1988年

1. Hirose, M., Masuda, A., Fukushima, S., Ito, N.: Effects of subsequent antioxidant treatment on 7,12-dimethylbenz[a]anthracene-initiated carcinogenesis of the mammary gland, ear duct and forestomach in Sprague-Dawley rats. Carcinogenesis, 9: 101-104, 1988.

2. Tatematsu, M., Mera, Y., Inoue, T., Satoh, K., Sato, K., Ito, N.: Stable phenotypic expression of glutathione S-transferase placental type and unstable phenotypic expression of γ-glutamyltransferase in rat liver preneoplastic and neoplastic lesions. Carcinogenesis, 9: 215-220, 1988.

3. Tatematsu, M., Aoki, T., Kagawa, M., Mera, Y., Ito, N.: Reciprocal relationship between development of glutathione S-transferase positive liver foci and proliferation of surrounding hepatocytes in rats. Carcinogenesis, 9: 221-225, 1988.

4. Masui, T., Shirai, T., Imaida, K., Uwagawa, S., Fukushima, S.: Effects of urinary crystals induced by acetazolamide, uracil, and diethylene glycol on urinary bladder carcinogenesis in N-butyl-N-(4-hydroxybutyl)nitrosamine-initiated rats. Toxicol Lett, 40: 119-126, 1988.

5. Ito, N., Tsuda, H., Tatematsu, M., Inoue, T., Tagawa, Y., Aoki, T., Uwagawa, S., Kagawa, M., Ogiso, T., Masui, T., Imaida, K., Fukushima, S., Asamoto, M.: Enhancing effect of various hepatocarcinogens on induction of preneoplastic glutathione S-transferase placental form positive foci in rat — an approach for a new medium-term bioassay system. Carcinogenesis, 9: 387-394, 1988.

6. Tatematsu, M., Aoki, T., Inoue, T., Mutai, M., Furihata, C., Ito, N.: Coefficient induction of pepsinogen 1-decreased pyloric glands and gastric cancers in five different strains of rats treated with N-methyl-N’-nitro-N-nitrosoguanidine. Carcinogenesis, 9: 495-498, 1988.

7. Hayashi, M., Tsuda, H., Okumura, M., Sakata, T., Ito, N., Suchi, T.: Histopathological classification of malignant lymphomas in slaughtered swine. J Comp Pathol, 98: 11-21, 1988.

8. Shirai, T., Yamamoto, K., Adachi, T., Imaida, K., Masui, T., Ito, N.: Condyloma acuminatum of the bladder in two autopsy cases. Acta Pathol Jpn, 38: 399-405, 1988.

9. Mori, S., Takeuchi, Y., Toyama, M., Makino, S., Harauchi, T., Kurata, Y., Fukushima, S.: Assessment of L-ascorbic acid requirement for prolonged survival in ODS rats and their susceptibility to urinary bladder carcinogenesis by N-butyl-N-(4-hydroxybutyl)nitrosamine. Cancer Lett, 38: 275-282, 1988.

10. Tsuda, H., Moore, MA., Asamoto, M., Inoue, T., Ito, N., Satoh, K., Ichihara, A., Nakamura, T., Amelizad, Z., Oesch, F.: Effect of modifying agents on the phenotypic expression of cytochrome P-450, glutathione S-transferase molecular forms, microsomal epoxide hydrolase, glucose-6-phosphate dehydrogenase and γ-glutamyltranspeptidase in rat liver preneoplastic lesions. Carcinogenesis, 9: 547-554, 1988.

11. Nakanowatari, JI., Fukushima, S., Imaida, K., Ito, N., Nagase, S.: Strain differences in N-butyl-N-(4-hydroxybutyl)nitrosamine bladder carcinogenesis in rats. Jpn J Cancer Res (Gann), 79: 453-459, 1988.

12. Ito, N., Imaida, K., Tsuda, H., Shibata, MA., Aoki, T., de Camargo, JLV., Fukushima, S.: Wide-spectrum initiation models: possible applications to medium-term multiple organ bioassays for carcinogenesis modifiers. Jpn J Cancer Res (Gann), 79: 413-417, 1988.

13. Shirai, T., Masuda, A., Imaida, K., Ogiso, T., Ito, N.: Effects of phenobarbital and carbazole on carcinogenesis of the lung, thyroid, kidney, and bladder of rats pretreated with N-Bis(2-hydroxypropyl)nitrosamine. Jpn J Cancer Res (Gann), 79: 460-465, 1988.

14. Masui, T., Asamoto, M., Imaida, K., Fukushima, S., Okamura, T., Ohtaguro, K.: Primary choriocarcinoma of the urinary bladder. Jpn J Clin Oncol, 18: 59-64, 1988.

