1996年

1. Takahashi, S., Hall, J., Montesano, R.: Temporal cell-type-specific mRNA expression of O6-methylguanine-DNA methyltransferases in liver of rats treated with dimethylnitrosamine. Am J Pathol, 148: 497-507, 1996.

2. Yaono, M., Hasegawa, R., Kato, K., Kimura, J., Cui, L., Tada, M., Shirai, T.: Immunohistochemical demonstration of 3,2′-dimethyl-4-aminobiphenyl DNA adduct formation in various organs of Syrian golden hamsters. Cancer Lett, 98: 145-149, 1996.

3. Cui, L., Hasegawa, R., Ogawa, K., Yamada, Y., Takahashi, S., Shirai, T.: Histopathological analysis of invasive bladder carcinomas induced by 3,2′-dimethyl-4-aminobiphenyl in hamsters. Jpn J Cancer Res, 87: 37-43, 1996.

4. Ogawa, K., Imaida, K., Masui, T., Kawabe, M., Hasegawa, R., Kato, K., Ito, N., Shirai, T.: Chemically induced lung and forestomach neoplasias in transgenic mice carry mutant forms of the human c-Ha-ras transgene. Carcinogenesis, 17: 341-345, 1996.

5. Totsuka, Y., Fukutome, K., Takahashi, M., Takahashi, S., Tada, A., Sugimura, T., Wakabayashi, K.: Presence of N2-(deoxyguanosin-8-yl)-2-amino3,8-dimethylimidazo[4,5-f]quinoxaline (dG-C8-MeIQx) in human tissues. Carcinogenesis, 17: 1029-1034, 1996.

6. Chemin, I., Takahashi, S., Belloc, C., Lang, MA., Ando, K., Guidotti, LG., Chisari, FV., Wild, CP.: Differential induction of carcinogen metabolizing enzymes in a transgenic mouse model of fulminant hepatitis. Hepatology, 24: 649-656, 1996.

7. Kimura, J., Hasegawa, R., Yaono, M., Kato, T., Wakabayashi, K., Sugimura, T., Ito, N., Shirai, T.: Inhibitory potential of pregnancy and lactation on mammary carcinogenesis induced by a food-derived carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, in Sprague-Dawley rats. Cancer Lett, 101: 73-78, 1996.

8. Kato, T., Hasegawa, R., Nakae, D., Hirose, M., Yaono, M., Cui, L., Kobayashi, Y., Konishi, Y., Ito, N., Shirai, T.: Dose-dependent induction of 8-hydroxyguanine and preneoplastic foci in rat liver by a food-derived carcinogen, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline, at low dose levels., Jpn J Cancer Res, 87: 127-133, 1996.

9. Wada, S., Kato, T., Mutai, M., Ozaki, K., Yamaguchi, S., Kim, DJ., Baba-Toriyama, H., Asamoto, M., Ito, N., Tsuda, H.: Modifying influence of swine serum-induced liver fibrosis on development of preneoplastic lesions in rat liver. Jpn J Cancer Res, 87: 240-246, 1996.

10. Ito, N., Hasegawa, R., Imaida, K., Hirose, M., Shirai, T.: Medium-term liver and multi-organ carcinogenesis bioassays for carcinogens and chemopreventive agents. Exp Toxicol Pathol, 48: 113-119, 1996.

11. Tanaka, H., Hasegawa, R., Takesada, Y., Ogiso, T., Hirose, M., Shirai, T.: Effects of carbamate insecticides in a rat medium-term bioassay for hepatocarcinogens. J Toxicol Environ Health, 47: 493-498, 1996.

12. Kawabe, M., Takesada, Y., Tamano, S., Hagiwara, A., Ito, N., Shirai, T.: Subchronic toxicity study of L-isoleucine in F344 rats. J Toxicol Environ Health, 47: 499-508, 1996.

13. Wild, CP., Hasegawa, R., Barraud, L., Chutimataewin, S., Chapot, B., Ito, N., Montesano, R.: Aflatoxin-albumin adducts: A basis for comparative carcinogenesis between animals and humans. Cancer Epidemiol Biomarkers Prev, 5: 179-189, 1996.

14. Futakuchi, M., Hasegawa, R., Yamamoto, A., Cui, L., Ogiso, T., Ito, N., Shirai, T.: Low susceptibility of the spontaneously hypertensive rat (SHR) to quinoline-induction of hepatic hemangioendothelial sarcomas. Cancer Lett, 104: 37-41, 1996.

15. Sano, M., Miyata, E., Tamano, S., Hagiwara, A., Ito, N., Shirai, T.: Lack of carcinogenicity of tamarind seed polysaccharide in B6C3F1 mice. Fd Chem Toxicol, 34: 463-467, 1996.

16. Mori, T., Cui, L., Kato, K., Takahashi, S., Imaida, K., Iwasaki, S., Ito, N., Shirai, T.: Direct effects of testosterone, dihydrotestosterone and estrogen on 3,2′-dimethyl-4-aminobiphenyl-induced prostate carcinogenesis in castrated F344 rats. Jpn J Cancer Res, 87: 570-574, 1996.

