1. Shirai, T., Sano, M., Tamano, S., Takahashi, S., Hirose, M., Futakuchi, M., Hasegawa, R., Imaida, K., Matsumoto, K., Wakabayashi, K., Sugimura, T., Ito, N.: The prostate: A target for carcinogenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) derived from cooked foods. Cancer Res, 57: 195-198, 1997.

2. Masui, T., Nakanishi, H., Inada, K., Imai, T., Mizoguchi, Y., Yada, H., Futakuchi, M., Shirai, T., Tatematsu, M.: Highly metastatic hepatocellular carcinomas induced in male F344 rats treated with N-nitrosomorpholine in combination with other hepatocarcinogens show a high incidence of p53 gene mutations along with altered mRNA expression of tumor-related genes. Cancer Lett, 112: 33-45, 1997.

3. Hirose, M., Mizoguchi, Y., Yaono, M., Tanaka, H., Yamaguchi, T., Shirai, T.: Effects of green tea catechins on the progression or late promotion stage of mammary gland carcinogenesis in female Sprague-Dawley rats pretreated with 7,12-dimethylbenz(a)anthracene. Cancer Lett, 112: 141-147, 1997.

4. Kim, DJ., Han, BS., Ahn, B., Hasegawa, R., Shirai, T., Ito, N., Tsuda, H.: Enhancement by indole-3-carbinol of liver and thyroid gland neoplastic development in a rat medium-term multiorgan carcinogenesis model. Carcinogenesis, 18: 377-381, 1997.

5. Takaba, K., Hirose, M., Yoshida, Y., Kimura, J., Ito, N., Shirai, T.: Effects of n-tritriacontane-16,18-dione, curcumin, chlorophyllin, dihydroguaiaretic acid, tannic acid and phytic acid on the initiation stage in a rat multi-organ carcinogenesis model. Cancer Lett, 113: 39-46, 1997.

6. Asamoto, M., Iwahori, Y., Okamura, T., Shirai, T., Tsuda, H.: Decreased expression of the p16/MTS1 gene without mutation is frequent in human urinary bladder carcinomas. Jpn J Clin Oncol, 27: 22-25, 1997.

7. Saeki, K., Kadoi, M., Kawazoe, Y., Futakuchi, M., Tiwawech, D., Shirai, T.: Modification of the carcinogenic potency of quinoline, a hepatocarcinogen, by fluorine atom substitution: evaluation of carcinogenicity by a medium-term assay. Biol Pharm Bull, 20: 40-43, 1997.

8. Imaida, K., Hasegawa, R., Kato, T., Futakuchi, M., Takahashi, S., Ogawa, K., Asamoto, M., Yamamoto, T., Suzuki, K., Inagaki, T., Shinagawa, N., Shirai, T.: Clinicopathological analysis on cancers of autopsy cases in a geriatric hospital. Pathol Int, 47: 293-300, 1997.

9. Ito, N., Hasegawa, R., Imaida, K., Hirose, M., Shirai, T., Tamano, S., Hagiwara, A.: Medium-term rat liver bioassay for rapid detection of hepatocarcinogenic substances. J Toxicol Pathol, 10: 1-11, 1997.

10. Yada, H., Hasegawa, R., Hirose, M., Shirai, T., Ito, N.: Effects of verapamil on PhIP-induced tumorigenesis in F344 rats. J Toxicol Pathol, 10: 45-49, 1997.

11. Kawabe, M., Shibata, MA., Sano, M., Takesada, Y., Tamano, S., Ito, N., Shirai, T.: Decrease of prostaglandin E2 and 5-bromo-2′-deoxyuridine labeling but not prostate tumor development by indomethacin treatment of rats given 3,2′-dimethyl-4-aminobiphenyl and testosterone propionate. Jpn J Cancer Res, 88: 350-355, 1997.

