1986

1. Hirose, M., Masuda, A., Kurata, Y., Ikawa, E., Mera, Y., Ito, N.: Histologic and autoradiographic studies on the forestomach of hamsters treated with 2-tert-butylated hydroxyanisole, 3-tert-butylated hydroxyanisole, crude butylated hydroxyanisole, or butylated hydroxytoluene. J Natl Cancer Inst, 76: 143-149, 1986.

2. Fukushima, S., Thamavit, W., Kurata, Y., Ito, N.: Sodium citrate: A promoter of bladder carcinogenesis. Jpn J Cancer Res (Gann), 77: 1-4, 1986.

3. Moore, MA., Thamavit, W., Tsuda, H., Sato, K., Ichihara, A., Ito, N.: Modifying influence of dehydroepiandrosterone on the development of dihydroxy-di-n-propylnitrosamine-initiated lesions in the thyroid, lung and liver of F344 rats. Carcinogenesis, 7: 311-316, 1986.

4. Moore, MA., Tsuda, H., Ito, N.: Dehydrogenase histochemistry of N-ethyl-N-hydroxyethylnitrosamine- induced focal liver lesions in the rat — increase in NADPH-generating capacity. Carcinogenesis, 7: 339-342, 1986.

5. Moore, MA., Nakamura, T., Shirai, T., Ichihara, A., Ito, N.: Immunohistochemical demonstration of increased glucose-6-phosphate dehydrogenase in preneoplastic and neoplastic lesions induced by propylnitrosamines in F344 rats and syrian hamsters. Jpn J Cancer Res (Gann), 77: 131-138, 1986.

6. Moore, MA., Thamavit, W., Tsuda, H., Ito, N.: The influence of subsequent dehydroepiandrosterone, diaminopropane, phenobarbital, butylated hydroxyanisole and butylated hydroxytoluene treatment on the development of preneoplastic and neoplastic lesions in the rat initiated with di-hydroxy-di-N-propyl nitrosamine. Cancer Lett, 30: 153-160, 1986.

7. Hirose, M., Hagiwara, A., Masui, T., Inoue, K., Ito, N.: Combined effects of butylated hydroxyanisole and other antioxidants in induction of forestomach lesions in rats. Cancer Lett, 30: 169-174, 1986.

8. Masui, T., Tsuda, H., Inoue, K., Ogiso, T., Ito, N.: Inhibitory effects of ethoxyquin, 4,4′-diaminodiphenylmethane and acetaminophen on rat hepatocarcinogenesis. Jpn J Cancer Res (Gann), 77: 231-237, 1986.

9. Tatematsu, M., Furihata, C., Mera, Y., Shirai, T., Matsushima, T., Ito, N.: Immunohistochemical demonstration of induction of pyloric glands with low pepsinogen 1 (Pg 1) content in rat stomach by N-methyl-N’-nitro-N-nitrosoguanidine. Jpn J Cancer Res (Gann), 77: 238-243, 1986.

10. Nishio, Y., Kakizoe, T., Ohtani, M., Sato, S., Sugimura, T., Fukushima, S.: L-isoleucine and L-leucine: Tumor promoters of bladder cancer in rats. Science, 231: 843-845, 1986.

11. Ikawa, E., Tsuda, H., Sakata, T., Masui, T., Satoh, K., Sato, K., Ito, N.: Modification potentials of ethyl alcohol and acetaldehyde on development of preneoplastic gultathione S-transferase p-form-positive liver cell foci initiated by diethylnitrosamine in the rat. Cancer Lett, 31: 53-60, 1986.

12. Fukushima, S., Shibata, MA., Shirai, T., Tamano, S., Ito, N.: Roles of urinary sodium ion concentration and pH in promotion by ascorbic acid of urinary bladder carcinogenesis in rats. Cancer Res, 46: 1623-1626, 1986.

13. Ohtani, M., Kakizoe, T., Nishio, Y., Sato, S., Sugimura, T., Fukushima, S., Niijima, T.: Sequential changes of mouse bladder epithelium during induction of invasive carcinomas by N-butyl-N-(4-hydroxybutyl)nitrosamine. Cancer Res, 46: 2001-2004, 1986.