15. Ito, N., Imaida, K., de Camargo, JLV., Takahashi, S., Asamoto, M., Tsuda, H.: A new medium-term bioassay system for detection of environmental carcinogens using diethylnitrosamine-initiated rat liver followed by D-galactosamine treatment and partial hepatectomy. Jpn J Cancer Res (Gann), 79: 573-575, 1988.

16. Thamavit, W., Moore, MA., Hiasa, Y., Ito, N.: Enhancement of DHPN induced hepatocellular, cholangiocellular and pancreatic carcinogenesis by Opisthorchis viverrini infestation in Syrian golden hamsters. Carcinogenesis, 9: 1095-1098, 1988.

17. Tsuda, H., Asamoto, M., Kagawa, M., Uwagawa, S., Inoue, K., Inui, M., Ito, N.: Positive influence of dietary deoxycholic acid on development of pre-neoplastic lesions initiated by N-methyl-N-nitrosourea in rat liver. Carcinogenesis, 9: 1103-1105, 1988.

18. Ichinose, M., Miki, K., Tatematsu, M., Furihata, C., Nobuhara, M., Ichihara, Y., Tanji, M., Sogawa, K., Fujii-Kuriyama, Y., Oka, H., Takahashi, T., Kageyama, T., Takahashi, K.: Hypomethylation and expression of pepsinogen A genes in the fundic mucosa of human stomach. Biochem Biophys Res Commun, 151: 275-282, 1988.

19. Ichinose, M., Miki, K., Furihata, C., Tatematsu, M., Ichihara, Y., Ishihara, T., Katsura, I., Sogawa, K., Fujii-Kuriyama, Y., Tanji, M., Oka, H., Matsushima, T., Takahashi, K.: DNA methylation and expression of the rat pepsinogen gene in embryonic, adult, and neoplastic tissues. Cancer Res, 48: 1603-1609, 1988.

20. Sumitomo, S., Tatemoto, Y., Tanimura, T., Mori, M., Nakamura, T., Fukushima, S., Ito, N.: Immunohistochemical identification of keratin, involucrin, and epithelial membrane antigen in Paget’s disease. Acta Histochem Cytochem, 21: 61-72, 1988.

21. Tsuda, H., Asamoto, M., Ogiso, T., Inoue, T., Ito, N., Nagao, M.: Does-dependent induction of liver and thyroid neoplastic lesions by short-term administration of 2-amino-3-methylimidazo[4,5-f]quinoline combined with partial hepatectomy followed by phenobarbital or low does 3′-methyl-4-dimethylaminoazobenzene promotion. Jpn J Cancer Res (Gann), 79: 691-697, 1988.

22. Inoue, T., Imaida, K., Suzuki, E., Okada, M., Fukushima, S.: Combined effects of L-ascorbic acid, citric acid or their sodium salts on tumor induction by N-butyl-N-(4-hydroxybutyl)nitrosamine or N-ethyl-N-(4-hydroxybutyl)nitrosamine in the rat urinary bladder. Cancer Lett, 40: 265-273, 1988.

23. Masui, T., Fukushima, S., Katoh, F., Yamasaki, H., Ito, N.: Effects of sodium L-ascorbate, uracil, butylated hydroxyanisole and extracellular pH on junctional intercellular communication of BALB/c 3T3 cells. Carcinogenesis, 9: 1143-1146, 1988.

24. Moore, MA., Thamavit, W., Hiasa, Y., Ito, N.: Early lesions induced by DHPN in Syrian golden hamsters: influence of concomitant Opisthorchis infestation, dehydroepiandrosterone or butylated hydroxyanisole administration. Carcinogenesis, 9: 1185-1189, 1988.

25. Fukushima, S., Tamano, S., Shibata, MA., Kurata, Y., Hirose, M., Ito, N.: The role of urinary pH and sodium ion concentration in the promotion stage of two-stage carcinogenesis of the rat urinary bladder. Carcinogenesis, 9: 1203-1206, 1988.

26. Tatematsu, M., Ichinose, M., Miki, K., Tatematsu, K., Kishikawa, H., Ito, N.: Gastric phenotypic expression in human gallbladder cancers revealed by pepsinogen immunohistochemistry and mucin histochemistry. Virchow Archiv A Pathol Anat, 413: 25-32, 1988.

27. Thamavit, W., Moore, MA., Hiasa, Y., Ito, N.: Generation of high yields of Syrian hamster cholangiocellular carcinomas and hepatocellular nodules by combined nitrite and aminopyrine administration and Opisthorchis viverrini infection. Jpn J Cancer Res (Gann), 79: 909-916, 1988.

28. Ito, N., Shirai, T., Tagawa, Y., Nakamura, A., Fukushima, S.: Variation in tumor yield in the prostate and other target organs of the rat in response to varied dosage and duration of administration of 3,2′-dimethyl-4-aminobiphenyl. Cancer Res, 48: 4629-4632, 1988.

