1. Sato, S., Suzuki, S., Naiki-Ito, A., Komiya, M., Long, N., Kato, H., Sagawa, H., Yamashita, Y., Shirai, T., Takahashi, S.: Establishment of an invasive prostate cancer model in transgenic rats by intermittent testosterone administration. J Toxicol Pathol, 27: 43-49, 2014.

2. Okamoto, Y., Shinjo, K., Shimizu, Y., Sano, T., Yamao, K., Gao, W., Fujii, M., Osada, H., Sekido, Y., Murakami, S., Tanaka, Y., Joh, T., Sato, S., Takahashi, S., Wakita, T., Zhu, J., Issa, J-PJ., Kondo, Y.: Hepatitis virus infection affects DNA methylation in mice with humanized livers. Gastroenterology, 146: 562-572, 2014.

3. Chew, SH., Okazaki, Y., Nagai, H., Misawa, N., Akatsuka, S., Yamashita, K., Jiang, L., Yamashita, Y., Noguchi, M., Hosoda, K., Sekido, Y., Takahashi, T., Toyokuni, S.: Cancer-promoting role of adipocytes in asbestos-induced mesothelial carcinogenesis through dysregulated adipocytokine production. Carcinogenesis, 35: 164-172, 2014.

4. Kawakubo, T., Yasukochi, A., Toyama, T., Takahashi, S., Okamoto, K., Tsukuba, T., Nakamura, S., Ozaki, Y., Nishigaki, K., Yamashita, H., Yamamoto, K.: Repression of cathepsin E increases the risk of mammary carcinogenesis and links to poor prognosis in breast cancer patients. Carcinogenesis, 35: 714-726, 2014.

5. Nakasuka, K., Ito, S., Miyata, K., Inomata, M., Yoshida, T., Tamai, N., Suzuki, S., Murakami, Y., Sato, K., Suzuki, S., Eishi, Y., Morimoto, S.: A case of idiopathic giant cell myocarditis with a past history of sarcoidosis. J Card Cases, 9: 35-39, 2014.

6. Kimura, Y., Sato, S., Hitomi, E., Ohyama, M., Adachi, K., Inagaki, Y., Yamakawa, Y., Hirano, A., Kawai, H., Tsuchida, K., Senoo, K., Katsumi, K., Joh, T.: Coexpression of organic anion-transporting polypeptides 1B3 and multidrug-resistant protein 2 increases the enhancement effects of gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid on hepatocellular carcinoma in magnetic resonance imaging. Hepatol Res, 44: 327-337, 2014.

7. Dodmane, PR., Arnold, LL., Muirhead, DE., Suzuki, S., Yokohira, M., Pennington, KL., Dave, BJ., Lu, X., Le, XC., Cohen, SM.: Characterization of intracellular inclusions in the urothelium of mice exposed to inorganic arsenic. Toxicol Sci, 137: 36-46, 2014.

8. Shimura, T., Ebi, M., Yamada, T., Hirata, Y., Nishiwaki, H., Mizushima, T., Asukai, K., Togawa, S., Takahashi, S., Joh, T.: Multicenter, prospective, comparative trial of magnifying chromoendoscopy and endoscopic ultrasonography to predict invasion depth of early colorectal cancer. Clin Gastroenterol Hepatol, 12: 662-668, 2014.

9. Fujii, K., Yamashita, Y., Yamamoto, T., Takahashi, K., Hashimoto, K., Miyata, T., Kawai, K., Kikkawa, F., Toyokuni, S., Nagasaka, T. Ovarian mucinous tumors arising from mature cystic teratomas. A molecular genetic approach for understanding the cellular origin. Hum Pathol, 45: 717-724, 2014.

10. Tsujiuchi, T., Natsume, A., Motomura, K., Kondo, G., Ranjit, M., Hachisu, R., Sugimura, I., Tomita, S., Takehara, I., Woolley, M., Barua, NU., Gill, SS., Bienemann, AS., Yamashita, Y., Toyokuni, S., Wakabayashi, T.: Preclinical evaluation of an O6-methylguanine-DNA methyltransferase-siRNA/liposome complex administered by convection-enhanced delivery to rat and porcine brains. Am J Transl Res, 6: 169-178, 2014.

11. Miyabe, K., Notohara, K., Nakazawa, T., Hayashi, K., Naitoh, I., Okumura, F., Shimizu, S., Yoshida, M., Yamashita, H., Takahashi, S., Ohara, H., Joh, T.: Histological evaluation of obliterative phlebitis for the diagnosis of autoimmune pancreatitis. J Gastroenterol, 49: 715-726, 2014.

12. Oseto, K., Suzumori, N., Nishikawa, R., Nishikawa, H., Arakawa, A., Ozaki, Y., Asai, H., Kawai, M., Mizuno, K., Takahashi, S., Shirai, T., Yamada-Namikawa, C., Nakanishi, M., Kajiyama, H., Kikkawa, F., Sugiura-Ogasawara, M.: Mutational analysis of FOXL2 p.C134W and expression of bone morphogenetic protein 2 in Japanese patients with granulosa cell tumor of ovary. J Obst Gynecol Res, 40: 1197-1204, 2014.

13. Shinjo, K., Yamashita, Y., Yamamoto, E., Akatsuka, S., Uno, N., Kamiya, A., Niimi, K., Sakaguchi, Y., Nagasaka, T., Takahashi, T., Shibata, K., Kajiyama, H., Kikkawa, F., Toyokuni, S.: Expression of chromobox homolog 7 (CBX7) is associated with poor prognosis in ovarian clear cell adenocarcinoma via TRAIL-induced apoptotic pathway regulation. Int J Cancer, 135: 308-318, 2014.

14. Oomura, M., Sakakibara, N., Suzuki, S., Wakita, A., Mori, Y., Kamimoto, K.: Intravascular lymphomatosis mimicking primary central nervous system lymphoma: A case report and literature review. Case Rep Neurol, 6: 101-108, 2014.

15. Kuno, T., Hata, K., Takamatsu, M., Hara, A., Hirose, Y., Takahashi, S., Imaida, K., Tanaka, T.: The peroxisome proliferator-activated receptor (PPAR) α agonist fenofibrate suppresses chemically induced lung alveolar proliferative lesions in male obese hyperlipidemic mice. Int J Mol Sci, 15: 9160-9172, 2014.

16. Arnold, LL., Suzuki, S., Yokohira, M., Kakiuchi-Kiyota, S., Pennington, KL., Cohen SM.: Time course of urothelial changes in rats and mice orally administered arsenite. Toxicol Pathol, 42: 855-862, 2014.

17. Yamashita, Y., Ito, Y., Isomura, H., Takemura, N., Okamoto, A., Motomura, K., Tsujiuchi, T., Natsume, A., Wakabayashi, T., Toyokuni, S., Tsurumi, T.: Lack of presence of the human cytomegalovirus in human glioblastoma. Mod Pathol, 27: 922-929, 2014.

18. Yamashita, H., Naitoh, I., Nakazawa, T., Hayashi, K., Miyabe, K., Shimizu, S., Kondo, H., Yoshida, M., Umemura, S., Hori, Y., Ohara, H., Takahashi, S., Joh, T.: A comparison of the diagnostic efficacy in type 1 autoimmune pancreatitis based on biopsy specimens from various organs. Pancreatology, 14: 186-192, 2014.

19. Endo, Y., Yu, D., Yoshimoto, N., Asano, T., Hato, Y., Yamashita, H., Sato, S., Takahashi, S., Fujii, Y., Toyama, T.: HER2 mutation status in Japanese HER2-negative breast cancer patients. Jpn J Clin Oncol, 44: 619-623, 2014.

20. Johmura, Y., Shimada, M., Misaki, T., Naiki-Ito, A., Miyoshi, H., Motoyama, N., Ohtani, N., Hara, E., Nakamura, M., Morita, A., Takahashi, S., Nakanishi, M.: Necessary and sufficient role for a mitosis skip in senescence induction. Mol Cell, 55: 73-84, 2014.

21. Jiang, L., Yamashita, Y., Chew, SH, Akatsuka, S., Ukai, S., Wang, S., Nagai, H., Okazaki, Y., Takahashi, T., Toyokuni, S.: Connective tissue growth factor and β-catenin constitute an autocrine loop for activation in rat sarcomatoid mesothelioma. J Pathol, 233: 402-414, 2014.

22. Naiki, T., Naiki-Ito, A., Asamoto, M., Kawai, N., Tozawa, K., Etani, T., Sato, S., Suzuki, S., Shirai, T., Kohri, K., Takahashi, S.: GPX2 overexpression is involved in cell proliferation and prognosis of castration-resistant prostate cancer. Carcinogenesis, 35: 1962-1967, 2014.

23. Hachiya, K., Wakami, K., Tani, T., Yoshida, A., Suzuki, S., Suda, H., Ohte, N.: Double-valve replacement for mitral and aortic regurgitation in a patient with Libman-Sacks endocarditis. Intern Med, 53: 1769-1773, 2014.

24. Arima, H., Hirate, H., Sugiura, T., Suzuki, S., Takahashi, S., Sobue, K.: IV injection of polystyrene beads for mouse model of sepsis causes severe glomerular injury. J Intensive Care, 2: 21, 2014.

25. Shirai, T., Imai, N., Wang, J., Takahashi, S., Kawabe, M., Wake, K., Kawai, H., Watanabe, S., Furukawa, F., Fujiwara, O.: Multigenerational effects of whole body exposure to 2.14 GHz W-CDMA cellular phone signals on brain function in rats. Bioelectromagnetics,
35: 497-511, 2014.

26. Tozawa, K., Yasui, T., Umemoto, Y., Mizuno, K., Okada, A., Kawai, N., Takahashi, S., Kohri, K.: The pitfalls of robot-assisted radical prostatectomy: A comparison of positive surgical margins between robotic and laparoscopic surgery. Int J Urol, 21: 976-979, 2014.