14. Shirai, T., Ikawa, E., Fukushima, S., Masui, T., Ito, N.: Uracil-induced urolithiasis and the development of reversible papillomatosis in the urinary bladder of F344 rats. Cancer Res, 46: 2062-2067, 1986.

15. Sato, A., Yonekura, I., Asakawa, M., Nakahara, H., Nakajima, T., Ohta, S., Shirai, T., Ito, N.: Augmentation of ethanol-induced enhancement of dimethylnitrosamine and diethylnitrosamine metabolism by lowered carbohydrate intake. Jpn J Cancer Res (Gann), 77: 125-130, 1986.

16. Moore, MA., Fukushima, S., Ichihara, A., Sato, K., Ito, N.: Intestinal metaplasia and altered enzyme expression in propylnitrosamine-induced syrian hamster cholangiocellular and gallbladder lesions. Virchows Arch [Cell Pathol], 51: 29-38, 1986.

17. Moore, MA., Thamavit, W., Ichihara, A., Sato, K., Ito, N.: Influence of dehydroepiandrosterone, diaminopropane and butylated hydroxyanisole treatment during the induction phase of rat liver nodular lesions in a short-term system. Carcinogenesis, 7: 1059-1063, 1986.

18. Hirose, M., Masuda, A., Inoue, T., Fukushima, S., Ito, N.: Modification by antioxidants and p,p’-diaminodiphenylmethane of 7,12-dimethylbenz[a]anthracene-induced carcinogenesis of the mammary gland and ear duct in CD rats. Carcinogenesis, 7: 1155-1159, 1986.

19. Hirose, M., Inoue, T., Asamoto, M., Tagawa, Y., Ito, N.: Comparison of the effects of 13 phenolic compounds in induction of proliferative lesions of the forestomach and increase in the labeling indices of the glandular stomach and urinary bladder epithelium of
Syrian golden hamsters. Carcinogenesis, 7: 1285-1289, 1986.

20. Moore, MA., Nakamura, T., Thamavit, W., Ichihara, A., Ito, N.: Immunohistochemically demonstrated suppressed expression of tryptophan oxygenase, a marker for liver differentiation, within putative preneoplastic rat liver lesions. Carcinogenesis, 7: 1393-1396, 1986.

21. Hasegawa, R., Tsuda, H., Shirai, T., Kurata, Y., Masuda, A., Ito, N.: Effect of timing of partial hepatectomy on the induction of preneoplastic liver foci in rats given hepatocarcinogens. Cancer Lett, 32: 15-23, 1986.

22. Hirose, M., Thamavit, W., Asamoto, M., Osawa, T., Ito, N.: Inhibition of glutathione S-transferase P type-positive foci development by linolic acid hydroperoxides and their secondary oxidative products in a rat in vivo mid-term test for liver carcinogens. Toxicol Lett, 32: 51-58, 1986.

23. Tsuda, H., Hacker, HJ., Katayama, H., Masui, T., Ito, N., Bannasch, P.: Correlative histochemical studies on preneoplastic and neoplastic lesions in the kidney of rats treated with nitrosamines. Virchows Arch [Cell Pathol], 51: 385-404, 1986.

24. Tatematsu, M., Furihata, C., Katsuyama, T., Miki, K., Honda, H., Konishi, Y., Ito, N.: Gastric and intestinal phenotypic expressions of human signet ring cell carcinomas revealed by their biochemistry, mucin histochemistry, and ultrastructure. Cancer Res, 46: 4866-4872, 1986.

25. Moore, MA., Nakamura, T., Ito, N.: Immunohistochemically demonstrated glucose-6-phosphate dehydrogenase, γ-glutamyl transpeptidase, ornithine decarboxylase and glutathione S-transferase enzymes: absence of direct correlation with cell proliferation in rat liver putative preneoplastic lesions. Carcinogenesis, 7: 1419-1424, 1986.

26. Masui, T., Asamoto, M., Hirose, M., Fukushima, S., Ito, N.: Disappearance of upward proliferation and persistence of downward basal cell proliferation in rat forestomach papillomas induced by butylated hydroxyanisole. Jpn J Cancer Res (Gann), 77: 854-857, 1986.

