1. Ogawa, K., Kimoto, N., Asamoto, M., Nakanishi, M., Takahashi, S., Shirai, T.: Aberrant expression of p27Kip1 is associated with malignant transformation of the rat urinary bladder epithelium. Carcinogenesis, 21: 117-121, 2000.

2. Zhang, R., Suzuki, T., Takahashi, S., Yoshida, A., Kawaguchi, H., Maruyama, H., Yabu, Y., Fu, J., Shirai, T., Ohta, N.: Cloning and molecular characterization of calpain, a calcium-activated neutral proteinase, from different strains of Schistosoma japonicum. Parasitol Int, 48: 233-242, 2000.

3. Cui, L., Takahashi, S., Tada, M., Kato, K., Yamada, Y., Kohri, K., Shirai, T.: Immunohistochemical detection of carcinogen-DNA adducts in normal human prostate tissues transplanted into the subcutis of athymic nude mice: Results with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and 3,2′-dimethyl-4-aminobiphenyl (DMAB) and relation to cytochrome P450s and N-acetyltransferase activity. Jpn J Cancer Res, 91: 52-58, 2000.

4. Imaida, K., Ogawa, K., Takahashi, S., Ito, T., Yamaguchi, T., Totsuka, Y., Wakabayashi, K., Tanaka, K., Ito, N., Shirai, T.: Delay of DNA-adduct repair and severe toxicity in xeroderma pigmentosum group A gene (XPA) deficient mice treated with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Cancer Lett, 150: 63-69, 2000.

5. Yaono, M., Tamano, S., Mori, T., Kato, K., Imaida, K., Asamoto, M., Shirai, T.: Lobe specific effects of testosterone and estrogen on 3,2′-dimethyl-4-aminobiphenyl-induced rat prostate carcinogenesis. Cancer Lett, 150: 33-40, 2000.

6. Takahashi, S., Ikeda, Y., Kimoto, N., Okochi, E., Cui, L., Nagao, M., Ushijima, T., Shirai, T.: Mutation induction by mechanical irritation caused by uracil-induced urolithiasis in Big Blue rats. Mutat Res, 447: 275-280, 2000.

7. Maruyama, H., Osada, Y., Yoshida, A., Futakuchi, M., Kawaguchi, H., Zhang, R., Fu, J., Shirai, T., Kojima, S., Ohta, N.: Protective mechanisms against the intestinal nematode Strongyloides venezuelensis in Schistosoma japonicum-infected mice. Parasite Immunol, 22: 279-286, 2000.

8. Ito, N., Imaida, K., Asamoto, M., Shirai, T.: Early detection of carcinogenic substances and modifiers in rats. Mutat Res, 462: 209-217, 2000.

9. Shirai, T., Takahashi, S., Cui, L., Futakuchi, M., Kato, K., Tamano, S., Imaida, K.: Experimental prostate carcinogenesis—rodent models. Mutat Res, 462: 219-226, 2000.

10. Imaida, K., Hagiwara, A., Yoshino, H., Tamano, S., Sano, M., Futakuchi, M., Ogawa, K., Asamoto, M., Shirai, T.: Inhibitory effects of low doses of melatonin on induction of preneoplastic liver lesions in a medium-term liver bioassay in F344 rats: relation to the influence of electromagnetic near field exposure. Cancer Lett, 155: 105-114, 2000.

11. Archer, CL., Morse, P., Jones, RF., Shirai, T., Haas, GP., Wang, CY.: Carcinogenicity of the N-hydroxy derivative of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, 2-amino-3,8-dimethylimidazo[4,5-f]- quinoxaline and 3,2′-dimethyl-4-aminobiphenyl in the rat. Cancer Lett, 155: 55-60, 2000.

12. Hirose, M., Yamaguchi, T., Cui, L., Kimoto, N., Futakuchi, M., Kono, T., Nishibe, S., Shirai, T.: Effects of arctiin on PhIP-induced mammary, colon and pancreatic carcinogenesis in female Sprague-Dawley rats and MeIQx-induced hepatocarcinogenesis in male F344 rats. Cancer Lett, 155: 79-88, 2000.

13. Kato, K., Takahashi, S., Cui, L., Toda, T., Suzuki, S., Futakuchi, M., Sugiura, S., Shirai, T.: Suppressive effects of dietary genistin and daidzin on rat prostate carcinogenesis. Jpn J Cancer Res, 91: 786-791, 2000.

14. Takahashi, S., Ikeda, Y., Orita, S., Sakakibara, M., Kimoto, N., Suzuki, S., Imaida, K., Shirai, T.: Enhancing effects of 2-amino-4,5-diphenylthiazole-induced polycystic kidneys on renal carcinogenesis in rats treated with dimethylnitrosamine. Toxicol Appl Pharmacol, 167: 12-17, 2000.

15. Akaza, H., Tsukamoto, S., Morita, T., Yamauchi, A., Onozawa, M., Shimazui, T., Ideyama, Y., Shirai, T.: Promoting effects of antiandrogenic agents on rat ventral prostate carcinogenesis induced by 3,2′-dimethyl-4-aminobiphenyl (DMAB). Prostate Cancer Prostatic Dis, 3: 115-119, 2000.

16. Tiwawech, D., Hirose, M., Futakuchi, M., Cui, L., Thamavit, W., Ito, N., Shirai, T.: Enhancing effects of Thai edible plants on 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline-hepatocarcinogenesis in a rat medium-term bioassay. Cancer Lett, 158: 195-201, 2000.

17. Cohen, S.M., Shirai, T., Steineck, G.: Epidemiology and etiology of premalignant and malignant urothelial changes. Scand J Urol Nephrol Suppl, 205: 105-115, 2000.

18. Kawabe, M., Cui, L., Kimoto, N., Sano, M., Hirose, M., Shirai, T.: Modifying effects of propolis on MeIQx promotion of rat hepatocarcinogenesis and in a female rat two-stage carcinogenesis model after multiple carcinogen initiation. Nutr Cancer, 37: 179-186, 2000.

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