27. Hayashi, Y., Sasaki, H., Takeshita, S., Nishikawa, R., Nishikawa, H., Arakawa, A., Yamashita, Y., Takahashi, S., Sugiura-Ogasawara, M.: Usefulness of immunohistochemistry for detection of the BRAF V600E mutation in serous ovarian tumors. Oncol Rep, 32:1815-1819, 2014.

28. Asano, T., Sato, S., Yoshimoto, N., Endo, Y., Hato, Y., Yu, D., Takahashi, S., Fujii, Y., Toyama, T.: High expression of LMTK3 is an independent factor indicating a poor prognosis in Japanese estrogen receptor α-positive breast cancer patients. Jpn J Clin Oncol, 44: 889-897, 2014.

29. Punfa, W., Suzuki, S., Pitchakarn, P., Yodkeeree, S., Naiki, T., Takahashi, S., Limtrakul, P.: Curcumin-loaded PLGA nanoparticles conjugated with anti-P-glycoprotein antibody to overcome multidrug resistance. Asian Pac J Cancer Prev, 15: 9249-9258, 2014.

30. Katano, H., Yamada, K., Sakurai, K., Takahashi, S.: Depiction of the vasa vasorum during carotid endarterectomy by intraoperative videoangiography. J Stroke Cerebrovasc Dis, 23: 2920-2927, 2014.

31. Endo, Y., Yamashita, H., Takahashi S., Sato, S., Yoshimoto, N., Asano, T., Hato, Y., Dong, Y., Fujii, Y., Toyama, T.: Immunohistochemical determination of the miR-1290 target arylamine N-acetyltransferase 1 (NAT1) as a prognostic biomarker in breast cancer. BMC Cancer, 14: 990, 2014.

32. Goshima, T., Sato, S., Haruta, M., Murata, K., Takahashi, S., Chiba, Y., Sharif, J., Koseki, H., Nakanishi, M., Shimada, M.: Predominant expression of MPP8 in spermatocytes and its implication for regulation of spermatogenesis. Nagoya Med J, 54: 51-60, 2014.

33. 内木綾、内木拓、高橋智：前立腺癌の発生. 臨床泌尿器科, 68: 27-31, 2014.

34. 佐藤慎哉、鈴木周五、内木綾、白井智之、高橋智：前立腺癌に対するHDAC阻害剤の予防および治療効果の検討. 泌尿器外科, 27: 1217-1219, 2014.

35. 白井智之：職業発がんの歴史. 日本の現状. 病理と臨床, 32: 606-613, 2014.

36. 山下依子、長坂徹郎：急速に再発した子宮内膜間質肉腫の一例. 日本婦人科病理学, 5: 81-84, 2014.

1. Suzuki, S., Shiraga, K., Sato, S., Punfa, W., Naiki-Ito, A., Yamashita, Y., Shirai, T., Takahashi, S.: Apocynin, an NADPH oxidase inhibitor, suppresses rat prostate carcinogenesis. Cancer Sci, 104: 1711-1717, 2013.

2. Suzuki, S., Pitchakarn, P., Sato, S., Shirai, T., Takahashi, S.: Apocynin, an NADPH oxidase inhibitor, suppresses progression of prostate cancer via Rac1 dephosphorylation. Exp Toxicol Pathol, 65: 1035-1041, 2013.

3. Osada, S., Suzuki, S., Yoshimi, C., Matsumoto, M., Shirai, T., Takahashi, S., Imagawa, M.: Elevated expression of coactivator-associated arginine methyltransferase 1 is associated with early hepatocarcinogenesis. Oncol Rep, 30: 1669-1674, 2013.

4. Suzuki, S., Pitchakarn, P., Ogawa, K., Naiki-Ito, A., Chewonarin, T., Punfa, W., Asamoto, M., Shirai, T., Takahashi, S.: Expression of glutathione peroxidase 2 is associated with not only early hepatocarcinogenesis but also late stage metastasis. Toxicology, 311: 115-123, 2013.

5. Tokuda, N., Numata, S., Li, XJ., Nomura, T., Takizawa, M., Kondo, Y., Yamashita, Y., Hashimoto, N., Kiyono, T., Urano, T., Furukawa, K., Furukawa K.: β4GalT6 is involved in the synthesis of lactosylceramide with less intensity than β4GalT5. Glycobiology, 10: 1175-1183, 2013.

6. Natsume, A., Ito, M., Katsushima, K., Ohka, F., Hatanaka, A., Shinjo, K., Sato, S., Takahashi, S., Ishikawa, Y., Takeuchi, I., Shimogawa, H., Uesugi, M., Okano, H., Kim, S.U., Wakabayashi, T., Issa, JP., Sekido, Y., Kondo, Y.: Chromatin regulator PRC2 is a key regulator of epigenetic plasticity in glioblastoma. Cancer Res, 73: 4559-4570, 2013.

7. Endo, Y., Sugiura, H., Yamashita, H., Takahashi, S., Yoshimoto, N., Iwasa, M., Asano, T., Toyama, T.: Myoepithelial carcinoma of the breast treated with surgery and chemotherapy. Case Rep Oncol Med, 2013: 164761, 2013.

8. Ogawa, K., Murasaki, T., Sugiura, S., Nakanishi, M., Shirai, T.: Organ differences in the impact of p27 (kip1) deficiency on carcinogenesis induced by N-methyl-N-nitrosourea. J Appl Toxcol, 33: 471-479, 2013.

9. Long, N., Suzuki, S., Sato, S., Naiki-Ito, A., Sakatani, K., Shirai, T., Takahashi, S.: Purple corn color inhibition of prostate carcinogenesis by targeting cell growth pathways. Cancer Sci, 104: 298-303, 2013.

10. Endo, Y., Toyama, T., Takahashi, S., Yoshimoto, N., Iwasa, M., Asano, T., Fujii, Y., Yamashita, H.: MiR-1290 and its potential targets are associated with characteristics of estrogen receptor a-positive breast cancer. Endocr Relat Cancer, 20: 91-102, 2013.

11. Yasui, T., Tozawa, K., Kurosawa, S., Umemoto, Y., Okada, A., Mizuno, K., Kubota, Y., Kawai, N., Sasaki, S., Hayashi, Y., Takeuchi, M., Shibamoto, Y., Takahashi, S., Kojima, Y., Kohri, K.: Outcomes of robot-assisted laparoscopic prostatectomy with a posterior approach to the seminal vesicle in 150 Japanese patients. Nagoya Med J, 53: 11-25, 2013.

12. Kobayashi, D., Kawai, N., Sato, S., Naiki, T., Yamada, K., Tozawa, K., Kobayashi, T., Takahashi, S., Kohri, K.: Thermotherapy using magnetic cationic liposomes powerfully suppresses prostate cancer bone metastasis in a novel rat model. Prostate, 73: 913-922, 2013.

13. Tang, D., Kryvenko, ON., Wang, Y., Trudeau, S., Rundle, A., Takahashi, S., Shirai, T., Rybicki, BA.: Elevated 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-DNA adducts in benign prostate and subsequent risk for prostate cancer. Int J Cancer, 133: 961-971, 2013.

14. Pitchakarn, P., Chewonarin, T., Ogawa, K., Suzuki, S., Asamoto, M., Takahashi, S., Shirai, T., Limtrakul, P.: Ellagic acid inhibits migration and invasion by prostate cancer cell lines. Asian Pac J Cancer Prev, 14: 2859-2863, 2013.

15. Yamashita, Y., Akatsuka, S., Shinjo, K., Yatabe, Y., Kobayashi, H., Seko, H., Kajiyama, H., Kikkawa, F., Takahashi, T., Toyokuni, S.: Met is the most frequently amplified gene in endometriosis-associated ovarian clear cell adenocarcinoma and correlates with worsened prognosis. PLoS One, 8: e57724, 2013.

16. 高橋智：前立腺癌に対する化学予防研究. Nagoya Med J, 53: 57-61, 2013.

17. 白井智之：食事要因と前立腺癌：予防にむけて. 日本食品化学学会誌, 20: 1-8, 2013.

1. Naiki, T., Asamoto, M., Toyoda-Hokaiwado, N., Naiki-Ito, A., Tozawa, K., Kohri, K., Takahashi, S., Shirai, T. Organ specific Gst-pi expression of the metastatic androgen independent prostate cancer cells in nude mice. Prostate, 72: 533-541, 2012.

2. Ogawa, K., Mamiya, S., Sato, S., Naiki-Ito, A., Suzuki, S., Takahashi, S., Cohen, SM., Shirai, T.: Immunohistochemical analysis of uroplakins, urothelial specific proteins, in sinonasal Schneiderian papillomas. Histopathology, 60: 365-369, 2012.

3. Ogawa, K., Pitchakarn, P., Suzuki, S., Chewonarin, T., Tang, M., Takahashi, S., Naiki-Ito, A., Sato, S., Takahashi, S., Asamoto, M., Shirai, T.: Silencing of connexin 43 suppresses invasion, migration and lung metastasis of rat hepatocellular carcinoma cells. Cancer Sci, 103: 860-867, 2012.

4. Pitchakarn, P., Suzuki, S., Ogawa, K., Pompimon, W., Takahashi, S., Asamoto, M., Limtrakul, P., Shirai, T.: Kuguacin J, a triterpenoid from Momordica charantia leaf, modulates the progression of androgen-independent human prostate cancer cell line, PC3. Fd Chem Toxicol, 50: 840-847, 2012.

5. Takahashi, S., Uemura, H., Seeni, A., Tang, M., Komiya, M., Long, N., Ishiguro, H., Kubota, Y., Shirai, T.: Therapeutic targeting of angiotensin II receptor type 1 to regulate androgen receptor in prostate cancer. Prostate, 72: 1559-1572, 2012.

6. Toyama, T., Kondo, N., Endo, Y., Sugiura, H., Yoshimoto, N., Iwasa, M., Takahashi, S., Fujii, Y., Yamashita, H.: High expression of microRNA-210 is an independent factor indicating a poor prognosis in Japanese triple-negative breast cancer patients. Jpn J Clin Oncol, 42: 256-263, 2012.

