1. Kawakami M., Kawakami, K., Takahashi, S., Abe, M., Puri, RK.: Analysis of interleukin-13 receptor α2 expression in human pediatric brain tumors. Cancer, 101: 1036-1042, 2004.

2. Futakuchi, M., Ogawa, K., Tamano, S., Takahashi, S., Shirai, T.: Suppression of metastasis by nuclear factor kappaB inhibitors in an in vivo lung metastasis model of chemically induced hepatocellular carcinoma. Cancer Sci, 95: 18-24, 2004.

3. Hokaiwado, N., Asamoto, M., Tsujimura, K., Hirota, T., Ichihara, T., Satoh, T., Shirai, T.: Rapid analysis of gene expression changes caused by liver carcinogens and chemopreventive agents using a newly developed three-dimensional microarray system. Cancer Sci, 95: 123-130, 2004.

4. Tsutsumi, T., Ichihara, T., Kawabe, M., Yoshino, H., Asamoto, M., Suzuki, S., Shirai, T.: Renal toxicity induced by folic acid is associated with the enhancement of male reproductive toxicity of di(n-butyl)phthalate in rats. Reprod Toxicol, 18: 35-42, 2004.

5. Suzuki, S., Asamoto, M., Tsujimura, K., Shirai, T.: Specific differences in gene expression profile revealed by cDNA microarray analysis of glutathione S-transferase placental form (GST-P) immunohistochemically positive rat liver foci and surrounding tissue. Carcinogenesis, 25: 439-443, 2004.

6. Hikosaka, A., Asamoto, M., Hokaiwado, N., Kato, K., Kuzutani, K., Kohri, K., Shirai, T.: Inhibitory effects of soy isoflavones on rat prostate carcinogenesis induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Carcinogenesis, 25: 381-387, 2004.

7. Kikuchi, M., Inagaki, T., Ogawa, K., Banno, S., Matsumoto, Y., Ueda, R., Hanaki, H.: Histopathological investigation of salivary glands in the asymptomatic elderly. Arch Gerontol Geriatr, 38: 131-138, 2004.

8. Ogawa, K., Tada, T., Takeuchi, Y., Suenaga, M., Suzuki, S., Shirai, T.: Reactive angioendotheliomatosis of the intestine. Am J Surg Pathol, 28: 257-261, 2004.

9. Ogawa, K., Tada, T., Takahashi, S., Sugiyama, N., Inaguma, S., Takahashi, SS., Shirai, T.: Malignant solitary fibrous tumor of the meninges. Virchows Arch, 444: 459-464, 2004.

10. Orita, S., Hirose, M., Takahashi, S., Imaida, K., Ito, N., Shudo, K., Ohigashi, H., Murakami, A., Shirai, T.: Modifying effects of 1′-acetoxychavicol acetate (ACA) and the novel synthetic retinoids Re-80, Am-580 and Am-55P in a two-stage carcinogenesis model in female rats. Toxicol Pathol, 32: 250-257, 2004.

11. Fukushima, S., Wanibuchi, H., Morimura, K., Iwai, S., Nakae, D., Kishida, H., Tsuda, H., Uehara, N., Imaida, K., Shirai, T., Tatematsu, M., Tsukamoto, T., Hirose, M., Furukawa, F.: Existence of a threshold for induction of aberrant crypt foci in the rat colon with low doses of 2-amino-1-methyl-6-phenolimidazo[4,5-b]pyridine. Toxicol Sci, 80: 109-114, 2004.

12. Qin, LQ., Xu, JY., Wang, PY., Ganmaa, D., Li, J., Wang, J., Kaneko, T., Hoshi, K., Shirai, T., Sato, A.: Low-fat milk promotes the development of 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary tumors in rats. Int J Cancer, 110: 491-496, 2004.

13. Asamoto, M., Hokaiwado, N., Murasaki, T., Shirai, T.: Connexin 32 dominant-negative mutant transgenic rats are resistant to hepatic damage by chemicals. Hepatology, 40: 205-210, 2004.

14. Inaguma, S., Takahashi, S., Imaida, K., Suzuki, S., Shirai, T.: p-Nonylphenol pretreatment during the late neonatal period has no effect on 3,2′-dimethyl-4-aminobiphenyl-induced prostate carcinogenesis in male F344 rats. Cancer Lett, 212: 159-166, 2004.

15. Suzuki, S., Sato, K., Katada, E., Kuno, Y., Mizoguchi, N., Tokuda, H., Inaguma, S., Asamoto, M., Dohi, Y.: Periampullary somatostatinoma and multiple gastrointestinal stromal tumors associated with von Recklinghausen’s disease. J Gastroenterol, 39: 1011-1012, 2004.

16. Jin, M., Sawa, H., Suzuki, T., Shimizu, K., Makino, Y., Tanaka, S., Nojima, T., Fujioka, Y., Asamoto, M., Suko, N., Fujita, M., Nagashima, K.: Investigation of simian virus 40 large T antigen in 18 autopsied malignant mesothelioma patients in Japan. J Med Virol, 74: 668-676, 2004.

17. Ohnishi, H., Asamoto, M., Tsujimura, K., Hokaiwado, N., Takahashi, S., Ogawa, K., Kuribayashi, M., Ogiso, T., Okuyama, H., Shirai, T.: Inhibition of cell proliferation by nobiletin, a dietary phytochemical, associated with apoptosis and characteristic gene expression, but lack of effect on early rat hepatocarcinogenesis in vivo. Cancer Sci, 95: 936-942, 2004.

18. Naito, A., Suzuki, A., Ueda, S., Nomoto, H., Toriyama-Baba, H., Asamoto, M., Tsuda, H.: Preferential mammary carcinogenic effects of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in human c-Ha-ras proto-oncogene transgenic rats. Cancer Sci, 95: 399-403, 2004.

19. Uchida, A., Oka, Y., Aoyama, M., Suzuki, S., Yokoi, T., Katano, H., Mase, M., Tada, T., Asai, K., Yamada, K.: Expression of myelencephalon-specific protease in transient middle cerebral artery occlusion model of rat brain. Brain Res Mol Brain Res, 126: 129-136, 2004.

20. 白井智之：高周波電磁波と発がん性、pp224-230. 大森豊明 編、生体物理刺激と生体反応.（株）フジ・テクノシステム, 2004.

21. 萩原昭裕、土井悠子、大本俊郎、後藤康慶、浅井以和夫、中村幹雄、白井智之：新規キサンタンガム（サンエースｨ NXG-S）のF344ラットにおける90日間混餌投与毒性試験. Foods Food Ingredients J Jpn, 209: 982-990, 2004.

1. Ito, N., Tamano, S., Shirai, T.: A medium-term rat liver bioassay for rapid in vivo detection of carcinogenic potential of chemicals. Cancer Sci. 94: 3-8, 2003.

2. Neal, GE., Judah, DJ., Hard, GG., Ito, N.: Differences in ethoxyquin nephrotoxicity between male and female F344 rats. Fd Chem Toxicol, 41: 193-200, 2003.

3. Takahashi, S., Suzuki, S., Inaguma, S., Ikeda, Y., Cho, YM., Hayashi, N., Inoue, T., Sugimura, Y., Nishiyama, N., Fujita, T., Chao, J., Ushijima, T., Shirai, T.: Down-regulated expression of prostasin in high-grade or hormone-refractory human prostate cancers. Prostate. 54: 187-193, 2003.

4. Cho, YM., Takahashi, S., Asamoto, M., Suzuki, S., Inaguma, S., Hokaiwado, N., Shirai, T.: Age-dependent histopathological findings in the prostate of probasin/SV40 T antigen transgenic rats: Lack of influence of carcinogen or testosterone treatment. Cancer Sci, 94: 153-157, 2003.

5. Fukushima, S., Wanibuchi, H., Morimura, K., Wei, M., Kanae, D., Konishi, Y., Tsuda, H., Takasuka, N., Imaida, K., Shirai, T., Tatematsu, M., Tsukamoto, T., Hirose, M., Furukawa, F.: Lack of initiation activity in rat liver of low doses of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline. Cancer Lett, 191: 35-40, 2003.

6. Suzuki, T., Mizuo, K., Nakazawa, H., Funae, Y., Fushiki, S., Fukushima, S., Shirai, T., Narita, M.: Prenatal and neonatal exposure to bisphenol-A enhances the central dopamine D1 receptor-mediated action in mice: Enhancement of the methamphetamine-induced abuse state. Neuroscience, 117: 639-644, 2003.

7. Zhu, J., Chang, P., Bondy, ML., Sahin, AA., Singletary, SE., Takahashi, S., Shirai, T., Li, D.: Detection of 2-amino-1-methyl-6-phenylimidazo[4,5-b]-pyridine-DNA adducts in normal breast tissues and risk of breast cancer. Cancer Epidemiol Biomarkers Prev, 12: 830-837, 2003.

8. Sugiura, S., Ogawa, K., Hirose, M., Takeshita, F., Asamoto, M., Shirai, T.: Reversibility of proliferative lesions and induction of non-papillary tumors in rat urinary bladder treated with phenylethyl isothiocyanate. Carcinogenesis, 24: 547-553, 2003.

9. Takeshita, F., Ogawa, K., Asamoto, M., Shirai, T.: Mechanistic approach of contrasting modifying effects of caffeine on carcinogenesis in the rat colon and mammary gland induced with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. Cancer Lett, 194: 25-35, 2003.

10. Ito, A., Asamoto, M., Hokaiwado, N., Shirai, T.: Regulation of cell proliferation by induction of p21/WAF1 in rat bladder carcinoma cells using the Cre-loxP system. Cancer Lett, 193: 183-188, 2003.

11. Kuno, A., Yamada, T., Masuda, K., Ogawa, K., Sogawa, M., Nakamura, S., Nakazawa, T., Ohara, H., Nomura, T., Joh, T., Shirai, T., Itoh, M.: Angiotensin-converting enzyme inhibitor attenuates pancreatic inflammation and fibrosis in male Wistar Bonn/Kobori rats. Gastroenterology, 124: 1010-1019, 2003.

12. Cheng, JL., Futakuchi, M., Ogawa, K., Iwata, T., Kasai, M., Tokudome, S., Hirose, M., Shirai, T.: Dose response study of conjugated fatty acid derived from safflower oil on mammary and colon carcinogenesis pretreated with 7,12-dimethylbenz[a]anthracene (DMBA) and 1,2-dimethylhydrazine (DMH) in female Sprague-Dawley rats. Cancer Lett, 196: 161-168, 2003.

13. Cheng, J., Ogawa, K., Kuriki, K., Yokoyama, Y., Kamiya, T., Seno, K., Okuyama, H., Wang, J., Luo, C., Fujii, T., Ichikawa, H., Shirai, T., Tokudome, S.: Increased intake of n-3 polyunsaturated fatty acids elevates the level of apoptosis in the normal sigmoid colon of patients polypectomized for adenomas/tumors. Cancer Lett, 193: 17-24, 2003.

14. Hagiwara, A., Imai, N., Ichihara, T., Sano, M., Tamano, S., Aoki, H., Yasuhara, K., Koda, T., Nakamura, M., Shirai, T.: A thirteen-week oral toxicity study of annatto extract (norbixin), a natural food color extracted from the seed coat of annatto (Bixa orellana L.), in Sprague-Dawley rats. Fd Chem Toxicol, 41: 1157-1164, 2003.

15. Akagi, K., Sano, M., Ogawa, K., Hirose, M., Goshima, H., Shirai, T.: Involvement of toxicity as an early event in urinary bladder carcinogenesis induced by phenethyl isothiocyanate, benzyl isothiocyanate, and analogues in F344 rats. Toxicol Pathol, 31: 388-396, 2003.

