1. Ito, N., Tamano, S., Shirai, T.: A medium-term rat liver bioassay for rapid in vivo detection of carcinogenic potential of chemicals. Cancer Sci. 94: 3-8, 2003.

2. Neal, GE., Judah, DJ., Hard, GG., Ito, N.: Differences in ethoxyquin nephrotoxicity between male and female F344 rats. Fd Chem Toxicol, 41: 193-200, 2003.

3. Takahashi, S., Suzuki, S., Inaguma, S., Ikeda, Y., Cho, YM., Hayashi, N., Inoue, T., Sugimura, Y., Nishiyama, N., Fujita, T., Chao, J., Ushijima, T., Shirai, T.: Down-regulated expression of prostasin in high-grade or hormone-refractory human prostate cancers. Prostate. 54: 187-193, 2003.

4. Cho, YM., Takahashi, S., Asamoto, M., Suzuki, S., Inaguma, S., Hokaiwado, N., Shirai, T.: Age-dependent histopathological findings in the prostate of probasin/SV40 T antigen transgenic rats: Lack of influence of carcinogen or testosterone treatment. Cancer Sci, 94: 153-157, 2003.

5. Fukushima, S., Wanibuchi, H., Morimura, K., Wei, M., Kanae, D., Konishi, Y., Tsuda, H., Takasuka, N., Imaida, K., Shirai, T., Tatematsu, M., Tsukamoto, T., Hirose, M., Furukawa, F.: Lack of initiation activity in rat liver of low doses of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline. Cancer Lett, 191: 35-40, 2003.

6. Suzuki, T., Mizuo, K., Nakazawa, H., Funae, Y., Fushiki, S., Fukushima, S., Shirai, T., Narita, M.: Prenatal and neonatal exposure to bisphenol-A enhances the central dopamine D1 receptor-mediated action in mice: Enhancement of the methamphetamine-induced abuse state. Neuroscience, 117: 639-644, 2003.

7. Zhu, J., Chang, P., Bondy, ML., Sahin, AA., Singletary, SE., Takahashi, S., Shirai, T., Li, D.: Detection of 2-amino-1-methyl-6-phenylimidazo[4,5-b]-pyridine-DNA adducts in normal breast tissues and risk of breast cancer. Cancer Epidemiol Biomarkers Prev, 12: 830-837, 2003.

8. Sugiura, S., Ogawa, K., Hirose, M., Takeshita, F., Asamoto, M., Shirai, T.: Reversibility of proliferative lesions and induction of non-papillary tumors in rat urinary bladder treated with phenylethyl isothiocyanate. Carcinogenesis, 24: 547-553, 2003.

9. Takeshita, F., Ogawa, K., Asamoto, M., Shirai, T.: Mechanistic approach of contrasting modifying effects of caffeine on carcinogenesis in the rat colon and mammary gland induced with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. Cancer Lett, 194: 25-35, 2003.

10. Ito, A., Asamoto, M., Hokaiwado, N., Shirai, T.: Regulation of cell proliferation by induction of p21/WAF1 in rat bladder carcinoma cells using the Cre-loxP system. Cancer Lett, 193: 183-188, 2003.

11. Kuno, A., Yamada, T., Masuda, K., Ogawa, K., Sogawa, M., Nakamura, S., Nakazawa, T., Ohara, H., Nomura, T., Joh, T., Shirai, T., Itoh, M.: Angiotensin-converting enzyme inhibitor attenuates pancreatic inflammation and fibrosis in male Wistar Bonn/Kobori rats. Gastroenterology, 124: 1010-1019, 2003.

12. Cheng, JL., Futakuchi, M., Ogawa, K., Iwata, T., Kasai, M., Tokudome, S., Hirose, M., Shirai, T.: Dose response study of conjugated fatty acid derived from safflower oil on mammary and colon carcinogenesis pretreated with 7,12-dimethylbenz[a]anthracene (DMBA) and 1,2-dimethylhydrazine (DMH) in female Sprague-Dawley rats. Cancer Lett, 196: 161-168, 2003.

13. Cheng, J., Ogawa, K., Kuriki, K., Yokoyama, Y., Kamiya, T., Seno, K., Okuyama, H., Wang, J., Luo, C., Fujii, T., Ichikawa, H., Shirai, T., Tokudome, S.: Increased intake of n-3 polyunsaturated fatty acids elevates the level of apoptosis in the normal sigmoid colon of patients polypectomized for adenomas/tumors. Cancer Lett, 193: 17-24, 2003.

14. Hagiwara, A., Imai, N., Ichihara, T., Sano, M., Tamano, S., Aoki, H., Yasuhara, K., Koda, T., Nakamura, M., Shirai, T.: A thirteen-week oral toxicity study of annatto extract (norbixin), a natural food color extracted from the seed coat of annatto (Bixa orellana L.), in Sprague-Dawley rats. Fd Chem Toxicol, 41: 1157-1164, 2003.