7. Sato, S., Takahashi, S., Asamoto, M., Nakanishi, M., Wakita, T., Ogura, Y., Yatabe, Y., Shirai, T.: Histone H1 expression in human prostate cancer tissues and cell lines. Pathol Int, 62: 84-92, 2012.

8. Yasui, Y., Yamada, K., Takahashi, S., Sugiura-Ogasawara, M., Sato, K., Miyazawa, D., Sugiyama, T., Kitade, Y., Ueda, H.: PMA induces GCMa phosphorylation and alters its stability via the PKC- and ERK-dependent pathway. Biochem Biophys Res Comm, 417: 1127-1132, 2012.

9. Naitoh, I., Nakazawa, T., Hayashi, K., Miyabe, K., Shimizu, S., Kondo, H., Yoshida, M., Yamashita H., Nojiri, S., Takahashi, S., Joh, T.: A case of IgG4-related sclerosing cholangitis overlapping with primary biliary cirrhosis. Intern. Med, 51: 1695-1699, 2012.

10. Delhase, M., Kim, SY., Lee, H., Naiki-Ito, A., Chen, Y., Ahn, ER., Murata, K., Kim, SJ., Lautsch, N., Kobayashi, K. S., Shirai, T., Karin, M., Nakanishi, M.: TANK-binding kinase 1(TBK1) controls cell survival through PAI-2/serpinB2 and transglutaminase 2. Proc Natl Acad Sci USA, 109: 177-186, 2012.

11. Shibata, MA., Khan, IA., Iinuma, M., Shirai, T.: Natural Products for Medicine. J Biomed Biotechnol, 2012: 147120, 2012.

12. Naiki-Ito, A., Kato, H., Asamoto, M., Naiki, T., Shirai, T.: Age-dependent carcinogenic susceptibility in rat liver is related to potential of gap junctional intercellular communication. Toxicol Pathol, 40: 715-721, 2012.

13. Suzuki, S., Arnold, LL., Pennington, KL., Kakiuchi-Kiyota, S., Chen, B., Lu, X., Le, XC., Cohen, SM.: Effects of co-administration of dietary sodium arsenate and 2,3-dimercaptopropane-1-sulfonic acid (DMPS) on the rat bladder epithelium. Toxicology, 299: 155-159, 2012.

14. Shirai, T., Takahashi, S., Suzuki, S., Sato, S., Naiki-Ito, A., Asamoto, M.: Experimental chemoprevention of prostate cancer: rat model. In: Shirai, T. et al. (eds.), Prostate cancer: biology, carcinogenesis and prevention. pp95-99, Princess Takamatsu Cancer Research Fund, Tokyo, 2012.

15. 金井秀樹、山下伸子、橋本信和、小川久美子、鈴木周五：頭蓋骨転移で発症した悪性paragangliomaの１例. 脳神経外科, 40: 711-716, 2012.

16. 鈴木周五、髙橋智：腎臓症候群（第２版）上　〜その他の腎臓疾患を含めて〜腎腺腫. 別冊日本臨牀　新領域別症候群シリーズ, 17: 654-656, 2012.

17. 佐藤慎哉、鈴木周五、内木綾、朝元誠人、髙橋智：多様な環境下での前立腺癌の増殖におけるヒストンアセチル化の関与. 泌尿器外科, 25: 1609-1611, 2012.

18. 髙橋智、白井智之：第６章泌尿生殖系　第３節前立腺　in モデル動物利用マニュアル,疾患モデルの作成と利用,がん. Edited by 中村卓郎, Life-Science Information Center,569-575 2012.

19. 内木綾、佐藤慎哉、吉田篤博、髙橋智：骨髄異形成症候群合併末期腎不全に発症したBurkitt様リンパ腫の1症例. 現代医学, 60: 461-466, 2012.

1. Sano, H., Nakazawa, T., Ando, T., Hayashi, K., Naitoh, I., Okumura, F., Miyabe, K., Yoshida, M., Takahashi, S., Ohara, H., Joh, T.: Clinical characteristics of inflammatory bowel disease associated with primary sclerosing cholangitis. J Hepatobiliary Pancreat Sci, 18: 154-161, 2011.

2. Miyaki, T., Nojiri, S., Shinkai, N., Senda, K., Kusakabe, A., Matsuura, K., Iio, E., Takahashi, S., Joh, T.: Pitavastatin improves steatosis and fibrosis in nonalcoholic steatohepatitis model rats. Hepatol Res, 41: 375-385, 2011.

3. Yamashita, H., Iwase, H., Toyama, T., Takahashi, S., Sugiura, H., Yoshimoto, N., Endo, Y., Fujii, Y., Kobayashi, S.: Estrogen receptor-positive breast cancer in Japanese women: trends in incidence, characteristics and prognosis. Ann Oncol, 22: 1318-1325, 2011.

4. Wei, M., Wanibuchi, H., Nakae, D., Tsuda, H., Takahashi, S., Hirose, M., Totsuka, Y., Tatematsu, M., Fukushima, S.: Low-dose carcinogenicity of 2-amino-3-methylimidazo[4,5-f]quinoxaline in rats: Evidence for the existence of no-effect levels and a mechanism involving p21Cip/WAF1. Cancer Sci, 102: 88-94, 2011.

5. Imai, N., Kawabe, M., Hikage, T., Nojima, T., Takahashi, S., Shirai, T.: Effects on rat testis of 1.95-GHz W-CDMA for IMT-2000 cellular phones. Syst Biol Rep Med, 57: 204-209, 2011.

6. Takeshita, K., Takahashi, S., Tang, M., Seeni, A., Asamoto, M., Shirai, T.: Hypertension is positively associated with prostate cancer development in the TRAP transgenic rat model. Pathol Int, 61: 202-209, 2011.

7. Endo, Y., Toyama, T., Takahashi, S., Sugiura, H., Yoshimoto, N., Iwasa, M., Kobayashi, S., Fujii, Y., Yamashita, H.: High estrogen receptor expression and low Ki67 expression are associated with improved time to progression during first-line endocrine therapy with aromatase inhibitors in breast cancer. Int J Clin Oncol, 16: 512-518, 2011.

8. Pitchakarn, P., Suzuki, S., Ogawa, K., Pompimon, W., Takahashi, S., Asamoto, M., Limtrakul, P., Shirai, T.: Induction of G1 arrest and apoptosis in androgen-dependent human prostate cancer by Kuguacin J, a triterpenoid from Momordica charantia leaf. Cancer Lett, 306: 142-150, 2011.

9. Tanaka, M., Kataoka, H., Mabuchi, M., Sakuma, S., Takahashi, S., Tsujii, R., Akashi, H., Ohi, H., Yano, S., Morita, A., Joh, T.: Anti-cancer effects of novel photodynamic therapy with glycoconjugated chlorin for gastric and colon cancer. Anticancer Res, 31: 763-769, 2011.

10. Yoshimoto, N., Nishiyama, T., Toyama, T., Takahashi, S., Shiraki, N., Sugiura, H., Endo, Y., Iwasa, M., Fujii, Y., Yamashita, H.: Genetic and environmental predictors, endogenous hormones and growth factors and risk of estrogen receptor-positive breast cancer in Japanese women. Cancer Sci, 102: 2065-2072, 2011.

11. Yoshimoto, N., Toyama, T., Takahashi, S., Sugiura, H., Endo, Y., Iwasa, M., Fujii, Y., Yamashita, H. Distinct expressions of microRNAs that directly target estrogen receptor α in human breast cancer. Breast Cancer Res Treat, 130: 331-339, 2011.

12. Suzuki, S., Pitchakarn, P., Takeshita, K., Asamoto, M., Takahashi, S., Sato, S., Shirai, T. Roles for rat hepatocyte malignant transforming factor (HMTF) in late-stage of hepatocarcinogenesis. Toxicol Pathol, 39: 1084-1090, 2011.

13. Rybicki, BA., Neslund-Dudas, C., Bock, CH., Nock, NL., Rundle, A., Jankowski, M., Levin, AM., Beebe-Dimmer, J., Savera, AT., Takahashi, S., Shirai, T., Tang, D. Red wine consumption is inversely associated with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-DNA adduct levels in prostate. Cancer Prev Res, 4: 1636-1644, 2011.

14. Ito, S., Nakasuka, K., Miyata, K., Inomata, M., Yoshida, T., Tamai, N., Suzuki, S., Murakami, Y., Suzuki, S., Sato, K.: Late in-stent restenosis after sirolimus-eluting stent implantation is related to thrombus formation-insight from a case with IVUS,OCT,and histological findings. J Cardiol, 5: 83-86, 2011.

15. Tang, M., Ogawa, K., Asamoto, M., Chewonarin, T., Suzuki, S., Tanaka, T., Shirai, T.: Effects of nobiletin on PhIP-Induced prostate and colon carcinogenesis in F344 rats. Nutr Cancer, 63: 227-33, 2011.

16. Matsumoto, H., Yakabe, Y., Saito, F., Saito, K., Sumida, K., Sekijima, M., Nakayama, K., Miyaura, H., Otsuka, M., Shirai, T.: New short term prediction method for chemical carcinogenicity by hepatic transcript profiling following 28-day toxicity tests in rats. Cancer Informatics, 10: 259-271, 2011.

17. Doi, Y., Tamano, S., Kawabe, M., Sano, M., Imai, N., Nakashima, H., Furukawa, F., Hagiwara, A., Otsuka, M., Shirai, T.: Concordance between results of medium-term liver carcinogenesis bioassays and long-tern findings for carcinogenic 2-nitropropane and non-carcinogenic 1-nitropropane in F344 rats. J Toxicol Pathol, 24: 207-213, 2011.

