1. Iwasaki, S., Kato, K., Mori, T., Takahashi, S., Futakuchi, M., Shirai, T.: Development of androgen-independent carcinomas from androgen-dependent preneoplastic lesions in the male accessory sex organs of rats treated with 3,2′-dimethyl-4-aminobiphenyl and testosterone propionate. Jpn J Cancer Res, 90: 23-30, 1999.

2. Moore, MA., Tsuda, H., Tamano, S., Hagiwara, A., Imaida, K., Shirai, T., Ito, N.: Marriage of a medium-term liver model to surrogate markers — a practical approach for risk and benefit assessment. Toxicol Pathol, 27: 237-242, 1999.

3. Hagiwara, A., Murai, T., Yoshino, H., Goshima, H., Mori, S., Takashima, A., Shirai, T., Fukushima, S.: Hepatocarcinogenic activity of N-butyl-N-(4-hydroxybutyl)nitrosamine in rats is not modified by sodium L-ascorbate. Teratog Carcinog Mutagen, 19: 33-42, 1999.

4. Hagiwara, A., Boonyaphiphat, P., Tanaka, H., Kawabe, M., Tamano, S., Kaneko, H., Matsui, M., Hirose, M., Ito, N., Shirai, T.: Organ-dependent modifying effects of caffeine, and two naturally occurring antioxidants -tocopherol and n-tritriacontane-16,18-dione, on 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)- induced mammary and colonic carcinogenesis in female F344 rats. Jpn J Cancer Res, 90: 399-405, 1999.

5. Ogawa, K., Tsuda, H., Shirai, T., Ogiso, T., Wakabayashi, K., Dalgard, DW., Thorgeirsson, UP., Thorgeirsson, SS., Adamson, RH., Sugimura, T.: Lack of carcinogenicity of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in cynomolgus monkeys. Jpn J Cancer Res, 90: 622-628, 1999.

6. Hirose, M., Hakoi, K., Takahashi, S., Hoshiya, T., Akagi, K., Cui, L., Saito, K., Kaneko, H., Shirai, T.: Sequential morphological and biological changes in the glandular stomach induced by oral administration of catechol to male F344 rats. Toxicol Pathol, 27: 448-455, 1999.

7. Sano, M., Hagiwara, A., Tamano, S., Hasegawa, R., Imaida, K., Ito, N., Shirai, T.: Dose-dependent induction of carcinomas and glutathione S-transferase placental form negative eosinophilic foci in the rat liver by di(2-ethylhexyl)phthalate after diethylnitrosamine initiation. J Toxicol Sci, 24: 177-186, 1999.

8. Kimura, S., Kawabe, M., Ward, JM., Morishima, H., Kadlubar, FF., Hammons, GJ., Fernandez-Salguero, P., Gonzalez, FJ.: CYP1A2 is not the primary enzyme responsible for 4-aminobiphenyl-induced hepatocarcinogenesis in mice. Carcinogenesis, 20: 1825-1830, 1999.

9. Richie, JP., Bono, A., Denis, LJ., Jewett, MA., Kakizoe, T., Kotake, T., Shirai, T., Ten Kate, FJ.: Tumor, nodes, metastasis (TNM) classification of bladder cancer., Urol Oncol, 4: 90-93, 1998.

10. Shirai, T.: Commentary: Oncosis and apoptosis: Two faces of necrosis in a new proposal to clear up the confusion regarding cell death. Toxicol Pathol, 27: 495-496, 1999.

11. Shirai, T., Cui, L., Takahashi, S., Futakuchi, M., Asamoto, M., Kato, K., Ito, N.: Carcinogenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in the rat prostate and induction of invasive carcinomas by subsequent treatment with testosterone propionate. Cancer Lett, 143: 217-221, 1999.

12. Hirose, M., Takahashi, S., Ogawa, K., Futakuchi, M., Shirai, T., Shibutani, M., Uneyama, C., Toyoda, K., Iwata, H.: Chemoprevention of heterocyclic amine-induced carcinogenesis by phenolic compounds in rats. Cancer Lett, 143: 173-178, 1999.

13. Okochi, E., Watanabe, N., Shimada, Y., Takahashi, S., Wakazono, K., Shirai, T., Sugimura, T., Nagao, M., Ushijima, T.: Preferential induction of guanine deletion at 5′-GGGA-3′ in rat mammary glands by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. Carcinogenesis, 20: 1933-1938, 1999.

14. Futakuchi, M., Hirose, M., Ogiso, T., Kato, K., Sano, M., Ogawa, K., Shirai, T.: Establishment of an in vivo highly metastatic rat hepatocellular carcinoma model. Jpn J Cancer Res, 90: 1196-1202, 1999.

15. Ikeda, Y., Takahashi, S., Kimura, J., Cho, YM., Imaida, K., Shirai, S., Shirai, T.: Anophthalmia in litters of female rats treated with the food-derived carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. Toxicol Pathol, 27: 628-631, 1999.

16. Hirose, M., Fukushima, S., Imaida, K., Ito, N., Shirai, T.: Modifying effects of phytic acid and gamma-oryzanol on the promotion stage of rat carcinogenesis. Anticancer Res, 19: 3665-3670, 1999.

17. Ogawa, K., St. John, M., de Oliveira, ML., Arnold, L., Shirai, T., Sun, TT., Cohen, SM.: Comparison of uroplakin expression during urothelial carcinogenesis induced by N-butyl-N-(4-hydroxybutyl)nitrosamine in rats and mice. Toxicol Pathol, 27: 645-651, 1999.

18. Hirose, M., Takahashi, S., Ogawa, K., Futakuchi, M., Shirai, T.: Phenolics: Blocking agents for heterocyclic amine-induced carcinogenesis. Fd Chem Toxicol, 37: 985-992, 1999.

19. Ogawa, K., Johansson, SL., Cohen, SM.: Immunohistochemical analysis of uroplakins, urothelial specific proteins, in ovarian Brenner tumors, normal tissues, and benign and neoplastic lesions of the female genital tract. Am J Pathol, 155: 1047-1050, 1999.

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21. Hirose, M., Ito, N.: Forestomach and glandular stomach carcinogenesis. In: Kitchin, KT. (ed.) Carcinogenicity — Testing, predicting, and interpreting chemical effects. pp467-497. Marcel Dekker, Inc., New York, 1999.

22. Thamavit, W., Shirai, T., Ito, N.: Liver flukes and biliary cancer. In: Parsonnet, J. (ed.) Microbes and malignancy — Infection as a cause of human cancers. pp346-371. Oxford University Press, New York, Oxford, 1999.