16. Ichihara, T., Yoshino, H., Imai, N., Tsutsumi, T., Kawabe, M., Tamano, S., Inaguma, S., Suzuki, S., Shirai, T.: Lack of carcinogenic risk in the prostate with transplacental and lactational exposure to bisphenol A in rats. J Toxicol Sci, 28: 165-171, 2003.

17. Kato, T., Miyamoto, M., Date, T., Yasui, K., Taya, C., Yonekawa, H., Ohue, C., Yagi, S., Seki, E., Hirano, T., Fujimoto, J., Shirai, T., Wakita, T.: Repeated hepatocyte injury promotes hepatic tumorigenesis in hepatitis C virus transgenic mice. Cancer Sci. 94: 679-685, 2003.

18. Hagiwara, A., Imai, N., Doi, Y., Nabae, K., Hirota, T., Yoshino, H., Kawabe, M., Tsushima, Y., Aoki, H., Yasuhara, K., Koda, T., Nakamura, M., Shirai, T.: Absence of liver tumor promoting effects of annatto extract (norbixin), a natural carotenoid food color, in a medium-term liver carcinogenesis bioassay using male F344 rats. Cancer Lett. 199: 9-17, 2003.

19. Inaguma, S., Takahashi, S., Ohnishi, H., Suzuki, S., Cho, YM., Shirai, T.: High susceptibility of the ACI and spontaneously hypertensive rat (SHR) strains to 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) prostate carcinogenesis. Cancer Sci., 94: 974-979, 2003.

20. Yoshida, M., Shimomoto, T., Katashima, S., Shirai, T., Nakae, D., Watanabe, G., Taya, K., Maekawa, A.: Effects of maternal exposure to nonylphenol on growth and development of the female reproductive system and uterine carcinogenesis in rats. J Toxicol Pathol, 16: 259-266, 2003.

21. Hokaiwado, N., Asamoto, M., Cho, YM., Tsuda, H., Shirai, T.: Lack of effect of human c-Ha-ras proto-oncogene overexpression on prostate carcinogenesis in probasin/SV40 T antigen transgenic rats. Cancer Sci, 94: 1042-1045, 2003.

22. Yamada, T., Kuno, A., Masuda, K., Ogawa, K., Sogawa, M., Nakamura, S., Ando, T., Sano, H., Nakazawa, T., Ohara, H., Nomura, T., Joh, T., Itoh, M.: Candesartan, an angiotensin II receptor antagonist, suppresses pancreatic inflammation and fibrosis in rats. J Pharmacol Exp Ther, 307: 17-23, 2003.

23. Hagiwara, A., Sano, M., Ichihara, T., Yoshino, H., Miyata, E., Tamano, S., Aoki, H., Yukawa, C., Koda, T., Nakamura, M., Shirai, T.: Four-week oral toxicity study of 1-carboxy-5,7-dibromo-6-hydroxy-2,3,4- trichloroxanthone (HXCA), an impurity of Phloxine B, in F344 rats. J Toxicol Sci, 28: 445-453, 2003.

24. Nakamura, S., Yamada, T., Hashimoto, T., Takahashi, S., Sogawa, M., Ohara, H., Nakazawa, T., Sano, H., Kuno, A., Joh, T., Nomura, T., Arakawa, T., Itoh, M.: Estradiol alleviates acinar cell apoptosis and chronic pancreatitis in male Wistar Bonn/Kobori rats. Pancreas, 26:e59-e66, 2003.

25. Hasegawa, C., Yamada, T., Ohara, H., Nakazawa, T., Sano, H., Ando, H., Kunimatsu, M., Ozaki, Y., Takahashi, S., Nomura, T., Joh, T., Itoh, M.: Taurochenodeoxycholic acid-induced biphasic hepatotoxicity in isolated perfused rat liver: Roles of Ca2+ and calpain. Hepatogastroenterology, 50: 972-978, 2003.

26. Yamada, T., Takahashi, S., Masuda, K., Ohara, H., Nakazawa, T., Sano, H., Ando, T., Nakamura, S., Kobayashi, S., Kuno, A., Aoki, S., Nomura, T., Joh, T., Itoh, M.: Kupffer cell depletion attenuates colonic and extracolonic granulomatous inflammation in chronic colitis. J Lab Clin Med, 142: 268-277, 2003.

27. Shirai, T., Asamoto, M.: Application of toxicogenomics to the endocrine disruption issue. Pure Appl Chem, 75: 2419-2422, 2003.

28. Imaida, K., Tamano, S., Hagiwara, A., Fukushima, S., Shirai, T., Ito, N.: Application of rat medium-term bioassays for detecting carcinogenic and modifying potentials of endocrine active substances. Pure Appl Chem, 75: 2491-2495, 2003.

29. 二口充、朝元誠人、小川久美子、白井智之：ラット肝癌肺転移モデルを用いた肺転移規定因子の検索. 名古屋市立大学医学会雑誌, 54: 63-69, 2003.

30. 横江正道、水野芳樹、服部孝平、金倉みのり、西祐二、熊田和徳、服部康平、高野裕子、小川久美子：胆嚢原発悪性リンパ腫の1例. 日本消化器病学会雑誌, 100: 1219-1223, 2003.

31. 白井智之、二口充：動物の自然転移モデル. 日本臨牀, 61: 44-48, 2003.

32. 堤友子、今井田克己、萩原昭裕、玉野静光、朝元誠人、白井智之：遺伝子組換えトウモロコシ（T-25）のラットを用いた13週間反復投与毒性試験. 日本食品化学学会誌, 10: 149-154, 2003.

33. 増渕麻里子、二口充、白井智之：ラット肝細胞癌の肺転移形成におけるMatrix Metalloproteinases（MMPs）の関与. 名古屋市厚生院紀要, 29: 37-42, 2003.

34. 二口充、高橋青志郎、白井智之：ラット肝細胞癌肺転移モデルを用いたperindoprilの転移抑制作用の検討. 名古屋市厚生院紀要, 29: 59-61, 2003.

35. 二口充、高橋青志郎、関健司：厚生院における病理解剖（XXII）. 名古屋市厚生院紀要, 29: 63-64, 2003.

36. 中村聡一、山田珠樹、橋本貴至、高橋智、十河光栄、大原弘隆、中沢貴宏、佐野仁、久野篤、城卓志、埜村智之、荒川哲男、伊藤誠：Estradiolは雄性Wistar Bonn/Koboriラットの膵腺房細胞のapoptosisと慢性膵炎を抑制する. 膵臓、18:620-622, 2003.

1. Hagiwara, A., Sano, M., Tanaka, H., Kawabe, M., Tamano, S., Kadota, T., Yanagisawa, T., Maemura, S., Ito, N., Shirai, T.: Lack of enhancing effect of two Kampo medicines, Sho-saiko-to (TJ-9) and Sairei-to (TJ-114), on rat urinary bladder carcinogenesis initiated with N-butyl-N-(4-hydroxybutyl)nitrosamine. Teratog Carcinog Mutagen, 22: 41-50, 2002.

2. Takahashi, S., Suzuki, S., Inaguma, S., Ikeda, Y., Cho, YM., Nishiyama, N., Fujita, T., Inoue, T., Hioki, T., Sugimura, Y., Ushijima, T., Shirai, T.: Down-regulation of human X-box binding protein 1 (hXBP-1) expression correlates with tumor progression in human prostate cancers. Prostate, 50: 154-161, 2002.

3. Hagiwara, A., Yoshino, H., Ichihara, T., Kawabe, M., Tamano, S., Aoki, H., Koda, T., Nakamura, M., Imaida, K., Ito, N., Shirai, T.: Prevention by natural food anthocyanins, purple sweet potato color and red cabbage color, of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-associated colorectal carcinogenesis in rats initiated with 1,2-dimethylhydrazine. J Toxicol Sci, 27: 57-68, 2002.

4. Futakuchi, M., Hirose, M., Imaida, K., Takahashi, S., Ogawa, K., Asamoto, M., Miki, T., Shirai, T.: Chemoprevention of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced colon carcinogenesis by 1-O-hexyl-2,3,5-trimethylhydroquinone after initiation with 1,2-dimethylhydrazine in F344 rats. Carcinogenesis, 23: 283-287, 2002.

5. Asamoto, M., Hokaiwado, N., Cho, YM., Shirai, T.: Effects of genetic background on prostate and taste bud carcinogenesis due to SV40 T antigen expression under probasin gene promoter control. Carcinogenesis, 23: 463-467, 2002.

6. Hirose, M., Nishikawa, A., Shibutani, M., Imai, T., Shirai, T.: Chemoprevention of heterocyclic amine-induced mammary carcinogenesis in rats. Environ Mol Mutagen, 39: 271-278, 2002.

7. Futakuchi, M., Cheng, JL., Hirose, M., Kimoto, N., Cho, YM., Iwata, T., Kasai, M., Tokudome, S., Shirai, T.: Inhibition of conjugated fatty acids derived from safflower or perilla oil of induction and development of mammary tumors in rats induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Cancer Lett, 178: 131-139, 2002.

8. Kuroda, H., Ohtsuru, A., Futakuchi, M., Kawashita, Y., Nagayama, Y., Fukuda, E., Namba, H., Shirai, T., Kanematsu, T., Yamashita, S.: Distinctive gene expression of receptor-type tyrosine kinase families during rat hepatocarcinogenesis. Int J Mol Med, 9: 473-480, 2002.

9. Takahashi, S., Suzuki, S., Inaguma, S., Cho, YM., Ikeda, Y., Hayashi, N., Inoue, T., Sugimura, Y., Nishiyama, N., Fujita, T., Ushijima, T., Shirai, T.: Down-regulation of Lsm1 is involved in human prostate cancer progression. Br J Cancer, 86: 940-946, 2002.

10. Takahashi, S., Inaguma, S., Cho, YM., Imaida, K., Wang, J., Fujiwara, O., Shirai, T.: Lack of mutation induction with exposure to 1.5 GHz electromagnetic near fields used for cellular phones in brains of Big Blue mice. Cancer Res, 62: 1956-1960, 2002.

11. Williams, GM., Iatropoulos, MJ., Jeffrey, AM., Shirai, T.: Protective effect of acetaminophen against colon cancer initiation effects of 3,2′-dimethyl-4-aminobiphenyl in rats. Eur J Cancer Prev, 11: 39-48, 2002.

12. Takahashi, S., Inaguma, S., Sakakibara, M., Cho, YM., Suzuki, S., Ikeda, Y., Cui, L., Shirai, T.: DNA methylation in the androgen receptor gene promotor region in rat prostate cancer, Prostate, 52: 82-88, 2002.

13. Inoue, T., Hioki, T., Hayashi, N., Takahashi, S., Shirai, T., Sugimura, Y.: Preoperative predictors of cancerous involvement of the neurovascular bundles in patients with localized prostate cancer. Int J Urol, 9: 47-53, 2002.

14. Tamano, S., Sano, M., Kawabe, M., Hagiwara, A., Nakamura, M., Imaida, K., Shirai, T.: Purple sweet potato color lacks tumor promoting or carcinogenic potential in a medium-term multi-organ carcinogenesis bioassay in male rats. Jpn J Fd Chem, 9: 22-29, 2002.

15. Ito, N.: Genetically modified foods: Hazard identification and risk assessment. Exp Toxicol Pathol, 54: 57-59, 2002.

16. Asamoto, M., Hokaiwado, N., Cho, YM., Shirai, T.: A transgenic rat model of prostate carcinogenesis, J Toxicol Pathol, 15: 191-196, 2002.