18. Kakiuchi-Kiyota, S., Arnold, LL., Yokohira, M., Koza-Taylor, P., Suzuki, S., Varney, M., Pennington, KL., Cohen, SM.: Evaluation of direct and indirect effects of the PPARγ agonist troglitazone on mouse endothelial cell proliferation. Toxicol Pathol, 39: 1032-1045, 2011.

19. Kakiuchi-Kiyota, S., Arnold, LL., Yokohira, M., Suzuki, S., Pennington, KL., Cohen, SM.: Evaluation of PPARγ agonists on rodent endothelial cell proliferation. Toxicology, 287: 91-98, 2011.

20. Ito, S., Yoshida, T., Suzki, S.: A case of extended late-phase in-stent restenosis after implantation of a bare-metal stent: intravascular ultrasound, optical coherence tomography and immunoihistochemical findings. J Invasive Cardiol, 23: E86-91, 2011.

21. Yokohira, M., Arnold, LL., Pennington, KL., Suzuki, S., Kakiuchi-Kiyota, S., Herbin-Davis, K., Thomas, DJ., Cohen, SM.: Effect of sodium arsenite dose administered in the drinking water on the urinary bladder epithelium of female arsenic (+3 oxidation state) methyltransferase knockout mice. Toxicol Sci, 121: 257-266, 2011.

22. Naiki, T., Hamamoto, S., Kawai, N., Naiki-Ito, A., Kojima, Y., Yasui, T., Tozawa, K., Kohri, K.: Giant retroperitoneal mucinous tumor supportively diagnosed as a dedifferentiated liposarcoma by fluorescence in situ hybridiazation of MDM2 gene. ISRN Urol, 2011: 261735, 2011.

23. 白井智之、朝元誠人、高橋智：ポリフェノールと前立腺がん. Functional Food, 4: 334-339, 2011.

24. 高橋智、佐藤慎哉、白井智之：前立腺癌の化学予防. 日本臨牀, 69: 56-60, 2011.

25. 白井智之：前立腺癌の発生と食事要因-前立腺癌は予防できるか. Foods Food Ingredients J. Jpn., 216: 191-193, 2011.

1. Sato, S., Takahashi, S., Asamoto, M., Naiki, T., Naiki-Ito, A., Asai, K., Shirai, T.: Tranilast suppresses prostate cancer growth and osteoclast differentiation in vivo and in vitro. Prostate, 70:229-238, 2010.

2. Takahashi, S., Imai, N., Nabae, K., Wake, K., Kawai, H., Wang, J., Watanabe, S., Kawabe, M., Fujiwara, O., Ogawa, K., Tamano, S., Shirai, T.: Lack of adverse effects of whole-body exposure to a mobile telecommunication electromagnetic field on the rat fetus. Radiation Res, 173:362-372, 2010.

3. Naiki-Ito, A., Asamoto, M., Naiki, T., Ogawa, K., Takahashi, S., Sato, S., Shirai, T.: Gap junction dysfunction reduces acetaminophen hepatotoxicity with impact on apoptotic signaling and connexin 43 protein induction in rat. Toxicol Pathol, 38: 280-286, 2010.

4. Suzuki, S., Takeshita, K., Doi, Y., Asamoto, M., Takahashi, S., Naiki-Ito, A., Shirai, T.: 2-Amino-3,8-dimethylimidazo[4,5-f]quinoline (MeIQx)-induced hepatocarcinogenesis is not enhanced by CYP1A inducers, alpha- and beta-naphthoflavone; relationship to interlobular distribution of CYP1A expression. Toxicol Pathol, 38:568-582, 2010.

5. Kubota, E., Kataoka, H., Aoyama, M., Mizoshita, T., Mori, Y., Shimura, T., Sasaki, M., Takahashi, S., Asai, K., Joh, T.: Role of ES cell-expressed Ras, ERas in tumorigenicity of gastric cancer. Am J Pathol, 177:955-963, 2010.

6. Pitchakarn, P., Ogawa, K., Suzuki, S., Takahashi, S., Asamoto, M., Chewonarin, T., Limtrakul, P., Shirai, T.: Momordica Charantia leaf extract suppresses rat prostate cancer progression in vitro and in vivo. Cancer Sci, 101:2234-2240, 2010.

7. Tsuda, H., Futakuchi, M., Fukamachi, K., Shirai, T., Imaida, K., Fukushima, S., Tatematsu, M., Furukawa, F., Tamano, S., Ito, N.: A medium-term, rapid rat bioassay model for the detection of carcinogenic potential of chemicals. Toxicol Pathol, 38: 182-187, 2010.

8. Yamaguchi, T., Kanemitsu, H., Yamamoto, S., Komatsu, M., Uemura, H., Tamura, K., Shirai, T.: N,N’-bis(2-chloroethyl)- N-nitrosourea (BCNU)-induced apoptosis of neural progenitor cells in the developing fetal rat brain. J Toxicol Pathol, 23: 25-30, 2010.

9. Ichikawa, K., Tagawa, Y., Kawai, M., Asamoto, M., Shirai, T.: Promoting effects of streptozotocin-induced diabetes on Induction of hepatic preneoplastic Lesions by diethylnitrosamine in rats. J Toxicol Pathol, 23: 125-131, 2010.

10. Niida, H., Murata, K., Shimada, M., Ogawa, K., Ohta, K., Suzuki, K., Fujigaki, H., Khaw, AK., Banerjee, B., Hande, M., Miyamoto, T., Miyoshi, I., Shirai, T., Motoyama, N., Delhase, M., Appella, E., Nakanishi, M.: Cooperative functions of Chk1 and Chk2 reduce tumour susceptibility in vivo. EMBO J, 29: 3558-3570, 2010.

11. Yachida, S., Imaida, K., Yokohira, M., Hashimoto, N., Suzuki, S., Okano, K., Wakabayashi, H., Maeta, H., Suzuki, Y.: Jun activation domain binding protein 1 is overexpressed from the very early stages of hepatocarcinogenesis. Ann Surg Oncol, 17: 3386-3393, 2010.

12. Yokohira, M., Arnold, LL., Pennington, KL., Suzuki, S., Kakiuchi-Kiyota, S., Herbin-Davis, K., Thomas, DJ., Cohen, SM.: Severe systemic toxicity and urinary bladder cytotoxicity and regenerative hyperplasia induced by arsenite in arsenic (+3 oxidation state) methyltransferase knockout mice. A preliminary report. Toxicol Appl Pharmacol, 246: 1-7, 2010.

13. Suzuki, S., Arnold, LL., Pennington, KL., Chen, B., Naranmandura, H., Le, XC., Cohen, SM.: Dietary administration of sodium arsenite to rats: relations between dose and urinary concentrations of methylated and thio-metabolites and effects on the rat urinary bladder epithelium. Toxicol Appl Pharmacol, 244: 99-105, 2010.

14. Suzuki, S., Arnold, LL., Pennington, KL., Kakiuchi-Kiyota, S., Wei, M., Wanibuchi, H., Cohen, SM.: Effects of pioglitazone, a peroxisome proliferator-activated receptor gamma agonist, on the urine and urothelium of the rat. Toxicol Sci, 113: 349-357, 2010.

15. 山田貴之、谷崎由紀子、甲谷知代、佐藤茂、高橋智：Q14　尿細胞診の作製方法と観察のポイントについて教えてください。( 特集　泌尿器科検査のここがポイント C　尿検査　尿細胞診 ). 臨床泌尿器科, 64巻4号: 67-70, 2010.

16. 白井智之：低悪性度乳頭状尿路上皮腫瘍. 病理と臨床, 28 (臨時増刊号): 212-213, 2010.

17. 吉田道弘、林香月、大原弘隆、宮部勝之、奥村文浩、内藤格、田中創始、安藤朝章、中沢貴宏、高橋智、城卓志：難治性皮疹を契機に発見された多発性膵グルカゴノーマの１例. 日本消化器病学会雑誌, 107: 930-936, 2010.

18. 前田祐三、矢野智紀、森山悟、藤井義敬、高橋智：肺原発primitive neuroectodermal tumorの1例. 日本臨床外科学会雑誌、71:2846-2850, 2010.

1. Takada, H., Nakazawa, T., Ohara, H., Ando, T., Hayashi, K., Naito, I., Okumura, F., Tanaka, H., Yamada, T., Takahashi, S., Joh, T.: Role of osteopontin in calcification in autoimmune pancreatitis Dig Dis Sci, 54: 793-801, 2009.

2. Takahashi, S., Takeshita, K., Seeni, A., Sugiura, S., Tang, M., Sato, S., Kuriyama, H., Nakadate, M., Abe, K., Maeno, Y., Nagao M., Shirai, T.: Suppression of prostate cancer in a transgenic rat model via γ-tocopherol activation of caspase signaling. Prostate, 69: 644-651, 2009.

3. Harper, CE., Patel, BB., Cook, LM., Wang, J., Shirai, T., Eltoum, IA., Lamartiniere, CA.: Characterization of SV-40 Tag rats as a model to study prostate cancer. BMC Cancer, 9: 30, 2009.

4. Suzuki, S., Takeshita, K., Asamoto, M., Takahashi, S., Kandori, H., Tsujimura, K., Saito, F., Masuko, K., Shirai, T.: High mobility group box associated with cell proliferation appears to play an important role in hepatocellular carcinogenesis in rats and humans. Toxicology, 255: 160-170, 2009.

5. Takeuchi, M., Sasaki, S., Ito, M., Okada, S., Takahashi, S., Kawai, T., Suzuki, K., Oshima, H., Hara, M., Shibamoto, Y.: Urinary bladder cancer: diffusion-weighted MR imaging–accuracy for diagnosing T stage and estimating histologic grade. Radiology, 251: 112-121, 2009.

6. Inawaka, K., Kawabe, M., Takahashi, S., Doi, Y., Tomigahara, Y., Tarui, H., Abe, J., Kawamura, S., Shirai, T.: Maternal exposure to anti-androgenic compounds, vinclozolin, flutamide and procymidone, has no effects on spermatogenesis and DNA methylation in male rats of subsequent generations. Toxicol Appl Pharmacol, 237: 178-187, 2009.