12. Miyata, E., Kawabe, M., Sano, M., Takesada, Y., Takahashi, S., Shirai, T.: Effects of tamoxifen, an antiestrogen, on rat prostate carcinogenesis by 3,2′-dimethyl-4-aminobiphenyl and testosterone do not support an estrogen role in testosterone promotion. Prostate, 31: 9-13, 1997.

13. Ozaki, M., Shibata, MA., Takahashi, S., Orita, S., Kawabe, M., Shirai, T.: Lack of involvement of p53 gene mutations in N-methyl-N-nitrosourea-induced bladder tumor progression in N-butyl-N-(4-hydroxybutyl)- nitrosamine-treated rats and no suppression by indomethacin. Cancer Lett, 115: 249-255, 1997.

14. Tanaka, H., Hirose, M., Kawabe, M., Sano, M., Takesada, Y., Hagiwara, A., Shirai, T.: Post-initiation inhibitory effects of green tea catechins on 7,12-dimethylbenz[a]anthracene-induced mammary gland carcinogenesis in female Sprague-Dawley rats. Cancer Lett, 116: 47-52, 1997.

15. Ito, N., Hasegawa, R., Imaida, K., Tamano, S., Hagiwara, A., Hirose, M., Shirai, T.: Carcinogenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in the rat. Mutat Res, 376: 107-114, 1997.

16. Shirai, T.: A medium-term rat liver bioassay as a rapid In vivo test for carcinogenic potential: A historical review of model development and summary of results from 291 tests. Toxicol Pathol, 25: 453-460, 1997.

17. Shirai, T.: Society of Toxicologic Pathologists — Japanese Society of Toxicologic Pathology: a long and fruitful partnership. Toxicol Pathol, 25: 668-669, 1997.

18. Hirose, M., Shirai, T., Lee, MS., Wang, CY., King, CM.: Carcinogenicity of the N-acyl derivatives of N-hydroxy-trans-4-aminostilbene in CD rats. Chem Biol Interact, 106: 123-132, 1997.

19. Pfau, W., Schulze, C., Shirai, T., Hasegawa, R., Brockstedt, U.: Identification of the major hepatic DNA adduct formed by the food mutagen 2-amino-9H-pyrido[2,3-b]indole (AαC). Chem Res Toxicol, 10: 1192-1197, 1997.

20. Pfau, W., Brockstedt, U., Shirai, T., Ito, N., Marquardt, H.: Pancreatic DNA adducts formed in vitro and in vivo by the food mutagens 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine(PhIP) and 2-amino-3-methyl- 9H-pyrido[2,3-b]indole (MeAaC). Mutat Res, 378: 13-22, 1997.

21. Hagiwara, A., Kawabe, M., Tanaka, H., Kokubo, Y., Sano, M., Tamano, S., Kadota, T., Nakamura, M., Imaida, K.: Two different constituents of madder colors lack tumor promoting or carcinogenic potential in a medium-term multi-organ carcinogenesis bioassay in rats. Jpn J Fd Chem, 4: 99-106, 1997.

22. Fukushima, S., Takada, N., Takahashi, S., Wanibuchi, H.: Development of medium-term bioassays for detection of chemopreventive agents. In: Ohigashi, H. et al. (eds.), Food factors for cancer prevention. pp88-91, Springer-Verlag Tokyo, Tokyo, 1997.

23. Hirose, M., Hasegawa, R., Futakuchi, M., Tanaka, H., Miki, T., Kaneko, H., Shirai, T.: Prevention of chemically induced rat carcinogenesis by antioxidants: Focus on HTHQ. I In: Ohigashi, H. et al. (eds.), Food factors for cancer prevention. pp82-87, Springer-Verlag Tokyo, Tokyo, 1997.

24. Shirai, T., Takahashi, S., Tamano, S.: Preneoplasia and neoplasia of the rat male genital tract. In: Bannasch, P. & Gössner, W. (eds.), Pathology of Neoplasia and Preneoplasia in Rodents, Vol. 2, pp141-162, Schattauer, Stuttgart, Germany, 1997.