17. Fukushima, S., Wanibuchi, H., Morimura, K., Wei, M., Nakae, D., Konishi, Y., Tsuda, H., Uehara, N., Imaida, K., Shirai, T., Tatematsu, M., Tsukamoto, T., Hirose, M., Furukawa, F., Wakabayashi, K., Totsuka, Y.: Lack of a dose-response relationship for carcinogenicity in the rat liver with low doses of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline or N-nitrosodiethylamine. Jpn J Cancer Res, 93: 1076-1082, 2002.

18. Futakuchi, M., Ogawa, K., Sano, M., Tamano, S., Takeshita, F., Shirai, T.: Suppression of lung metastasis by aspirin but not indomethacin in an in vivo model of chemically induced hepatocellular carcinoma. Jpn J Cancer Res, 93: 1175-1181, 2002.

19. Shirai, T., Kato, K., Futakuchi, M., Takahashi, S., Suzuki, S., Imaida, K., Asamoto, M.: Organ differences in the enhancing potential of 2-amino-1-methy-6-phenylimidazo[4,5-b]pyridine on carcinogenicity in the prostate, colon and pancreas. Mutat Res, 506-507: 129-136, 2002.

20. Suzuki, S., Takahashi, S., Asamoto, M., Inaguma, S., Ogiso, T., Hirose, M., Shirai, T.: Lack of modification of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx)-induced hepatocarcinogenesis in rats by fenbendazole – a CYP1A2 inducer. Cancer Lett, 185: 39-45, 2002.

21. Yoshino, H., Ichihara, T., Kawabe, M., Imai, N., Hagiwara, A., Asamoto, M., Shirai, T. Lack of significant alteration in the prostate or testis of F344 rat offspring after transplacental and lactational exposure to bisphenol A. J Toxicol Sci, 27: 433-439, 2002.

22. Hirose, M., Yamaguchi, T., Mizoguchi, Y., Akagi, K., Futakuchi, M., Shirai, T.: Lack of inhibitory effects of green tea catechins in 1,2-dimetylhydrazine-induced rat intestinal carcinogenesis model: comparison of the different formulations, administration routes and doses. Cancer Lett, 188: 163-170, 2002.

23. Shirai, T., Asamoto, A., Takahashi, S., Imaida, K.: Diet and prostate cancer. Toxicology, 181-182: 89-94, 2002.

24. Yada, H., Hirose, M., Tamano, S., Kawabe, M., Sano, M., Takahashi, S., Futakuchi, M., Miki, T., Shirai, T.: Effects of antioxidant 1-O-hexyl-2,3,5-trimethylhydroquinone or ascorbic acid on carcinogenesis induced by administration of aminopyrine and sodium nitrite in a rat multi-organ carcinogenesis model. Jpn J Cancer Res, 93: 1299-1307, 2002.

25. Fujiwara, H., Emi, M., Nagai, H., Nishimura, T., Konishi, N., Kubota, Y., Ichikawa, T., Takahashi, S., Shuin, T., Habuchi, T., Ogawa, O., Inoue, K., Skolnick, MH., Swensen, J., Camp, NJ., Tavtigian, SV.: Association of common missense changes in ELAC2 (HPC2) with prostate cancer in a Japanese case-control series. J Hum Genet, 47: 641-648, 2002.

26. 二口充、小川久美子、関健司：厚生院における病理解剖 (XXI). 名古屋市厚生院紀要, 28: 75-84, 2002.

27. 二口充、彦坂敦也、白井智之：造骨性変化を伴うラット前立腺癌骨浸潤モデルを用いた抗Parathyroid related peptide (PTHrP)中和抗体の抑制作用の検討. 名古屋市厚生院紀要, 28: 29-36, 2002.

1. Hagiwara, A., Miyashita, K., Yoshino, H., Sano, M., Tamano, S., Koda, T., Nakamura, M., Imaida, K., Shirai, T.: Four-week feeding study of Kusagi color, a natural blue food colorant, in F344 rats. Jpn J Fd Chem, 8: 174-179, 2001.

2. Ogawa, K., Hirose, M., Sugiura, S., Cui, L., Imaida, K., Ogiso, T., Shirai, T.: Dose-dependent promotion by phenylethyl isothiocyanate, a known chemopreventer, of two-stage rat urinary bladder and liver carcinogenesis. Nutr Cancer, 40: 134-139, 2001.

3. Tamano, S., Hagiwara, A., Kawabe, M., Sano, M., Tanaka, H, Imaida, K., Shirai, T., Ito, N.: Summary of test results of medium-term carcinogenesis bioassays targeting the liver or multi-organs. Toxicol Pathol, 29(Suppl.): 320-322, 2001.

4. Tamano, S., Hatahara, Y., Sano, M., Hagiwara, A., Nakamura, M., Washino, T., Imaida, K.: 13-week oral toxicity and 4-week recovery study of enzymatically modified isoquecitrin in F344/DuCrj rats Jpn. J Fd Chem., 8: 161-167, 2001.

5. Hokaiwado, N., Asamoto, M., Cho, YM., Imaida, K., Shirai, T.: Frequent c-Ha-ras gene mutations in rat mammary carcinomas induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. Cancer Lett, 163: 187-190, 2001.

6. Imaida, K., Tamano, S., Kato, K., Ikeda, Y., Asamoto, M., Takahashi, S., Nir, Z., Murakoshi, M., Nishino, H., Shirai, T.: Lack of chemopreventive effects of lycopene and curcumin on experimental rat prostate carcinogenesis. Carcinogenesis, 22: 467-472, 2001.

7. Hagiwara A, Miyashita K, Nakanishi T, Sano M, Tamano S, Asai I, Nakamura M, Imaida K, Ito N, Shirai, T.: Lack of tumor promotion effects of carrageenan on 1,2-dimethylhydrazine-induced colorectal carcinogenesis in male F344 rats. J Toxicol Pathol, 14: 37-43, 2001.

8. Ogawa, K., Nakanishi, H., Takeshita, F., Futakuchi, M., Asamoto, M., Imaida, K., Tatematsu, M., Shirai, T.: Establishment of rat hepatocellular carcinoma cell lines with differing metastatic potential in nude mice. Int J Cancer, 91: 797-802, 2001.

9. Watanabe, N., Okochi, E., Hirayama, Y., Shimada, Y., Yanagihara, K., Yoshida, MC., Takahashi, S., Mochizuki, M., Sugimura, T., Nagao, M., Ushijima, T.: Single nucleotide instability without microsatellite instability in rat mammary carcinomas. Cancer Res, 61: 2632-2640, 2001.

10. Thamavit, W., Pratoomtone, P., Kongtim, S., Shirai, T., Ito, N.: Inhibition by vitamin E of cholangiocarcinoma induction due to combined nitrite and aminopyrine. Asian Pac J Cancer Prev, 2: 69-70, 2001.

11. Kimoto, N., Hirose, M., Futakuchi, M., Iwata, T., Kasai, M., Shirai, T.: Site-dependent modulating effects of conjugated fatty acids from safflower oil in a rat two-stage carcinogenesis model in female Sprague-Dawley rats. Cancer Lett, 168: 15-21, 2001.

12. Hirose, M., Hoshiya, T., Mizoguchi, Y., Nakamura, A., Akagi, K., Shirai, T.: Green tea catechins enhance tumor development in the colon without effects in the lung or thyroid after pretreatment with 1,2-dimethylhydrazine or 2,2′-dihydroxy-di-n-propylnitrosamine in male F344 rats. Cancer Lett, 168: 23-29, 2001.

13. Hagiwara, A., Takesada, Y., Tanaka, H., Tamano, S., Hirose, M., Ito, N., Shirai, T.: Dose-dependent induction of glandular stomach preneoplastic and neoplastic lesions in male F344 rats treated with catechol chronically. Toxicol Pathol, 29: 180-186, 2001.

14. Tatsura, H., Ogawa, K., Sakata, T., Okamura, T.: A nested variant of transitional cell carcinoma of the urinary bladder: a case report. Jpn J Clin Oncol, 31: 287-289, 2001.

15. Asamoto, M., Hokaiwado, N., Cho, YM., Takahashi, S., Ikeda, Y., Imaida, K., Shirai, T.: Prostate carcinomas developing in transgenic rats with SV40 T antigen expression under probasin promoter control are strictly androgen dependent. Cancer Res, 61: 4693-4700, 2001.

16. Asamoto, M., Hokaiwado, N., Cho, YM., Ikeda, Y., Takahashi, S., Shirai, T. : Metastasizing neuroblastomas from taste buds in rats transgenic for the simian virus 40 large T antigen under control of the probasin gene promoter. Toxicol Pathol, 29: 363-368, 2001.

17. Imaida, K., Sano, M., Tamano, S., Asamoto, M., Ogawa, K., Futakuchi, M., Shirai, T.: Organ dependent enhancement of rat 3,2′-dimethyl-4-aminobiphenyl (DMAB) carcinogenesis by 2-amino-1-methyl-6-phenyl- imidazo[4,5-b]pyridine (PhIP): positive effects on the intestine but not the prostate. Carcinogenesis, 22: 1295-1299, 2001.

18. Hagiwara, A., Miyashita, K., Nakanishi, T., Sano, M., Tamano, S., Kadota, T., Koda, T., Nakamura, M., Imaida, K., Ito, N., Shirai, T.: Pronounced inhibition by a natural anthocyanin, purple corn color, of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-associated colorectal carcinogenesis in male F344 rats pretreated with 1,2-dimethylhydrazine. Cancer Lett, 171: 17-25, 2001.

19. Shimizu, K., Iida, M., Takahashi, S.: Hodgkin’s disease producing granulocyte colony stimulating factor. Am J Hematol, 68: 134, 2001.

20. Mori, T., Imaida, K., Tamano, S., Sano, M., Takahashi, S., Asamoto, M., Takeshita, M., Ueda, H., Shirai, T.: Beef tallow, but not perilla or corn oil, promotion of rat prostate and intestinal carcinogenesis by 3,2′-dimethyl-4-aminobiphenyl. Jpn J Cancer Res, 92: 1026-1033, 2001.

21. Imaida, K., Kuzutani, K., Wang, J., Fujiwara, O., Ogiso, T., Kato, K., Shirai, T.: Lack of promotion of 7,12-dimethhylbenz[a]anthracene-initiated mouse skin carcinogenesis by 1.5 GHz electromagnetic near fields. Carcinogenesis, 22: 1837-1841, 2001.

22. Ito, N.: Genetically modified foods – hazard identification and risk assessment. J Toxicol Pathol, 14: 327-329, 2001.

23. 白井智之 : 膀胱. 病理と臨床　臨時増刊号, 19: 133-138, 2001.

24. 朝元誠人、白井智之 : 前立腺発癌への食餌要因の影響. 腎泌予防医誌, 9: 22-25, 2001.

25. 白井智之：内分泌かく乱物質研究の最前線. pp15-31.(社)日本化学会 編、季刊化学総説, Vol.50, 学会出版センター, 東京, 2001.

26. 小川久美子、関健司 : 厚生院における病理解剖 (XX). 名古屋市厚生院紀要, 27: 100-108, 2001.

27. 小川久美子、竹下文隆、白井智之 : 加熱分解産物、2-amino-1-methyl-6-phenylimidazo[4,5-b]- pyridine (PhIP)誘発ラット発がんに対するカフェインによる修飾作用の臓器特異性. 名古屋市厚生院紀要, 27: 74-80, 2001.

28. 吉野裕子、河部真弓、玉野静光、萩原昭裕、鷲野乾、中村幹雄、今井田克己 : ヤマモモ抽出物の1年間反復投与毒性試験. 日本食品化学学会誌, 8: 94-99, 2001.