7. Tanida, S., Kataoka, H., Kubota, E., Mori, Y., Sasaki, M., Ogasawara, N., Wada, T., Mizoshita, T., Shimura, T., Murakami, K., Mizushima, T., Hirata, Y., Okamoto, Y., Mabuchi, M., Ebi, M., Tanaka, M., Kamiya, T., Takahashi, S., Joh, T.: Combination chemotherapy with cisplatin and gemcitabine in malignant peritoneal mesothelioma. Int J Clin Oncol, 14: 266-269, 2009.

8. Ogawa, K., Nabae, K., Wang, J., Wake, K., Watanabe, S., Kawabe, M., Fujiwara, O., Takahashi, S., Ichihara, T., Tamano, S., Shirai, T.: Effects of gestational exposure to 1.95-GHz W-CDMA signals for IMT-2000 cellular phones: Lack of embryotoxicity and teratogenicity in rats. Bioelectromagnetics, 30: 205-212, 2009.

9. Tang, M., Asamoto, M., Ogawa, K., Naiki-Ito, A., Sato, S., Takahashi, S., Shirai, T.: Induction of apoptosis in the LNCaP human prostate carcinoma cell line and prostate adenocarcinomas of SV40T antigen transgenic rats by the Bowman-Birk inhibitor. Pathol. Int., 59: 790-796, 2009.

10. Sugiyama, M., Tanaka, Y., Kurbanov, F., Maruyama, I., Shimada, T., Takahashi, S., Shirai, T., Hino, K., Sakaida, I., Mizokami, M.: Direct cytopathic effects of particular hepatitis B virus genotypes in severe combined immunodeficiency transgenic with urokinase-type plasminogen activator mouse with human hepatocytes. Gastroenterology, 136: 652-662, 2009.

11. Yamashita, H., Takahashi, S., Ito, Y., Yamashita, T., Ando, Y., Toyama, T., Sugiura, H.,Yoshimoto, N., Kobayashi, S., Fujii, Y., Iwase, H.: Predictors of response to exemestane as primary endocrine therapy in estrogen receptor-positive breast cancer. Cancer Sci, 100: 2028-2033, 2009.

12. Matsumoto, H., Yakabe, Y., Saito, K., Sumida, K., Sekijima, M., Nakayama, K., Miyaura, H., Saito, F., Otsuka, M., Shirai, T.: Discrimination of carcinogens by hepatic transcript profiling in rats following 28-day administration. Cancer Inform, 7: 253-269 2009.

13. Naitoh, I., Nakazawa, T., Ohara, H., Sano, H., Ando, T., Hayashi, K., Tanaka, H., Okumura, F., Miyabe, K., Yoshida, M., Takahashi, S., Joh, T.: Autoimmune pancreatitis associated with various extrapancreatic lesions during a long-term clinical course successfully treated with azathioprine and corticosteroid maintenance therapy. Intern Med, 48: 2003-2007, 2009.

14. Said, MM., Ogawa, K., Pitchakarn, P., Takahashi, S., Asamoto, M., Shirai, T.: Cyclooxygenase 2 and prostaglandin E2 are not involved in N-nitrosodiethylamine-initiated early rat hepatocarcinogenesis. J Toxicol Pathol, 22: 263-271, 2009.

15. Futakuchi, M., Nannuru, KC., Varney, ML., Sadanandam, A., Nakao, K., Asai, K., Shirai, T., Sato, SY., Singh, RK.: Transforming growth factor-beta signaling at the tumor-bone interface promotes mammary tumor growth and osteoclast activation. Cancer Sci, 100: 71-81, 2009.

16. Long, N., Hardiville, S., Pierce, A., Fukamachi, K., Futakuchi, M., Alexander, DB., Shirai, T., Tsuda, H.: Construction of a multi-functional helper-dependent adenovirus based system for cancer gene therapy. Asian Pac J Cancer Prev, 10: 939-960, 2009.

17. Naitoh, I., Nakazawa, T., Ohara, H., Ando, T., Hayashi, K., Tanaka, H., Okumura, F., Takahashi, S., Joh, T.: Endoscopic transpapillary intraductal ultrasonography and biopsy in the diagnosis of IgG4-related sclerosing cholangitis. J Gastroenterol, 44:1147-1155, 2009.

18. Suzuki, S., Arnold, LL., Pennington, KL., Chen, B., Le, XC., Cohen, SM.: Effects of an epidermal growth factor receptor inhibitor on arsenic associated toxicity in the rat bladder epithelium. Toxicol Lett, 187: 124-129, 2009.

19. Suzuki, S., Arnold, LL., Pennington, KL., Kakiuchi-Kiyota, S., Cohen, SM.: Effects of co-administration of dietary sodium arsenite and an NADPH oxidase inhibitor on the rat bladder epithelium. Toxicology, 261: 41-46, 2009.

20. Kakiuchi-Kiyota, S., Vetro, JA., Suzuki, S., Varney, ML., Han, HY., Nascimento, M., Pennington, KL., Arnold, LL., Singh, RK., Cohen, SM.: Effects of the PPARgamma agonist troglitazone on endothelial cells in vivo and in vitro: differences between human and mouse. Toxicol Appl Pharmacol, 237: 83-90, 2009.

21. 白井智之：動物実験と病理学. 病理と臨床, 27（臨時増刊号）: 376-381, 2009.

22. 内木綾：乳腺発がんに重要な遺伝子同定の試み. Nagoya Med J, 50: 107-111, 2009.

23. 白井智之、佐藤慎哉、内木綾：化学物質による肝発癌. 日本臨床, 67（増刊号3）: 151-155, 2009.

24. 広瀬真仁、伊藤恭典、新美和寛、黒川覚史、高橋智、郡健二郎：急速に進展した微小乳頭状膀胱癌. 臨床泌尿器科, 63: 619-623, 2009.

25. 朝元誠人、内木拓、白井智之：ラット前立腺癌モデルTransgenic rat for adenocarcinoma of the prostate(TRAP)由来細胞株の樹立とその性質. 泌尿器外科, 22: 945-946, 2009.

26. 大橋実、鈴木孝幸、今井淳、小川久美子：Hematoxylin S solutionを用いたセルブロック法の有用性. 日本臨床細胞学会雑誌, 48: 159-165, 2009.

27. 内藤格、大原弘隆、林香月、奥村文浩、安藤朝章、中沢貴宏、坂本雅樹、佐藤幹則、髙橋智、城卓志：小腸内視鏡にて観察し得た回腸原発腺扁平上皮癌の１例.　日本消化器内視鏡学会雑誌, 51: 355-361, 2009.

1. Shirai, T.: Significance of chemoprevention for prostate cancer development: Experimental in vivo approaches to chemoprevention. Pathol. Int., 58: 1-16, 2008.

2. Hikosaka, A., Ogawa, K., Sugiura, S., Asamoto, M., Takeshita, F., Sato, SY., Nakanishi, M., Kohri, K., Shirai, T.: Susceptibility of p27kip1 knockout mice to urinary bladder carcinogenesis induced by N-butyl-N-(4-hydroxybutyl)nitrosamine may not simply be due to enhanced proliferation. Int J Cancer, 122: 1222-1228, 2008.

3. Nabae, K., Hayashi, SM., Kawabe, M., Ichihara, T., Hagiwara, A., Tamano, S., Tsushima, Y., Uchida, K., Koda, T., Nakamura, M., Ogawa, K., Shirai, T.: A 90-day oral toxicity study of purple corn color, a natural food colorant, in F344 rats. Fd Chem Toxicol, 46: 774-780, 2008.

4. Yamashita, S., Takahashi, S., McDonell, N., Watanabe, N., Niwa, T., Hosoya, K., Tsujino, Y., Shirai, T., Ushijima, T.: Methylation silencing of transforming growth Factor-β receptor type II in rat prostate cancers. Cancer Res., 68: 2112-2121, 2008.

5. Yamanaka, H., Yakabe, Y., Saito, K., Sekijima, M., Sato, H., Shirai, T.: High-accuracy prediction of carcinogenicity by global quantitative analysis of post-translational modifications in a 28-day in vivo rat study. Cancer Genomics Proteomics, 5: 105-116, 2008.

6. Seeni, A., Takahashi, S., Takeshita, K., Tang, M., Sugiura, S., Sato, S., Shirai, T.: Suppression of prostate cancer growth by resveratrol in the transgenic rat for adenocarcinoma of prostate (TRAP) model. Asian Pac J Cancer Prev, 9: 7-14, 2008.

7. Hokaiwado, N., Takeshita, F., Naiki-Ito, A., Asamoto, M., Ochiya, T., Shirai, T.: Glutathione S-transferase pi mediates proliferation of androgen-independent prostate cancer cells. Carcinogenesis, 29: 1134-1138, 2008.

8. Tanaka, Y., Sanchez, LV., Sugiyama, M., Sakamoto, T., Kurbanov, F., Tatematsu, K., Roman, S., Takahashi, S., Shirai, T., Panduro, A., Mizokami, M.: Characteristics of hepatitis B virus genotype G coinfected with genotype H in chimeric mice carrying human hepatocytes. Virology, 376: 408–415, 2008.

9. Mizoguchi, Y., Ogawa, K., Futakuchi, M., Takahashi, S., Hirose, M., Shirai, T.: Differences in expression patterns of cell cycle regulators after cessation of genotoxic and non-genotoxic carcinogen treatment in the rat forestomach. J Toxicol Pathol, 21: 77-87, 2008.

10. Hagiwara, H., Sato, H., Ohde, Y., Takano, Y., Seki, T., Ariga, T., Hokaiwado, N., Asamoto, M., Shirai, T., Nagashima, Y., Yano, T.: 5-Aza-2’-deoxycytidine suppresses human renal carcinoma cell growth in a xenograft model via up-regulation of the connexin 32 gene. Br J Pharmacol, 153: 1373-1381, 2008.

