., Fukushima, S.: Timing effects of uracil-induced urolithiasis on amplification of second-stage promotion in rat bladder carcinogenesis. Jpn J Cancer Res, 82: 1077-1084, 1991.

23. Shirai, T., Joong, KD., Hakoi, K., Thamavit, W., Pairojkul, C., Hoshiya, T., Hasegawa, R., Ito, N.: Promotion of rat hepatocarcinogenesis by praziquantel. Jpn J Cancer Res, 82: 1085-1088, 1991.

24. Hirose, M., Uwagawa, S., Ozaki, K., Takaba, K., Ito, N.: Effects of butylated hydroxyanisole pretreatment on low dose N-methyl-N’-nitro-N-nitrosoguanidine- or N,N-dibutylnitrosamine-induced rat forestomach or esophageal carcinogenesis. Carcinogenesis, 12: 1773-1776, 1991.

25. Hirose, M., Ozaki, K., Takaba, K., Fukushima, S., Shirai, T., Ito, N.: Modifying effects of the naturally occurring antioxidants γ-oryzanol, phytic acid, tannic acid and n-tritriacontane-16,18-dione in a rat wide-spectrum organ carcinogenesis model. Carcinogenesis, 12: 1917-1921, 1991.

26. Mori, S., Murai, T., Takeuchi, Y., Hosono, M., Ohhara, T., Makino, S., Hayashi, Y., Shibata, MA., Kurata, Y., Hagiwara, A., Fukushima, S.: No promotion of urinary bladder carcinogenesis by sodium L-ascorbate in male ODS/Shi-od/od rats lacking L-ascorbic acid-synthesizing ability. Carcinogenesis, 12: 1869-1873, 1991.

27. Shibata, MA., Hirose, M., Tanaka, H., Asakawa, E., Shirai, T., Ito, N.: Induction of renal cell tumors in rats and mice, and enhancement of hepatocellular tumor development in mice after long-term hydroquinone treatment. Jpn J Cancer Res, 82:1211-1219, 1991.

28. Shirai, T., Yamamoto, A., Iwasaki, S., Tamano, S., Masui, T.: Induction of invasive carcinomas of the seminal vesicles and coagulating glands of F344 rats by administration of N-methyl-nitrosourea or N-nitrosobis(2-oxopropyl)amine and followed by testosterone propionate with or without high-fat diet. Carcinogenesis, 12:2169-2173, 1991.

29. Hagiwara, A., Tanaka, H., Tiwawech, D., Shirai, T., Ito, N.: Oral toxicity study of tragacanth gum in B6C3F1 mice: Development of squamous-cell hyperplasia in the forestomach and its reversibility. J Toxicol Environ Health, 34: 207-218, 1991.

30. de Camargo, JLV., Shirai, T., Kato, T., Asamoto, M., Fukushima, S.: Summation effects of uracil and other promoters on epithelial lesion development in the F344 rat urinary bladder initiated by N-butyl-N-(4-hydroxybutyl)nitrosamine. Jpn J Cancer Res, 82: 1220-1225, 1991.

31. Fukushima, S., Mutai, M., Hasegawa, R., Takahashi, S., de Camargo, JLV., Shirai, T.: Enhancing effects of carcinogens or promoters on bladder carcinogenesis in rats. J Toxicol Pathol, 4: 159-164, 1991.

32. Hagiwara, A., Hirose, M., Takahashi, S., Ogawa, K., Shirai, T., Ito, N.: Forestomach and kidney carcinogenicity of caffeic acid in F344 rats and C57BL/6NxC3H/HeN F1 mice. Cancer Res, 51: 5655-5660, 1991.

33. Murai, T., Mori, S., Hosono, M., Takeuchi, Y., Ohara, T., Makino, S., Takeda, R., Hayashi, Y., Fukushima, S.: Renal pelvic carcinoma which shows metastatic potential to distant organs, induced by N-butyl-N-(4-hydroxybutyl)nitrosamine in NON/Shi mice. Jpn J Cancer Res, 82: 1371-1377, 1991.

