1. Kioi, M., Takahashi, S., Kawakami, M., Kawakami, K., Kreitman, RJ., Puri, RK.: Expression and targeting of interleukin-4 receptor for primary and advanced ovarian cancer therapy. Cancer Res, 65: 8388-8396, 2005.

2. Shirai, T., Kawabe, M., Ichihara, T., Fujiwara, O., Taki, M., Watanabe, S., Wake, K., Yamanaka, Y., Imaida, K., Asamoto, M., Tamano, S.: Chronic exposure to a 1.439 GHz electromagnetic field used for cellular phones does not promote N-ethylnitrosourea induced central nervous system tumors in F344 rats. Bioelectromagnetics, 26: 59-68, 2005.

3. Ichihara, T., Miyashita, K., Kawabe, M., Imaida, K., Asamoto, M., Ogiso, T., Tamano, S., Hirose, M., Shirai, T.: Lack of combination hepatocarcinogenicity of harman, norharman and amitrole when given with NaNO2 in the rat. J Toxicol Sci, 30: 1-6, 2005.

4. Ito, A., Asamoto, M., Hokaiwado, N., Takahashi, S., Shirai, T.: Tbx3 expression is related to apoptosis and cell proliferation in rat bladder both hyperplastic epithelial cells and carcinoma cells. Cancer Lett, 219: 105-112, 2005.

5. Ozaki, M., Ozaki, K., Watanabe, T., Uwagawa, S., Okuno, Y., Shirai, T.: Susceptibilities of p53 knockout and rasH2 transgenic mice to urethane-induced lung carcinogenesis are inherited from their original strains. Toxicol Pathol, 33: 267-271, 2005.

6. Ichihara, T., Tamano, S., Yoshino, H., Imaida, K., Ishikawa, H., Kakizoe, T., Shirai, T.: Lack of chemoprevention or promotion effects of docosahexaenoic acid on small intestine, colon, liver, lung, thyroid, esophagus, kidney, and forestomach carcinogenesis in a rat medium-term multi-organ carcinogenesis model. J Toxicol Pathol, 18: 53-59, 2005.

7. Ichihara, T., Imai, N., Toda, Y., Hagiwara, A., Tamano, S., Shirai, T.: Evidence of a threshold dose for promotion of hepatocarcinogenesis by hexachlorobenzene in a rat medium-term liver bioassay. J Toxicol Pathol, 18: 7-11, 2005.

8. Yamashita, S., Suzuki, S., Nomoto, T., Kondo, Y., Wakazono, K., Tsujino, Y., Sugimura, T., Shirai, T., Homma, Y., Ushijima, T.: Linkage and microarray analyses of susceptibility genes in ACI/Seg rats: a model for prostate cancers in the aged. Cancer Res., 65: 2610-2616, 2005.

9. Lynch, CC., Hikosaka, A., Acuff, HB., Martin, MD., Kawai, N., Singh, RK., Vargo-Gogola, TC., Begtrup, JL., Peterson, TE., Fingleton, B., Shirai, T., Matrisian, LM., Futakuchi, M.: MMP-7 promotes prostate cancer-induced osteolysis via the solubilization of RANKL. Cancer Cell, 7: 485-496, 2005.

10. Ogawa, K., Asamoto, M., Suzuki, S., Tsujimura, K., Shirai, T.: Downregulation of apoptosis revealed by laser microdissection and cDNA microarray analysis of related genes in rat liver preneoplastic lesions. Med Mol Morphol, 38: 23-29, 2005.

11. Yamada, T., Kuno, A., Ogawa, K., Tang, M., Masuda, K., Nakamura, S., Ando, T., Okamoto, T., Ohara, H., Nomura, T., Joh, T., Shirai, T., Itoh, M.: Combination therapy with an angiotensin-converting enzyme inhibitor and an angiotensin II receptor blocker synergistically suppresses chronic pancreatitis in rats. J Pharmacol Exp Ther, 313: 36-45, 2005.

12. Fukushima, S., Wanibuchi, H., Morimura, K., Nakae, D., Tsuda, H., Imaida, K., Shirai, T., Tatematsu, M., Tsukamoto, T., Hirose, M., Furukawa, F.: Lack of potential of low dose N-nitrosodimethylamine to induce preneoplastic lesions, glutathione S-transferase placental form-positive foci, in rat liver. Cancer Lett, 222: 11-15, 2005.

13. Kawabe, M., Ichihara, T., Sano, M., Hagiwara, A., Tamano, S., Ogawa, K., Shirai, T.: Lack of carcinogenicity of silicone resin (KS66) in F344 rats. Fd Chem Toxicol, 43: 1065-1071, 2005.

14. Sugiura, S., Asamoto, M., Hokaiwado, N., Hirose, M., Shirai, T.: Harman and norharman suppressed but NaNO2 enhanced the development of preneoplastic liver cell foci in 2-amino-3,8-dimethylimidazo- [4,5-f]quinoxaline (MeIQx)-treated rats. J Toxicol Pathol, 18: 99-104, 2005.