11. Nakagawa, M., Hara, M., Shibamoto, Y., Yano, M., Takahashi, S.: CT findings of bronchial glandular papilloma. J Thorac Imaging, 23: 210-212, 2008.

12. Nakagawa, M., Hara, M., Oshima, H., Shibamoto, Y., Sato, Y., Kondo, S., Suzuki, T., Takahashi, S.: Pleural bronchogenic cysts: Imaging findings. J Thorac Imaging, 23: 284-288, 2008.

13. Kawabe, M., Futakuchi, M., Tamano, S., Shirai, T., Hirose, M.: Modifying effects of chitin, chitosan and their related compounds on 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in a rat medium-term hepatocarcinogenesis model, and their post-initiation effects in a female rat 2-stage multi-organ carcinogenesis model. Fd Chem Toxicol, 46: 2758-2763, 2008.

14. Sato, S., Futakuchi, M., Ogawa, K., Asamoto, M., Nakao, K., Asai, K., Shirai, T.: Transforming growth factor beta derived from bone matrix promotes cell proliferation of prostate cancer and osteoclast activation-associated osteolysis in the bone microenvironment. Cancer Sci, 99: 316-323, 2008.

15. Wang, Z., Luque, RM., Kineman, RD., Ray, VH., Christov, KT., Lantvit, DD., Shirai, T., Hedayat, S., Unterman, TG., Bosland, MC., Prins, GS., Swanson, SM.: Disruption of growth hormone signaling retards prostate carcinogenesis in the probasin/TAg rat. Endocrinology, 149: 1366-1376, 2008.

16. Kawai, N., Futakuchi, M., Yoshida, T., Ito, A., Sato, S., Naiki, T., Honda, H., Shirai, T., Kohri, K.: Effect of heat therapy using magnetic nanoparticles conjugated with cationic liposomes on prostate tumor in bone. Prostate, 68: 784-792, 2008.

17. Toyama, T., Yamashita, H., Kondo, N., Okuda, K., Takahashi, S., Sasaki, H., Sugiura, H., Iwase, H., Fujii, Y.: Frequently increased epidermal growth factor receptor (EGFR) copy numbers and decreased BRCA1 mRNA expression in Japanese triple-negative breast cancers. BMC Cancer, 8: 309, 2008.

18. Uemura, H., Ishiguro, H., Ishiguro, Y., Hoshino, K., Takahashi, S., Kubota, Y.: Angiotensin II induces oxidative stress in prostate cancer. Mol Cancer Res, 6: 250-258, 2008.

19. Suzuki, S., Arnold, LL., Ohnishi, T., Cohen, SM.: Effects of inorganic arsenic on the rat and mouse urinary bladder. Toxicol Sci, 106: 350-363, 2008.

20. Nascimento, MG., Suzuki, S., Wei, M., Tiwari, A., Arnold, LL., Lu, X., Le, XC., Cohen, SM.: Cytotoxicity of combinations of arsenicals on rat urinary bladder urothelial cells in vitro. Toxicology, 249: 69-74, 2008.

21. 白井智之、高橋智、朝元誠人：前立腺癌の発生と予防. 日本医事新報, 4395: 44-47, 2008.

22. 廣川高久、山本稔、坂本雅樹、沢井博純、竹山廣光、真辺忠夫、髙橋智：虫垂原発のinflammatory myofibroblastic tumorの１例. 日本消化器外科学会雑誌, 41: 446-451, 2008.

23. 佐藤慎哉、関健司、白井智之：名古屋市厚生院附属病院患者の剖検例における膵病変について. 名古屋市厚生院紀要, 34: 11-13, 2008.

24. 佐藤慎哉、関健司：厚生院における病理解剖（XXVII）. 名古屋市厚生院紀要, 34: 53-54, 2008.

1. Sumida, K., Saito, K., Oeda, K., Otsuka, M., Tsujimura, K., Miyaura, H., Nakayama, K., Kawano, Y., Kawakami, Y., Asamoto, M., Shirai, T.: Optimization of an animal test protocol for toxicogenomics studies (i); requirement study of a protocol. J Toxicol Sci, 32: 19-32, 2007.

2. Sumida, K., Saito, K., Oeda, K., Otsuka, M., Tsujimura, K., Miyaura, H., Nakayama, K., Kawano, Y., Kawakami, Y., Asamoto, M., Shirai, T.: Optimization of an animal test protocol for toxicogenomics studies (ii); a-cross-laboratory gene expression analysis. J Toxicol Sci, 32: 33-45, 2007.

3. Tang, M., Ogawa, K., Asamoto, M., Hokaiwado, N., Seeni, A., Suzuki, S., Takahashi, S., Tanaka, T., Ichikawa, K., Shirai, T.: Protective effects of citrus nobiletin and auraptene in transgenic rats developing adenocarcinoma of the prostate (TRAP) and human prostate carcinoma cells. Cancer Sci, 98: 471-477, 2007.

4. Cho, YM., Takahashi, S., Asamoto, M., Suzuki, S., Tang, M., Shirai, T.: Suppressive effects of antiandrogens, finasteride and flutamide, on development of prostatic lesions in a transgenic rat model. Prostate Cancer Prostatic Dis, 10: 378-383, 2007.

5. Sugiyama, M., Tanaka, Y., Sakamoto, T., Maruyama, I., Shimada, T., Takahashi, S., Shirai, T., Kato, H., Nagao, M., Miyakawa, Y., Mizokami, M.: Early dynamics of hepatitis B virus in chimeric mice carrying human hepatocytes monoinfected or coinfected with genotype G. Hepatology, 45: 929-937, 2007.

6. Imazawa, T., Nishikawa, A., Miyauchi, M., Okazaki, K., Takahashi, S., Umemura, T., Hirose, M.: DNA adduct formation, nucleolar segregation and cell proliferation in rats treated with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. J Toxicol Pathol, 20: 39-47, 2007.

7. Tsuda, H., Iigo, M., Takasuka, N., Ueda, S., Ohshima, Y., Fukamachi, K., Shirai, T., Hirano, S., Matsuda, E., Wakabayashi, K.: Possible enhancing activity of diacylglycerol on 4-nitroquinoline 1-oxide induced carcinogenesis of the tongue in human c-Ha-ras proto-oncogene transgenic rats. Fd Chem Toxicol, 45: 1013-1019, 2007.

8. Yamanaka, H., Yakabe, Y., Saito, K., Sekijima, M., Shirai, T.: Quantitative proteomic analysis of rat liver for carcinogenicity prediction in a 28-day repeated dose study. Proteomics, 7: 781-795, 2007.

9. Shirai, T., Ichihara, T., Wake, K., Watanabe, S., Yamanaka, Y., Kawabe, M., Taki, M., Fujiwara, O., Wang, J., Takahashi, S., Tamano, S.: Lack of promoting effects of chronic exposure to 1.95-GHz W-CDMA signals for IMT-2000 cellular system on development of N-ethylnitrosourea-induced central nervous system tumors in F344 rats. Bioelectromagnetics, 28: 562-572, 2007.

10. Hokaiwado, N., Asamoto, M., Futakuchi, M., Ogawa, K., Takahashi, S., Shirai, T.: Both early and late stages of hepatocarcinogenesis are enhanced in Cx32 dominant negative mutant transgenic rats with disrupted gap junctional intercellular communication. J Membrane Biol, 218: 101-106, 2007.

11. Naiki-Ito, A., Asamoto, M., Hokaiwado, N., Takahashi, S., Yamashita, H., Tsuda, H., Ogawa, K., Shirai, T.: Gpx2 is an overexpressed gene in rat breast cancers induced by three different chemical carcinogens. Cancer Res, 67: 11353-11358, 2007.

12. Futakuchi, M., Hirose, M., Kawabe, M., Yamaguchi, T., Sato, S., Shirai, T.: Combined chemopreventive effects of perilla or corn oil and indomethacin in a rat medium-term multiorgan carcinogenesis model. J Toxicol Pathol, 20: 245-252, 2007.

13. Toyama, T., Zhang, Z., Nishio, M., Hamaguchi, M., Kondo, N., Iwase, H., Iwata, H., Takahashi, S., Yamashita, H., Fujii, Y.: Association of TP53 codon 72 polymorphisms and the outcome of adjuvant therapy in breast cancer patients. Breast Cancer Res, 9: R34, 2007.

14. Kato, T., Hashimoto, Y., Okada, S., Tozawa, K., Takahashi, S., Kohri, K.: Carbohydrate antigen 19-9-positive prostatic ductal adenocarcinoma effectively treated with cisplatin and gemcitabine. Int J Urol, 14:1103-1106, 2007.

15. 朝元誠人：質疑応答, 病理学, ザクロ果汁中成分も抗前立腺癌作用. 日本医事新報, 4318: 92-93, 2007.

16. 白井智之：遺伝子発現プロファイリングに基づく化学物質の発がん予測. 病理と臨床, 25: 744-750, 2007.

17. 佐藤慎哉、二口充、白井智之：骨・肺転移巣における前率腺癌の進展に対する血管新生の関与. 名古屋市厚生院紀要, 33: 7-10, 2007.

18. 鈴木周五、佐藤慎哉、関健司：厚生院における病理解剖（XXVI）. 名古屋市厚生院紀要, 33: 73-74, 2007.

19. 中沢貴宏、大原弘隆、安藤朝章、今井英人、林香月、田中創始、小川観人、内藤格、野尻俊輔、中尾春壽、高橋智、佐野仁、城卓志: 自己免疫性膵炎の病理組織学的診断. 胆と膵, 28: 951-956, 2007.

20. 遠藤友美、山下啓子、髙橋智、杉浦博士、斎藤慎一郎、岩瀬弘敬：術前ホルモン療法が著効した閉経後乳癌の１例. 乳癌の臨床, 22: 493-496, 2007.

21. 苅谷清徳、渡辺正一、山本あい、久野治人、加藤裕史、馬場二三八、髙橋智、千葉高司、森田明理：メルケル細胞癌の１例. 術後放射線補助照射の必要性. Skin Cancer, 22:157-161, 2007.