29. Ward, JM., Ito, N.: Development of new medium-term bioassays for carcinogens. Cancer Res, 48: 5051-5054, 1988.

30. Hirose, M., Fukushima, S., Kurata, Y., Tsuda, H., Tatematsu, M., Ito, N.: Modification of N-methyl-N’-nitro-N-nitrosoguanidine-induced forestomach and glandular stomach carcinogenesis by phenolic antioxidants in rats. Cancer Res., 48: 5310-5315, 1988.

31. Masui, T., Shirai, T., Takahashi, S., Mutai, M., Fukushima, S.: Summation effect of uracil on the two-stage and multistage models of urinary bladder carcinogenesis in F344 rats initiated by N-butyl-N-(4-hydroxybutyl)nitrosamine. Carcinogenesis, 9: 1981-1985, 1988.

32. Tamano, S., Hagiwara, A., Shibata, MA., Kurata, Y., Fukushima, S., Ito, N.: Spontaneous tumors in aging (C57BL/6N×C3H/HeN)F1 (B6C3F1) mice. Toxicol Pathol, 16: 321-326, 1988.

33. Fukushima, S., Imaida, K., Shibata, MA., Tamano, S., Kurata, Y., Shirai, T.: L-ascorbic acid amplification of second-stage bladder carcinogenesis promotion by NaHCO3. Cancer Res, 48: 6317-6320, 1988.

34. Hirose, M., Hagiwara, A., Inoue, K., Ito, N., Kaneko, H., Saito, K., Matsunaga, H., Isobe, N., Yoshitake, A., Miyamoto, J.: Metabolism of 2- and 3-tert-butyl-4-hydroxyanisole in the rat (III): Metabolites in the urine and feces. Toxicology, 53: 33-43, 1988.

35. Kitagawa, Y., Sakai, R., Tahira, T., Tsuda, H., Ito, N., Sugimura, T., Nagao, M.: Molecular cloning of rat phosphoprotein phosphatase 2Aβ cDNA and increased expressions of phosphatase 2Aα and 2Aβ in rat liver tumors. Biochem Biophys Res Commmun, 157: 821-827, 1988.

36. Shirai, T., Tagawa, Y., Taguchi, O., Ikawa, E., Mutai, M., Fukushima, S., Ito, N.: Low tumorigenic response to 3,2′-dimethyl-4-aminobiphenyl administration in the prostate of rats castrated at birth. Jpn J Cancer Res (Gann), 79: 1293-1296, 1988.

37. Imaida, K., Fukushima, S., Inoue, K., Masui, T., Hirose, M., Ito, N.: Modifying effects of concomitant treatment with butylated hydroxyanisole or butylated hydroxytoluene on N,N-dibutylnitrosamine-induced liver, forestomach and urinary bladder carcinogenesis in F344 male rats. Cancer Lett, 43: 167-172, 1988.

38. Ichinose, M., Miki, K., Tatematsu, M., Mizuno, T., Mutai, M., Furihata, C., Ichihara, Y., Ishihara, T., Tanji, M., Oka, H., Hinohara, Y., Takahashi, T., Kageyama, T., Takahashi, K.: Cell-specific hypomethylation of the pepsinogen gene in pepsinogen-producing cells. Biochem Biophys Res Commmun, 155: 670-677, 1988.

39. Yamada, H., Shirai, T., Ito, N., Wang, CY.: Species- and strain-specific O-acetylation of N-hydroxy-3,2′-dimethyl-4-aminobiphenyl by liver and prostate cytosol. In: King, CM., Romano, LJ., Schuetzle, D. (eds.) Carcinogenic and Mutagenic Responses to Aromatic Amines and Nitroarenes, pp.223-226. Elsevier Science Publishing Co. Inc., 1988.

40. Wang, CY., Zukowski, K., Imaida, K., Lee, MS.: Effects of arylamine urinary metabolites on urothelial cells. In: King, CM., Romano, LJ., Schuetzle, D. (eds.) Carcinogenic and Mutagenic Responses to Aromatic Amines and Nitroarenes, pp227-236. Elsevier Science Publishing Co. Inc., 1988.

41. Ito, N., Tsuda, H., Masui, T.: In vivo promotion assay of four compounds on enhancement of the development of γ-glutamyl transpeptidase-positive liver cell foci in male F344 rats. In: Ashby, J. et al (eds.) Evaluation of Short-term Tests for Carcinogens, Vol.1, pp1334-1337. Cambridge University Press, New York, 1988.

42. Tsuda, H., Uwagawa, S., Aoki, T., Fukushima, S., Imaida, K., Ito, N., Sato, K., Nakamura, T., Oesch, F.: Analysis of the effects of modifying agents on six different phenotypes in preneoplastic foci in the liver in medium-term bioassay model in rats. In: Feo, F. et al. (eds.) Chemical Carcinogenesis, pp399-405: Plenum Publishing Co., 1988.