17. Kimura, J., Takahashi, S., Ogiso, T., Yoshida, Y., Akagi, K., Hasegawa, R., Kurata, M., Hirose, M., Shirai, T.: Lack of chemoprevention effects of the monoterpene d-limonene in a rat multi-organ carcinogenesis model. Jpn J Cancer Res, 87: 589-594, 1996.

18. Cui, L., Hasegawa, R., Ogawa, K., Futakuchi, M., Shirai, T.: Enhancing effects of high-fat diet on 3,2′-dimethyl-4-aminobiphenyl urinary bladder carcinogenesis in the hamster. J Toxicol Pathol, 9: 169-174, 1996.

19. Takahashi, S., Imaida, K., Shirai, T., Wakabayashi, K., Nagao, M., Sugimura, T., Ito, N.: Chronic administration of the mutagenic heterocyclic amine, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine induces cardiac damage with characteristic mitochondrial changes in Fischer rats. Toxicol Pathol, 24: 273-277, 1996.

20. Hagiwara, A., Miyata, E., Tamano, S., Shibata, MA., Sugiura, S., Inoue, M., Hirose, M.: Non-carcinogenicity of 2,2′-[(4-aminophenyl)imino]bisethanol sulfate in a long-term feeding study in Fischer 344 rats. Fd Chem Toxicol, 34: 537-546, 1996.

21. Thamavit, W., Tiwawech, D., Moore, MA., Ito, N., Shirai, T.: Equivocal evidence of complete carcinogenicity after repeated infection of Syrian hamsters with Opisthorchis viverrini. Toxicol Pathol, 24: 493-497, 1996.

22. Futakuchi, M., Lijinsky, W., Hasegawa, R., Hirose, M., Ito, N., Shirai, T.: Effects of low dose mixtures of four N-nitroso compounds on hepatic foci development in the rat. Cancer Lett, 106: 263-269, 1996.

23. Hasegawa, R., Shirai, T., Ito, N.: Synergism in hepatocarcinogenesis induced by heterocyclic amines in rats. J Toxicol Pathol, 9: 241-248, 1996.

24. Tamano, S., Hagiwara, A., Tanaka, H., Kawabe, M., Sano, M., Takahashi, S., Shirai, T.: Histopathological evaluation of spontaneous hepatocellular tumors in B6C3F1 hybrid mice. J Toxicol Pathol, 9: 263-271, 1996.

25. Tamano, S., Rehm, S., Waalkes, MP., Ward, JM.: High incidence and histogenesis of seminal vesicle adenocarcinoma and lower incidence of prostate carcinomas in the Lobund-Wistar prostate cancer rat model using N-nitrosomethylurea and testosterone. Vet Pathol, 33: 557-567, 1996.

26. Imaida, K., Hagiwara, A., Yada, H., Masui, T., Hasegawa, R., Hirose, M., Sugimura, T., Ito, N., Shirai, T.: Dose-dependent induction of mammary carcinomas in female Sprague-Dawley rats with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. Jpn J Cancer Res, 87: 1116-1120, 1996.

27. Hasegawa, R., Yoshimura, I., Imaida, K., Ito, N., Shirai, T.: Analysis of synergism in hepatocarcinogenesis based on preneoplastic foci induction by 10 heterocyclic amines in the rat. Jpn J Cancer Res, 87: 1125-1133, 1996.

28. Hashimoto, Y., Asamoto, M., Futakuchi, M., Okamura, T., Kohri, K., Shirai, T.: Immunohistochemical demonstration of p53 protein nuclear accumulation in preneoplastic and neoplastic lesions of the human urinary bladder. J Urol Pathol, 5: 21-27, 1996.

29. Imaida, K., Fukushima, S.: Initiation-promotion model for assessment of carcinogenicity: Medium-term liver bioassay in rats for rapid detection of carcinogenic agents. J Toxicol Sci, 21: 483-487, 1996.

30. Tamano, S., Ward, JM., Diwan, BA., Keefer, LK., Weghorst, CM., Calvert, RJ., Henneman, JR., Ramljak, D., Rice, JM.: Histogenesis and the role of p53 and K-ras mutations in hepatocarcinogenesis by glyceryl trinitrate (nitroglycerin) in male F344 rats. Carcinogenesis, 17: 2477-2486, 1996.

31. Nakanishi, H., Takeuchi, S., Kato, K., Shimizu, S., Kobayashi, K., Tatematsu, M., Shirai, T.: Establishment and characterization of three androgen-independent, metastatic carcinoma cell lines from 3,2′-dimethyl-4-aminobiphenyl-induced prostatic tumors in F344 rats. Jpn J Cancer Res, 87: 1218-1226, 1996.

32. Kobayashi, K., Nakanishi, H., Inada, K., Fujimitsu, Y., Yamachika, T., Shirai, T., Tatematsu, M.: Growth characteristics in the initial stage of micrometastasis formation by bacterial lacZ gene-tagged rat prostatic adenocarcinoma cells. Jpn J Cancer Res, 87: 1227-1234, 1996.