29. 伊藤由香、横山真由美、浅井由美、筧文枝、加藤浩司、小木曽正 : サクラ標本ブロック加湿器における吹出口の自由可動への改良. 実験病理組織技術研究会誌, 10: 1-3, 2001

1. Ogawa, K., Kimoto, N., Asamoto, M., Nakanishi, M., Takahashi, S., Shirai, T.: Aberrant expression of p27Kip1 is associated with malignant transformation of the rat urinary bladder epithelium. Carcinogenesis, 21: 117-121, 2000.

2. Zhang, R., Suzuki, T., Takahashi, S., Yoshida, A., Kawaguchi, H., Maruyama, H., Yabu, Y., Fu, J., Shirai, T., Ohta, N.: Cloning and molecular characterization of calpain, a calcium-activated neutral proteinase, from different strains of Schistosoma japonicum. Parasitol Int, 48: 233-242, 2000.

3. Cui, L., Takahashi, S., Tada, M., Kato, K., Yamada, Y., Kohri, K., Shirai, T.: Immunohistochemical detection of carcinogen-DNA adducts in normal human prostate tissues transplanted into the subcutis of athymic nude mice: Results with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and 3,2′-dimethyl-4-aminobiphenyl (DMAB) and relation to cytochrome P450s and N-acetyltransferase activity. Jpn J Cancer Res, 91: 52-58, 2000.

4. Imaida, K., Ogawa, K., Takahashi, S., Ito, T., Yamaguchi, T., Totsuka, Y., Wakabayashi, K., Tanaka, K., Ito, N., Shirai, T.: Delay of DNA-adduct repair and severe toxicity in xeroderma pigmentosum group A gene (XPA) deficient mice treated with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Cancer Lett, 150: 63-69, 2000.

5. Yaono, M., Tamano, S., Mori, T., Kato, K., Imaida, K., Asamoto, M., Shirai, T.: Lobe specific effects of testosterone and estrogen on 3,2′-dimethyl-4-aminobiphenyl-induced rat prostate carcinogenesis. Cancer Lett, 150: 33-40, 2000.

6. Takahashi, S., Ikeda, Y., Kimoto, N., Okochi, E., Cui, L., Nagao, M., Ushijima, T., Shirai, T.: Mutation induction by mechanical irritation caused by uracil-induced urolithiasis in Big Blue rats. Mutat Res, 447: 275-280, 2000.

7. Maruyama, H., Osada, Y., Yoshida, A., Futakuchi, M., Kawaguchi, H., Zhang, R., Fu, J., Shirai, T., Kojima, S., Ohta, N.: Protective mechanisms against the intestinal nematode Strongyloides venezuelensis in Schistosoma japonicum-infected mice. Parasite Immunol, 22: 279-286, 2000.

8. Ito, N., Imaida, K., Asamoto, M., Shirai, T.: Early detection of carcinogenic substances and modifiers in rats. Mutat Res, 462: 209-217, 2000.

9. Shirai, T., Takahashi, S., Cui, L., Futakuchi, M., Kato, K., Tamano, S., Imaida, K.: Experimental prostate carcinogenesis—rodent models. Mutat Res, 462: 219-226, 2000.

10. Imaida, K., Hagiwara, A., Yoshino, H., Tamano, S., Sano, M., Futakuchi, M., Ogawa, K., Asamoto, M., Shirai, T.: Inhibitory effects of low doses of melatonin on induction of preneoplastic liver lesions in a medium-term liver bioassay in F344 rats: relation to the influence of electromagnetic near field exposure. Cancer Lett, 155: 105-114, 2000.

11. Archer, CL., Morse, P., Jones, RF., Shirai, T., Haas, GP., Wang, CY.: Carcinogenicity of the N-hydroxy derivative of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, 2-amino-3,8-dimethylimidazo[4,5-f]- quinoxaline and 3,2′-dimethyl-4-aminobiphenyl in the rat. Cancer Lett, 155: 55-60, 2000.

12. Hirose, M., Yamaguchi, T., Cui, L., Kimoto, N., Futakuchi, M., Kono, T., Nishibe, S., Shirai, T.: Effects of arctiin on PhIP-induced mammary, colon and pancreatic carcinogenesis in female Sprague-Dawley rats and MeIQx-induced hepatocarcinogenesis in male F344 rats. Cancer Lett, 155: 79-88, 2000.

13. Kato, K., Takahashi, S., Cui, L., Toda, T., Suzuki, S., Futakuchi, M., Sugiura, S., Shirai, T.: Suppressive effects of dietary genistin and daidzin on rat prostate carcinogenesis. Jpn J Cancer Res, 91: 786-791, 2000.

14. Takahashi, S., Ikeda, Y., Orita, S., Sakakibara, M., Kimoto, N., Suzuki, S., Imaida, K., Shirai, T.: Enhancing effects of 2-amino-4,5-diphenylthiazole-induced polycystic kidneys on renal carcinogenesis in rats treated with dimethylnitrosamine. Toxicol Appl Pharmacol, 167: 12-17, 2000.

15. Akaza, H., Tsukamoto, S., Morita, T., Yamauchi, A., Onozawa, M., Shimazui, T., Ideyama, Y., Shirai, T.: Promoting effects of antiandrogenic agents on rat ventral prostate carcinogenesis induced by 3,2′-dimethyl-4-aminobiphenyl (DMAB). Prostate Cancer Prostatic Dis, 3: 115-119, 2000.

16. Tiwawech, D., Hirose, M., Futakuchi, M., Cui, L., Thamavit, W., Ito, N., Shirai, T.: Enhancing effects of Thai edible plants on 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline-hepatocarcinogenesis in a rat medium-term bioassay. Cancer Lett, 158: 195-201, 2000.

17. Cohen, S.M., Shirai, T., Steineck, G.: Epidemiology and etiology of premalignant and malignant urothelial changes. Scand J Urol Nephrol Suppl, 205: 105-115, 2000.

18. Kawabe, M., Cui, L., Kimoto, N., Sano, M., Hirose, M., Shirai, T.: Modifying effects of propolis on MeIQx promotion of rat hepatocarcinogenesis and in a female rat two-stage carcinogenesis model after multiple carcinogen initiation. Nutr Cancer, 37: 179-186, 2000.

19. Shirai, T., Imaida, K., Ito, N. Prostate. In: Nagao, M. and Sugimura, T. eds, Food Born Carcinogens — heterocyclic amines. pp270-274, John Wiley & Sons, Ltd, 2000.

20. Imaida, K., Shirai, T., Ito, N. Degenerative Changes. In: Nagao, M. and Sugimura, T. eds, Food Born Carcinogens — heterocyclic amines, pp275-284, John Wiley & Sons, Ltd, 2000.

21. 白井智之 : 内分泌攪乱化学物質. Cancer Frontier, 2: 69-72, 2000.

22. 小畑直子、神谷典男、後藤節子、高橋智：子宮頸癌91例（子宮頸部上皮内腫瘍38例を含む）の臨床病理学的検討. 産科と婦人科 別冊, 67: 919-924, 2000.

23. 小川久美子、杉浦諭、白井智之、中西真 : p27KIP1 欠損マウスにおける膀胱発がん感受性の検討. 名古屋市厚生院紀要, 26: 29-34, 2000.

24. 小川久美子、関健司：厚生院における病理解剖 (XIX). 名古屋市厚生院紀要, 26: 102-110, 2000.

25. 今井田克己、白井智之：発がんプロモーション作用の検討. pp199-204, 井上達、今井清、長村義之、 加藤正信、菅野純 編, 内分泌撹乱化学物質の生物試験研究法,シュプリンガー・フェアラーク, 東京, 2000.

26. 白井智之 : 超臨界抽出プロポリスは乳腺の発ガンを抑制した. 日経ヘルス, 11: 101-102, 2000.

27. 今井田克己、白井智之 : 内分泌撹乱化学物質と発癌. 日本臨牀, 58: 2527-2532, 2000.

1. Iwasaki, S., Kato, K., Mori, T., Takahashi, S., Futakuchi, M., Shirai, T.: Development of androgen-independent carcinomas from androgen-dependent preneoplastic lesions in the male accessory sex organs of rats treated with 3,2′-dimethyl-4-aminobiphenyl and testosterone propionate. Jpn J Cancer Res, 90: 23-30, 1999.

2. Moore, MA., Tsuda, H., Tamano, S., Hagiwara, A., Imaida, K., Shirai, T., Ito, N.: Marriage of a medium-term liver model to surrogate markers — a practical approach for risk and benefit assessment. Toxicol Pathol, 27: 237-242, 1999.

3. Hagiwara, A., Murai, T., Yoshino, H., Goshima, H., Mori, S., Takashima, A., Shirai, T., Fukushima, S.: Hepatocarcinogenic activity of N-butyl-N-(4-hydroxybutyl)nitrosamine in rats is not modified by sodium L-ascorbate. Teratog Carcinog Mutagen, 19: 33-42, 1999.

4. Hagiwara, A., Boonyaphiphat, P., Tanaka, H., Kawabe, M., Tamano, S., Kaneko, H., Matsui, M., Hirose, M., Ito, N., Shirai, T.: Organ-dependent modifying effects of caffeine, and two naturally occurring antioxidants -tocopherol and n-tritriacontane-16,18-dione, on 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)- induced mammary and colonic carcinogenesis in female F344 rats. Jpn J Cancer Res, 90: 399-405, 1999.

5. Ogawa, K., Tsuda, H., Shirai, T., Ogiso, T., Wakabayashi, K., Dalgard, DW., Thorgeirsson, UP., Thorgeirsson, SS., Adamson, RH., Sugimura, T.: Lack of carcinogenicity of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in cynomolgus monkeys. Jpn J Cancer Res, 90: 622-628, 1999.

6. Hirose, M., Hakoi, K., Takahashi, S., Hoshiya, T., Akagi, K., Cui, L., Saito, K., Kaneko, H., Shirai, T.: Sequential morphological and biological changes in the glandular stomach induced by oral administration of catechol to male F344 rats. Toxicol Pathol, 27: 448-455, 1999.

7. Sano, M., Hagiwara, A., Tamano, S., Hasegawa, R., Imaida, K., Ito, N., Shirai, T.: Dose-dependent induction of carcinomas and glutathione S-transferase placental form negative eosinophilic foci in the rat liver by di(2-ethylhexyl)phthalate after diethylnitrosamine initiation. J Toxicol Sci, 24: 177-186, 1999.

8. Kimura, S., Kawabe, M., Ward, JM., Morishima, H., Kadlubar, FF., Hammons, GJ., Fernandez-Salguero, P., Gonzalez, FJ.: CYP1A2 is not the primary enzyme responsible for 4-aminobiphenyl-induced hepatocarcinogenesis in mice. Carcinogenesis, 20: 1825-1830, 1999.

9. Richie, JP., Bono, A., Denis, LJ., Jewett, MA., Kakizoe, T., Kotake, T., Shirai, T., Ten Kate, FJ.: Tumor, nodes, metastasis (TNM) classification of bladder cancer., Urol Oncol, 4: 90-93, 1998.

10. Shirai, T.: Commentary: Oncosis and apoptosis: Two faces of necrosis in a new proposal to clear up the confusion regarding cell death. Toxicol Pathol, 27: 495-496, 1999.

11. Shirai, T., Cui, L., Takahashi, S., Futakuchi, M., Asamoto, M., Kato, K., Ito, N.: Carcinogenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in the rat prostate and induction of invasive carcinomas by subsequent treatment with testosterone propionate. Cancer Lett, 143: 217-221, 1999.