43. Ito, N., Tsuda, H., Tatematsu, M., Imaida, K., Kagawa, M., Nakamura, A.,Yamaguchi, S., Mutai, M.: Development and application of an in vivo medium-term bioassay system for the screening of hapatocarcinogens and inhibiting agents of hepatocarcinogenesis. In: Feo, F.et al. (eds.) Chemical Carcinogenesis, pp425-432: Plenum Publishing Co., 1988.

44. 細田勝彦:前癌病変を指標とした肝発癌過程におけるイニシエーターとプロモーターの相互作用に関する実験的研究. 名古屋市立大学医学会雑誌, 39: 201-224, 1988.

45. 福島昭治:老化と発癌. 発癌に関する加齢の影響は臓器によって異なる. 医学のあゆみ, 144: 843, 1988.

46. 津田洋幸:日本学術振興会日米癌研究協力事業セミナー報告 「発癌物質中期検索法の進歩」に出席して. トキコロジーフォーラム, 11: 211-216, 1988.

47. 立松正衛, 津田洋幸, 伊東信行:BrdUによるDNAラベリング法. トキシコロジーフォーラム, 11: 269-278, 1988.

48. 岡村武彦, 渡瀬秀樹, 渡辺秀輝, 佐々木昌一, 加藤誠, 上田公介, 大田黒和生, 中村隆昭, 増井恒夫, 福島昭治:膀胱繊毛癌の1例. 日本泌尿器科学会雑誌, 79: 160-163, 1988.

49. 福島昭治, 今井田克己, 萩原昭裕, 香川雅孝, 荒井昌之:N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) によるラット膀胱の初期変化と癌発生における用量相関. J Toxicol Pathol, 1: 25-32, 1988.

50. 白井智之, 田川義章, 増田あつ子, 中村厚, 高橋智:各種濃度の N-butyl-N-(4-hydroxybutyl) nitrosamine(BBN) による膀胱発癌過程に対するウラシル結石のプロモーション作用およびウラシルのイニシエーション作用の有無に関する研究. J Toxicol Pathol, 1: 33-38, 1988.

51. 伊藤寛, 本多英邦, 堀内格, 成瀬博昭, 坂上充志, 船曳孝彦, 杉上勝美, 松原俊樹, 亀井克彦, 笠原正男, 福島昭治:円柱状総胆管拡張症に発生したfm 胆管癌の1例. 胆と膵, 9: 965-970, 1988.

52. 伊東信行, 白井智之:前立腺癌のモデル. 代謝, 25(臨時増刊号「癌’88」): 9-14, 1988.

53. 伊東信行, 白井智之, 津田洋幸, 福島昭治:ヒト膀胱粘膜病変の加齢による推移に関する病理学的研究. 病態生理, 7: 580-581, 1988.

54. 中野渡純一:膀胱発癌におけるラット系統差に関する実験的研究. 名古屋市立大学医学会雑誌, 39: 615-640, 1988.

55. 武内俊彦, 伊藤誠, 加藤政仁, 伊東信行, 福島昭治, 津田洋幸, 今井田克己:故大原孝吉名誉教授の病歴ならびに剖検記録. 名古屋市立大学医学会雑誌, 39: 641-644, 1988.

56. 増田あつ子:乳腺腫瘍の発生と進展に及ぼす酸化防止剤の効果に関する実験的研究. 名古屋市立大学医学会雑誌, 39: 365-386, 1988.

57. 立松正衛, 小木曽正, 務台衛, 田中光, 福島昭治:膀胱部分切除、偏側尿管結紮、および経尿道生理食塩水注入のラット膀胱粘膜上皮細胞増殖におよぼす影響. J Toxicol Pathol, 1: 179-184, 1988.

58. 広瀬雅雄, 白井智之, 倉田靖, 山口修司, 浅川恵美子:腎障害物質のラット肝および腎腫瘍発生に及ぼす影響. J Toxicol Pathol, 1: 193-198, 1988.

59. 福島昭治:膀胱癌の動物モデル. 抗癌剤効果判定試験へのアプローチ. 泌尿器科紀要, 34: 1923-1927, 1988.

60. 朝元誠人:各系ラットにおける肝発癌過程でのチトクローム P-450 およびグルタチオンS-トランスフェラーゼの誘導に関する病理組織学的解析. 名古屋市立大学医学会雑誌, 39: 729-750, 1988.

61. 堀内格, 伊藤寛, 坂上充志, 本多英邦, 荻野高敏, 後藤玄夫, 福島昭治:肝内胆管形成不全症の1例. 名古屋市立病院紀要, 11: 87-90, 1988.