33. Hagiwara, A., Matsuda, T., Tamano, S., Kitano, M., Imaoka, S., Funae, Y., Takesada, Y., Shirai, T., Fukushima, S.: Dose-related increases in quantitative values for altered hepatocytic foci and cytochrome P-450 levels in the livers of rats exposed to phenobarbital in a medium-term bioassay. Cancer Lett, 110: 155-162, 1996.

34. Ito, N., Hagiwara, A., Tamano, S., Futakuchi, M., Imaida, K., Shirai, T.: Effects of pesticide mixtures at the acceptable daily intake levels on rat carcinogenesis. Fd Chem Toxicol, 34: 1091-1096, 1996.

35. Cabral, R., Hoshiya, T., Hakoi, K., Hasegawa, R., Ito, N.: Medium-term bioassay for the hepatocarcinogenicity of hexachlorobenzene., Cancer Lett, 100: 223-226, 1996.

36. Hasegawa, R., Kato, T., Hirose, M., Takahashi, S., Shirai, T., Ito, N.: Enhancement of hepatocarcinogenesis by combined administration of food-derived heterocyclic amines at low doses in the rat. Fd Chem Toxicol, 34: 1097-1101, 1996.

37. Sano, M., Tamano, S., Hagiwara, A., Kawabe, M., Nakamura, M., Imaida, K., Hirose, M.: 13-week oral toxicity study of pigments extracted from the purple sweet potato in F344/DuCrj rats. Jpn J Fd Chem, 3: 99-105, 1996.

38. Hagiwara, A., Kokubo, Y., Takesada, Y., Tanaka, H., Tamano, S., Hirose, M., Shirai, T., Ito, N.: Inhibitory effects of phenolic compounds on development of naturally occurring preneoplastic hepatocytic foci in long-term feeding studies using male F344 rats. Teratog Carcinog Mutagen, 16: 317-325, 1996.

39. Sano, M., Tamano, S., Hagiwara, A., Shirai, T., Hasegawa, R., Imaida, K., Ito, N.: Dose-response study of di(2-ethylhexyl)phthalate associated rat hepatocarcinogenesis. In: Tahara, E., Sugimachi, K., Oohara, T. (eds.), Recent Advances in Gastroenterological Carcinogenesis I. pp501-511. Monduzzi Editore S.p.A., Bologna, 1996.

40. Hagiwara, A., Tamano, S., Hirose, M.: Changes in the heart. In: U. Mohr, U. et al. (eds.), Pathobiology of the Aging Mouse. pp361-371, International Life Sciences Institute Press, Washington, DC., 1996.

41. Ito, N., Hirose, M., Futakuchi, M., Tamano, S., Shirai, T.: Chemoprevention of heterocyclic amine-induced carcinogenesis by exogenous agents: Stage dependent paradoxical effects. In: Conney, AH. Et al. (eds.), Fundamentals of Cancer Prevention. pp48-51. Princess Takamatsu Cancer Research Fund, Tokyo, 1996.

42. 広瀬雅雄:BHAの発癌性をめぐる最近の動向.Foods Food Ingredients J Jpn, 167: 98-104, 1996.

43. 白井智之、広瀬雅雄:動物を用いた研究の重要性 — 酸化防止剤の発がん性と癌予防作用の研究を通して. 名古屋市立大学医学部動物実験施設年報, 3: 3-10, 1996.

44. 和田重次:4-Methoxyphenol のラットにおける発癌性と前胃および諸臓器に対する発癌修飾作用に関する実験的研究. 名古屋市立大学医学会雑誌, 47: 119-138, 1996.

45. 二口充:ヒト前立腺の三次元立体再構築像による前立腺肥大症および潜在癌の研究. 名古屋市立大学医学会雑誌,
46: 469-483, 1996.

46. 広瀬雅雄、二口充、白井智之:抗酸化剤によるヘテロサイリックアミン発癌の抑制. 日本環境変異原学会誌, 18: 67-71, 1996.

47. 倉田三男:ウラシルによるラット膀胱発癌および作用機構に関する研究 — 結石形成と発癌の関連性. 名古屋市立大学医学会雑誌, 47: 203-216, 1996.

48. 七野裕:上部および下部消化管発癌に対するカテコールなどのDihydroxybenzen誘導体の修飾効果に関する実験的研究. 名古屋市立大学医学会雑誌, 47: 217-238, 1996.

49. 岩崎省吾:3,2′-Dimethyl-4-aminobiphenyl (DMAB) によるラット前立腺浸潤癌の誘発ならびにテストステロンの用量依存的修飾作用. 名古屋市立大学医学会雑誌, 47: 257-272, 1996.

50. 渡辺広美、加藤浩司、小木曽正:標本薄切時のパラフィン屑受けの考案. 実験病理組織技術研究会誌, 5: 31-
32, 1996.

51. 神岡直美、牛嶌克実、早河秀治、中村千衣、木戸内清、加藤敏行、相原徳孝、橋本伸和、高木卓爾、加藤俊男、今井田克己:松果体部に発生した Pure germinomaの1例. 名古屋市立病院紀要, 19: 77-80, 1996.