12. Hirose, M., Takahashi, S., Ogawa, K., Futakuchi, M., Shirai, T., Shibutani, M., Uneyama, C., Toyoda, K., Iwata, H.: Chemoprevention of heterocyclic amine-induced carcinogenesis by phenolic compounds in rats. Cancer Lett, 143: 173-178, 1999.

13. Okochi, E., Watanabe, N., Shimada, Y., Takahashi, S., Wakazono, K., Shirai, T., Sugimura, T., Nagao, M., Ushijima, T.: Preferential induction of guanine deletion at 5′-GGGA-3′ in rat mammary glands by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. Carcinogenesis, 20: 1933-1938, 1999.

14. Futakuchi, M., Hirose, M., Ogiso, T., Kato, K., Sano, M., Ogawa, K., Shirai, T.: Establishment of an in vivo highly metastatic rat hepatocellular carcinoma model. Jpn J Cancer Res, 90: 1196-1202, 1999.

15. Ikeda, Y., Takahashi, S., Kimura, J., Cho, YM., Imaida, K., Shirai, S., Shirai, T.: Anophthalmia in litters of female rats treated with the food-derived carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. Toxicol Pathol, 27: 628-631, 1999.

16. Hirose, M., Fukushima, S., Imaida, K., Ito, N., Shirai, T.: Modifying effects of phytic acid and gamma-oryzanol on the promotion stage of rat carcinogenesis. Anticancer Res, 19: 3665-3670, 1999.

17. Ogawa, K., St. John, M., de Oliveira, ML., Arnold, L., Shirai, T., Sun, TT., Cohen, SM.: Comparison of uroplakin expression during urothelial carcinogenesis induced by N-butyl-N-(4-hydroxybutyl)nitrosamine in rats and mice. Toxicol Pathol, 27: 645-651, 1999.

18. Hirose, M., Takahashi, S., Ogawa, K., Futakuchi, M., Shirai, T.: Phenolics: Blocking agents for heterocyclic amine-induced carcinogenesis. Fd Chem Toxicol, 37: 985-992, 1999.

19. Ogawa, K., Johansson, SL., Cohen, SM.: Immunohistochemical analysis of uroplakins, urothelial specific proteins, in ovarian Brenner tumors, normal tissues, and benign and neoplastic lesions of the female genital tract. Am J Pathol, 155: 1047-1050, 1999.

20. Shirai, T., Hirose, M., Ito, N. : Medium-term bioassays in rats for rapid detection of the carcinogenic potential of chemicals. In: McGregor, DB., Rice, JM., Venitt, D. (eds.), The use of short- and medium-term tests for carcinogens and data on genetic effects in carcinogenic hazard evaluation. IARC Scientific Publications No. 146, pp251-272. International Agency for Research on Cancer, Lyon, 1999.

21. Hirose, M., Ito, N.: Forestomach and glandular stomach carcinogenesis. In: Kitchin, KT. (ed.) Carcinogenicity — Testing, predicting, and interpreting chemical effects. pp467-497. Marcel Dekker, Inc., New York, 1999.

22. Thamavit, W., Shirai, T., Ito, N.: Liver flukes and biliary cancer. In: Parsonnet, J. (ed.) Microbes and malignancy — Infection as a cause of human cancers. pp346-371. Oxford University Press, New York, Oxford, 1999.

23. 白井智之：実験的前立腺発癌.飯島宗一、石川栄世、影山圭三　編, 日本人の病気と病理学,病理と臨床 臨時増刊号, Vol.17, pp332.文光堂, 東京, 1999.

24. 古里征国、白井智之、白石泰三、小西登、高橋智、小山徹也、Allsbrook, WC. Jr., Namiki, TS., 原田昌興：「本邦における前立腺癌のGrade分類はこれで良いか」—The First Meeting of the Gunma Seminar on Prostate Cancerから— 10 症例における Gleason Gradeの検討. 泌尿器外科, 12: 1047-1069, 1999.

25. 山中英壽、鈴木慶二、Allsbrook, WC. Jr., Namiki, TS., 原田昌興、白井智之、古里政国、荒井陽一、深貝隆志、鈴木孝憲：「本邦における前立腺癌のGrade分類はこれで良いか」—The First Meeting of the Gunma Seminar on Prostate Cancerから— Round Table Discussion. 泌尿器外科, 12: 1070-1079, 1999.

26. 小川久美子、朝元誠人、二口充、白井智之、中西速夫：化学発がん物質誘発転移性ラット肝細胞癌細胞株の樹立. 名古屋市厚生院紀要, 25: 23-28, 1999.

27. 山下年成、伊藤寛、全並秀司、谷脇聡、佐藤陽子、水野幸太郎、本多弓弥、渡辺勇、高橋智：学童期に発見された先天性嚢胞状腺腫様奇形 (Congenital cystic adenomatoid malformation : CCAM) の１例. 日本小児外科学会雑誌, 35: 739-744, 1999.

1. Shirai, T., Takahashi, S., Cui, L., Yamada, Y., Tada, M., Kadlubar, FF., Ito, N.: Use of polyclonal antibodies against carcinogen-DNA adducts in analysis of carcinogenesis. Toxicol Lett, 102-103: 441-446, 1998.

2. Cui, L., Mori, T., Takahashi, S., Imaida, K., Akagi, K., Yada, H., Yaono, M., Shirai, T.: Slight promotion effects of intermittent administration of testosterone propionate and/or diethylstilbestrol on 3,2′-dimethyl-4-aminobiphenyl-initiated rat prostate carcinogenesis. Cancer Lett, 122: 195-199, 1998.

3. Tsukamoto, S., Akaza, H., Onozawa, M., Shirai, T., Ideyama, Y.: A five-alpha reductase inhibitor or an antiandrogen prevents the progression of microscopic prostate carcinoma to macroscopic carcinoma in rats. Cancer, 82: 531-537, 1998.

4. Hasegawa, R., Futakuchi, M., Mizoguchi, Y., Yamaguchi, T., Shirai, T., Ito, N., Lijinsky, W.: Studies of initiation and promotion of carcinogenesis by N-nitroso compounds. Cancer Lett, 123: 185-191, 1998.

5. Imaida, K., Taki, M., Yamaguchi, T., Ito, T., Watanabe, S., Wake, K., Aimoto, A., Kamimura, Y., Ito, N., Shirai, T.: Lack of promoting effects of the electromagnetic near-field used for cellular phones (929.2 MHz) on rat liver carcinogenesis in a medium-term liver bioassay. Carcinogenesis, 19: 311-314, 1998.

6. Wada, S., Hirose, M., Shichino, Y., Ozaki, K., Hoshiya, T., Kato, K., Shirai, T.: Effects of catechol, sodium chloride and ethanol either alone or in combination on gastric carcinogenesis in rats pretreated with N-methyl-N’-nitro-N-nitrosoguanidine. Cancer Lett, 123: 127-134, 1998.

7. Hirose, M., Takesada, Y., Tanaka, H., Tamano, S., Kato, T., Shirai, T.: Carcinogenicity of antioxidants BHA, caffeic acid, sesamol, 4-methoxyphenol and catechol at low doses, either alone or in combination, and modulation of their effects in a rat medium-term multi-organ carcinogenesis model. Carcinogenesis, 19: 207-212, 1998.

8. Ogawa, K., Iwasaki, S., Esumi, H., Fukushima, S., Shirai, T.: Modification by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) of 3,2′-dimethyl-4-aminobiphenyl (DMAB)-induced rat pancreatic and intestinal tumorigenesis. Cancer Lett, 124: 31-37, 1998.

9. Takahashi, S., Hirose, M., Tamano, S., Ozaki, M., Orita, S., Ito, T., Takeuchi, M., Ochi, H., Fukada, S., Kasai, H., Shirai, T.: Immunohistochemical detection of 8-hydroxy-2′-deoxyguanosine in paraffin-embedded sections of rat liver after carbon tetrachloride treatment. Toxicol Pathol, 26: 247-252, 1998.

10. Kato, K., Takahashi, S., Mori, T., Futakuchi, M., Cui, L., Ito, N., Shirai, T.: Establishment of transplantable rat prostate carcinomas from primary lesions induced by 3,2′-dimethyl-4-aminobiphenyl and testosterone. J Toxicol Pathol, 11: 27-32, 1998.

11. Futakuchi, M., Hirose, M., Miki, T., Tanaka, H., Ozaki, M., Shirai, T.: Inhibition of DMBA-initiated rat mammary tumour development by 1-O-hexyl-2,3,5-trimethylhydroquinone, phenylethyl isothiocyanate, and novel synthetic ascorbic acid derivatives. Eur J Cancer Prev, 7: 153-159, 1998.

12. Kato, T., Hirose, M., Takahashi, S., Hasegawa, R., Kohno, T., Nishibe, S., Kato, K., Shirai, T.: Effects of the lignan, arctiin, on 17-β ethinyl estradiol promotion of preneoplastic liver cell foci development in rats. Anticancer Res, 18: 1053-1058, 1998.

13. Mizoguchi, Y., Hirose, M., Yamaguchi, T., Boonyaphiphat, P., Miki, T., Shirai, T.: Dose dependence of 1-O-hexyl-2,3,5-trimethylhydroquinone promotion of forestomach carcinogenesis in rats pretreated with N-ethylnitrosourethane., Jpn J Cancer Res, 89: 475-480, 1998.

14. Hirose, M., Futakuchi, M., Tanaka, H., Orita, SI., Ito, T., Miki, T., Shirai, T.: Prevention by antioxidants of heterocyclic amine-induced carcinogenesis in a rat medium-term liver bioassay: results of extended and combination treatment experiments. Eur J Cancer Prev, 7: 61-67, 1998.

15. Ogawa, K., Futakuchi, M., Hirose, M., Boonyaphiphat, P., Mizoguchi, Y., Miki, T., Shirai, T.: Stage and organ dependent effects of 1-O-hexyl-2,3,5-trimethylhydroquinone, ascorbic acid derivatives, n-heptadecane-8,10- dione and phenylethyl isothiocyanate in a rat multiorgan carcinogenesis model. Int J Cancer, 76: 851-856, 1998.

16. Tamano, S., Hirose, M., Tanaka, H., Hagiwara, A., Shirai, T.: Variation in susceptibility to the induction of forestomach tumours by butylated hydroxyanisole among rats of different strains. Fd Chem Toxicol, 36: 299-304, 1998.

17. Hirose, M., Ito, T., Takahashi, S., Ozaki, M., Ogiso, T., Nihro, Y., Miki, T., Shirai, T.: Prevention by synthetic phenolic antioxidants of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx)- or activated MeIQx-induced mutagenesis and MeIQx-induced rat hepatocarcinogenesis, and role of antioxidant activity in the prevention of carcinogenesis. Eur J Cancer Prev, 7: 233-241, 1998.

18. Asamoto, M., Hori, T., Baba-Toriyama, H., Sano, M., Takahashi, S., Tsuda, H., Shirai, T.: p16 gene overexpression in mouse bladder carcinomas. Cancer Lett, 127: 9-13, 1998.

19. Hirose, M., Yamaguchi, T., Kimoto, N., Ogawa, K., Futakuchi, M., Sano, M., Shirai, T.: Strong promoting activity of phenylethyl isothiocyanate and benzyl isothiocyanate on urinary bladder carcinogenesis in F344 male rats. Int J Cancer, 77: 773-777, 1998.

20. Lucia, MS., Bostwick, DG., Bosland, M., Cockett, AT., Knapp, DW., Leav, I., Pollard, M., Rinker-Schaeffer, C., Shirai, T., Watkins, BA.: Workgroup I: Rodent models of prostate cancer. Prostate, 36: 49-55, 1998.