34. Imaida, K., Furihata, C., Tatematsu, M., Yoon, CH., Furukawa, F., Uneyama, C., Takahashi, M., Ito, N., Hayashi, Y.: Immunohistochemical and biochemical identification of pepsinogen isozymes in the hamster lungs: Induction by polychlorinated biphenyls. Toxicol Pathol, 19: 230-236, 1991.

35. Hasegawa, R., Shirai, T., Hakoi, K., Takaba, K., Iwasaki, S., Hoshiya, T., Ito, N., Nagao, M., Sugimara, T.: Synergistic enhancement of glutathione S-transferase placental form-positive hepatic foci development in diethylnitrosamine-treated rats by combined administration of five heterocyclic amines at low doses. Jpn J Cancer Res, 82: 1378-1384, 1991.

36. Uwagawa, S., Tsuda, H., Inoue, T., Tagawa, Y., Aoki, T., Kagawa, M., Ogiso, T., Ito, N.: Enhancing potential of 6 different carcinogens on multi-organ tumorigenesis after initial treatment with N-methyl-N-nitrosourea in rats. Jpn J Cancer Res, 82:1397-1405, 1991.

37. Thamavit, W., Moore, MA., Ruchirawat, S., Ito, N.: Lack of modulation effects of praziquantel on DMN-induced lesion development in the Syrian hamster liver. Cancer Lett, 61:229-232, 1991.

38. Cabral, R., Hoshiya, T., Hakoi, K., Hasegawa, R., Fukushima, S., Ito, N.: A rapid in vivo bioassay for the carcinogenicity of pesticides. Tumori, 77: 185-188, 1991.

39. Shibata, MA., Kagawa, M., Kawabe, M., Hagiwara, A., Fukushima, S.: Comparative promoting activities of phosphate salts on rat two-stage bladder carcinogenesis under conditions of equivalent urinary Na+ or K+ levels. Teratog Carcinog Mutagen, 11: 305-316, 1991.

40. Ito, N., Shirai, T., Fukushima, S.: Medium-term bioassay for carcinogens using multiorgan models. In: Ito, N. & Sugano, H. (eds.) Modification of Tumor Development in Rodents, Vol. 33, pp.41-57. S. Karger, Basel, 1991.

41. Fukushima, S. Modification of tumors development in the urinary bladder. In: Ito, N. & Sugano, H. (eds.) Modification of Tumor Development in Rodents, Vol. 33, pp.154-174. S. Karger, Basel, 1991.

42. Ito, N., Shirai, T.: Tumors of the accessory male sex organs. In: Turusov, V. & Mohr, U. (eds.) Pathology of Tumours in Laboratory Animals, Vol.1, pp421-443. International Agency for Research on Cancer, Lyon, 1991.

43. Tsuda, H., Ozaki, K., Uwagawa, S., Takahashi, S., Hakoi, K., Kato, T., Fukushima, S., Sato, K., Ito, N.: Analysis of the effects of modifying agents on proliferation and enzyme phenotype in focal preneoplastic and neoplastic liver lesions in rats. In: Columbano, A. et al. (eds.) Chemical Carcinogenesis 2, pp219-229. Plenum Press, New York, 1991.

44. Moore, MA., Thamavit, W., Tiwawech, D., Ito, N.: Cell death and proliferation in Opisthorchis viverrini-DHPN induced carcinogenesis in the Syrian hamster hepato-pancreatic axis. In: Columbano, A. et al. (eds.) Chemical Carcinogenesis 2, pp502-510. Plenum Press, New York, 1991.

45. Fukushima, S., de Camargo, JLV, Asamoto, M., Hasegawa, R., Tsuda, H.: Amplifying effects of uracil on multi-stage bladder carcinogenesis in rats. In: Columbano, A. et al. (eds.) Chemical Carcinogenesis 2, pp611-618. Plenum Press, New York, 1991.