15. Akagi, K., Sano, M., Ogawa, K., Hirose, M., Goshima, H., Shirai, T.: Involvement of toxicity as an early event in urinary bladder carcinogenesis induced by phenethyl isothiocyanate, benzyl isothiocyanate, and analogues in F344 rats. Toxicol Pathol, 31: 388-396, 2003.

16. Ichihara, T., Yoshino, H., Imai, N., Tsutsumi, T., Kawabe, M., Tamano, S., Inaguma, S., Suzuki, S., Shirai, T.: Lack of carcinogenic risk in the prostate with transplacental and lactational exposure to bisphenol A in rats. J Toxicol Sci, 28: 165-171, 2003.

17. Kato, T., Miyamoto, M., Date, T., Yasui, K., Taya, C., Yonekawa, H., Ohue, C., Yagi, S., Seki, E., Hirano, T., Fujimoto, J., Shirai, T., Wakita, T.: Repeated hepatocyte injury promotes hepatic tumorigenesis in hepatitis C virus transgenic mice. Cancer Sci. 94: 679-685, 2003.

18. Hagiwara, A., Imai, N., Doi, Y., Nabae, K., Hirota, T., Yoshino, H., Kawabe, M., Tsushima, Y., Aoki, H., Yasuhara, K., Koda, T., Nakamura, M., Shirai, T.: Absence of liver tumor promoting effects of annatto extract (norbixin), a natural carotenoid food color, in a medium-term liver carcinogenesis bioassay using male F344 rats. Cancer Lett. 199: 9-17, 2003.

19. Inaguma, S., Takahashi, S., Ohnishi, H., Suzuki, S., Cho, YM., Shirai, T.: High susceptibility of the ACI and spontaneously hypertensive rat (SHR) strains to 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) prostate carcinogenesis. Cancer Sci., 94: 974-979, 2003.

20. Yoshida, M., Shimomoto, T., Katashima, S., Shirai, T., Nakae, D., Watanabe, G., Taya, K., Maekawa, A.: Effects of maternal exposure to nonylphenol on growth and development of the female reproductive system and uterine carcinogenesis in rats. J Toxicol Pathol, 16: 259-266, 2003.

21. Hokaiwado, N., Asamoto, M., Cho, YM., Tsuda, H., Shirai, T.: Lack of effect of human c-Ha-ras proto-oncogene overexpression on prostate carcinogenesis in probasin/SV40 T antigen transgenic rats. Cancer Sci, 94: 1042-1045, 2003.

22. Yamada, T., Kuno, A., Masuda, K., Ogawa, K., Sogawa, M., Nakamura, S., Ando, T., Sano, H., Nakazawa, T., Ohara, H., Nomura, T., Joh, T., Itoh, M.: Candesartan, an angiotensin II receptor antagonist, suppresses pancreatic inflammation and fibrosis in rats. J Pharmacol Exp Ther, 307: 17-23, 2003.

23. Hagiwara, A., Sano, M., Ichihara, T., Yoshino, H., Miyata, E., Tamano, S., Aoki, H., Yukawa, C., Koda, T., Nakamura, M., Shirai, T.: Four-week oral toxicity study of 1-carboxy-5,7-dibromo-6-hydroxy-2,3,4- trichloroxanthone (HXCA), an impurity of Phloxine B, in F344 rats. J Toxicol Sci, 28: 445-453, 2003.

24. Nakamura, S., Yamada, T., Hashimoto, T., Takahashi, S., Sogawa, M., Ohara, H., Nakazawa, T., Sano, H., Kuno, A., Joh, T., Nomura, T., Arakawa, T., Itoh, M.: Estradiol alleviates acinar cell apoptosis and chronic pancreatitis in male Wistar Bonn/Kobori rats. Pancreas, 26:e59-e66, 2003.

25. Hasegawa, C., Yamada, T., Ohara, H., Nakazawa, T., Sano, H., Ando, H., Kunimatsu, M., Ozaki, Y., Takahashi, S., Nomura, T., Joh, T., Itoh, M.: Taurochenodeoxycholic acid-induced biphasic hepatotoxicity in isolated perfused rat liver: Roles of Ca2+ and calpain. Hepatogastroenterology, 50: 972-978, 2003.

26. Yamada, T., Takahashi, S., Masuda, K., Ohara, H., Nakazawa, T., Sano, H., Ando, T., Nakamura, S., Kobayashi, S., Kuno, A., Aoki, S., Nomura, T., Joh, T., Itoh, M.: Kupffer cell depletion attenuates colonic and extracolonic granulomatous inflammation in chronic colitis. J Lab Clin Med, 142: 268-277, 2003.

27. Shirai, T., Asamoto, M.: Application of toxicogenomics to the endocrine disruption issue. Pure Appl Chem, 75: 2419-2422, 2003.

28. Imaida, K., Tamano, S., Hagiwara, A., Fukushima, S., Shirai, T., Ito, N.: Application of rat medium-term bioassays for detecting carcinogenic and modifying potentials of endocrine active substances. Pure Appl Chem, 75: 2491-2495, 2003.