1. Hikosaka, A., Futakuchi, M., Ogiso, T., Suzuki, S., Kohri, K., Shirai, T.: Lack of prophylactic effect of incadronate on skeletal lesions associated with implants of prostate cancer. Eur Urol., 49: 176-182, 2006.

2. Ohara, H., Nakazawa, T., Sano, H., Joh, T., Takahashi, S.: Histopathologic similarities of inflammatory pseudotumor to autoimmune pancreatitis: A morphologic and immunohistochemical study of 4 cases. Pancreas, 32:115-117, 2006.

3. Takahashi, S., Suzuki, S., Takahashi, S., Inaguma, S., Asamoto, M., Shirai, T.: Differences between latent and clinical prostate carcinomas: Lower cell proliferation activity in latent cases. Prostate, 66: 211-217, 2006.

4. Kuribayashi, M., Asamoto, M., Suzuki, S., Hokaiwado, N., Ogawa, K., Shirai, T.: Lack of modification of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) rat hepatocarcinogenesis by caffeine, a CYP1A2 inducer, points to complex counteracting influences. Cancer Lett, 232: 289-299, 2006.

5. Shirai, T., Ogawa, K., Takahashi, S.: Carcinogenic effects of mixtures of chemicals. J Toxicol Pathol, 19: 1-13, 2006.

6. Suzuki, S., Takahashi, S., Takahashi, S., Takeshita, K., Hikosaka, A., Wakita, T., Nishiyama, N., Fujita, T., Okamura, T., Shirai, T.: Expression of prothymosin alpha is correlated with development and progression in human prostate cancers. Prostate, 66: 463-469, 2006.

7. Kawabe, M., Sano, M., Hagiwara, A., Tamano, S., Suzuki, S., Shirai, T.: Lack of carcinogenicity of L-isoleucine in F344/DuCrj rats. Fd Chem Toxicol, 44: 278-285, 2006.

8. Kawai, N., Ito, A., Nakahara, Y., Honda, H., Kobayashi, T., Futakuchi, M., Shirai, T., Tozawa, K., Kohri, K.: Complete regression of experimental prostate cancer in nude mice by repeated hyperthermia using magnetite cationic liposomes and a newly developed solenoid containing a ferrite core. Prostate, 66: 718-727, 2006.

9. Ogawa, K., Masutani, M., Kato, K., Tang, M., Kamada, N., Suzuki, H., Nakagama, H., Sugimura, T., Shirai, T.: Parp-1 deficiency does not enhance liver carcinogenesis induced by 2-amino-3-methylimidazo[4,5-f]quinoline in mice. Cancer Lett, 236: 32-38, 2006.

10. Sunden, Y., Suzuki, T., Orba, Y., Umemura, T., Asamoto, M., Nagashima, K., Tanaka, S., Sawa, H.: Characterization and application of polyclonal antibodies that specifically recognize JC virus large T antigen. Acta Neuropathol, 111: 379-387, 2006.

11. Said, MM., Hokaiwado, N., Tang, M., Ogawa, K., Suzuki, S., Ghanem, HM., Esmat, AY., Asamoto, M., Rafaie, FM., Shirai, T.: Inhibition of prostate carcinogenesis in probasin/SV40 T antigen transgenic rats by leuprorelin, a luteinizing hormone-releasing hormone agonist. Cancer Sci, 97: 459-467, 2006.

12. Yamauchi, A., Kawai, K., Tsukamoto, S., Ideyama, Y., Shirai, T., Akaza, H.: Persistence of prostatic intraepithelial neoplasia after effective chemoprevention of microscopic prostate cancer with antiandrogen in a rat model. J Urol, 175: 348-352, 2006.

13. Murasaki, T., Asamoto, M., Hokaiwado, N., Ogawa, K., Shirai, T.: Limited effects of disrupted gap junctions in the liver on multi-organ carcinogenesis induced by diisopropanolnitrosamine in the mutant connexin 32 transgenic rat. J Toxicol Pathol, 19: 93-97, 2006.

14. Romanenko, AM., Morimura, K., Kinoshita, A., Wanibuchi, H., Takahashi, S., Zaparin, WK., Vinnichenko, WI., Vozianov, AF., Fukushima, S.: Upregulation of fibroblast growth factor receptor 3 and epidermal growth factor receptors, in association with Raf-1, in urothelial dysplasia and carcinoma in situ after the Chernobyl accident. Cancer Sci., 97:1168-1174, 2006.

15. Tamano, S., Kawabe, M., Ichihara, T., Hagiwara, A., Sano, M., Asamoto, M., Shirai, T.: Close relation of transforming growth factor-α positive hepatic foci to hepatocellular tumor development in the rat. J Toxicol Pathol, 19: 99-106, 2006.

16. Zhu, A., Rashid, A., Cleary, K., Abbruzzese, JL., Friess, H., Takahashi, S., Shirai, T., Li, D.: Detection of 2-amino-1-methy1-6-phenylimidazo[4,5-b]pyridine (PhIP)-DNA adducts in human pancreatic tissues. Biomarkers, 11: 319-328, 2006.

17. Imai, N., Doi, Y., Nabae, K., Tamano, S., Hagiwara, A., Kawabe, M., Ichihara, T., Ogawa, K., Shirai, T.: Lack of hinokitiol (beta-thujaplicin) carcinogenicity in F344/DuCrj rats. J Toxicol Sci, 31: 357-370, 2006.

18. Nabae, K., Doi, Y., Takahashi, S., Ichihara, T., Toda, C., Ueda, K., Okamoto, Y., Kojima, N., Tamano, S., Shirai, T.: Toxicity of di(2-ethylhexyl)phthalate (DEHP) and di(2-ethylhexyl)adipate (DEHA) under conditions of renal dysfunction induced with folic acid in rats: Enhancement of male reproductive toxicity of DEHP is associated with an increase of the mono-derivative. Reprod Toxicol, 22: 411-417, 2006.

19. Okamura, T., Uemoto, Y., Yamashita, K., Suzuki, S., Shirai, T., Hashimoto, Y., Kohri, K.: Pitfalls with MRI evaluation of prostate cancer detection: comparison of findings with histopathological assessment of retropubic radical prostatectomy specimens. Urol Int, 77: 301-306, 2006.

20. Nakayama, K., Kawano Y., Kawakami, Y., Moriwaki, N., Sekijima, M., Otsuka, M., Yakabe, Y., Miyaura, H., Saito, K., Sumida, K., Shirai, T.: Differences in gene expression profiles in the liver between carcinogenic and non-carcinogenic isomers of compounds given to rats in a 28-day repeat-dose toxicity study. Toxicol Appl Pharmacol, 217: 299-307, 2006.

21. Doi, Y., Ichihara, T., Hagiwara, A., Imai, N., Tamano, S., Orikoshi, H., Ogasawara, K., Sasaki, Y., Nakamura, M., Shirai, T.: A ninety-day oral toxicity study of a new type of processed gum arabic, from Acacia tree (Acacia senegal) exudates, in F344 rats. Fd Chem Toxicol, 44: 560-566, 2006.

22. Tsujimura, K., Asamoto, M., Suzuki, S., Hokaiwado, N., Ogawa, K., Shirai, T.: Prediction of carcinogenic potential by a toxicogenomic approach using rat hepatoma cells. Cancer Sci, 97: 1002-1010, 2006.

23. 白井智之：下部尿路、向井清, 真鍋俊名, 深山正久 編, 外科病理学.文光堂、pp920-940, 2006.

24. 鈴木周五、春田良介、白井智之：ラット初代肝細胞を用いた肝発がん物質投与による遺伝子発現変化の解析. 名古屋市厚生院紀要, 32: 11-14, 2006.

25. 大橋実、鈴木孝幸、小川久美子、本郷恵、白井智之：診断が困難であった肺吸虫症の細胞診. 名古屋市立病院紀要, 29: 69-72, 2006.

26. 高橋智：前立腺癌に対する化学予防の検討. 名古屋市立大学医学会雑誌, 57: 103-107, 2006.

27. 安藤由明、濱口真帆、三田圭子、遠山竜也、遠山淳子、髙橋智、藤井義敬、山下啓子：早期乳癌に対するセンチネルリンパ節生検の経験. 名古屋市立大学医学会雑誌, 57: 21-24, 2006.

28. 林香月、大原弘隆、喜多島康弘、田中創始、高田博樹、今井英人、安藤朝章、中沢貴宏、祖父江聡、中尾春壽、呉原裕樹、桑原義之、高橋智、城卓志：胃粘膜下腫瘍と鑑別が困難であった肝硬化性血管腫の１例. 肝臓, 47: 474-481, 2006.

1. Kioi, M., Takahashi, S., Kawakami, M., Kawakami, K., Kreitman, RJ., Puri, RK.: Expression and targeting of interleukin-4 receptor for primary and advanced ovarian cancer therapy. Cancer Res, 65: 8388-8396, 2005.

2. Shirai, T., Kawabe, M., Ichihara, T., Fujiwara, O., Taki, M., Watanabe, S., Wake, K., Yamanaka, Y., Imaida, K., Asamoto, M., Tamano, S.: Chronic exposure to a 1.439 GHz electromagnetic field used for cellular phones does not promote N-ethylnitrosourea induced central nervous system tumors in F344 rats. Bioelectromagnetics, 26: 59-68, 2005.

3. Ichihara, T., Miyashita, K., Kawabe, M., Imaida, K., Asamoto, M., Ogiso, T., Tamano, S., Hirose, M., Shirai, T.: Lack of combination hepatocarcinogenicity of harman, norharman and amitrole when given with NaNO2 in the rat. J Toxicol Sci, 30: 1-6, 2005.

4. Ito, A., Asamoto, M., Hokaiwado, N., Takahashi, S., Shirai, T.: Tbx3 expression is related to apoptosis and cell proliferation in rat bladder both hyperplastic epithelial cells and carcinoma cells. Cancer Lett, 219: 105-112, 2005.