27. Hasegawa, R., Fukushima, S., Furukawa, F., Takahashi, M., Ito, N.: Aberrant colonic epithelium in the bladder: Report of a case. J Urol, 136: 901-902, 1986.

28. Ito, N., Hirose, M., Fukushima, S., Tsuda, H., Tatematsu, M., Asamoto, M.: Modifying effects of antioxidants on chemical carcinogenesis. Toxicol Pathol, 14: 315-323, 1986.

29. Kurata, Y., Asamoto, M., Hagiwara, A., Masui, T., Fukushima, S.: Promoting effects of various agents in rat urinary bladder carcinogenesis initiated by N-butyl-N-(4-hydroxybutyl)nitrosamine. Cancer Lett, 32: 125-135, 1986.

30. Shibata, MA., Nakanishi, K., Shibata, M., Masui, T., Miyata, Y., Ito, N.: Promoting effect of sodium chloride in 2-stage urinary bladder carcinogenesis in rats initiated by N-butyl-N- (4-hydroxybutyl)nitrosamine. Urol Res, 14: 201-206, 1986.

31. Ohtani, M., Kakizoe, T., Sato, S., Sugimura, T., Fukushima, S.: Strain differences in mice with invasive bladder carcinomas induced by N-butyl-N-(4-hydroxybutyl)nitrosamine. J Cancer Res Clin Oncol, 112: 107-110, 1986.

32. Fukushima, S., Shibata, MA., Kurata, Y., Tamano, S., Masui, T.: Changes in the urine and scanning electron microscopically observed appearance of the rat bladder following treatment with tumor promoters. Jpn J Cancer Res (Gann), 77: 1074-1082, 1986.

33. Masui, T., Hirose, M., Imaida, K., Fukushima, S., Tamano, S., Ito, N.: Sequential changes of the forestomach of F344 rats, Syrian golden hamsters, and B6C3F1 mice treated with butylated hydroxyanisole. Jpn J Cancer Res (Gann), 77: 1083-1090, 1986.

34. Nakamura, TA., Fukushima, S., Ito, N., Takai, Y., Tatemoto, Y., Mori, M.: Histochemical observation of lectin-binding patterns in Paget’s disease. Acta Histochem Cytochem, 19: 451-464, 1986.

35. Tatematsu, M., Mera, Y., Kohda, K., Kawazoe, Y., Ito, N.: Ornithine decarboxylase activity and DNA synthesis in rats after long term treatment with butylated hydroxyanisole, sodium saccharin or phenobarbital. Cancer Lett, 33: 119-124, 1986.

36. Shirai, T., Fukushima, S., Ikawa, E., Tagawa, Y., Ito, N.: Induction of prostate carcinoma in situ at high incidence in F344 rats by a combination of 3,2′-dimethyl-4-aminobiphenyl and ethinyl estradiol. Cancer Res, 46: 6423-6426, 1986.

37. Ito, N., Fukushima, S., Tamano, S., Hirose, M., Hagiwara, A.: Dose response in butylated hydroxyanisole induction of forestomach carcinogenesis in F344 rats. J Natl Cancer Inst, 77: 1261-1265, 1986.

38. Ito, N., Hirose, M., Fukushima, S., Tsuda, H., Shirai, T., Tatematsu, M.: Studies on antioxidants: their carcinogenic and modifying effects on chemical carcinogenesis. Fd Chem Toxicol, 24: 1071-1082, 1986.

39. Hayashi, M., Tsuda, H., Okumura, M., Hirose, M., Ito, N.: Histopathological classification of nephroblastomas in slaughtered swine. J Comp Pathol, 96: 35-46, 1986.

40. Fukushima, S., Shirai, T., Hirose, M., Ito, N.: Significance of L-ascorbic acid and urinary electrolytes in promotion of rat bladder carcinogenesis. In: Hayashi, Y. et al (eds.) Diet, Nutrition and Cancer, pp159-168. Tokyo: Japan Sci Soc Press, Tokyo/VNU Sci Press, Utrecht, 1986.