21. Takahashi, S., Kimoto, N., Orita, S., Cui, L., Sakakibara, M., Shirai, T.: Relationship between CD44 expression and differentiation of human prostate adenocarcinomas. Cancer Lett, 129: 97-102, 1998.

22. Yamada, Y., Tozawa, K., Cui, L., Takahashi, S., Shirai, T., Kohri, K.: Characteristics of nonneoplastic human prostate tissue transplanted into nude mice. Prostate, 37: 109-115, 1998.

23. Kitano, M., Ichihara, T., Matsuda, T., Wanibuchi, H., Tamano, S., Hagiwara, A., Imaoka, S., Funae, Y., Shirai, T., Fukushima, S.: Presence of a threshold for promoting effects of phenobarbital on diethylnitrosamine-induced hepatic foci in the rat. Carcinogenesis, 19: 1475-1480, 1998.

24. Takahashi, S., Tamano, S., Hirose, M., Kimoto, N., Ikeda, Y., Sakakibara, M., Tada, M., Kadlubar, FF., Ito, N., Shirai, T.: Immunohistochemical demonstration of carcinogen-DNA adducts in tissues of rats given 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP): Detection in paraffin-embedded sections and tissue distribution. Cancer Res, 58: 4307-4313, 1998.

25. Zhang, R., Takahashi, S., Orita, S., Yoshida, A., Maruyama, H., Shirai, T., Ohta, N.: p53 gene mutations in rectal cancer associated with schistosomiasis japonica in Chinese patients. Cancer Lett, 131: 215-221, 1998.

26. Imaida, K., Taki, M., Watanabe, S., Kamimura, Y., Ito, T., Yamaguchi, T., Ito, N., Shirai, T.: The 1.5 GHz electromagnetic near-field used for cellular phones does not promote rat liver carcinogenesis in a medium-term liver bioassay. Jpn J Cancer Res, 89: 995-1002, 1998.

27. Ito, N., Imaida, K., Tamano, S., Hagiwara, A., Shirai, T.: Medium-term bioassays as alternative carcinogenicity test. J Toxicol Sci, 23 Suppl 2: 103-106, 1998.

28. Hashimoto, Y., Suzuki, T., Shimizu, Y., Otobe, Y., Nakamura, T., Nakamura, Y., Tanaka, M., Ito, K., Ueda, N., Hayashi, S., Manabe, T., Futakuchi, M., Shirai, T.: ABO-incompatible living related liver transplantation for fulminant hepatitis: report of a successful pediatric case with long-term follow-up. Transplant Proc, 30: 3510-3512, 1998.

29. Ito, N., Imaida, K., Hirose, M., Shirai, T.: Medium-term bioassays for carcinogenicity of chemical mixtures. Environ Health Perspect, 106 Suppl 6: 1331-1336, 1998.

30. Bosland, MC., Tuomari, DL., Elwell, MR., Shirai, T., Ward, JM., McConnel, RF.: Proliferative lesions of the prostate and other accessory sex glands in male rats. In: Guides for Toxicologic Pathology, pp1-20. STP/ARP/AFIP, Washington, DC, 1998.

31. Ito, N., Imaida, K., Hagiwara, A., Tamano, S., Shirai, T.: Effects of ingesting a combination of 20 or 40 pesticides at ADI levels on carcinogenesis in rats. In: Reviews in Toxicology 2, pp85-92, IOS Press, 1998.

32. 吉田康則：亜硝酸とフェノール系化合物, アスコルビン酸の同時投与によるラット前胃粘膜に対する細胞増殖作用ならびに亜硝酸とアスコルビン酸の同時投与による N-methyl-N’-nitro-N-nitrosoguanidine ラット胃発癌の促進. 名古屋市立大学医学会雑誌, 49: 33-53, 1998.

33. 小川久美子、白井智之：ウラシル投与によるラット膀胱結石モデルの解析. 名古屋市厚生院紀要, 24: 106-112, 1998.

34. 小川久美子、関健司：厚生院における病理解剖 (XVII). 名古屋市厚生院紀要, 24:139-146, 1998.

35. 白井智之、小川久美子：ヒト肝の発癌を探る — 寄生虫と胆管細胞癌. 肝胆膵, 37:173-179, 1998.

36. 高橋智、白井智之：前立腺癌の発生部位と生物学的特性. 病理と臨床, 16: 1370-1374, 1998.

37. 広瀬雅雄、白井智之：抗酸化物質の安全性. 吉川敏一　編, 抗酸化物質のすべて. pp321-330, 先端医学社, 東京, 1998.

38. 伊藤寛、全並秀司、山下年成、佐藤陽子、水野幸太郎、本多弓弥、岩瀬弘敬、高橋智：穿刺吸引細胞診が有用であった乳腺悪性葉状腫瘍の1例. 日本臨床外科学会雑誌, 59: 2254-2257, 1998.

39. 白井智之：Q30 腎盂・尿管癌の組織分類は？　田口鐵男、古武敏彦 編, 癌診療 Q&A — 腎癌、腎盂・尿管癌、膀胱癌. pp84-85. 医薬ジャーナル社, 東京, 1998.

40. 白井智之、広瀬雅雄：天然抗酸化物質の発がん抑制および促進作用.奥山治美、菊川清美 編, 脂質栄養と脂質過酸化 — 生体内脂質過酸化は傷害か防御か. pp194-201. 学会センター関西(株)学会出版センター, 大阪, 1998.

41. 岸本明比古、沓名健雄、小林邦生、河出昌也、緒方正樹、久保田英嗣、小笠原哲也、飯田昌幸、中田耕太郎、竹島彰彦、坂義満、伊藤龍雄、勝見康平、二口充、白井智之：血清および胸水中のCA125が異常高値を示した結核性胸膜炎の1例. 名古屋市立病院紀要, 21: 67-69, 1998.

1. Shirai, T., Sano, M., Tamano, S., Takahashi, S., Hirose, M., Futakuchi, M., Hasegawa, R., Imaida, K., Matsumoto, K., Wakabayashi, K., Sugimura, T., Ito, N.: The prostate: A target for carcinogenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) derived from cooked foods. Cancer Res, 57: 195-198, 1997.

2. Masui, T., Nakanishi, H., Inada, K., Imai, T., Mizoguchi, Y., Yada, H., Futakuchi, M., Shirai, T., Tatematsu, M.: Highly metastatic hepatocellular carcinomas induced in male F344 rats treated with N-nitrosomorpholine in combination with other hepatocarcinogens show a high incidence of p53 gene mutations along with altered mRNA expression of tumor-related genes. Cancer Lett, 112: 33-45, 1997.

3. Hirose, M., Mizoguchi, Y., Yaono, M., Tanaka, H., Yamaguchi, T., Shirai, T.: Effects of green tea catechins on the progression or late promotion stage of mammary gland carcinogenesis in female Sprague-Dawley rats pretreated with 7,12-dimethylbenz(a)anthracene. Cancer Lett, 112: 141-147, 1997.

4. Kim, DJ., Han, BS., Ahn, B., Hasegawa, R., Shirai, T., Ito, N., Tsuda, H.: Enhancement by indole-3-carbinol of liver and thyroid gland neoplastic development in a rat medium-term multiorgan carcinogenesis model. Carcinogenesis, 18: 377-381, 1997.

5. Takaba, K., Hirose, M., Yoshida, Y., Kimura, J., Ito, N., Shirai, T.: Effects of n-tritriacontane-16,18-dione, curcumin, chlorophyllin, dihydroguaiaretic acid, tannic acid and phytic acid on the initiation stage in a rat multi-organ carcinogenesis model. Cancer Lett, 113: 39-46, 1997.

6. Asamoto, M., Iwahori, Y., Okamura, T., Shirai, T., Tsuda, H.: Decreased expression of the p16/MTS1 gene without mutation is frequent in human urinary bladder carcinomas. Jpn J Clin Oncol, 27: 22-25, 1997.

7. Saeki, K., Kadoi, M., Kawazoe, Y., Futakuchi, M., Tiwawech, D., Shirai, T.: Modification of the carcinogenic potency of quinoline, a hepatocarcinogen, by fluorine atom substitution: evaluation of carcinogenicity by a medium-term assay. Biol Pharm Bull, 20: 40-43, 1997.

8. Imaida, K., Hasegawa, R., Kato, T., Futakuchi, M., Takahashi, S., Ogawa, K., Asamoto, M., Yamamoto, T., Suzuki, K., Inagaki, T., Shinagawa, N., Shirai, T.: Clinicopathological analysis on cancers of autopsy cases in a geriatric hospital. Pathol Int, 47: 293-300, 1997.

9. Ito, N., Hasegawa, R., Imaida, K., Hirose, M., Shirai, T., Tamano, S., Hagiwara, A.: Medium-term rat liver bioassay for rapid detection of hepatocarcinogenic substances. J Toxicol Pathol, 10: 1-11, 1997.

10. Yada, H., Hasegawa, R., Hirose, M., Shirai, T., Ito, N.: Effects of verapamil on PhIP-induced tumorigenesis in F344 rats. J Toxicol Pathol, 10: 45-49, 1997.

11. Kawabe, M., Shibata, MA., Sano, M., Takesada, Y., Tamano, S., Ito, N., Shirai, T.: Decrease of prostaglandin E2 and 5-bromo-2′-deoxyuridine labeling but not prostate tumor development by indomethacin treatment of rats given 3,2′-dimethyl-4-aminobiphenyl and testosterone propionate. Jpn J Cancer Res, 88: 350-355, 1997.

12. Miyata, E., Kawabe, M., Sano, M., Takesada, Y., Takahashi, S., Shirai, T.: Effects of tamoxifen, an antiestrogen, on rat prostate carcinogenesis by 3,2′-dimethyl-4-aminobiphenyl and testosterone do not support an estrogen role in testosterone promotion. Prostate, 31: 9-13, 1997.

13. Ozaki, M., Shibata, MA., Takahashi, S., Orita, S., Kawabe, M., Shirai, T.: Lack of involvement of p53 gene mutations in N-methyl-N-nitrosourea-induced bladder tumor progression in N-butyl-N-(4-hydroxybutyl)- nitrosamine-treated rats and no suppression by indomethacin. Cancer Lett, 115: 249-255, 1997.

14. Tanaka, H., Hirose, M., Kawabe, M., Sano, M., Takesada, Y., Hagiwara, A., Shirai, T.: Post-initiation inhibitory effects of green tea catechins on 7,12-dimethylbenz[a]anthracene-induced mammary gland carcinogenesis in female Sprague-Dawley rats. Cancer Lett, 116: 47-52, 1997.

15. Ito, N., Hasegawa, R., Imaida, K., Tamano, S., Hagiwara, A., Hirose, M., Shirai, T.: Carcinogenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in the rat. Mutat Res, 376: 107-114, 1997.

16. Shirai, T.: A medium-term rat liver bioassay as a rapid In vivo test for carcinogenic potential: A historical review of model development and summary of results from 291 tests. Toxicol Pathol, 25: 453-460, 1997.

17. Shirai, T.: Society of Toxicologic Pathologists — Japanese Society of Toxicologic Pathology: a long and fruitful partnership. Toxicol Pathol, 25: 668-669, 1997.

18. Hirose, M., Shirai, T., Lee, MS., Wang, CY., King, CM.: Carcinogenicity of the N-acyl derivatives of N-hydroxy-trans-4-aminostilbene in CD rats. Chem Biol Interact, 106: 123-132, 1997.

19. Pfau, W., Schulze, C., Shirai, T., Hasegawa, R., Brockstedt, U.: Identification of the major hepatic DNA adduct formed by the food mutagen 2-amino-9H-pyrido[2,3-b]indole (AαC). Chem Res Toxicol, 10: 1192-1197, 1997.