5. Ozaki, M., Ozaki, K., Watanabe, T., Uwagawa, S., Okuno, Y., Shirai, T.: Susceptibilities of p53 knockout and rasH2 transgenic mice to urethane-induced lung carcinogenesis are inherited from their original strains. Toxicol Pathol, 33: 267-271, 2005.

6. Ichihara, T., Tamano, S., Yoshino, H., Imaida, K., Ishikawa, H., Kakizoe, T., Shirai, T.: Lack of chemoprevention or promotion effects of docosahexaenoic acid on small intestine, colon, liver, lung, thyroid, esophagus, kidney, and forestomach carcinogenesis in a rat medium-term multi-organ carcinogenesis model. J Toxicol Pathol, 18: 53-59, 2005.

7. Ichihara, T., Imai, N., Toda, Y., Hagiwara, A., Tamano, S., Shirai, T.: Evidence of a threshold dose for promotion of hepatocarcinogenesis by hexachlorobenzene in a rat medium-term liver bioassay. J Toxicol Pathol, 18: 7-11, 2005.

8. Yamashita, S., Suzuki, S., Nomoto, T., Kondo, Y., Wakazono, K., Tsujino, Y., Sugimura, T., Shirai, T., Homma, Y., Ushijima, T.: Linkage and microarray analyses of susceptibility genes in ACI/Seg rats: a model for prostate cancers in the aged. Cancer Res., 65: 2610-2616, 2005.

9. Lynch, CC., Hikosaka, A., Acuff, HB., Martin, MD., Kawai, N., Singh, RK., Vargo-Gogola, TC., Begtrup, JL., Peterson, TE., Fingleton, B., Shirai, T., Matrisian, LM., Futakuchi, M.: MMP-7 promotes prostate cancer-induced osteolysis via the solubilization of RANKL. Cancer Cell, 7: 485-496, 2005.

10. Ogawa, K., Asamoto, M., Suzuki, S., Tsujimura, K., Shirai, T.: Downregulation of apoptosis revealed by laser microdissection and cDNA microarray analysis of related genes in rat liver preneoplastic lesions. Med Mol Morphol, 38: 23-29, 2005.

11. Yamada, T., Kuno, A., Ogawa, K., Tang, M., Masuda, K., Nakamura, S., Ando, T., Okamoto, T., Ohara, H., Nomura, T., Joh, T., Shirai, T., Itoh, M.: Combination therapy with an angiotensin-converting enzyme inhibitor and an angiotensin II receptor blocker synergistically suppresses chronic pancreatitis in rats. J Pharmacol Exp Ther, 313: 36-45, 2005.

12. Fukushima, S., Wanibuchi, H., Morimura, K., Nakae, D., Tsuda, H., Imaida, K., Shirai, T., Tatematsu, M., Tsukamoto, T., Hirose, M., Furukawa, F.: Lack of potential of low dose N-nitrosodimethylamine to induce preneoplastic lesions, glutathione S-transferase placental form-positive foci, in rat liver. Cancer Lett, 222: 11-15, 2005.

13. Kawabe, M., Ichihara, T., Sano, M., Hagiwara, A., Tamano, S., Ogawa, K., Shirai, T.: Lack of carcinogenicity of silicone resin (KS66) in F344 rats. Fd Chem Toxicol, 43: 1065-1071, 2005.

14. Sugiura, S., Asamoto, M., Hokaiwado, N., Hirose, M., Shirai, T.: Harman and norharman suppressed but NaNO2 enhanced the development of preneoplastic liver cell foci in 2-amino-3,8-dimethylimidazo- [4,5-f]quinoxaline (MeIQx)-treated rats. J Toxicol Pathol, 18: 99-104, 2005.

15. Ikeda, Y., Cho, YM., Takahashi, S., Tang, M., Asamoto, M., Ogawa, K., Shirai, T.: Equivocal impact of transplacental and lactational exposure to a food-derived carcinogen, 2-amino-1-methyl-6-phenylimidazo- [4,5-b]pyridine, on prostate and colon lesion development in F344 rats. Cancer Lett, 224: 23-30, 2005.

16. Nabae, K., Ichihara, T., Hagiwara, A., Hirota, T., Toda, Y., Tamano, S., Nishino, M., Ogasawara, T., Sasaki, Y., Nakamura, M., Shirai, T.: A 90-day oral toxicity study of beta-carotene derived from Blakeslea trispora, a natural food colorant, in F344 rats. Fd Chem Toxicol, 43: 1127-1133, 2005.

17. Kandori, H., Suzuki, S., Asamoto, M., Murasaki, T., Tang, M., Ogawa, K., Shirai, T.: Influence of atrazine administration and reduction of calorie intake on prostate carcinogenesis in probasin/SV40 T antigen transgenic rats. Cancer Sci, 96: 221-226, 2005.

18. Okamoto, T., Yamada, T., Kuno, A., Ogawa, K., Tang, M., Sano, H., Ohara, H., Nakao, H., Kataoka, H., Shirai, T., Itoh, M.: FTY720, an immunosuppressant, attenuates chronic pancreatitis in rats by suppressing T-cell infiltration. Pancreas, 30: e64-e70, 2005.

19. Kawai, N., Ito, A., Nakahara, Y., Futakuchi, M., Shirai, T., Honda, H., Kobayashi, T., Kohri, K.: Anticancer effect of hyperthermia on prostate cancer mediated by magnetite cationic liposomes and immune-response induction in transplanted syngeneic rats. Prostate, 64: 373-381, 2005.

20. Hagiwara, A., Yoshino, H., Sano, M., Kawabe, M., Tamano, S., Sakaue, K., Nakamura, M., Tada, M., Imaida, K., Shirai, T.: Thirteen-week feeding study of thaumatin (a natural proteinaceous sweetener), sterilized by electron beam irradiation, in Sprague-Dawley rats. Fd Chem Toxicol, 43: 1297-1302, 2005.

21. Zhao, L., Futakuchi, M., Suzuki, S., Ohhara, Y., Hashimoto, T., Suzuki, T., Manabe, T., Shirai, T.: Kinetics of marked development of lung metastasis of rat prostatic carcinomas transplanted in syngeneic rats. Clin Exp Metastasis, 22: 309-318, 2005.

22. Kuribayashi, M., Wang, J., Fujiwara, O., Doi, Y., Nabae, K., Tamano, S., Ogiso, T., Asamoto, M., Shirai, T.: Lack of effects of 1439 MHz electromagnetic near field exposure on the blood-brain barrier in immature and young rats. Bioelectromagnetics, 26: 578-588, 2005.

23. Yoshino, H., Futakuchi, M., Cho, YM., Ogawa, K., Takeshita, F., Imai, N., Tamano, S., Shirai, T.: Modification of an in vivo lung metastasis model of hepatocellular carcinoma by low dose N-nitrosomorpholine and diethylnitrosamine. Clin Exp Metastasis, 22: 441-447, 2005.

24. Yoshino, H., Imai, N., Nabae, K., Doi, Y., Tamano, S., Ogawa, K., Shirai, T.: Thirteen-week oral toxicity study of dokudami extract (Houttuynia Cordata Thunb.) in F344/DuCrj rats. J Toxicol Pathol, 18: 175-182, 2005.

25. Yoshino, H., Nabae, K., Doi, Y., Ichihara, T., Tamano, S., Suzuki, S., Shirai, T.: Lack of effects of gestational and lactational exposure to 4-nonylphenol on PhIP-induced rat prostate carcinogenesis. J Toxicol Pathol, 18: 183-188, 2005.

26. Hokaiwado, N., Asamoto, M., Ogawa, K., Shirai, T.: Transgenic disruption of gap junctional intercellular communication enhances early but not late stage hepatocarcinogenesis in the rat. Toxicol Pathol, 33: 695-701, 2005.

27. Asamoto, M., Hokaiwado, N., Shirai, T.: Transgenic disruption of gap junctional intercellular communication protects against hepatotoxicity while increasing susceptibility to liver carcinogenesis in rats. In: Tanaka, T. and Tsuda, H. eds., Carcinogenesis and Modification of Carcinogenesis. pp1-7, Research Signpost, Kerala, 2005.

28. Ogawa, K., Sugiura, S., Hirose, M., Shirai, T.: Promotion / carcinogenic effects of phenylethyl isothiocyanate, an established chemopreventive agent, in rat and mouse urinary bladder. In: Tanaka, T. and Tsuda, H. eds., Carcinogenesis and Modification of Carcinogenesis. pp253-266, Research Signpost, Kerala, 2005.

29. 白井智之：cDNAマイクロアレイを用いた4週間投与による化学物質の肝発がん性予測. 臨床薬理, 36: 8-9, 2005.

30. 筑紫聡、中島浩敦、鈴木周五、片桐浩久：転移性骨腫瘍におけるCTガイド下針生検の意義. 整形外科, 56: 525-528, 2005.

31. 白井智之：下部尿路、小池盛雄、恒吉正澄、深山正久、森永正二郎 編, 組織病理アトラス（第5版）文光堂、pp239-246, 2005.

32. 住田由美、小森文恵、福田真里、中島由美恵、伊藤由香、加藤浩司、小木曽正、古川文夫：湯浴式伸展による肝パラフィン薄切切片の温度と時間への影響. 実験病理組織技術研究会誌, 14: 29-33, 2005.

33. 朝元誠人：発がん性と毒性におけるギャップ結合蛋白コネキシンの役割〜遺伝子導入ラットを用いた解析〜. 名古屋市立大学医学会雑誌, 56: 41-43, 2005.

34. 後藤泰子、武田裕、堂森丈正、緒方正樹、近藤浩晃、茂山潤鐘、難波太夫、髙橋智、杉浦真人、福富達也、伊藤誠：重症肺高血圧がSLE様症状より先行した１剖検例. Prog Med, 25: 263-267, 2005.