46. Ito, N., Hirose, M., Takahashi, S.: Cellular proliferation and stomach carcinogenesis induced by antioxidants. In: Butterworth, BE. et al. (eds.) Chemically Induced Cell Proliferation: Implications for Risk Assessment, pp43-52. Wiley-Liss, Inc., New York, 1991.

47. Fukushima, S., Shibata, MA., Kurata, Y., Hasegawa, R.: The roles of L-ascorbic acid, urinary pH, and Na or K ion concentration in rat bladder epithelial cell proliferation with special reference to tumor promotion. In: Butterworth, BE. et al. (eds.) Chemically Induced Cell Proliferation: Implications for Risk Assessment, pp195-208. Wiley-Liss, Inc., New York, 1991.

48. Tatematsu, M., Shirai, T., Ogawa, K., Asamoto, M., Ito, N.: Proliferation kinetics and development of pepsinogen-altered pyloric gland cells in the glandular stomach of rats treated with chemicals. In: Butterworth, BE. et al. (eds.) Chemically Induced Cell Proliferation: Implications for Risk Assessment, pp445-455. Wiley-Liss, Inc., New York, 1991.

49. 広瀬雅雄, 伊東信行:酸化防止剤による発癌とその機序. Oncologia, 24: 31-37,1991.

50. 福島昭治, 玉野静光, 長谷川良平:実験的上皮内癌. 泌尿器外科, 4: 251-255,1991.

51. 森聖:L-アスコルビン酸合成能欠損 ODS-od/od 系ラットにおける膀胱発癌に関する病理学的研究. 名古屋市立大学医学会雑誌, 42: 447-472, 1991.

52. 奥村正直:ラット膀胱発癌に対する膀胱結石の促進作用に関する研究. 名古屋市立大学医学会雑誌, 42: 639-660, 1991.

53. 白井智之:ヒト前立腺癌モデルの確立. 医学のあゆみ, 159: 378, 1991.

54. 伊東信行, 長谷川良平:癌の多段階進展 (3)化学発癌の立場から. 臨床科学, 27: 1518-1523, 1991.

55. 伊藤寛, 近藤薫, 山下年成, 江口武史, 堀内格, 田中康之, 飯島祥彦, 高橋智, 津田洋幸:胆汁中からAeromonas sobria が検出された気腫性胆嚢炎の1例. 胆と膵, 12: 1529-1533, 1991.

56. 伊東信行, 増井恒夫:自然発症型腎疾患モデル 泌尿器癌. 腎と透析 臨時増刊号196-199,1991.

57. 井川悦男:3,2′-dimethyl-4-aminobiphenyl (DMAB) によるラット前立腺癌の実験的研究. 名古屋市立大学医学会雑誌, 42: 911-926, 1991.

58. 青木豊彦:ラット胃発癌過程におけるペプシノーゲン変異細胞の分化と増殖に関する研究. 名古屋市立大学医学会雑誌, 42: 977-999, 1991.

59. 伊東信行, 長谷川良平, 増井恒夫:発がん物質の中期検索法の有用性と問題点. 肝発がん物質試験法. 環境変異原研究, 13: 295-300, 1991.

60. 白井智之, 玉野静光, 萩原昭裕, 増井恒夫, 伊東信行:複数物質の組合わせによる発癌性の変化.多臓器中期発癌性試験. 環境変異原研究, 13: 329-337,1991.

61. 長谷川良平, 広瀬雅雄,高橋智, 伊東信行:カテコールのラット上部消化管に対する発癌性と発癌修飾作用. 消化器癌の発生と進展, 3: 295-298,1991.

62. 堀内格, 伊藤寛, 山下年成, 近藤薫, 本多英邦, 高橋智, 福島昭治:後腹膜原発 mucinous cystadenocarcinoma の1例. 癌の臨床, 37: 883-888, 1991.

63. 近藤薫, 伊藤寛, 江口武史, 山下年成, 髙橋智:CTが腸重積診断に有用であった空腸平滑筋肉腫による成人腸重積症の1例. 日本臨床外科学会雑誌, 52: 2955-2959, 1991.