20. Pfau, W., Brockstedt, U., Shirai, T., Ito, N., Marquardt, H.: Pancreatic DNA adducts formed in vitro and in vivo by the food mutagens 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine(PhIP) and 2-amino-3-methyl- 9H-pyrido[2,3-b]indole (MeAaC). Mutat Res, 378: 13-22, 1997.

21. Hagiwara, A., Kawabe, M., Tanaka, H., Kokubo, Y., Sano, M., Tamano, S., Kadota, T., Nakamura, M., Imaida, K.: Two different constituents of madder colors lack tumor promoting or carcinogenic potential in a medium-term multi-organ carcinogenesis bioassay in rats. Jpn J Fd Chem, 4: 99-106, 1997.

22. Fukushima, S., Takada, N., Takahashi, S., Wanibuchi, H.: Development of medium-term bioassays for detection of chemopreventive agents. In: Ohigashi, H. et al. (eds.), Food factors for cancer prevention. pp88-91, Springer-Verlag Tokyo, Tokyo, 1997.

23. Hirose, M., Hasegawa, R., Futakuchi, M., Tanaka, H., Miki, T., Kaneko, H., Shirai, T.: Prevention of chemically induced rat carcinogenesis by antioxidants: Focus on HTHQ. I In: Ohigashi, H. et al. (eds.), Food factors for cancer prevention. pp82-87, Springer-Verlag Tokyo, Tokyo, 1997.

24. Shirai, T., Takahashi, S., Tamano, S.: Preneoplasia and neoplasia of the rat male genital tract. In: Bannasch, P. & Gössner, W. (eds.), Pathology of Neoplasia and Preneoplasia in Rodents, Vol. 2, pp141-162, Schattauer, Stuttgart, Germany, 1997.

25. 勝見康平、梶野真一、沓名健雄、久保田英嗣、鈴村裕、中田耕太郎、竹島彰彦、坂義満、伊藤竜雄、岸本明比古、飯田昌幸、緒方正樹、白井智之：胃粘膜下腫瘍状の形態を示した胃癌の2例. 名古屋市立病院紀要, 20: 51-55, 1997.

26. 高橋智、白井智之：腎腺腫 腎臓症候群 — その他の腎臓疾患を含めて(上巻).日本臨牀 領域別症候群シリーズ, 16: 498-500, 1997.

27. 今井田克己、小川久美子、関健司：厚生院における病理解剖 (XVI). 名古屋市厚生院紀要, 23: 133-142, 1997.

28. 橋詰良夫、吉田眞理、汪寅、稲垣俊明、品川長夫、今井田克己：病理剖検所見 — 脳.田内久, 佐藤秩子, 渡辺務 編, 日本の百寿者 — 生命の医学的究極像を探る. pp242-252,中山書店, 東京, 1997.

29. 汪寅、橋詰良夫、吉田眞理、稲垣俊明、品川長夫、今井田克己、亀山隆：病理剖検所見 — 脊髄. 田内久, 佐藤秩子, 渡辺務 編, 日本の百寿者 — 生命の医学的究極像を探る. pp252-260, 中山書店, 東京, 1997.

30. 稲垣俊明、今井田克己、新見達治、山本俊明、品川長夫：症例報告 — 日本最高齢者116歳の臨床所見と剖検所見. 田内久, 佐藤秩子, 渡辺務 編, 日本の百寿者 — 生命の医学的究極像を探る. pp295-304, 中山書店, 東京, 1997.

1. Takahashi, S., Hall, J., Montesano, R.: Temporal cell-type-specific mRNA expression of O6-methylguanine-DNA methyltransferases in liver of rats treated with dimethylnitrosamine. Am J Pathol, 148: 497-507, 1996.

2. Yaono, M., Hasegawa, R., Kato, K., Kimura, J., Cui, L., Tada, M., Shirai, T.: Immunohistochemical demonstration of 3,2′-dimethyl-4-aminobiphenyl DNA adduct formation in various organs of Syrian golden hamsters. Cancer Lett, 98: 145-149, 1996.

3. Cui, L., Hasegawa, R., Ogawa, K., Yamada, Y., Takahashi, S., Shirai, T.: Histopathological analysis of invasive bladder carcinomas induced by 3,2′-dimethyl-4-aminobiphenyl in hamsters. Jpn J Cancer Res, 87: 37-43, 1996.

4. Ogawa, K., Imaida, K., Masui, T., Kawabe, M., Hasegawa, R., Kato, K., Ito, N., Shirai, T.: Chemically induced lung and forestomach neoplasias in transgenic mice carry mutant forms of the human c-Ha-ras transgene. Carcinogenesis, 17: 341-345, 1996.

5. Totsuka, Y., Fukutome, K., Takahashi, M., Takahashi, S., Tada, A., Sugimura, T., Wakabayashi, K.: Presence of N2-(deoxyguanosin-8-yl)-2-amino3,8-dimethylimidazo[4,5-f]quinoxaline (dG-C8-MeIQx) in human tissues. Carcinogenesis, 17: 1029-1034, 1996.

6. Chemin, I., Takahashi, S., Belloc, C., Lang, MA., Ando, K., Guidotti, LG., Chisari, FV., Wild, CP.: Differential induction of carcinogen metabolizing enzymes in a transgenic mouse model of fulminant hepatitis. Hepatology, 24: 649-656, 1996.

7. Kimura, J., Hasegawa, R., Yaono, M., Kato, T., Wakabayashi, K., Sugimura, T., Ito, N., Shirai, T.: Inhibitory potential of pregnancy and lactation on mammary carcinogenesis induced by a food-derived carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, in Sprague-Dawley rats. Cancer Lett, 101: 73-78, 1996.

8. Kato, T., Hasegawa, R., Nakae, D., Hirose, M., Yaono, M., Cui, L., Kobayashi, Y., Konishi, Y., Ito, N., Shirai, T.: Dose-dependent induction of 8-hydroxyguanine and preneoplastic foci in rat liver by a food-derived carcinogen, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline, at low dose levels., Jpn J Cancer Res, 87: 127-133, 1996.

9. Wada, S., Kato, T., Mutai, M., Ozaki, K., Yamaguchi, S., Kim, DJ., Baba-Toriyama, H., Asamoto, M., Ito, N., Tsuda, H.: Modifying influence of swine serum-induced liver fibrosis on development of preneoplastic lesions in rat liver. Jpn J Cancer Res, 87: 240-246, 1996.

10. Ito, N., Hasegawa, R., Imaida, K., Hirose, M., Shirai, T.: Medium-term liver and multi-organ carcinogenesis bioassays for carcinogens and chemopreventive agents. Exp Toxicol Pathol, 48: 113-119, 1996.

11. Tanaka, H., Hasegawa, R., Takesada, Y., Ogiso, T., Hirose, M., Shirai, T.: Effects of carbamate insecticides in a rat medium-term bioassay for hepatocarcinogens. J Toxicol Environ Health, 47: 493-498, 1996.

12. Kawabe, M., Takesada, Y., Tamano, S., Hagiwara, A., Ito, N., Shirai, T.: Subchronic toxicity study of L-isoleucine in F344 rats. J Toxicol Environ Health, 47: 499-508, 1996.

13. Wild, CP., Hasegawa, R., Barraud, L., Chutimataewin, S., Chapot, B., Ito, N., Montesano, R.: Aflatoxin-albumin adducts: A basis for comparative carcinogenesis between animals and humans. Cancer Epidemiol Biomarkers Prev, 5: 179-189, 1996.

14. Futakuchi, M., Hasegawa, R., Yamamoto, A., Cui, L., Ogiso, T., Ito, N., Shirai, T.: Low susceptibility of the spontaneously hypertensive rat (SHR) to quinoline-induction of hepatic hemangioendothelial sarcomas. Cancer Lett, 104: 37-41, 1996.

15. Sano, M., Miyata, E., Tamano, S., Hagiwara, A., Ito, N., Shirai, T.: Lack of carcinogenicity of tamarind seed polysaccharide in B6C3F1 mice. Fd Chem Toxicol, 34: 463-467, 1996.

16. Mori, T., Cui, L., Kato, K., Takahashi, S., Imaida, K., Iwasaki, S., Ito, N., Shirai, T.: Direct effects of testosterone, dihydrotestosterone and estrogen on 3,2′-dimethyl-4-aminobiphenyl-induced prostate carcinogenesis in castrated F344 rats. Jpn J Cancer Res, 87: 570-574, 1996.

17. Kimura, J., Takahashi, S., Ogiso, T., Yoshida, Y., Akagi, K., Hasegawa, R., Kurata, M., Hirose, M., Shirai, T.: Lack of chemoprevention effects of the monoterpene d-limonene in a rat multi-organ carcinogenesis model. Jpn J Cancer Res, 87: 589-594, 1996.

18. Cui, L., Hasegawa, R., Ogawa, K., Futakuchi, M., Shirai, T.: Enhancing effects of high-fat diet on 3,2′-dimethyl-4-aminobiphenyl urinary bladder carcinogenesis in the hamster. J Toxicol Pathol, 9: 169-174, 1996.

19. Takahashi, S., Imaida, K., Shirai, T., Wakabayashi, K., Nagao, M., Sugimura, T., Ito, N.: Chronic administration of the mutagenic heterocyclic amine, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine induces cardiac damage with characteristic mitochondrial changes in Fischer rats. Toxicol Pathol, 24: 273-277, 1996.

20. Hagiwara, A., Miyata, E., Tamano, S., Shibata, MA., Sugiura, S., Inoue, M., Hirose, M.: Non-carcinogenicity of 2,2′-[(4-aminophenyl)imino]bisethanol sulfate in a long-term feeding study in Fischer 344 rats. Fd Chem Toxicol, 34: 537-546, 1996.

21. Thamavit, W., Tiwawech, D., Moore, MA., Ito, N., Shirai, T.: Equivocal evidence of complete carcinogenicity after repeated infection of Syrian hamsters with Opisthorchis viverrini. Toxicol Pathol, 24: 493-497, 1996.

22. Futakuchi, M., Lijinsky, W., Hasegawa, R., Hirose, M., Ito, N., Shirai, T.: Effects of low dose mixtures of four N-nitroso compounds on hepatic foci development in the rat. Cancer Lett, 106: 263-269, 1996.

23. Hasegawa, R., Shirai, T., Ito, N.: Synergism in hepatocarcinogenesis induced by heterocyclic amines in rats. J Toxicol Pathol, 9: 241-248, 1996.

24. Tamano, S., Hagiwara, A., Tanaka, H., Kawabe, M., Sano, M., Takahashi, S., Shirai, T.: Histopathological evaluation of spontaneous hepatocellular tumors in B6C3F1 hybrid mice. J Toxicol Pathol, 9: 263-271, 1996.

25. Tamano, S., Rehm, S., Waalkes, MP., Ward, JM.: High incidence and histogenesis of seminal vesicle adenocarcinoma and lower incidence of prostate carcinomas in the Lobund-Wistar prostate cancer rat model using N-nitrosomethylurea and testosterone. Vet Pathol, 33: 557-567, 1996.

26. Imaida, K., Hagiwara, A., Yada, H., Masui, T., Hasegawa, R., Hirose, M., Sugimura, T., Ito, N., Shirai, T.: Dose-dependent induction of mammary carcinomas in female Sprague-Dawley rats with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. Jpn J Cancer Res, 87: 1116-1120, 1996.

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29. Imaida, K., Fukushima, S.: Initiation-promotion model for assessment of carcinogenicity: Medium-term liver bioassay in rats for rapid detection of carcinogenic agents. J Toxicol Sci, 21: 483-487, 1996.