15. Ikeda, Y., Cho, YM., Takahashi, S., Tang, M., Asamoto, M., Ogawa, K., Shirai, T.: Equivocal impact of transplacental and lactational exposure to a food-derived carcinogen, 2-amino-1-methyl-6-phenylimidazo- [4,5-b]pyridine, on prostate and colon lesion development in F344 rats. Cancer Lett, 224: 23-30, 2005.

16. Nabae, K., Ichihara, T., Hagiwara, A., Hirota, T., Toda, Y., Tamano, S., Nishino, M., Ogasawara, T., Sasaki, Y., Nakamura, M., Shirai, T.: A 90-day oral toxicity study of beta-carotene derived from Blakeslea trispora, a natural food colorant, in F344 rats. Fd Chem Toxicol, 43: 1127-1133, 2005.

17. Kandori, H., Suzuki, S., Asamoto, M., Murasaki, T., Tang, M., Ogawa, K., Shirai, T.: Influence of atrazine administration and reduction of calorie intake on prostate carcinogenesis in probasin/SV40 T antigen transgenic rats. Cancer Sci, 96: 221-226, 2005.

18. Okamoto, T., Yamada, T., Kuno, A., Ogawa, K., Tang, M., Sano, H., Ohara, H., Nakao, H., Kataoka, H., Shirai, T., Itoh, M.: FTY720, an immunosuppressant, attenuates chronic pancreatitis in rats by suppressing T-cell infiltration. Pancreas, 30: e64-e70, 2005.

19. Kawai, N., Ito, A., Nakahara, Y., Futakuchi, M., Shirai, T., Honda, H., Kobayashi, T., Kohri, K.: Anticancer effect of hyperthermia on prostate cancer mediated by magnetite cationic liposomes and immune-response induction in transplanted syngeneic rats. Prostate, 64: 373-381, 2005.

20. Hagiwara, A., Yoshino, H., Sano, M., Kawabe, M., Tamano, S., Sakaue, K., Nakamura, M., Tada, M., Imaida, K., Shirai, T.: Thirteen-week feeding study of thaumatin (a natural proteinaceous sweetener), sterilized by electron beam irradiation, in Sprague-Dawley rats. Fd Chem Toxicol, 43: 1297-1302, 2005.

21. Zhao, L., Futakuchi, M., Suzuki, S., Ohhara, Y., Hashimoto, T., Suzuki, T., Manabe, T., Shirai, T.: Kinetics of marked development of lung metastasis of rat prostatic carcinomas transplanted in syngeneic rats. Clin Exp Metastasis, 22: 309-318, 2005.

22. Kuribayashi, M., Wang, J., Fujiwara, O., Doi, Y., Nabae, K., Tamano, S., Ogiso, T., Asamoto, M., Shirai, T.: Lack of effects of 1439 MHz electromagnetic near field exposure on the blood-brain barrier in immature and young rats. Bioelectromagnetics, 26: 578-588, 2005.

23. Yoshino, H., Futakuchi, M., Cho, YM., Ogawa, K., Takeshita, F., Imai, N., Tamano, S., Shirai, T.: Modification of an in vivo lung metastasis model of hepatocellular carcinoma by low dose N-nitrosomorpholine and diethylnitrosamine. Clin Exp Metastasis, 22: 441-447, 2005.

24. Yoshino, H., Imai, N., Nabae, K., Doi, Y., Tamano, S., Ogawa, K., Shirai, T.: Thirteen-week oral toxicity study of dokudami extract (Houttuynia Cordata Thunb.) in F344/DuCrj rats. J Toxicol Pathol, 18: 175-182, 2005.

25. Yoshino, H., Nabae, K., Doi, Y., Ichihara, T., Tamano, S., Suzuki, S., Shirai, T.: Lack of effects of gestational and lactational exposure to 4-nonylphenol on PhIP-induced rat prostate carcinogenesis. J Toxicol Pathol, 18: 183-188, 2005.

26. Hokaiwado, N., Asamoto, M., Ogawa, K., Shirai, T.: Transgenic disruption of gap junctional intercellular communication enhances early but not late stage hepatocarcinogenesis in the rat. Toxicol Pathol, 33: 695-701, 2005.

27. Asamoto, M., Hokaiwado, N., Shirai, T.: Transgenic disruption of gap junctional intercellular communication protects against hepatotoxicity while increasing susceptibility to liver carcinogenesis in rats. In: Tanaka, T. and Tsuda, H. eds., Carcinogenesis and Modification of Carcinogenesis. pp1-7, Research Signpost, Kerala, 2005.

28. Ogawa, K., Sugiura, S., Hirose, M., Shirai, T.: Promotion / carcinogenic effects of phenylethyl isothiocyanate, an established chemopreventive agent, in rat and mouse urinary bladder. In: Tanaka, T. and Tsuda, H. eds., Carcinogenesis and Modification of Carcinogenesis. pp253-266, Research Signpost, Kerala, 2005.