30. Tamano, S., Ward, JM., Diwan, BA., Keefer, LK., Weghorst, CM., Calvert, RJ., Henneman, JR., Ramljak, D., Rice, JM.: Histogenesis and the role of p53 and K-ras mutations in hepatocarcinogenesis by glyceryl trinitrate (nitroglycerin) in male F344 rats. Carcinogenesis, 17: 2477-2486, 1996.

31. Nakanishi, H., Takeuchi, S., Kato, K., Shimizu, S., Kobayashi, K., Tatematsu, M., Shirai, T.: Establishment and characterization of three androgen-independent, metastatic carcinoma cell lines from 3,2′-dimethyl-4-aminobiphenyl-induced prostatic tumors in F344 rats. Jpn J Cancer Res, 87: 1218-1226, 1996.

32. Kobayashi, K., Nakanishi, H., Inada, K., Fujimitsu, Y., Yamachika, T., Shirai, T., Tatematsu, M.: Growth characteristics in the initial stage of micrometastasis formation by bacterial lacZ gene-tagged rat prostatic adenocarcinoma cells. Jpn J Cancer Res, 87: 1227-1234, 1996.

33. Hagiwara, A., Matsuda, T., Tamano, S., Kitano, M., Imaoka, S., Funae, Y., Takesada, Y., Shirai, T., Fukushima, S.: Dose-related increases in quantitative values for altered hepatocytic foci and cytochrome P-450 levels in the livers of rats exposed to phenobarbital in a medium-term bioassay. Cancer Lett, 110: 155-162, 1996.

34. Ito, N., Hagiwara, A., Tamano, S., Futakuchi, M., Imaida, K., Shirai, T.: Effects of pesticide mixtures at the acceptable daily intake levels on rat carcinogenesis. Fd Chem Toxicol, 34: 1091-1096, 1996.

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37. Sano, M., Tamano, S., Hagiwara, A., Kawabe, M., Nakamura, M., Imaida, K., Hirose, M.: 13-week oral toxicity study of pigments extracted from the purple sweet potato in F344/DuCrj rats. Jpn J Fd Chem, 3: 99-105, 1996.

38. Hagiwara, A., Kokubo, Y., Takesada, Y., Tanaka, H., Tamano, S., Hirose, M., Shirai, T., Ito, N.: Inhibitory effects of phenolic compounds on development of naturally occurring preneoplastic hepatocytic foci in long-term feeding studies using male F344 rats. Teratog Carcinog Mutagen, 16: 317-325, 1996.

39. Sano, M., Tamano, S., Hagiwara, A., Shirai, T., Hasegawa, R., Imaida, K., Ito, N.: Dose-response study of di(2-ethylhexyl)phthalate associated rat hepatocarcinogenesis. In: Tahara, E., Sugimachi, K., Oohara, T. (eds.), Recent Advances in Gastroenterological Carcinogenesis I. pp501-511. Monduzzi Editore S.p.A., Bologna, 1996.

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48. 七野裕：上部および下部消化管発癌に対するカテコールなどのDihydroxybenzen誘導体の修飾効果に関する実験的研究. 名古屋市立大学医学会雑誌, 47: 217-238, 1996.

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2. Hasegawa, R., Ogiso, T., Imaida, K., Shirai, T., Ito, N.: Analysis of the potential carcinogenicity of coffee and its related compounds in a medium-term liver bioassay of rats. Fd Chem Toxicol, 33: 15-20, 1995.

3. Shibata, MA., Sano, M., Hagiwara, A., Hasegawa, R., Shirai, T.: Modification by analgesics of lesion development in the urinary tract and various other organs of rats pretreated with dihydroxy-di-N- propylnitrosamine and uracil. Jpn J Cancer Res, 86: 160-167, 1995.

4. Tanaka, H., Hirose, M., Hagiwara, A., Imaida, K., Shirai, T., Ito, N.: Rat strain differences in catechol carcinogenicity to the stomach. Fd Chem Toxicol, 33: 93-98, 1995.

5. Ito, N., Hasegawa, R., Imaida, K., Kurata, Y., Hagiwara, A., Shirai, T.: Effect of ingestion of 20 pesticides in combination at acceptable daily intake levels on rat liver carcinogenesis. Fd Chem Toxicol, 33: 159-163, 1995.

6. Ito, N., Hagiwara, A., Tamano, S., Hasegawa, R., Imaida, K., Hirose, M., Shirai, T.: Lack of carcinogenicity of pesticide mixtures administered in the diet at acceptable daily intake (ADI) dose levels in rats. Toxicol Lett, 82-82: 513-520, 1995.

7. Hirose, M., Akagi, K., Hasegawa, R., Yaono, M., Satoh, T., Hara, Y., Wakabayashi, K., Ito, N.: Chemoprevention of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced mammary gland carcinogenesis by antioxidants in F344 female rats. Carcinogenesis, 16: 217-221, 1995.

8. Shirai, T., Shibata, MA., Takahashi, S., Tagawa, Y., Imaida, K., Hirose, M.: Differences in cell proliferation and apoptosis between reversible and irreversible mucosal lesions associated with uracil-induced urolithiasis in N-butyl-N-(4-hydroxybutyl)nitrosamine-pretreated rats. Carcinogenesis, 16: 501-505, 1995.

9. Tsukamoto, S., Akaza, H., Imada, S., Koiso, K., Shirai, T., Ideyama, Y., Kudo, M.: Chemoprevention of rat prostate carcinogenesis by use of finasteride or casodex. J Natl Cancer Inst, 87: 842-843, 1995.

10. Shibata, MA., Tanaka, H., Kawabe, M., Sano, M., Hagiwara, A., Shirai, T.: Lack of carcinogenicity of monosodium L-glutamate in Fischer 344 rats. Fd Chem Toxicol, 33: 383-391, 1995.

11. Iwata, H., Otoshi, T., Takada, N., Murai, T., Tamano, S., Watanabe, T., Katsura, Y., Fukushima, S.: Validation of silver-stained nucleolar organizer regions for evaluation of invasive character of urinary bladder carcinoma in rats and mice. Urol Res, 23: 27-32, 1995.

12. Tamano, S., Jakubczak, J., Takagi, H., Merlino, G., Ward, JM.: Increased susceptibility to N-nitrosomethylurea gastric carcinogenesis in transforming growth factor alpha transgenic mice with gastric hyperplasia. Jpn J Cancer Res, 86: 435-443, 1995.

13. Masui, T., Shirai, T., Imaida, K., Hirose, M., Futakuchi, M., Tatematsu, M., Ito, N.: Ki-ras mutations with frequent normal allele loss versus absence of p53 mutations in rat prostate and seminal vesicle carcinomas induced with 3,2′-dimethyl-4-aminobiphenyl. Mol Carcinog, 13: 21-26, 1995.

14. Liang, YY., Esteve, A., Martel-Planche, G., Takahashi, S., Lu, SH., Montesano, R., Hollstein, M.: p53 mutations in esophageal tumors from high-incidence areas of China. Int J Cancer, 61: 611-614, 1995.

15. Shirai, T., Tamano, S., Sano, M., Imaida, K., Hagiwara, A., Futakuchi, M., Takahashi, S., Hirose, M.: Site-specific effects of testosterone propionate on the prostate of rat pretreated with 3,2′-dimethyl-4-aminobiphenyl: Dose-dependent induction of invasive carcinomas. Jpn J Cancer Res, 86: 645-648, 1995.

16. Tiwawech, D., Shibata, MA., Hasegawa, R., Hagiwara, A., Shirai, T., Thamavit, W., Fukushima, S.: Weak synergistic effect of uracil and N-butyl-N-(4-hydroxybutyl)nitrosamine on urine composition, epithelial morphology, and DNA synthesis in the urinary bladder of Syrian golden hamster. J Toxicol Pathol, 8: 129-137, 1995.

17. Kataoka, H., Katsumi, K., Kutsuna, T., Suzumura, H., Kojima, S., Takeshima, A., Ban, Y., Itoh, T., Kishimoto, A., Kato, M., Iwata, F., Itoh, M., Takeuchi, T., Ogawa, K., Shirai, T.: A case of familial adenomatous polyposis associated with colon cancer, ureteral cancer and two early gastric cancers. Dig Endosc, 7: 278-284, 1995.

18. Akagi, K., Hirose, M., Hoshiya, T., Mizoguchi, Y., Ito, N., Shirai, T.: Modulating effects of ellagic acid, vanillin and quercetin in a rat medium term multi-organ carcinogenesis model. Cancer Lett. 94: 113-121, 1995.

19. Yaono, M., Hasegawa, R., Mizoguchi, Y., Futakuchi, M., Nakamura, T., Ito, N., Shirai, T.: Hepatocyte growth factor enhancement of preneoplastic hepatic foci development in rats treated with diethylnitrosamine and N-ethyl-N-hydroxyethylnitrosamine. Jpn J Cancer Res, 86: 718-723, 1995.

20. Shirai, T., Fradet, Y., Huland, H., Bollack, C., Droller, M., Janknegt, R., Jones, P., Kagawa, S.: The etiology of bladder cancer — Are there any new clues or predictors of behavior? Int J Urol, 2 Suppl 2: 64-75, 1995.

21. Hirose, M., Iwata, S., Ito, E., Nihro, Y., Takahashi, S., Mizoguchi, Y., Miki, T., Satoh, T., Ito, N., Shirai, T.: Strong anti-mutagenic activity of the novel lipophilic antioxidant 1-O-hexyl-2,3,5-trimethylhydroquinone against heterocyclic amine-induced mutagenesis in the Ames assay and its effect on metabolic activation of 2-amino-6-methyldipyrido [1,2-a:3′,2′-d] imidazole (Glu-P-1). Carcinogenesis, 16: 2227-2232, 1995.

22. Hasegawa, R., Hirose, M., Kato, T., Hagiwara, A., Boonyaphiphat, P., Nagao, M., Ito, N., Shirai, T.: Inhibitory effect of chlorophyllin on PhIP-induced mammary carcinogenesis in female F344 rats. Carcinogenesis, 16: 2243-2246, 1995.

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24. Hasegawa, R., Kimura, J., Yaono, M., Takahashi, S., Kato, T., Futakuchi, M., Fukutake, M., Fukutome, K., Wakabayashi, K., Sugimura, T., Ito, N., Shirai, T.: Increased risk of mammary carcinoma development following transplacental and trans-breast milk exposure to a food-derived carcinogen, 2-amino-1-methyl-6- phenylimidazo[4,5-b]pyridine (PhIP), in Sprague-Dawley rats. Cancer Res, 55: 4333-4338, 1995.

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29. Hirose, M., Hasegawa, R., Kimura, J., Akagi, K., Yoshida, Y., Tanaka, H., Miki, T., Satoh, T., Wakabayashi, K., Ito, N., Shirai, T.: Inhibitory effects of 1-O-hexyl-2,3,5-trimethylhydroquinone (HTHQ), green tea catechins and other antioxidants on 2-amino-6-methyldipyrido[1,2-a:3′,2′-d]imidazole (Glu-P-1)-induced rat hepatocarcinogenesis and dose-dependent inhibition by HTHQ of lesion induction by Glu-P-1 or 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline(MeIQx). Carcinogenesis, 16: 3049-3055, 1995.

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31. Shirai, T., Tamano, S., Sano, M., Masui, T., Hasegawa, R., Ito, N.: Carcinogenicity of 2-amino-1-methyl- 6-phenylimidazo[4,5-b]pyridine (PhIP) in rats: dose-response studies. In: Adamson, RH. et al. (eds.), Heterocyclic amines in cooked foods: Possible human carcinogens. pp232-239, Princeton Scientific Publishing Co. Inc., New Jersey, 1995.

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